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Protein

YY1-associated protein 1

Gene

YY1AP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enhances transcription activation by YY1. May play a role in cell cycle regulation.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
YY1-associated protein 1
Alternative name(s):
Hepatocellular carcinoma susceptibility protein
Hepatocellular carcinoma-associated protein 2
Gene namesi
Name:YY1AP1
Synonyms:HCCA2, YY1AP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30935. YY1AP1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670546.

Polymorphism and mutation databases

BioMutaiYY1AP1.
DMDMi147744601.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 796796YY1-associated protein 1PRO_0000076369Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei724 – 7241PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H869.
MaxQBiQ9H869.
PaxDbiQ9H869.
PeptideAtlasiQ9H869.
PRIDEiQ9H869.

PTM databases

iPTMnetiQ9H869.
PhosphoSiteiQ9H869.

Expressioni

Tissue specificityi

Ubiquitous. Detected in small intestine, skeletal muscle, lung, pancreas, brain, stomach, spleen, colon and heart. Detected at very low levels in healthy liver. Highly expressed in most liver carcinomas.3 Publications

Gene expression databases

BgeeiQ9H869.
ExpressionAtlasiQ9H869. baseline and differential.
GenevisibleiQ9H869. HS.

Organism-specific databases

HPAiHPA006986.

Interactioni

Subunit structurei

Interacts with YY1. Interacts with MAD2L2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ATXN1P542534EBI-946122,EBI-930964

Protein-protein interaction databases

BioGridi120540. 28 interactions.
IntActiQ9H869. 14 interactions.
MINTiMINT-1481820.
STRINGi9606.ENSP00000357323.

Structurei

3D structure databases

ProteinModelPortaliQ9H869.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410JQ2S. Eukaryota.
ENOG410XS4M. LUCA.
GeneTreeiENSGT00390000016256.
HOGENOMiHOG000038018.
HOVERGENiHBG074061.
InParanoidiQ9H869.
OMAiRHEKEAN.
OrthoDBiEOG771263.
PhylomeDBiQ9H869.
TreeFamiTF343327.

Family and domain databases

InterProiIPR033274. YY1AP1.
[Graphical view]
PANTHERiPTHR16088:SF9. PTHR16088:SF9. 2 hits.

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H869-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEEASRSAA ATNPGSRLTR WPPPDKREGS AVDPGKRRSL AATPSSSLPC
60 70 80 90 100
TLIALGLRHE KEANELMEDL FETFQDEMGF SNMEDDGPEE EERVAEPQAN
110 120 130 140 150
FNTPQALRFE ELLANLLNEQ HQIAKELFEQ LKMKKPSAKQ QKEVEKVKPQ
160 170 180 190 200
CKEVHQTLIL DPAQRKRLQQ QMQQHVQLLT QIHLLATCNP NLNPEASSTR
210 220 230 240 250
ICLKELGTFA QSSIALHHQY NPKFQTLFQP CNLMGAMQLI EDFSTHVSID
260 270 280 290 300
CSPHKTVKKT ANEFPCLPKQ VAWILATSKV FMYPELLPVC SLKAKNPQDK
310 320 330 340 350
ILFTKAEDNK YLLTCKTARQ LTVRIKNLNM NRAPDNIIKF YKKTKQLPVL
360 370 380 390 400
GKCCEEIQPH QWKPPIEREE HRLPFWLKAS LPSIQEELRH MADGAREVGN
410 420 430 440 450
MTGTTEINSD QGLEKDNSEL GSETRYPLLL PKGVVLKLKP VADRFPKKAW
460 470 480 490 500
RQKRSSVLKP LLIQPSPSLQ PSFNPGKTPA QSTHSEAPPS KMVLRIPHPI
510 520 530 540 550
QPATVLQTVP GVPPLGVSGG ESFESPAALP AMPPEARTSF PLSESQTLLS
560 570 580 590 600
SAPVPKVMMP SPASSMFRKP YVRRRPSKRR GARAFRCIKP APVIHPASVI
610 620 630 640 650
FTVPATTVKI VSLGGGCNMI QPVNAAVAQS PQTIPIATLL VNPTSFPCPL
660 670 680 690 700
NQPLVASSVS PLIVSGNSVN LPIPSTPEDK AHMNVDIACA VADGENAFQG
710 720 730 740 750
LEPKLEPQEL SPLSATVFPK VEHSPGPPPV DKQCQEGLSE NSAYRWTVVK
760 770 780 790
TEEGRQALEP LPQGIQESLN NSSPGDLEEV VKMEPEDATE EISGFL
Length:796
Mass (Da):87,944
Last modified:May 15, 2007 - v2
Checksum:iA2FC8B4DBA8DFDA7
GO
Isoform 2 (identifier: Q9H869-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: Missing.
     309-309: N → NLLALGLKHFEGTEFLNPLIS

Show »
Length:750
Mass (Da):83,088
Checksum:i35A05C3146FC95D7
GO
Isoform 3 (identifier: Q9H869-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.
     309-309: N → NLLALGLKHFEGTEFLNPLIS

Show »
Length:739
Mass (Da):81,702
Checksum:iAEE39032FCC83A53
GO
Isoform 4 (identifier: Q9H869-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: Missing.

Show »
Length:730
Mass (Da):80,893
Checksum:i3A7B22D694AE7E0B
GO
Isoform 5 (identifier: Q9H869-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-132: Missing.
     309-309: N → NLLALGLKHFEGTEFLNPLIS

Show »
Length:684
Mass (Da):75,330
Checksum:iE2F9E4BEAB76E3D5
GO
Isoform 6 (identifier: Q9H869-6) [UniParc]FASTAAdd to basket

Also known as: HCCA1

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.

Show »
Length:719
Mass (Da):79,508
Checksum:i3C3288D1B4E1CEF2
GO
Isoform 7 (identifier: Q9H869-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-329: Missing.

Show »
Length:467
Mass (Da):50,634
Checksum:i8A0B641CD01FAEC3
GO
Isoform 8 (identifier: Q9H869-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MEEEASRSAAATNPG → MAGVGRSGGP...LSLLLSRISA

Note: No experimental confirmation available.
Show »
Length:868
Mass (Da):95,521
Checksum:i07F36903760F9C75
GO
Isoform 9 (identifier: Q9H869-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MEEEASRSAAATNPG → MAGVGRSGGP...LSLLLSRISA
     309-309: N → NLLALGLKHFEGTEFLNPLIS

Note: No experimental confirmation available.
Show »
Length:888
Mass (Da):97,716
Checksum:i237B12A7917D6593
GO

Sequence cautioni

The sequence BAA91871.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271R → Q in BAB14748 (PubMed:14702039).Curated
Sequence conflicti498 – 4981H → R in BAG59954 (PubMed:14702039).Curated
Sequence conflicti541 – 5411P → L (PubMed:11710830).Curated
Sequence conflicti553 – 5531P → L in AAH01655 (PubMed:15489334).Curated
Sequence conflicti553 – 5531P → L in AAH01843 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti412 – 4121G → S.
Corresponds to variant rs35098429 [ dbSNP | Ensembl ].
VAR_051497
Natural varianti786 – 7861E → Q.
Corresponds to variant rs7539 [ dbSNP | Ensembl ].
VAR_051498

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 329329Missing in isoform 7. 1 PublicationVSP_016585Add
BLAST
Alternative sequencei1 – 132132Missing in isoform 5. 1 PublicationVSP_016586Add
BLAST
Alternative sequencei1 – 7777Missing in isoform 3 and isoform 6. 3 PublicationsVSP_016587Add
BLAST
Alternative sequencei1 – 6666Missing in isoform 2 and isoform 4. 2 PublicationsVSP_016588Add
BLAST
Alternative sequencei1 – 1515MEEEA…ATNPG → MAGVGRSGGPWGRTRGGRSG RLGVSLGALSSLPLEELPRP LCCRRCRRHFGFALRGETIP VSVAGSASSQFAPLALHLSL LLSRISA in isoform 8 and isoform 9. 2 PublicationsVSP_046858Add
BLAST
Alternative sequencei309 – 3091N → NLLALGLKHFEGTEFLNPLI S in isoform 2, isoform 3, isoform 5 and isoform 9. 3 PublicationsVSP_016589

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF206328 mRNA. Translation: AAL74055.1.
AF466401 mRNA. Translation: AAL75971.1.
AF203474 mRNA. Translation: AAO13249.1.
AY604179 mRNA. Translation: AAT34990.1.
AK001737 mRNA. Translation: BAA91871.1. Different initiation.
AK023976 mRNA. Translation: BAB14748.1.
AK297562 mRNA. Translation: BAG59954.1.
AK303386 mRNA. Translation: BAG64442.1.
AL162734, BX088689 Genomic DNA. Translation: CAH71642.1.
AL162734, BX088689 Genomic DNA. Translation: CAH71643.1.
AL162734, BX088689 Genomic DNA. Translation: CAH71644.1.
AL162734, BX088689 Genomic DNA. Translation: CAH71646.1.
BX088689, AL162734 Genomic DNA. Translation: CAH73350.1.
BX088689, AL162734 Genomic DNA. Translation: CAH73351.1.
BX088689, AL162734 Genomic DNA. Translation: CAH73352.1.
BX088689, AL162734 Genomic DNA. Translation: CAH73354.1.
BX088689, AL162734 Genomic DNA. Translation: CAQ07661.1.
AL162734, BX088689 Genomic DNA. Translation: CAQ09422.1.
CH471121 Genomic DNA. Translation: EAW53052.1.
CH471121 Genomic DNA. Translation: EAW53055.1.
CH471121 Genomic DNA. Translation: EAW53056.1.
CH471121 Genomic DNA. Translation: EAW53057.1.
CH471121 Genomic DNA. Translation: EAW53060.1.
BC001655 mRNA. Translation: AAH01655.2.
BC001843 mRNA. Translation: AAH01843.2.
BC003500 mRNA. No translation available.
BC008766 mRNA. Translation: AAH08766.2.
BC009358 mRNA. Translation: AAH09358.2.
BC014906 mRNA. Translation: AAH14906.1.
BC025272 mRNA. No translation available.
CCDSiCCDS1115.1. [Q9H869-1]
CCDS1116.1. [Q9H869-2]
CCDS55643.1. [Q9H869-4]
CCDS55644.1. [Q9H869-8]
CCDS55645.1. [Q9H869-9]
RefSeqiNP_001185828.1. NM_001198899.1. [Q9H869-3]
NP_001185829.1. NM_001198900.1. [Q9H869-3]
NP_001185830.1. NM_001198901.1. [Q9H869-2]
NP_001185831.1. NM_001198902.1. [Q9H869-2]
NP_001185832.1. NM_001198903.1. [Q9H869-9]
NP_001185833.1. NM_001198904.1. [Q9H869-8]
NP_001185834.1. NM_001198905.1. [Q9H869-4]
NP_001185835.1. NM_001198906.1.
NP_060723.2. NM_018253.3. [Q9H869-3]
NP_620829.1. NM_139118.2. [Q9H869-1]
NP_620830.1. NM_139119.2. [Q9H869-2]
NP_620832.1. NM_139121.2. [Q9H869-5]
XP_011508024.1. XM_011509722.1. [Q9H869-3]
UniGeneiHs.584927.

