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Q9H871

- RMD5A_HUMAN

UniProt

Q9H871 - RMD5A_HUMAN

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Protein

Protein RMD5 homolog A

Gene

RMND5A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein RMD5 homolog A
Gene namesi
Name:RMND5A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:25850. RMND5A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596388.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Protein RMD5 homolog APRO_0000272648Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9H871.
PaxDbiQ9H871.
PeptideAtlasiQ9H871.
PRIDEiQ9H871.

PTM databases

PhosphoSiteiQ9H871.

Expressioni

Gene expression databases

BgeeiQ9H871.
CleanExiHS_RMND5A.
ExpressionAtlasiQ9H871. baseline and differential.
GenevestigatoriQ9H871.

Organism-specific databases

HPAiHPA046795.

Interactioni

Protein-protein interaction databases

BioGridi122303. 33 interactions.
IntActiQ9H871. 3 interactions.
MINTiMINT-1197349.
STRINGi9606.ENSP00000283632.

Structurei

3D structure databases

ProteinModelPortaliQ9H871.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini114 – 14633LisHPROSITE-ProRule annotationAdd
BLAST
Domaini153 – 21058CTLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CTLH domain.PROSITE-ProRule annotation
Contains 1 LisH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5109.
GeneTreeiENSGT00720000108814.
HOGENOMiHOG000211399.
HOVERGENiHBG054339.
InParanoidiQ9H871.
OMAiTSENELP.
OrthoDBiEOG757CXZ.
PhylomeDBiQ9H871.
TreeFamiTF315176.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR013144. CRA_dom.
IPR024964. CTLH/CRA.
IPR006595. CTLH_C.
IPR006594. LisH_dimerisation.
IPR027370. Znf-RING_LisH.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF10607. CLTH. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
SMARTiSM00757. CRA. 1 hit.
SM00668. CTLH. 1 hit.
SM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H871-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDQCVTVERE LEKVLHKFSG YGQLCERGLE ELIDYTGGLK HEILQSHGQD
60 70 80 90 100
AELSGTLSLV LTQCCKRIKD TVQKLASDHK DIHSSVSRVG KAIDKNFDSD
110 120 130 140 150
ISSVGIDGCW QADSQRLLNE VMVEHFFRQG MLDVAEELCQ ESGLSVDPSQ
160 170 180 190 200
KEPFVELNRI LEALKVRVLR PALEWAVSNR EMLIAQNSSL EFKLHRLYFI
210 220 230 240 250
SLLMGGTTNQ REALQYAKNF QPFALNHQKD IQVLMGSLVY LRQGIENSPY
260 270 280 290 300
VHLLDANQWA DICDIFTRDA CALLGLSVES PLSVSFSAGC VALPALINIK
310 320 330 340 350
AVIEQRQCTG VWNQKDELPI EVDLGKKCWY HSIFACPILR QQTTDNNPPM
360 370 380 390
KLVCGHIISR DALNKMFNGS KLKCPYCPME QSPGDAKQIF F
Length:391
Mass (Da):43,993
Last modified:March 1, 2001 - v1
Checksum:iA6043EBEED61FBB7
GO
Isoform 2 (identifier: Q9H871-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-98: NFD → DSL
     99-391: Missing.

Note: No experimental confirmation available.

Show »
Length:98
Mass (Da):10,911
Checksum:iC1CCA6F429B0F92A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti181 – 1811E → G in BAB14257. (PubMed:14702039)Curated
Sequence conflicti187 – 1871N → D in BAB14257. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei96 – 983NFD → DSL in isoform 2. 1 PublicationVSP_022454
Alternative sequencei99 – 391293Missing in isoform 2. 1 PublicationVSP_022455Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022815 mRNA. Translation: BAB14257.1.
AK023972 mRNA. Translation: BAB14746.1.
AK025448 mRNA. Translation: BAB15135.1.
AC064848 Genomic DNA. Translation: AAX88863.1.
CH471053 Genomic DNA. Translation: EAW99442.1.
CH471053 Genomic DNA. Translation: EAW99443.1.
CH471053 Genomic DNA. Translation: EAW99445.1.
BC012165 mRNA. Translation: AAH12165.1.
BC047668 mRNA. Translation: AAH47668.1.
BC069048 mRNA. Translation: AAH69048.1.
CCDSiCCDS1991.1. [Q9H871-1]
RefSeqiNP_073617.1. NM_022780.3. [Q9H871-1]
UniGeneiHs.424184.
Hs.75277.

