Q9H869 (YYAP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
YY1-associated protein 1

Alternative name(s):
Hepatocellular carcinoma susceptibility protein
Hepatocellular carcinoma-associated protein 2

Gene names

Name:	YY1AP1
Synonyms:	HCCA2, YY1AP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	796 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Enhances transcription activation by YY1. May play a role in cell cycle regulation. Ref.2 Ref.8
Subunit structure	Interacts with YY1. Interacts with MAD2L2. Ref.2 Ref.8
Subcellular location	Cytoplasm. Nucleus Ref.1 Ref.2 Ref.3 Ref.8.
Tissue specificity	Ubiquitous. Detected in small intestine, skeletal muscle, lung, pancreas, brain, stomach, spleen, colon and heart. Detected at very low levels in healthy liver. Highly expressed in most liver carcinomas. Ref.1 Ref.2 Ref.3
Sequence caution	The sequence BAA91871.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of cell cycle Inferred from direct assay Ref.8. Source: UniProtKB regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay Ref.8. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction Ref.8. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ATXN1	P54253	4	EBI-946122,EBI-930964

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H869-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H869-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: Missing.
     309-309: N → NLLALGLKHFEGTEFLNPLIS

Isoform 3 (identifier: Q9H869-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.
     309-309: N → NLLALGLKHFEGTEFLNPLIS

Isoform 4 (identifier: Q9H869-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: Missing.

Isoform 5 (identifier: Q9H869-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-132: Missing.
     309-309: N → NLLALGLKHFEGTEFLNPLIS

Isoform 6 (identifier: Q9H869-6)

Also known as: HCCA1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.

Isoform 7 (identifier: Q9H869-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-329: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 796	796	YY1-associated protein 1		PRO_0000076369
Amino acid modifications
	Modified residue	724	1	Phosphoserine Ref.9
Natural variations
	Alternative sequence	1 – 329	329	Missing in isoform 7.		VSP_016585
	Alternative sequence	1 – 132	132	Missing in isoform 5.		VSP_016586
	Alternative sequence	1 – 77	77	Missing in isoform 3 and isoform 6.		VSP_016587
	Alternative sequence	1 – 66	66	Missing in isoform 2 and isoform 4.		VSP_016588
	Alternative sequence	309	1	N → NLLALGLKHFEGTEFLNPLI S in isoform 2, isoform 3 and isoform 5.		VSP_016589
	Natural variant	412	1	G → S. Corresponds to variant rs35098429 [ dbSNP | Ensembl ].		VAR_051497
	Natural variant	786	1	E → Q. Corresponds to variant rs7539 [ dbSNP | Ensembl ].		VAR_051498
Experimental info
	Sequence conflict	27	1	R → Q in BAB14748. Ref.4
	Sequence conflict	541	1	P → L Ref.1
	Sequence conflict	553	1	P → L in AAH01655. Ref.7
	Sequence conflict	553	1	P → L in AAH01843. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 15, 2007. Version 2. Checksum: A2FC8B4DBA8DFDA7	FASTA	796	87,944
	10 20 30 40 50 60 MEEEASRSAA ATNPGSRLTR WPPPDKREGS AVDPGKRRSL AATPSSSLPC TLIALGLRHE 70 80 90 100 110 120 KEANELMEDL FETFQDEMGF SNMEDDGPEE EERVAEPQAN FNTPQALRFE ELLANLLNEQ 130 140 150 160 170 180 HQIAKELFEQ LKMKKPSAKQ QKEVEKVKPQ CKEVHQTLIL DPAQRKRLQQ QMQQHVQLLT 190 200 210 220 230 240 QIHLLATCNP NLNPEASSTR ICLKELGTFA QSSIALHHQY NPKFQTLFQP CNLMGAMQLI 250 260 270 280 290 300 EDFSTHVSID CSPHKTVKKT ANEFPCLPKQ VAWILATSKV FMYPELLPVC SLKAKNPQDK 310 320 330 340 350 360 ILFTKAEDNK YLLTCKTARQ LTVRIKNLNM NRAPDNIIKF YKKTKQLPVL GKCCEEIQPH 370 380 390 400 410 420 QWKPPIEREE HRLPFWLKAS LPSIQEELRH MADGAREVGN MTGTTEINSD QGLEKDNSEL 430 440 450 460 470 480 GSETRYPLLL PKGVVLKLKP VADRFPKKAW RQKRSSVLKP LLIQPSPSLQ PSFNPGKTPA 490 500 510 520 530 540 QSTHSEAPPS KMVLRIPHPI QPATVLQTVP GVPPLGVSGG ESFESPAALP AMPPEARTSF 550 560 570 580 590 600 PLSESQTLLS SAPVPKVMMP SPASSMFRKP YVRRRPSKRR GARAFRCIKP APVIHPASVI 610 620 630 640 650 660 FTVPATTVKI VSLGGGCNMI QPVNAAVAQS PQTIPIATLL VNPTSFPCPL NQPLVASSVS 670 680 690 700 710 720 PLIVSGNSVN LPIPSTPEDK AHMNVDIACA VADGENAFQG LEPKLEPQEL SPLSATVFPK 730 740 750 760 770 780 VEHSPGPPPV DKQCQEGLSE NSAYRWTVVK TEEGRQALEP LPQGIQESLN NSSPGDLEEV 790 VKMEPEDATE EISGFL
	Isoform 2 [UniParc]. Checksum: 35A05C3146FC95D7	FASTA	750	83,088
	10 20 30 40 50 60 MEDLFETFQD EMGFSNMEDD GPEEEERVAE PQANFNTPQA LRFEELLANL LNEQHQIAKE 70 80 90 100 110 120 LFEQLKMKKP SAKQQKEVEK VKPQCKEVHQ TLILDPAQRK RLQQQMQQHV QLLTQIHLLA 130 140 150 160 170 180 TCNPNLNPEA SSTRICLKEL GTFAQSSIAL HHQYNPKFQT LFQPCNLMGA MQLIEDFSTH 190 200 210 220 230 240 VSIDCSPHKT VKKTANEFPC LPKQVAWILA TSKVFMYPEL LPVCSLKAKN PQDKILFTKA 250 260 270 280 290 300 EDNLLALGLK HFEGTEFLNP LISKYLLTCK TARQLTVRIK NLNMNRAPDN IIKFYKKTKQ 310 320 330 340 350 360 LPVLGKCCEE IQPHQWKPPI EREEHRLPFW LKASLPSIQE ELRHMADGAR EVGNMTGTTE 370 380 390 400 410 420 INSDQGLEKD NSELGSETRY PLLLPKGVVL KLKPVADRFP KKAWRQKRSS VLKPLLIQPS 430 440 450 460 470 480 PSLQPSFNPG KTPAQSTHSE APPSKMVLRI PHPIQPATVL QTVPGVPPLG VSGGESFESP 490 500 510 520 530 540 AALPAMPPEA RTSFPLSESQ TLLSSAPVPK VMMPSPASSM FRKPYVRRRP SKRRGARAFR 550 560 570 580 590 600 CIKPAPVIHP ASVIFTVPAT TVKIVSLGGG CNMIQPVNAA VAQSPQTIPI ATLLVNPTSF 610 620 630 640 650 660 PCPLNQPLVA SSVSPLIVSG NSVNLPIPST PEDKAHMNVD IACAVADGEN AFQGLEPKLE 670 680 690 700 710 720 PQELSPLSAT VFPKVEHSPG PPPVDKQCQE GLSENSAYRW TVVKTEEGRQ ALEPLPQGIQ 730 740 750 ESLNNSSPGD LEEVVKMEPE DATEEISGFL
	Isoform 3 [UniParc]. Checksum: AEE39032FCC83A53	FASTA	739	81,702
	10 20 30 40 50 60 MGFSNMEDDG PEEEERVAEP QANFNTPQAL RFEELLANLL NEQHQIAKEL FEQLKMKKPS 70 80 90 100 110 120 AKQQKEVEKV KPQCKEVHQT LILDPAQRKR LQQQMQQHVQ LLTQIHLLAT CNPNLNPEAS 130 140 150 160 170 180 STRICLKELG TFAQSSIALH HQYNPKFQTL FQPCNLMGAM QLIEDFSTHV SIDCSPHKTV 190 200 210 220 230 240 KKTANEFPCL PKQVAWILAT SKVFMYPELL PVCSLKAKNP QDKILFTKAE DNLLALGLKH 250 260 270 280 290 300 FEGTEFLNPL ISKYLLTCKT ARQLTVRIKN LNMNRAPDNI IKFYKKTKQL PVLGKCCEEI 310 320 330 340 350 360 QPHQWKPPIE REEHRLPFWL KASLPSIQEE LRHMADGARE VGNMTGTTEI NSDQGLEKDN 370 380 390 400 410 420 SELGSETRYP LLLPKGVVLK LKPVADRFPK KAWRQKRSSV LKPLLIQPSP SLQPSFNPGK 430 440 450 460 470 480 TPAQSTHSEA PPSKMVLRIP HPIQPATVLQ TVPGVPPLGV SGGESFESPA ALPAMPPEAR 490 500 510 520 530 540 TSFPLSESQT LLSSAPVPKV MMPSPASSMF RKPYVRRRPS KRRGARAFRC IKPAPVIHPA 550 560 570 580 590 600 SVIFTVPATT VKIVSLGGGC NMIQPVNAAV AQSPQTIPIA TLLVNPTSFP CPLNQPLVAS 610 620 630 640 650 660 SVSPLIVSGN SVNLPIPSTP EDKAHMNVDI ACAVADGENA FQGLEPKLEP QELSPLSATV 670 680 690 700 710 720 FPKVEHSPGP PPVDKQCQEG LSENSAYRWT VVKTEEGRQA LEPLPQGIQE SLNNSSPGDL 730 EEVVKMEPED ATEEISGFL
	Isoform 4 [UniParc]. Checksum: 3A7B22D694AE7E0B	FASTA	730	80,893
	10 20 30 40 50 60 MEDLFETFQD EMGFSNMEDD GPEEEERVAE PQANFNTPQA LRFEELLANL LNEQHQIAKE 70 80 90 100 110 120 LFEQLKMKKP SAKQQKEVEK VKPQCKEVHQ TLILDPAQRK RLQQQMQQHV QLLTQIHLLA 130 140 150 160 170 180 TCNPNLNPEA SSTRICLKEL GTFAQSSIAL HHQYNPKFQT LFQPCNLMGA MQLIEDFSTH 190 200 210 220 230 240 VSIDCSPHKT VKKTANEFPC LPKQVAWILA TSKVFMYPEL LPVCSLKAKN PQDKILFTKA 250 260 270 280 290 300 EDNKYLLTCK TARQLTVRIK NLNMNRAPDN IIKFYKKTKQ LPVLGKCCEE IQPHQWKPPI 310 320 330 340 350 360 EREEHRLPFW LKASLPSIQE ELRHMADGAR EVGNMTGTTE INSDQGLEKD NSELGSETRY 370 380 390 400 410 420 PLLLPKGVVL KLKPVADRFP KKAWRQKRSS VLKPLLIQPS PSLQPSFNPG KTPAQSTHSE 430 440 450 460 470 480 APPSKMVLRI PHPIQPATVL QTVPGVPPLG VSGGESFESP AALPAMPPEA RTSFPLSESQ 490 500 510 520 530 540 TLLSSAPVPK VMMPSPASSM FRKPYVRRRP SKRRGARAFR CIKPAPVIHP ASVIFTVPAT 550 560 570 580 590 600 TVKIVSLGGG CNMIQPVNAA VAQSPQTIPI ATLLVNPTSF PCPLNQPLVA SSVSPLIVSG 610 620 630 640 650 660 NSVNLPIPST PEDKAHMNVD IACAVADGEN AFQGLEPKLE PQELSPLSAT VFPKVEHSPG 670 680 690 700 710 720 PPPVDKQCQE GLSENSAYRW TVVKTEEGRQ ALEPLPQGIQ ESLNNSSPGD LEEVVKMEPE 730 DATEEISGFL
	Isoform 5 [UniParc]. Checksum: E2F9E4BEAB76E3D5	FASTA	684	75,330
	10 20 30 40 50 60 MKKPSAKQQK EVEKVKPQCK EVHQTLILDP AQRKRLQQQM QQHVQLLTQI HLLATCNPNL 70 80 90 100 110 120 NPEASSTRIC LKELGTFAQS SIALHHQYNP KFQTLFQPCN LMGAMQLIED FSTHVSIDCS 130 140 150 160 170 180 PHKTVKKTAN EFPCLPKQVA WILATSKVFM YPELLPVCSL KAKNPQDKIL FTKAEDNLLA 190 200 210 220 230 240 LGLKHFEGTE FLNPLISKYL LTCKTARQLT VRIKNLNMNR APDNIIKFYK KTKQLPVLGK 250 260 270 280 290 300 CCEEIQPHQW KPPIEREEHR LPFWLKASLP SIQEELRHMA DGAREVGNMT GTTEINSDQG 310 320 330 340 350 360 LEKDNSELGS ETRYPLLLPK GVVLKLKPVA DRFPKKAWRQ KRSSVLKPLL IQPSPSLQPS 370 380 390 400 410 420 FNPGKTPAQS THSEAPPSKM VLRIPHPIQP ATVLQTVPGV PPLGVSGGES FESPAALPAM 430 440 450 460 470 480 PPEARTSFPL SESQTLLSSA PVPKVMMPSP ASSMFRKPYV RRRPSKRRGA RAFRCIKPAP 490 500 510 520 530 540 VIHPASVIFT VPATTVKIVS LGGGCNMIQP VNAAVAQSPQ TIPIATLLVN PTSFPCPLNQ 550 560 570 580 590 600 PLVASSVSPL IVSGNSVNLP IPSTPEDKAH MNVDIACAVA DGENAFQGLE PKLEPQELSP 610 620 630 640 650 660 LSATVFPKVE HSPGPPPVDK QCQEGLSENS AYRWTVVKTE EGRQALEPLP QGIQESLNNS 670 680 SPGDLEEVVK MEPEDATEEI SGFL
	Isoform 6 (HCCA1) [UniParc]. Checksum: 3C3288D1B4E1CEF2	FASTA	719	79,508
	10 20 30 40 50 60 MGFSNMEDDG PEEEERVAEP QANFNTPQAL RFEELLANLL NEQHQIAKEL FEQLKMKKPS 70 80 90 100 110 120 AKQQKEVEKV KPQCKEVHQT LILDPAQRKR LQQQMQQHVQ LLTQIHLLAT CNPNLNPEAS 130 140 150 160 170 180 STRICLKELG TFAQSSIALH HQYNPKFQTL FQPCNLMGAM QLIEDFSTHV SIDCSPHKTV 190 200 210 220 230 240 KKTANEFPCL PKQVAWILAT SKVFMYPELL PVCSLKAKNP QDKILFTKAE DNKYLLTCKT 250 260 270 280 290 300 ARQLTVRIKN LNMNRAPDNI IKFYKKTKQL PVLGKCCEEI QPHQWKPPIE REEHRLPFWL 310 320 330 340 350 360 KASLPSIQEE LRHMADGARE VGNMTGTTEI NSDQGLEKDN SELGSETRYP LLLPKGVVLK 370 380 390 400 410 420 LKPVADRFPK KAWRQKRSSV LKPLLIQPSP SLQPSFNPGK TPAQSTHSEA PPSKMVLRIP 430 440 450 460 470 480 HPIQPATVLQ TVPGVPPLGV SGGESFESPA ALPAMPPEAR TSFPLSESQT LLSSAPVPKV 490 500 510 520 530 540 MMPSPASSMF RKPYVRRRPS KRRGARAFRC IKPAPVIHPA SVIFTVPATT VKIVSLGGGC 550 560 570 580 590 600 NMIQPVNAAV AQSPQTIPIA TLLVNPTSFP CPLNQPLVAS SVSPLIVSGN SVNLPIPSTP 610 620 630 640 650 660 EDKAHMNVDI ACAVADGENA FQGLEPKLEP QELSPLSATV FPKVEHSPGP PPVDKQCQEG 670 680 690 700 710 LSENSAYRWT VVKTEEGRQA LEPLPQGIQE SLNNSSPGDL EEVVKMEPED ATEEISGFL
