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Q9H898

- ZMAT4_HUMAN

UniProt

Q9H898 - ZMAT4_HUMAN

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Protein
Zinc finger matrin-type protein 4
Gene
ZMAT4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri14 – 4431Matrin-type 1
Add
BLAST
Zinc fingeri72 – 10635Matrin-type 2
Add
BLAST
Zinc fingeri145 – 17531Matrin-type 3
Add
BLAST
Zinc fingeri198 – 22831Matrin-type 4
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger matrin-type protein 4
Gene namesi
Name:ZMAT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:25844. ZMAT4.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670525.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Zinc finger matrin-type protein 4
PRO_0000298916Add
BLAST

Proteomic databases

PaxDbiQ9H898.
PRIDEiQ9H898.

PTM databases

PhosphoSiteiQ9H898.

Expressioni

Gene expression databases

ArrayExpressiQ9H898.
BgeeiQ9H898.
CleanExiHS_ZMAT4.
GenevestigatoriQ9H898.

Interactioni

Protein-protein interaction databases

BioGridi122819. 3 interactions.
IntActiQ9H898. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9H898.
SMRiQ9H898. Positions 7-105, 142-183, 199-228.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG68898.
HOGENOMiHOG000008682.
HOVERGENiHBG061007.
InParanoidiQ9H898.
OMAiLGEQPAI.
OrthoDBiEOG7N8ZW8.
PhylomeDBiQ9H898.
TreeFamiTF350019.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR022755. Znf_C2H2_jaz.
IPR003604. Znf_U1.
[Graphical view]
PfamiPF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
SM00451. ZnF_U1. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H898-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKSSDIDQDL FTDSYCKVCS AQLISESQRV AHYESRKHAS KVRLYYMLHP    50
RDGGCPAKRL RSENGSDADM VDKNKCCTLC NMSFTSAVVA DSHYQGKIHA 100
KRLKLLLGEK TPLKTTATPL SPLKPPRMDT APVVASPYQR RDSDRYCGLC 150
AAWFNNPLMA QQHYDGKKHK KNAARVALLE QLGTTLDMGE LRGLRRNYRC 200
TICSVSLNSI EQYHAHLKGS KHQTNLKNK 229
Length:229
Mass (Da):25,833
Last modified:March 1, 2001 - v1
Checksum:iDB60004B797EEEFB
GO
Isoform 2 (identifier: Q9H898-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-192: Missing.

Show »
Length:153
Mass (Da):17,340
Checksum:i77BB52CB63E67E92
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti201 – 2011T → A.1 Publication
Corresponds to variant rs17851751 [ dbSNP | Ensembl ].
VAR_034736

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei117 – 19276Missing in isoform 2.
VSP_027476Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK023904 mRNA. Translation: BAB14719.1.
BC019598 mRNA. Translation: AAH19598.1.
CCDSiCCDS34885.1. [Q9H898-1]
CCDS47848.1. [Q9H898-2]
RefSeqiNP_001129203.1. NM_001135731.1. [Q9H898-2]
NP_078921.1. NM_024645.2. [Q9H898-1]
UniGeneiHs.591850.

Genome annotation databases

EnsembliENST00000297737; ENSP00000297737; ENSG00000165061. [Q9H898-1]
ENST00000315769; ENSP00000319785; ENSG00000165061. [Q9H898-2]
GeneIDi79698.
KEGGihsa:79698.
UCSCiuc003xnr.3. human. [Q9H898-1]
uc003xns.3. human. [Q9H898-2]

Polymorphism databases

DMDMi74733790.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK023904 mRNA. Translation: BAB14719.1 .
BC019598 mRNA. Translation: AAH19598.1 .
CCDSi CCDS34885.1. [Q9H898-1 ]
CCDS47848.1. [Q9H898-2 ]
RefSeqi NP_001129203.1. NM_001135731.1. [Q9H898-2 ]
NP_078921.1. NM_024645.2. [Q9H898-1 ]
UniGenei Hs.591850.

3D structure databases

ProteinModelPortali Q9H898.
SMRi Q9H898. Positions 7-105, 142-183, 199-228.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122819. 3 interactions.
IntActi Q9H898. 5 interactions.

PTM databases

PhosphoSitei Q9H898.

Polymorphism databases

DMDMi 74733790.

Proteomic databases

PaxDbi Q9H898.
PRIDEi Q9H898.

Protocols and materials databases

DNASUi 79698.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000297737 ; ENSP00000297737 ; ENSG00000165061 . [Q9H898-1 ]
ENST00000315769 ; ENSP00000319785 ; ENSG00000165061 . [Q9H898-2 ]
GeneIDi 79698.
KEGGi hsa:79698.
UCSCi uc003xnr.3. human. [Q9H898-1 ]
uc003xns.3. human. [Q9H898-2 ]

Organism-specific databases

CTDi 79698.
GeneCardsi GC08M040388.
HGNCi HGNC:25844. ZMAT4.
neXtProti NX_Q9H898.
PharmGKBi PA142670525.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG68898.
HOGENOMi HOG000008682.
HOVERGENi HBG061007.
InParanoidi Q9H898.
OMAi LGEQPAI.
OrthoDBi EOG7N8ZW8.
PhylomeDBi Q9H898.
TreeFami TF350019.

Miscellaneous databases

GenomeRNAii 79698.
NextBioi 68996.
PROi Q9H898.

Gene expression databases

ArrayExpressi Q9H898.
Bgeei Q9H898.
CleanExi HS_ZMAT4.
Genevestigatori Q9H898.

Family and domain databases

InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR022755. Znf_C2H2_jaz.
IPR003604. Znf_U1.
[Graphical view ]
Pfami PF12171. zf-C2H2_jaz. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 4 hits.
SM00451. ZnF_U1. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Thyroid.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-201.
    Tissue: Brain.

Entry informationi

Entry nameiZMAT4_HUMAN
AccessioniPrimary (citable) accession number: Q9H898
Secondary accession number(s): Q8WUT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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