Genome annotation databases

EnsembliENST00000295566; ENSP00000295566; ENSG00000163374. [Q9H869-1]
ENST00000311573; ENSP00000311138; ENSG00000163374. [Q9H869-6]
ENST00000347088; ENSP00000316079; ENSG00000163374. [Q9H869-2]
ENST00000355499; ENSP00000347686; ENSG00000163374. [Q9H869-2]
ENST00000359205; ENSP00000352134; ENSG00000163374. [Q9H869-3]
ENST00000361831; ENSP00000355298; ENSG00000163374. [Q9H869-3]
ENST00000368330; ENSP00000357314; ENSG00000163374. [Q9H869-2]
ENST00000368339; ENSP00000357323; ENSG00000163374. [Q9H869-9]
ENST00000368340; ENSP00000357324; ENSG00000163374. [Q9H869-8]
ENST00000404643; ENSP00000385390; ENSG00000163374. [Q9H869-4]
ENST00000407221; ENSP00000385791; ENSG00000163374. [Q9H869-6]
GeneIDi55249.
KEGGihsa:55249.
UCSCiuc001flh.4. human. [Q9H869-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF206328 mRNA. Translation: AAL74055.1.
AF466401 mRNA. Translation: AAL75971.1.
AF203474 mRNA. Translation: AAO13249.1.
AY604179 mRNA. Translation: AAT34990.1.
AK001737 mRNA. Translation: BAA91871.1. Different initiation.
AK023976 mRNA. Translation: BAB14748.1.
AK297562 mRNA. Translation: BAG59954.1.
AK303386 mRNA. Translation: BAG64442.1.
AL162734, BX088689 Genomic DNA. Translation: CAH71642.1.
AL162734, BX088689 Genomic DNA. Translation: CAH71643.1.
AL162734, BX088689 Genomic DNA. Translation: CAH71644.1.
AL162734, BX088689 Genomic DNA. Translation: CAH71646.1.
BX088689, AL162734 Genomic DNA. Translation: CAH73350.1.
BX088689, AL162734 Genomic DNA. Translation: CAH73351.1.
BX088689, AL162734 Genomic DNA. Translation: CAH73352.1.
BX088689, AL162734 Genomic DNA. Translation: CAH73354.1.
BX088689, AL162734 Genomic DNA. Translation: CAQ07661.1.
AL162734, BX088689 Genomic DNA. Translation: CAQ09422.1.
CH471121 Genomic DNA. Translation: EAW53052.1.
CH471121 Genomic DNA. Translation: EAW53055.1.
CH471121 Genomic DNA. Translation: EAW53056.1.
CH471121 Genomic DNA. Translation: EAW53057.1.
CH471121 Genomic DNA. Translation: EAW53060.1.
BC001655 mRNA. Translation: AAH01655.2.
BC001843 mRNA. Translation: AAH01843.2.
BC003500 mRNA. No translation available.
BC008766 mRNA. Translation: AAH08766.2.
BC009358 mRNA. Translation: AAH09358.2.
BC014906 mRNA. Translation: AAH14906.1.
BC025272 mRNA. No translation available.
CCDSiCCDS1115.1. [Q9H869-1]
CCDS1116.1. [Q9H869-2]
CCDS55643.1. [Q9H869-4]
CCDS55644.1. [Q9H869-8]
CCDS55645.1. [Q9H869-9]
RefSeqiNP_001185828.1. NM_001198899.1. [Q9H869-3]
NP_001185829.1. NM_001198900.1. [Q9H869-3]
NP_001185830.1. NM_001198901.1. [Q9H869-2]
NP_001185831.1. NM_001198902.1. [Q9H869-2]
NP_001185832.1. NM_001198903.1. [Q9H869-9]
NP_001185833.1. NM_001198904.1. [Q9H869-8]
NP_001185834.1. NM_001198905.1. [Q9H869-4]
NP_001185835.1. NM_001198906.1.
NP_060723.2. NM_018253.3. [Q9H869-3]
NP_620829.1. NM_139118.2. [Q9H869-1]
NP_620830.1. NM_139119.2. [Q9H869-2]
NP_620832.1. NM_139121.2. [Q9H869-5]
XP_011508024.1. XM_011509722.1. [Q9H869-3]
UniGeneiHs.584927.

3D structure databases

ProteinModelPortaliQ9H869.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120540. 28 interactions.
IntActiQ9H869. 14 interactions.
MINTiMINT-1481820.
STRINGi9606.ENSP00000357323.

PTM databases

iPTMnetiQ9H869.
PhosphoSiteiQ9H869.