	Isoform 7 [UniParc]. Checksum: 8A0B641CD01FAEC3	FASTA	467	50,634
	10 20 30 40 50 60 MNRAPDNIIK FYKKTKQLPV LGKCCEEIQP HQWKPPIERE EHRLPFWLKA SLPSIQEELR 70 80 90 100 110 120 HMADGAREVG NMTGTTEINS DQGLEKDNSE LGSETRYPLL LPKGVVLKLK PVADRFPKKA 130 140 150 160 170 180 WRQKRSSVLK PLLIQPSPSL QPSFNPGKTP AQSTHSEAPP SKMVLRIPHP IQPATVLQTV 190 200 210 220 230 240 PGVPPLGVSG GESFESPAAL PAMPPEARTS FPLSESQTLL SSAPVPKVMM PSPASSMFRK 250 260 270 280 290 300 PYVRRRPSKR RGARAFRCIK PAPVIHPASV IFTVPATTVK IVSLGGGCNM IQPVNAAVAQ 310 320 330 340 350 360 SPQTIPIATL LVNPTSFPCP LNQPLVASSV SPLIVSGNSV NLPIPSTPED KAHMNVDIAC 370 380 390 400 410 420 AVADGENAFQ GLEPKLEPQE LSPLSATVFP KVEHSPGPPP VDKQCQEGLS ENSAYRWTVV 430 440 450 460 KTEEGRQALE PLPQGIQESL NNSSPGDLEE VVKMEPEDAT EEISGFL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of a novel human hepatocellular carcinoma-associated gene." Wang Z.-X., Wang H.-Y., Wu M.-C. Br. J. Cancer Suppl. 85:1162-1167(2001) [PubMed: 11710830] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7), SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Placenta.
[2]	"YY1AP, a novel co-activator of YY1." Wang C.-Y., Liang Y.-J., Lin Y.-S., Shih H.-M., Jou Y.-S., Yu W.C.Y. J. Biol. Chem. 279:17750-17755(2004) [PubMed: 14744866] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH YY1, TISSUE SPECIFICITY. Tissue: Cervix carcinoma.
[3]	"Molecular cloning and characterization of a novel gene which is highly expressed in hepatocellular carcinoma." Zeng J.Z., Wang H.-Y., Chen Z.J., Ullrich A., Wu M.-C. Oncogene 21:4932-4943(2002) [PubMed: 12118372] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6), SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Placenta.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Retinoblastoma, Teratocarcinoma and Thymus.
[5]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 4 AND 5). Tissue: Colon, Muscle, Skin and Uterus.
[8]	"Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2." Li L., Shi Y., Wu H., Wan B., Li P., Zhou L., Shi H., Huo K. Mol. Cell. Biochem. 304:297-304(2007) [PubMed: 17541814] [Abstract] Cited for: FUNCTION, INTERACTION WITH MAD2L2, SUBCELLULAR LOCATION.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-724, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF206328 mRNA. Translation: AAL74055.1. AF466401 mRNA. Translation: AAL75971.1. AF203474 mRNA. Translation: AAO13249.1. AY604179 mRNA. Translation: AAT34990.1. AK001737 mRNA. Translation: BAA91871.1. Different initiation. AK023976 mRNA. Translation: BAB14748.1. AK303386 mRNA. Translation: BAG64442.1. AL162734, BX088689 Genomic DNA. Translation: CAH71642.1. AL162734, BX088689 Genomic DNA. Translation: CAH71643.1. AL162734, BX088689 Genomic