Genome annotation databases

EnsembliENST00000283632; ENSP00000283632; ENSG00000153561. [Q9H871-1]
GeneIDi64795.
KEGGihsa:64795.
UCSCiuc002srr.2. human. [Q9H871-1]

Polymorphism databases

DMDMi74733774.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022815 mRNA. Translation: BAB14257.1 .
AK023972 mRNA. Translation: BAB14746.1 .
AK025448 mRNA. Translation: BAB15135.1 .
AC064848 Genomic DNA. Translation: AAX88863.1 .
CH471053 Genomic DNA. Translation: EAW99442.1 .
CH471053 Genomic DNA. Translation: EAW99443.1 .
CH471053 Genomic DNA. Translation: EAW99445.1 .
BC012165 mRNA. Translation: AAH12165.1 .
BC047668 mRNA. Translation: AAH47668.1 .
BC069048 mRNA. Translation: AAH69048.1 .
CCDSi CCDS1991.1. [Q9H871-1 ]
RefSeqi NP_073617.1. NM_022780.3. [Q9H871-1 ]
UniGenei Hs.424184.
Hs.75277.

3D structure databases

ProteinModelPortali Q9H871.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122303. 33 interactions.
IntActi Q9H871. 3 interactions.
MINTi MINT-1197349.
STRINGi 9606.ENSP00000283632.

PTM databases

PhosphoSitei Q9H871.

Polymorphism databases

DMDMi 74733774.

Proteomic databases

MaxQBi Q9H871.
PaxDbi Q9H871.
PeptideAtlasi Q9H871.
PRIDEi Q9H871.

Protocols and materials databases

DNASUi 64795.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000283632 ; ENSP00000283632 ; ENSG00000153561 . [Q9H871-1 ]
GeneIDi 64795.
KEGGi hsa:64795.
UCSCi uc002srr.2. human. [Q9H871-1 ]

Organism-specific databases

CTDi 64795.
GeneCardsi GC02P086947.
HGNCi HGNC:25850. RMND5A.
HPAi HPA046795.
neXtProti NX_Q9H871.
PharmGKBi PA144596388.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5109.
GeneTreei ENSGT00720000108814.
HOGENOMi HOG000211399.
HOVERGENi HBG054339.
InParanoidi Q9H871.
OMAi TSENELP.
OrthoDBi EOG757CXZ.
PhylomeDBi Q9H871.
TreeFami TF315176.

Miscellaneous databases

ChiTaRSi RMND5A. human.
GenomeRNAii 64795.
NextBioi 66868.
PROi Q9H871.

Gene expression databases

Bgeei Q9H871.
CleanExi HS_RMND5A.
ExpressionAtlasi Q9H871. baseline and differential.
Genevestigatori Q9H871.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR013144. CRA_dom.
IPR024964. CTLH/CRA.
IPR006595. CTLH_C.
IPR006594. LisH_dimerisation.
IPR027370. Znf-RING_LisH.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF10607. CLTH. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view ]
SMARTi SM00757. CRA. 1 hit.
SM00668. CTLH. 1 hit.
SM00667. LisH. 1 hit.
[Graphical view ]
PROSITEi PS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Eye, Muscle and Testis.
  5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRMD5A_HUMAN
AccessioniPrimary (citable) accession number: Q9H871
Secondary accession number(s): D6W5M6
, Q6NTF0, Q9H6W5, Q9H9H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3