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Q9H898 (ZMAT4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger matrin-type protein 4
Gene names
Name:ZMAT4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length229 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus Potential.

Sequence similarities

Contains 4 matrin-type zinc fingers.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H898-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H898-2)

The sequence of this isoform differs from the canonical sequence as follows:
     117-192: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 229229Zinc finger matrin-type protein 4
PRO_0000298916

Regions

Zinc finger14 – 4431Matrin-type 1
Zinc finger72 – 10635Matrin-type 2
Zinc finger145 – 17531Matrin-type 3
Zinc finger198 – 22831Matrin-type 4

Natural variations

Alternative sequence117 – 19276Missing in isoform 2.
VSP_027476
Natural variant2011T → A. Ref.2
Corresponds to variant rs17851751 [ dbSNP | Ensembl ].
VAR_034736

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: DB60004B797EEEFB

FASTA22925,833
        10         20         30         40         50         60 
MKSSDIDQDL FTDSYCKVCS AQLISESQRV AHYESRKHAS KVRLYYMLHP RDGGCPAKRL 

        70         80         90        100        110        120 
RSENGSDADM VDKNKCCTLC NMSFTSAVVA DSHYQGKIHA KRLKLLLGEK TPLKTTATPL 

       130        140        150        160        170        180 
SPLKPPRMDT APVVASPYQR RDSDRYCGLC AAWFNNPLMA QQHYDGKKHK KNAARVALLE 

       190        200        210        220 
QLGTTLDMGE LRGLRRNYRC TICSVSLNSI EQYHAHLKGS KHQTNLKNK 

« Hide

Isoform 2 [UniParc].

Checksum: 77BB52CB63E67E92
Show »

FASTA15317,340

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Thyroid.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-201.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK023904 mRNA. Translation: BAB14719.1.
BC019598 mRNA. Translation: AAH19598.1.
RefSeqNP_001129203.1. NM_001135731.1.
NP_078921.1. NM_024645.2.
UniGeneHs.591850.

3D structure databases

ProteinModelPortalQ9H898.
SMRQ9H898. Positions 7-228.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122819. 3 interactions.
IntActQ9H898. 5 interactions.

PTM databases

PhosphoSiteQ9H898.

Polymorphism databases

DMDM74733790.

Proteomic databases

PaxDbQ9H898.
PRIDEQ9H898.

Protocols and materials databases

DNASU79698.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000297737; ENSP00000297737; ENSG00000165061. [Q9H898-1]
ENST00000315769; ENSP00000319785; ENSG00000165061. [Q9H898-2]
GeneID79698.
KEGGhsa:79698.
UCSCuc003xnr.3. human. [Q9H898-1]
uc003xns.3. human. [Q9H898-2]

Organism-specific databases

CTD79698.
GeneCardsGC08M040388.
HGNCHGNC:25844. ZMAT4.
neXtProtNX_Q9H898.
PharmGKBPA142670525.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG68898.
HOGENOMHOG000008682.
HOVERGENHBG061007.
InParanoidQ9H898.
OMACNAWFNN.
OrthoDBEOG7N8ZW8.
PhylomeDBQ9H898.
TreeFamTF350019.

Gene expression databases

ArrayExpressQ9H898.
BgeeQ9H898.
CleanExHS_ZMAT4.
GenevestigatorQ9H898.

Family and domain databases

InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR022755. Znf_C2H2_jaz.
IPR003604. Znf_U1.
[Graphical view]
PfamPF12171. zf-C2H2_jaz. 1 hit.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 4 hits.
SM00451. ZnF_U1. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi79698.
NextBio68996.
PROQ9H898.

Entry information

Entry nameZMAT4_HUMAN
AccessionPrimary (citable) accession number: Q9H898
Secondary accession number(s): Q8WUT8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM