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Protein

Zinc finger matrin-type protein 4

Gene

ZMAT4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri14 – 4431Matrin-type 1Add
BLAST
Zinc fingeri72 – 10635Matrin-type 2Add
BLAST
Zinc fingeri145 – 17531Matrin-type 3Add
BLAST
Zinc fingeri198 – 22831Matrin-type 4Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger matrin-type protein 4
Gene namesi
Name:ZMAT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:25844. ZMAT4.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670525.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Zinc finger matrin-type protein 4PRO_0000298916Add
BLAST

Proteomic databases

PaxDbiQ9H898.
PRIDEiQ9H898.

PTM databases

PhosphoSiteiQ9H898.

Expressioni

Gene expression databases

BgeeiQ9H898.
CleanExiHS_ZMAT4.
ExpressionAtlasiQ9H898. baseline and differential.
GenevestigatoriQ9H898.

Interactioni

Protein-protein interaction databases

BioGridi122819. 4 interactions.
IntActiQ9H898. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9H898.
SMRiQ9H898. Positions 7-105, 142-183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 4 matrin-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri14 – 4431Matrin-type 1Add
BLAST
Zinc fingeri72 – 10635Matrin-type 2Add
BLAST
Zinc fingeri145 – 17531Matrin-type 3Add
BLAST
Zinc fingeri198 – 22831Matrin-type 4Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG68898.
GeneTreeiENSGT00510000046606.
HOGENOMiHOG000008682.
HOVERGENiHBG061007.
InParanoidiQ9H898.
OMAiNPGMAQQ.
OrthoDBiEOG7N8ZW8.
PhylomeDBiQ9H898.
TreeFamiTF350019.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR022755. Znf_C2H2_jaz.
IPR003604. Znf_U1.
[Graphical view]
PfamiPF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
SM00451. ZnF_U1. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H898-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSSDIDQDL FTDSYCKVCS AQLISESQRV AHYESRKHAS KVRLYYMLHP
60 70 80 90 100
RDGGCPAKRL RSENGSDADM VDKNKCCTLC NMSFTSAVVA DSHYQGKIHA
110 120 130 140 150
KRLKLLLGEK TPLKTTATPL SPLKPPRMDT APVVASPYQR RDSDRYCGLC
160 170 180 190 200
AAWFNNPLMA QQHYDGKKHK KNAARVALLE QLGTTLDMGE LRGLRRNYRC
210 220
TICSVSLNSI EQYHAHLKGS KHQTNLKNK
Length:229
Mass (Da):25,833
Last modified:March 1, 2001 - v1
Checksum:iDB60004B797EEEFB
GO
Isoform 2 (identifier: Q9H898-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-192: Missing.

Show »
Length:153
Mass (Da):17,340
Checksum:i77BB52CB63E67E92
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti201 – 2011T → A.1 Publication
Corresponds to variant rs17851751 [ dbSNP | Ensembl ].
VAR_034736

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei117 – 19276Missing in isoform 2. 1 PublicationVSP_027476Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023904 mRNA. Translation: BAB14719.1.
BC019598 mRNA. Translation: AAH19598.1.
CCDSiCCDS34885.1. [Q9H898-1]
CCDS47848.1. [Q9H898-2]
RefSeqiNP_001129203.1. NM_001135731.1. [Q9H898-2]
NP_078921.1. NM_024645.2. [Q9H898-1]
UniGeneiHs.591850.

Genome annotation databases

EnsembliENST00000297737; ENSP00000297737; ENSG00000165061. [Q9H898-1]
ENST00000315769; ENSP00000319785; ENSG00000165061. [Q9H898-2]
GeneIDi79698.
KEGGihsa:79698.
UCSCiuc003xnr.3. human. [Q9H898-1]
uc003xns.3. human. [Q9H898-2]

Polymorphism databases

DMDMi74733790.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023904 mRNA. Translation: BAB14719.1.
BC019598 mRNA. Translation: AAH19598.1.
CCDSiCCDS34885.1. [Q9H898-1]
CCDS47848.1. [Q9H898-2]
RefSeqiNP_001129203.1. NM_001135731.1. [Q9H898-2]
NP_078921.1. NM_024645.2. [Q9H898-1]
UniGeneiHs.591850.

3D structure databases

ProteinModelPortaliQ9H898.
SMRiQ9H898. Positions 7-105, 142-183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122819. 4 interactions.
IntActiQ9H898. 5 interactions.

PTM databases

PhosphoSiteiQ9H898.

Polymorphism databases

DMDMi74733790.

Proteomic databases

PaxDbiQ9H898.
PRIDEiQ9H898.

Protocols and materials databases

DNASUi79698.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297737; ENSP00000297737; ENSG00000165061. [Q9H898-1]
ENST00000315769; ENSP00000319785; ENSG00000165061. [Q9H898-2]
GeneIDi79698.
KEGGihsa:79698.
UCSCiuc003xnr.3. human. [Q9H898-1]
uc003xns.3. human. [Q9H898-2]

Organism-specific databases

CTDi79698.
GeneCardsiGC08M040388.
HGNCiHGNC:25844. ZMAT4.
neXtProtiNX_Q9H898.
PharmGKBiPA142670525.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG68898.
GeneTreeiENSGT00510000046606.
HOGENOMiHOG000008682.
HOVERGENiHBG061007.
InParanoidiQ9H898.
OMAiNPGMAQQ.
OrthoDBiEOG7N8ZW8.
PhylomeDBiQ9H898.
TreeFamiTF350019.

Miscellaneous databases

ChiTaRSiZMAT4. human.
GenomeRNAii79698.
NextBioi68996.
PROiQ9H898.

Gene expression databases

BgeeiQ9H898.
CleanExiHS_ZMAT4.
ExpressionAtlasiQ9H898. baseline and differential.
GenevestigatoriQ9H898.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR022755. Znf_C2H2_jaz.
IPR003604. Znf_U1.
[Graphical view]
PfamiPF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
SM00451. ZnF_U1. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Thyroid.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-201.
    Tissue: Brain.

Entry informationi

Entry nameiZMAT4_HUMAN
AccessioniPrimary (citable) accession number: Q9H898
Secondary accession number(s): Q8WUT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: March 1, 2001
Last modified: February 4, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.