Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9H871

- RMD5A_HUMAN

UniProt

Q9H871 - RMD5A_HUMAN

Protein

Protein RMD5 homolog A

Gene

RMND5A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein RMD5 homolog A
    Gene namesi
    Name:RMND5A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:25850. RMND5A.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA144596388.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 391391Protein RMD5 homolog APRO_0000272648Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9H871.
    PaxDbiQ9H871.
    PeptideAtlasiQ9H871.
    PRIDEiQ9H871.

    PTM databases

    PhosphoSiteiQ9H871.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H871.
    BgeeiQ9H871.
    CleanExiHS_RMND5A.
    GenevestigatoriQ9H871.

    Organism-specific databases

    HPAiHPA046795.

    Interactioni

    Protein-protein interaction databases

    BioGridi122303. 10 interactions.
    IntActiQ9H871. 3 interactions.
    MINTiMINT-1197349.
    STRINGi9606.ENSP00000283632.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H871.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini114 – 14633LisHPROSITE-ProRule annotationAdd
    BLAST
    Domaini153 – 21058CTLHPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CTLH domain.PROSITE-ProRule annotation
    Contains 1 LisH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5109.
    HOGENOMiHOG000211399.
    HOVERGENiHBG054339.
    InParanoidiQ9H871.
    OMAiTSENELP.
    OrthoDBiEOG757CXZ.
    PhylomeDBiQ9H871.
    TreeFamiTF315176.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR013144. CRA_dom.
    IPR024964. CTLH/CRA.
    IPR006595. CTLH_C.
    IPR006594. LisH_dimerisation.
    IPR027370. Znf-RING_LisH.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF10607. CLTH. 1 hit.
    PF13445. zf-RING_UBOX. 1 hit.
    [Graphical view]
    SMARTiSM00757. CRA. 1 hit.
    SM00668. CTLH. 1 hit.
    SM00667. LisH. 1 hit.
    [Graphical view]
    PROSITEiPS50897. CTLH. 1 hit.
    PS50896. LISH. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H871-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDQCVTVERE LEKVLHKFSG YGQLCERGLE ELIDYTGGLK HEILQSHGQD    50
    AELSGTLSLV LTQCCKRIKD TVQKLASDHK DIHSSVSRVG KAIDKNFDSD 100
    ISSVGIDGCW QADSQRLLNE VMVEHFFRQG MLDVAEELCQ ESGLSVDPSQ 150
    KEPFVELNRI LEALKVRVLR PALEWAVSNR EMLIAQNSSL EFKLHRLYFI 200
    SLLMGGTTNQ REALQYAKNF QPFALNHQKD IQVLMGSLVY LRQGIENSPY 250
    VHLLDANQWA DICDIFTRDA CALLGLSVES PLSVSFSAGC VALPALINIK 300
    AVIEQRQCTG VWNQKDELPI EVDLGKKCWY HSIFACPILR QQTTDNNPPM 350
    KLVCGHIISR DALNKMFNGS KLKCPYCPME QSPGDAKQIF F 391
    Length:391
    Mass (Da):43,993
    Last modified:March 1, 2001 - v1
    Checksum:iA6043EBEED61FBB7
    GO
    Isoform 2 (identifier: Q9H871-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         96-98: NFD → DSL
         99-391: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:98
    Mass (Da):10,911
    Checksum:iC1CCA6F429B0F92A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti181 – 1811E → G in BAB14257. (PubMed:14702039)Curated
    Sequence conflicti187 – 1871N → D in BAB14257. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei96 – 983NFD → DSL in isoform 2. 1 PublicationVSP_022454
    Alternative sequencei99 – 391293Missing in isoform 2. 1 PublicationVSP_022455Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022815 mRNA. Translation: BAB14257.1.
    AK023972 mRNA. Translation: BAB14746.1.
    AK025448 mRNA. Translation: BAB15135.1.
    AC064848 Genomic DNA. Translation: AAX88863.1.
    CH471053 Genomic DNA. Translation: EAW99442.1.
    CH471053 Genomic DNA. Translation: EAW99443.1.
    CH471053 Genomic DNA. Translation: EAW99445.1.
    BC012165 mRNA. Translation: AAH12165.1.
    BC047668 mRNA. Translation: AAH47668.1.
    BC069048 mRNA. Translation: AAH69048.1.
    CCDSiCCDS1991.1. [Q9H871-1]
    RefSeqiNP_073617.1. NM_022780.3. [Q9H871-1]
    UniGeneiHs.424184.
    Hs.75277.

