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Protein

Protein RMD5 homolog A

Gene

RMND5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein RMD5 homolog A
Gene namesi
Name:RMND5A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000153561.12
HGNCiHGNC:25850 RMND5A
neXtProtiNX_Q9H871

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000153561
PharmGKBiPA144596388

Polymorphism and mutation databases

BioMutaiRMND5A
DMDMi74733774

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002726481 – 391Protein RMD5 homolog AAdd BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9H871
MaxQBiQ9H871
PaxDbiQ9H871
PeptideAtlasiQ9H871
PRIDEiQ9H871
ProteomicsDBi81195
81196 [Q9H871-2]

PTM databases

iPTMnetiQ9H871
PhosphoSitePlusiQ9H871

Expressioni

Gene expression databases

BgeeiENSG00000153561
CleanExiHS_RMND5A
GenevisibleiQ9H871 HS

Organism-specific databases

HPAiHPA046795
HPA060843

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2P502223EBI-2797992,EBI-748397

Protein-protein interaction databases

BioGridi122303, 65 interactors
CORUMiQ9H871
IntActiQ9H871, 17 interactors
MINTiQ9H871
STRINGi9606.ENSP00000283632

Structurei

3D structure databases

ProteinModelPortaliQ9H871
SMRiQ9H871
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 146LisHPROSITE-ProRule annotationAdd BLAST33
Domaini153 – 210CTLHPROSITE-ProRule annotationAdd BLAST58

Phylogenomic databases

eggNOGiKOG2817 Eukaryota
COG5109 LUCA
GeneTreeiENSGT00720000108814
HOGENOMiHOG000211399
HOVERGENiHBG054339
InParanoidiQ9H871
OMAiWVKIQKR
OrthoDBiEOG091G0OLL
PhylomeDBiQ9H871
TreeFamiTF315176

Family and domain databases

CDDicd16794 dRING_RMD5A, 1 hit
InterProiView protein in InterPro
IPR013144 CRA_dom
IPR024964 CTLH/CRA
IPR006595 CTLH_C
IPR006594 LisH
IPR037680 RMD5A_dRING
PfamiView protein in Pfam
PF10607 CLTH, 1 hit
SMARTiView protein in SMART
SM00757 CRA, 1 hit
SM00668 CTLH, 1 hit
SM00667 LisH, 1 hit
PROSITEiView protein in PROSITE
PS50897 CTLH, 1 hit
PS50896 LISH, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H871-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDQCVTVERE LEKVLHKFSG YGQLCERGLE ELIDYTGGLK HEILQSHGQD
60 70 80 90 100
AELSGTLSLV LTQCCKRIKD TVQKLASDHK DIHSSVSRVG KAIDKNFDSD
110 120 130 140 150
ISSVGIDGCW QADSQRLLNE VMVEHFFRQG MLDVAEELCQ ESGLSVDPSQ
160 170 180 190 200
KEPFVELNRI LEALKVRVLR PALEWAVSNR EMLIAQNSSL EFKLHRLYFI
210 220 230 240 250
SLLMGGTTNQ REALQYAKNF QPFALNHQKD IQVLMGSLVY LRQGIENSPY
260 270 280 290 300
VHLLDANQWA DICDIFTRDA CALLGLSVES PLSVSFSAGC VALPALINIK
310 320 330 340 350
AVIEQRQCTG VWNQKDELPI EVDLGKKCWY HSIFACPILR QQTTDNNPPM
360 370 380 390
KLVCGHIISR DALNKMFNGS KLKCPYCPME QSPGDAKQIF F
Length:391
Mass (Da):43,993
Last modified:March 1, 2001 - v1
Checksum:iA6043EBEED61FBB7
GO
Isoform 2 (identifier: Q9H871-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-98: NFD → DSL
     99-391: Missing.

Note: No experimental confirmation available.
Show »
Length:98
Mass (Da):10,911
Checksum:iC1CCA6F429B0F92A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti181E → G in BAB14257 (PubMed:14702039).Curated1
Sequence conflicti187N → D in BAB14257 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02245496 – 98NFD → DSL in isoform 2. 1 Publication3
Alternative sequenceiVSP_02245599 – 391Missing in isoform 2. 1 PublicationAdd BLAST293

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022815 mRNA Translation: BAB14257.1
AK023972 mRNA Translation: BAB14746.1
AK025448 mRNA Translation: BAB15135.1
AC064848 Genomic DNA Translation: AAX88863.1
CH471053 Genomic DNA Translation: EAW99442.1
CH471053 Genomic DNA Translation: EAW99443.1
CH471053 Genomic DNA Translation: EAW99445.1
BC012165 mRNA Translation: AAH12165.1
BC047668 mRNA Translation: AAH47668.1
BC069048 mRNA Translation: AAH69048.1
CCDSiCCDS1991.1 [Q9H871-1]
RefSeqiNP_073617.1, NM_022780.3 [Q9H871-1]
UniGeneiHs.424184
Hs.75277

Genome annotation databases

EnsembliENST00000283632; ENSP00000283632; ENSG00000153561 [Q9H871-1]
GeneIDi64795
KEGGihsa:64795
UCSCiuc002srr.3 human [Q9H871-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRMD5A_HUMAN
AccessioniPrimary (citable) accession number: Q9H871
Secondary accession number(s): D6W5M6
, Q6NTF0, Q9H6W5, Q9H9H2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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