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Q9H841 (NPAL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NIPA-like protein 2
Gene names
Name:NIPAL2
Synonyms:NPAL2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the NIPA family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionmagnesium ion transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 368368NIPA-like protein 2
PRO_0000242148

Regions

Transmembrane46 – 6621Helical; Potential
Transmembrane88 – 10821Helical; Potential
Transmembrane110 – 13021Helical; Potential
Transmembrane144 – 16421Helical; Potential
Transmembrane177 – 19721Helical; Potential
Transmembrane209 – 22921Helical; Potential
Transmembrane243 – 26321Helical; Potential
Transmembrane278 – 29821Helical; Potential
Transmembrane306 – 32621Helical; Potential

Amino acid modifications

Glycosylation331N-linked (GlcNAc...) Potential
Glycosylation2741N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9H841 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 8221F45E85273782

FASTA36840,785
        10         20         30         40         50         60 
MAAVAPAGPG DSASAALDEL SLNFTYGAPG AGNGSLSGDW YRRNQIHLFG VLLAILGNLV 

        70         80         90        100        110        120 
ISISLNIQKY SHLQLAQQEH PRPYFKSVLW WGGVLLMAVG ETGNFAAYGF APITLIAPLG 

       130        140        150        160        170        180 
CVSVTGSAII SVTFLKDNLR ASDLLGTTLA FAGTYLLVNF APNITQAISA RTVQYYLVGW 

       190        200        210        220        230        240 
QFLIYVILEI LIFCILLYFY KRKGMKHMVI LLTLVAILAS LTVISVKAVS GMITFSVMDK 

       250        260        270        280        290        300 
MQLTYPIFYI MFIIMIASCV FQVKFLNQAT KLYNTTTVVP VNHIFFTISA IIAGIIFYQE 

       310        320        330        340        350        360 
FLGAPFLTVF IYLFGCFLSF LGVFLVTRNR EKEHLQQSYI DFGNIPDTTP ERKAWRETNV 


GQNTTRFT 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK024017 mRNA. Translation: BAB14779.1.
RefSeqNP_079035.1. NM_024759.1.
UniGeneHs.309489.

3D structure databases

ProteinModelPortalQ9H841.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM74733759.

Proteomic databases

PaxDbQ9H841.
PRIDEQ9H841.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000341166; ENSP00000339256; ENSG00000104361.
GeneID79815.
KEGGhsa:79815.
UCSCuc003yil.1. human.

Organism-specific databases

CTD79815.
GeneCardsGC08M099278.
HGNCHGNC:25854. NIPAL2.
neXtProtNX_Q9H841.
PharmGKBPA164723926.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG249324.
HOGENOMHOG000230865.
HOVERGENHBG069791.
InParanoidQ9H841.
PhylomeDBQ9H841.
TreeFamTF313214.

Gene expression databases

ArrayExpressQ9H841.
BgeeQ9H841.
CleanExHS_NPAL2.
GenevestigatorQ9H841.

Family and domain databases

InterProIPR008521. Mg_trans_NIPA.
[Graphical view]
PANTHERPTHR12570. PTHR12570. 1 hit.
PfamPF05653. Mg_trans_NIPA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi79815.
NextBio69418.
PROQ9H841.

Entry information

Entry nameNPAL2_HUMAN
AccessionPrimary (citable) accession number: Q9H841
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM