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Q9H898

- ZMAT4_HUMAN

UniProt

Q9H898 - ZMAT4_HUMAN

Protein

Zinc finger matrin-type protein 4

Gene

ZMAT4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri14 – 4431Matrin-type 1Add
    BLAST
    Zinc fingeri72 – 10635Matrin-type 2Add
    BLAST
    Zinc fingeri145 – 17531Matrin-type 3Add
    BLAST
    Zinc fingeri198 – 22831Matrin-type 4Add
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. zinc ion binding Source: InterPro

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger matrin-type protein 4
    Gene namesi
    Name:ZMAT4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:25844. ZMAT4.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670525.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 229229Zinc finger matrin-type protein 4PRO_0000298916Add
    BLAST

    Proteomic databases

    PaxDbiQ9H898.
    PRIDEiQ9H898.

    PTM databases

    PhosphoSiteiQ9H898.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H898.
    BgeeiQ9H898.
    CleanExiHS_ZMAT4.
    GenevestigatoriQ9H898.

    Interactioni

    Protein-protein interaction databases

    BioGridi122819. 3 interactions.
    IntActiQ9H898. 5 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H898.
    SMRiQ9H898. Positions 7-105, 142-183, 199-228.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 4 matrin-type zinc fingers.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri14 – 4431Matrin-type 1Add
    BLAST
    Zinc fingeri72 – 10635Matrin-type 2Add
    BLAST
    Zinc fingeri145 – 17531Matrin-type 3Add
    BLAST
    Zinc fingeri198 – 22831Matrin-type 4Add
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG68898.
    HOGENOMiHOG000008682.
    HOVERGENiHBG061007.
    InParanoidiQ9H898.
    OMAiLGEQPAI.
    OrthoDBiEOG7N8ZW8.
    PhylomeDBiQ9H898.
    TreeFamiTF350019.

    Family and domain databases

    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR022755. Znf_C2H2_jaz.
    IPR003604. Znf_U1.
    [Graphical view]
    PfamiPF12171. zf-C2H2_jaz. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 4 hits.
    SM00451. ZnF_U1. 4 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H898-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKSSDIDQDL FTDSYCKVCS AQLISESQRV AHYESRKHAS KVRLYYMLHP    50
    RDGGCPAKRL RSENGSDADM VDKNKCCTLC NMSFTSAVVA DSHYQGKIHA 100
    KRLKLLLGEK TPLKTTATPL SPLKPPRMDT APVVASPYQR RDSDRYCGLC 150
    AAWFNNPLMA QQHYDGKKHK KNAARVALLE QLGTTLDMGE LRGLRRNYRC 200
    TICSVSLNSI EQYHAHLKGS KHQTNLKNK 229
    Length:229
    Mass (Da):25,833
    Last modified:March 1, 2001 - v1
    Checksum:iDB60004B797EEEFB
    GO
    Isoform 2 (identifier: Q9H898-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         117-192: Missing.

    Show »
    Length:153
    Mass (Da):17,340
    Checksum:i77BB52CB63E67E92
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti201 – 2011T → A.1 Publication
    Corresponds to variant rs17851751 [ dbSNP | Ensembl ].
    VAR_034736

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei117 – 19276Missing in isoform 2. 1 PublicationVSP_027476Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK023904 mRNA. Translation: BAB14719.1.
    BC019598 mRNA. Translation: AAH19598.1.
    CCDSiCCDS34885.1. [Q9H898-1]
    CCDS47848.1. [Q9H898-2]
    RefSeqiNP_001129203.1. NM_001135731.1. [Q9H898-2]
    NP_078921.1. NM_024645.2. [Q9H898-1]
    UniGeneiHs.591850.

    Genome annotation databases

    EnsembliENST00000297737; ENSP00000297737; ENSG00000165061. [Q9H898-1]
    ENST00000315769; ENSP00000319785; ENSG00000165061. [Q9H898-2]
    GeneIDi79698.
    KEGGihsa:79698.
    UCSCiuc003xnr.3. human. [Q9H898-1]
    uc003xns.3. human. [Q9H898-2]

    Polymorphism databases

    DMDMi74733790.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK023904 mRNA. Translation: BAB14719.1 .
    BC019598 mRNA. Translation: AAH19598.1 .
    CCDSi CCDS34885.1. [Q9H898-1 ]
    CCDS47848.1. [Q9H898-2 ]
    RefSeqi NP_001129203.1. NM_001135731.1. [Q9H898-2 ]
    NP_078921.1. NM_024645.2. [Q9H898-1 ]
    UniGenei Hs.591850.

    3D structure databases

    ProteinModelPortali Q9H898.
    SMRi Q9H898. Positions 7-105, 142-183, 199-228.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122819. 3 interactions.
    IntActi Q9H898. 5 interactions.

    PTM databases

    PhosphoSitei Q9H898.

    Polymorphism databases

    DMDMi 74733790.

    Proteomic databases

    PaxDbi Q9H898.
    PRIDEi Q9H898.

    Protocols and materials databases

    DNASUi 79698.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000297737 ; ENSP00000297737 ; ENSG00000165061 . [Q9H898-1 ]
    ENST00000315769 ; ENSP00000319785 ; ENSG00000165061 . [Q9H898-2 ]
    GeneIDi 79698.
    KEGGi hsa:79698.
    UCSCi uc003xnr.3. human. [Q9H898-1 ]
    uc003xns.3. human. [Q9H898-2 ]

    Organism-specific databases

    CTDi 79698.
    GeneCardsi GC08M040388.
    HGNCi HGNC:25844. ZMAT4.
    neXtProti NX_Q9H898.
    PharmGKBi PA142670525.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG68898.
    HOGENOMi HOG000008682.
    HOVERGENi HBG061007.
    InParanoidi Q9H898.
    OMAi LGEQPAI.
    OrthoDBi EOG7N8ZW8.
    PhylomeDBi Q9H898.
    TreeFami TF350019.

    Miscellaneous databases

    GenomeRNAii 79698.
    NextBioi 68996.
    PROi Q9H898.

    Gene expression databases

    ArrayExpressi Q9H898.
    Bgeei Q9H898.
    CleanExi HS_ZMAT4.
    Genevestigatori Q9H898.

    Family and domain databases

    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR022755. Znf_C2H2_jaz.
    IPR003604. Znf_U1.
    [Graphical view ]
    Pfami PF12171. zf-C2H2_jaz. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 4 hits.
    SM00451. ZnF_U1. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Thyroid.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-201.
      Tissue: Brain.

    Entry informationi

    Entry nameiZMAT4_HUMAN
    AccessioniPrimary (citable) accession number: Q9H898
    Secondary accession number(s): Q8WUT8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3