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Protein

PRKR-interacting protein 1

Gene

PRKRIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PRKR-interacting protein 1
Gene namesi
Name:PRKRIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21894. PRKRIP1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134952162.

Polymorphism and mutation databases

BioMutaiPRKRIP1.
DMDMi74733776.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 184184PRKR-interacting protein 1PRO_0000324787Add
BLAST

Proteomic databases

EPDiQ9H875.
MaxQBiQ9H875.
PaxDbiQ9H875.
PRIDEiQ9H875.

PTM databases

iPTMnetiQ9H875.
PhosphoSiteiQ9H875.

Expressioni

Gene expression databases

BgeeiQ9H875.
CleanExiHS_PRKRIP1.
ExpressionAtlasiQ9H875. baseline and differential.
GenevisibleiQ9H875. HS.

Organism-specific databases

HPAiHPA051146.

Interactioni

Subunit structurei

Interacts with EIF2AK2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP70Q8NHQ13EBI-744488,EBI-739624
TRAF2Q129333EBI-744488,EBI-355744

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122824. 13 interactions.
IntActiQ9H875. 6 interactions.
MINTiMINT-1484534.
STRINGi9606.ENSP00000381010.

Structurei

3D structure databases

ProteinModelPortaliQ9H875.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5050Interaction with EIF2AK2By similarityAdd
BLAST
Regioni51 – 14393Required for RNA-bindingBy similarityAdd
BLAST
Regioni126 – 13813Required for nuclear localizationBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili91 – 15262Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi162 – 1654Poly-Ser
Compositional biasi172 – 1765Poly-Glu

Sequence similaritiesi

Belongs to the PRKRIP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4055. Eukaryota.
ENOG4111T1J. LUCA.
GeneTreeiENSGT00390000005003.
HOGENOMiHOG000020927.
HOVERGENiHBG103101.
InParanoidiQ9H875.
OMAiETPSFIM.
OrthoDBiEOG7M98JK.
PhylomeDBiQ9H875.
TreeFamiTF314382.

Family and domain databases

InterProiIPR009548. DUF1168.
[Graphical view]
PANTHERiPTHR13507. PTHR13507. 1 hit.
PfamiPF06658. DUF1168. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H875-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASPAASSVR PPRPKKEPQT LVIPKNAAEE QKLKLERLMK NPDKAVPIPE
60 70 80 90 100
KMSEWAPRPP PEFVRDVMGS SAGAGSGEFH VYRHLRRREY QRQDYMDAMA
110 120 130 140 150
EKQKLDAEFQ KRLEKNKIAA EEQTAKRRKK RQKLKEKKLL AKKMKLEQKK
160 170 180
QEGPGQPKEQ GSSSSAEASG TEEEEEVPSF TMGR
Length:184
Mass (Da):20,997
Last modified:March 1, 2001 - v1
Checksum:i0374DA48DD8D4B22
GO
Isoform 2 (identifier: Q9H875-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.
     132-184: QKLKEKKLLA...EEVPSFTMGR → TRSAQGAGVQ...FGSFSPARTR

Note: No experimental confirmation available.
Show »
Length:157
Mass (Da):17,806
Checksum:i9D07DBE66D8112F5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71S → A.
Corresponds to variant rs6951185 [ dbSNP | Ensembl ].
VAR_039882
Natural varianti106 – 1061D → Y.1 Publication
Corresponds to variant rs11556160 [ dbSNP | Ensembl ].
VAR_039883

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3838Missing in isoform 2. 1 PublicationVSP_056088Add
BLAST
Alternative sequencei132 – 18453QKLKE…FTMGR → TRSAQGAGVQQLCGGIWNRG GGGSAQFHHGAMTMFATASA WNLARAVTRRERRLFGSFSP ARTR in isoform 2. 1 PublicationVSP_056089Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023964 mRNA. Translation: BAB14742.1.
AK294664 mRNA. Translation: BAG57833.1.
AC005088 Genomic DNA. No translation available.
AC073517 Genomic DNA. No translation available.
AC091390 Genomic DNA. No translation available.
CH471197 Genomic DNA. Translation: EAW50241.1.
BC014298 mRNA. Translation: AAH14298.1.
AL833837 mRNA. Translation: CAD38697.2.
CCDSiCCDS34714.1. [Q9H875-1]
RefSeqiNP_078929.1. NM_024653.3. [Q9H875-1]
UniGeneiHs.722104.

Genome annotation databases

EnsembliENST00000397912; ENSP00000381010; ENSG00000128563. [Q9H875-1]
ENST00000496391; ENSP00000419270; ENSG00000128563. [Q9H875-1]
GeneIDi79706.
KEGGihsa:79706.
UCSCiuc003uzh.3. human. [Q9H875-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023964 mRNA. Translation: BAB14742.1.
AK294664 mRNA. Translation: BAG57833.1.
AC005088 Genomic DNA. No translation available.
AC073517 Genomic DNA. No translation available.
AC091390 Genomic DNA. No translation available.
CH471197 Genomic DNA. Translation: EAW50241.1.
BC014298 mRNA. Translation: AAH14298.1.
AL833837 mRNA. Translation: CAD38697.2.
CCDSiCCDS34714.1. [Q9H875-1]
RefSeqiNP_078929.1. NM_024653.3. [Q9H875-1]
UniGeneiHs.722104.

3D structure databases

ProteinModelPortaliQ9H875.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122824. 13 interactions.
IntActiQ9H875. 6 interactions.
MINTiMINT-1484534.
STRINGi9606.ENSP00000381010.

PTM databases

iPTMnetiQ9H875.
PhosphoSiteiQ9H875.

Polymorphism and mutation databases

BioMutaiPRKRIP1.
DMDMi74733776.

Proteomic databases

EPDiQ9H875.
MaxQBiQ9H875.
PaxDbiQ9H875.
PRIDEiQ9H875.

Protocols and materials databases

DNASUi79706.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397912; ENSP00000381010; ENSG00000128563. [Q9H875-1]
ENST00000496391; ENSP00000419270; ENSG00000128563. [Q9H875-1]
GeneIDi79706.
KEGGihsa:79706.
UCSCiuc003uzh.3. human. [Q9H875-1]

Organism-specific databases

CTDi79706.
GeneCardsiPRKRIP1.
HGNCiHGNC:21894. PRKRIP1.
HPAiHPA051146.
neXtProtiNX_Q9H875.
PharmGKBiPA134952162.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4055. Eukaryota.
ENOG4111T1J. LUCA.
GeneTreeiENSGT00390000005003.
HOGENOMiHOG000020927.
HOVERGENiHBG103101.
InParanoidiQ9H875.
OMAiETPSFIM.
OrthoDBiEOG7M98JK.
PhylomeDBiQ9H875.
TreeFamiTF314382.

Miscellaneous databases

ChiTaRSiPRKRIP1. human.
GenomeRNAii79706.
PROiQ9H875.

Gene expression databases

BgeeiQ9H875.
CleanExiHS_PRKRIP1.
ExpressionAtlasiQ9H875. baseline and differential.
GenevisibleiQ9H875. HS.

Family and domain databases

InterProiIPR009548. DUF1168.
[Graphical view]
PANTHERiPTHR13507. PTHR13507. 1 hit.
PfamiPF06658. DUF1168. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Thyroid.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT TYR-106.
    Tissue: Lung.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-184 (ISOFORM 1).
    Tissue: Uterus.
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPKRI1_HUMAN
AccessioniPrimary (citable) accession number: Q9H875
Secondary accession number(s): B4DGM2, Q8NDM6, Q96CF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.