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Protein

PRKR-interacting protein 1

Gene

PRKRIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
PRKR-interacting protein 1
Gene namesi
Name:PRKRIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000128563.13
HGNCiHGNC:21894 PRKRIP1
MIMi617458 gene
neXtProtiNX_Q9H875

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000128563
PharmGKBiPA134952162

Polymorphism and mutation databases

BioMutaiPRKRIP1
DMDMi74733776

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003247871 – 184PRKR-interacting protein 1Add BLAST184

Proteomic databases

EPDiQ9H875
MaxQBiQ9H875
PaxDbiQ9H875
PeptideAtlasiQ9H875
PRIDEiQ9H875

PTM databases

iPTMnetiQ9H875
PhosphoSitePlusiQ9H875

Expressioni

Gene expression databases

BgeeiENSG00000128563
CleanExiHS_PRKRIP1
ExpressionAtlasiQ9H875 baseline and differential
GenevisibleiQ9H875 HS

Organism-specific databases

HPAiHPA051146

Interactioni

Subunit structurei

Interacts with EIF2AK2.By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122824, 15 interactors
CORUMiQ9H875
IntActiQ9H875, 7 interactors
STRINGi9606.ENSP00000381010

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XJCelectron microscopy3.60X1-184[»]
ProteinModelPortaliQ9H875
SMRiQ9H875
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 50Interaction with EIF2AK2By similarityAdd BLAST50
Regioni51 – 143Required for RNA-bindingBy similarityAdd BLAST93
Regioni126 – 138Required for nuclear localizationBy similarityAdd BLAST13

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili91 – 152Sequence analysisAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi162 – 165Poly-Ser4
Compositional biasi172 – 176Poly-Glu5

Sequence similaritiesi

Belongs to the PRKRIP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4055 Eukaryota
ENOG4111T1J LUCA
GeneTreeiENSGT00390000005003
HOGENOMiHOG000020927
HOVERGENiHBG103101
InParanoidiQ9H875
OMAiKEWNPRA
OrthoDBiEOG091G0ZLQ
PhylomeDBiQ9H875
TreeFamiTF314382

Family and domain databases

InterProiView protein in InterPro
IPR009548 DUF1168
PANTHERiPTHR13507 PTHR13507, 1 hit
PfamiView protein in Pfam
PF06658 DUF1168, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H875-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASPAASSVR PPRPKKEPQT LVIPKNAAEE QKLKLERLMK NPDKAVPIPE
60 70 80 90 100
KMSEWAPRPP PEFVRDVMGS SAGAGSGEFH VYRHLRRREY QRQDYMDAMA
110 120 130 140 150
EKQKLDAEFQ KRLEKNKIAA EEQTAKRRKK RQKLKEKKLL AKKMKLEQKK
160 170 180
QEGPGQPKEQ GSSSSAEASG TEEEEEVPSF TMGR
Length:184
Mass (Da):20,997
Last modified:March 1, 2001 - v1
Checksum:i0374DA48DD8D4B22
GO
Isoform 2 (identifier: Q9H875-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.
     132-184: QKLKEKKLLA...EEVPSFTMGR → TRSAQGAGVQ...FGSFSPARTR

Note: No experimental confirmation available.
Show »
Length:157
Mass (Da):17,806
Checksum:i9D07DBE66D8112F5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0398827S → A. Corresponds to variant dbSNP:rs6951185Ensembl.1
Natural variantiVAR_039883106D → Y1 PublicationCorresponds to variant dbSNP:rs11556160Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0560881 – 38Missing in isoform 2. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_056089132 – 184QKLKE…FTMGR → TRSAQGAGVQQLCGGIWNRG GGGSAQFHHGAMTMFATASA WNLARAVTRRERRLFGSFSP ARTR in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023964 mRNA Translation: BAB14742.1
AK294664 mRNA Translation: BAG57833.1
AC005088 Genomic DNA No translation available.
AC073517 Genomic DNA No translation available.
AC091390 Genomic DNA No translation available.
CH471197 Genomic DNA Translation: EAW50241.1
BC014298 mRNA Translation: AAH14298.1
AL833837 mRNA Translation: CAD38697.2
CCDSiCCDS34714.1 [Q9H875-1]
RefSeqiNP_078929.1, NM_024653.3 [Q9H875-1]
UniGeneiHs.722104

Genome annotation databases

EnsembliENST00000397912; ENSP00000381010; ENSG00000128563 [Q9H875-1]
ENST00000496391; ENSP00000419270; ENSG00000128563 [Q9H875-1]
GeneIDi79706
KEGGihsa:79706
UCSCiuc003uzh.3 human [Q9H875-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPKRI1_HUMAN
AccessioniPrimary (citable) accession number: Q9H875
Secondary accession number(s): B4DGM2, Q8NDM6, Q96CF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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