DNA. Translation: CAH71644.1. AL162734, BX088689 Genomic DNA. Translation: CAH71646.1. BX088689, AL162734 Genomic DNA. Translation: CAH73350.1. BX088689, AL162734 Genomic DNA. Translation: CAH73351.1. BX088689, AL162734 Genomic DNA. Translation: CAH73352.1. BX088689, AL162734 Genomic DNA. Translation: CAH73354.1. BX088689, AL162734 Genomic DNA. Translation: CAQ07661.1. AL162734, BX088689 Genomic DNA. Translation: CAQ09422.1. CH471121 Genomic DNA. Translation: EAW53052.1. CH471121 Genomic DNA. Translation: EAW53055.1. CH471121 Genomic DNA. Translation: EAW53056.1. CH471121 Genomic DNA. Translation: EAW53057.1. CH471121 Genomic DNA. Translation: EAW53060.1. BC001655 mRNA. Translation: AAH01655.2. BC001843 mRNA. Translation: AAH01843.2. BC003500 mRNA. No translation available. BC008766 mRNA. Translation: AAH08766.2. BC009358 mRNA. Translation: AAH09358.2. BC014906 mRNA. Translation: AAH14906.1.
IPI	IPI00375458. IPI00376951. IPI00419581. IPI00640856. IPI00657727. IPI00657728. IPI00939489.
RefSeq	NP_001185828.1. NM_001198899.1. NP_001185829.1. NM_001198900.1. NP_001185830.1. NM_001198901.1. NP_001185831.1. NM_001198902.1. NP_001185832.1. NM_001198903.1. NP_001185833.1. NM_001198904.1. NP_001185834.1. NM_001198905.1. NP_001185835.1. NM_001198906.1. NP_060723.2. NM_018253.3. NP_620829.1. NM_139118.2. NP_620830.1. NM_139119.2. NP_620832.1. NM_139121.2.
UniGene	Hs.584927.
3D structure databases
ProteinModelPortal	Q9H869.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H869. 12 interactions.
MINT	MINT-1481820.
STRING	Q9H869.
PTM databases
PhosphoSite	Q9H869.
Polymorphism databases
DMDM	147744601.
Proteomic databases
PRIDE	Q9H869.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000295566; ENSP00000295566; ENSG00000163374.
GeneID	55249.
KEGG	hsa:55249.
UCSC	uc001flg.1. human. uc001fln.1. human.
Organism-specific databases
CTD	55249.
GeneCards	GC01M155630.
H-InvDB	HIX0001134. HIX0028706.
HGNC	HGNC:30935. YY1AP1.
HPA	HPA006986.
MIM	607860. gene.
neXtProt	NX_Q9H869.
PharmGKB	PA142670546.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000016256.
HOVERGEN	HBG074061.
PhylomeDB	Q9H869.
Gene expression databases
ArrayExpress	Q9H869.
Bgee	Q9H869.
Genevestigator	Q9H869.
GermOnline	ENSG00000163374. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	59304.
SOURCE	Search...

Entry information

Entry name

YYAP1_HUMAN

Accession

Primary (citable) accession number: Q9H869
Secondary accession number(s): B0QZ54 , B4E0I0, D3DV96, D3DV98, Q5VYZ4, Q5VYZ7, Q7L4C3, Q7L5E2, Q8IXA6, Q8TEW5, Q8TF04, Q96HB6, Q9BQ64, Q9NV84

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	May 15, 2007
Last modified:	January 25, 2012
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.