    Genome annotation databases

    EnsembliENST00000283632; ENSP00000283632; ENSG00000153561. [Q9H871-1]
    GeneIDi64795.
    KEGGihsa:64795.
    UCSCiuc002srr.2. human. [Q9H871-1]

    Polymorphism databases

    DMDMi74733774.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022815 mRNA. Translation: BAB14257.1 .
    AK023972 mRNA. Translation: BAB14746.1 .
    AK025448 mRNA. Translation: BAB15135.1 .
    AC064848 Genomic DNA. Translation: AAX88863.1 .
    CH471053 Genomic DNA. Translation: EAW99442.1 .
    CH471053 Genomic DNA. Translation: EAW99443.1 .
    CH471053 Genomic DNA. Translation: EAW99445.1 .
    BC012165 mRNA. Translation: AAH12165.1 .
    BC047668 mRNA. Translation: AAH47668.1 .
    BC069048 mRNA. Translation: AAH69048.1 .
    CCDSi CCDS1991.1. [Q9H871-1 ]
    RefSeqi NP_073617.1. NM_022780.3. [Q9H871-1 ]
    UniGenei Hs.424184.
    Hs.75277.

    3D structure databases

    ProteinModelPortali Q9H871.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122303. 10 interactions.
    IntActi Q9H871. 3 interactions.
    MINTi MINT-1197349.
    STRINGi 9606.ENSP00000283632.

    PTM databases

    PhosphoSitei Q9H871.

    Polymorphism databases

    DMDMi 74733774.

    Proteomic databases

    MaxQBi Q9H871.
    PaxDbi Q9H871.
    PeptideAtlasi Q9H871.
    PRIDEi Q9H871.

    Protocols and materials databases

    DNASUi 64795.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000283632 ; ENSP00000283632 ; ENSG00000153561 . [Q9H871-1 ]
    GeneIDi 64795.
    KEGGi hsa:64795.
    UCSCi uc002srr.2. human. [Q9H871-1 ]

    Organism-specific databases

    CTDi 64795.
    GeneCardsi GC02P086947.
    HGNCi HGNC:25850. RMND5A.
    HPAi HPA046795.
    neXtProti NX_Q9H871.
    PharmGKBi PA144596388.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5109.
    HOGENOMi HOG000211399.
    HOVERGENi HBG054339.
    InParanoidi Q9H871.
    OMAi TSENELP.
    OrthoDBi EOG757CXZ.
    PhylomeDBi Q9H871.
    TreeFami TF315176.

    Miscellaneous databases

    ChiTaRSi RMND5A. human.
    GenomeRNAii 64795.
    NextBioi 66868.
    PROi Q9H871.

    Gene expression databases

    ArrayExpressi Q9H871.
    Bgeei Q9H871.
    CleanExi HS_RMND5A.
    Genevestigatori Q9H871.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR013144. CRA_dom.
    IPR024964. CTLH/CRA.
    IPR006595. CTLH_C.
    IPR006594. LisH_dimerisation.
    IPR027370. Znf-RING_LisH.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF10607. CLTH. 1 hit.
    PF13445. zf-RING_UBOX. 1 hit.
    [Graphical view ]
    SMARTi SM00757. CRA. 1 hit.
    SM00668. CTLH. 1 hit.
    SM00667. LisH. 1 hit.
    [Graphical view ]
    PROSITEi PS50897. CTLH. 1 hit.
    PS50896. LISH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Eye, Muscle and Testis.
    5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRMD5A_HUMAN
    AccessioniPrimary (citable) accession number: Q9H871
    Secondary accession number(s): D6W5M6
    , Q6NTF0, Q9H6W5, Q9H9H2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3