Q9H898 (ZMAT4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger matrin-type protein 4

Gene names

Name:

ZMAT4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus Potential.
Sequence similarities	Contains 4 matrin-type zinc fingers.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H898-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H898-2)

The sequence of this isoform differs from the canonical sequence as follows:
     117-192: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 229	229	Zinc finger matrin-type protein 4		PRO_0000298916
Regions
	Zinc finger	14 – 44	31	Matrin-type 1
	Zinc finger	72 – 106	35	Matrin-type 2
	Zinc finger	145 – 175	31	Matrin-type 3
	Zinc finger	198 – 228	31	Matrin-type 4
Natural variations
	Alternative sequence	117 – 192	76	Missing in isoform 2.		VSP_027476
	Natural variant	201	1	T → A. Ref.2 Corresponds to variant rs17851751 [ dbSNP | Ensembl ].		VAR_034736

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: DB60004B797EEEFB	FASTA	229	25,833
	10 20 30 40 50 60 MKSSDIDQDL FTDSYCKVCS AQLISESQRV AHYESRKHAS KVRLYYMLHP RDGGCPAKRL 70 80 90 100 110 120 RSENGSDADM VDKNKCCTLC NMSFTSAVVA DSHYQGKIHA KRLKLLLGEK TPLKTTATPL 130 140 150 160 170 180 SPLKPPRMDT APVVASPYQR RDSDRYCGLC AAWFNNPLMA QQHYDGKKHK KNAARVALLE 190 200 210 220 QLGTTLDMGE LRGLRRNYRC TICSVSLNSI EQYHAHLKGS KHQTNLKNK
	Isoform 2 [UniParc]. Checksum: 77BB52CB63E67E92	FASTA	153	17,340
	10 20 30 40 50 60 MKSSDIDQDL FTDSYCKVCS AQLISESQRV AHYESRKHAS KVRLYYMLHP RDGGCPAKRL 70 80 90 100 110 120 RSENGSDADM VDKNKCCTLC NMSFTSAVVA DSHYQGKIHA KRLKLLLGEK TPLKTTGLRR 130 140 150 NYRCTICSVS LNSIEQYHAH LKGSKHQTNL KNK

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Thyroid.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-201. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK023904 mRNA. Translation: BAB14719.1. BC019598 mRNA. Translation: AAH19598.1.
IPI	IPI00002880. IPI00177490.
RefSeq	NP_001129203.1. NM_001135731.1. NP_078921.1. NM_024645.2.
UniGene	Hs.591850.
3D structure databases
ProteinModelPortal	Q9H898.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H898. 4 interactions.
PTM databases
PhosphoSite	Q9H898.
Polymorphism databases
DMDM	74733790.
Proteomic databases
PaxDb	Q9H898.
PRIDE	Q9H898.
Protocols and materials databases
DNASU	79698.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000297737; ENSP00000297737; ENSG00000165061. ENST00000315769; ENSP00000319785; ENSG00000165061.
GeneID	79698.
KEGG	hsa:79698.
UCSC	uc003xnr.3. human. uc003xns.3. human.
Organism-specific databases
CTD	79698.
GeneCards	GC08M040388.
HGNC	HGNC:25844. ZMAT4.
neXtProt	NX_Q9H898.
PharmGKB	PA142670525.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG68898.
HOGENOM	HOG000008682.
HOVERGEN	HBG061007.
InParanoid	Q9H898.
OMA	DSDRYCQ.
OrthoDB	EOG4KWJTM.
Gene expression databases
ArrayExpress	Q9H898.
Bgee	Q9H898.
CleanEx	HS_ZMAT4.
Genevestigator	Q9H898.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR022755. Znf_C2H2_jaz. IPR003604. Znf_U1. [Graphical view]
Pfam	PF12171. zf-C2H2_jaz. 1 hit. [Graphical view]
SMART	SM00355. ZnF_C2H2. 4 hits. SM00451. ZnF_U1. 4 hits. [Graphical view]
PROSITE	PS50171. ZF_MATRIN. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	79698.
NextBio	68996.

Entry information

Entry name

ZMAT4_HUMAN

Accession

Primary (citable) accession number: Q9H898
Secondary accession number(s): Q8WUT8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	March 1, 2001
Last modified:	May 29, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.