Polymorphism and mutation databases

BioMutaiYY1AP1.
DMDMi147744601.

Proteomic databases

EPDiQ9H869.
MaxQBiQ9H869.
PaxDbiQ9H869.
PeptideAtlasiQ9H869.
PRIDEiQ9H869.

Protocols and materials databases

DNASUi55249.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295566; ENSP00000295566; ENSG00000163374. [Q9H869-1]
ENST00000311573; ENSP00000311138; ENSG00000163374. [Q9H869-6]
ENST00000347088; ENSP00000316079; ENSG00000163374. [Q9H869-2]
ENST00000355499; ENSP00000347686; ENSG00000163374. [Q9H869-2]
ENST00000359205; ENSP00000352134; ENSG00000163374. [Q9H869-3]
ENST00000361831; ENSP00000355298; ENSG00000163374. [Q9H869-3]
ENST00000368330; ENSP00000357314; ENSG00000163374. [Q9H869-2]
ENST00000368339; ENSP00000357323; ENSG00000163374. [Q9H869-9]
ENST00000368340; ENSP00000357324; ENSG00000163374. [Q9H869-8]
ENST00000404643; ENSP00000385390; ENSG00000163374. [Q9H869-4]
ENST00000407221; ENSP00000385791; ENSG00000163374. [Q9H869-6]
GeneIDi55249.
KEGGihsa:55249.
UCSCiuc001flh.4. human. [Q9H869-1]

Organism-specific databases

CTDi55249.
GeneCardsiYY1AP1.
H-InvDBHIX0028706.
HGNCiHGNC:30935. YY1AP1.
HPAiHPA006986.
MIMi607860. gene.
neXtProtiNX_Q9H869.
PharmGKBiPA142670546.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JQ2S. Eukaryota.
ENOG410XS4M. LUCA.
GeneTreeiENSGT00390000016256.
HOGENOMiHOG000038018.
HOVERGENiHBG074061.
InParanoidiQ9H869.
OMAiRHEKEAN.
OrthoDBiEOG771263.
PhylomeDBiQ9H869.
TreeFamiTF343327.

Miscellaneous databases

ChiTaRSiYY1AP1. human.
GeneWikiiYY1AP1.
GenomeRNAii55249.
PROiQ9H869.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H869.
ExpressionAtlasiQ9H869. baseline and differential.
GenevisibleiQ9H869. HS.

Family and domain databases

InterProiIPR033274. YY1AP1.
[Graphical view]
PANTHERiPTHR16088:SF9. PTHR16088:SF9. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a novel human hepatocellular carcinoma-associated gene."
    Wang Z.-X., Wang H.-Y., Wu M.-C.
    Br. J. Cancer Suppl. 85:1162-1167(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH YY1, TISSUE SPECIFICITY.
    Tissue: Cervix carcinoma.
  3. "Molecular cloning and characterization of a novel gene which is highly expressed in hepatocellular carcinoma."
    Zeng J.Z., Wang H.-Y., Chen Z.J., Ullrich A., Wu M.-C.
    Oncogene 21:4932-4943(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Placenta.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 9).
    Tissue: Brain, Retinoblastoma, Teratocarcinoma and Thymus.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 4; 5 AND 8).
    Tissue: Colon, Lung, Muscle, Skin and Uterus.
  8. "Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2."
    Li L., Shi Y., Wu H., Wan B., Li P., Zhou L., Shi H., Huo K.
    Mol. Cell. Biochem. 304:297-304(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH MAD2L2, SUBCELLULAR LOCATION.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-724, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.

Entry informationi

Entry nameiYYAP1_HUMAN
AccessioniPrimary (citable) accession number: Q9H869
Secondary accession number(s): B0QZ54
, B4DMP2, B4E0I0, D3DV96, D3DV98, H7BY62, Q5VYZ1, Q5VYZ4, Q5VYZ7, Q7L4C3, Q7L5E2, Q8IXA6, Q8TEW5, Q8TF04, Q96HB6, Q9BQ64, Q9NV84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 15, 2007
Last modified: July 6, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.