Q9H841 (NPAL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NIPA-like protein 2

Gene names

Name:	NIPAL2
Synonyms:	NPAL2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	368 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the NIPA family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	magnesium ion transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 368	368	NIPA-like protein 2		PRO_0000242148
Regions
	Transmembrane	46 – 66	21	Helical; Potential
	Transmembrane	88 – 108	21	Helical; Potential
	Transmembrane	110 – 130	21	Helical; Potential
	Transmembrane	144 – 164	21	Helical; Potential
	Transmembrane	177 – 197	21	Helical; Potential
	Transmembrane	209 – 229	21	Helical; Potential
	Transmembrane	243 – 263	21	Helical; Potential
	Transmembrane	278 – 298	21	Helical; Potential
	Transmembrane	306 – 326	21	Helical; Potential
Amino acid modifications
	Glycosylation	33	1	N-linked (GlcNAc...) Potential
	Glycosylation	274	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9H841 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 8221F45E85273782	FASTA	368	40,785
	10 20 30 40 50 60 MAAVAPAGPG DSASAALDEL SLNFTYGAPG AGNGSLSGDW YRRNQIHLFG VLLAILGNLV 70 80 90 100 110 120 ISISLNIQKY SHLQLAQQEH PRPYFKSVLW WGGVLLMAVG ETGNFAAYGF APITLIAPLG 130 140 150 160 170 180 CVSVTGSAII SVTFLKDNLR ASDLLGTTLA FAGTYLLVNF APNITQAISA RTVQYYLVGW 190 200 210 220 230 240 QFLIYVILEI LIFCILLYFY KRKGMKHMVI LLTLVAILAS LTVISVKAVS GMITFSVMDK 250 260 270 280 290 300 MQLTYPIFYI MFIIMIASCV FQVKFLNQAT KLYNTTTVVP VNHIFFTISA IIAGIIFYQE 310 320 330 340 350 360 FLGAPFLTVF IYLFGCFLSF LGVFLVTRNR EKEHLQQSYI DFGNIPDTTP ERKAWRETNV GQNTTRFT

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK024017 mRNA. Translation: BAB14779.1.
IPI	IPI00414756.
RefSeq	NP_079035.1. NM_024759.1.
UniGene	Hs.309489.
3D structure databases
ProteinModelPortal	Q9H841.
ModBase	Search...
Polymorphism databases
DMDM	74733759.
Proteomic databases
PaxDb	Q9H841.
PRIDE	Q9H841.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341166; ENSP00000339256; ENSG00000104361.
GeneID	79815.
KEGG	hsa:79815.
UCSC	uc003yil.1. human.
Organism-specific databases
CTD	79815.
GeneCards	GC08M099278.
HGNC	HGNC:25854. NIPAL2.
neXtProt	NX_Q9H841.
PharmGKB	PA164723926.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG249324.
HOGENOM	HOG000230865.
HOVERGEN	HBG069791.
InParanoid	Q9H841.
PhylomeDB	Q9H841.
Gene expression databases
ArrayExpress	Q9H841.
Bgee	Q9H841.
CleanEx	HS_NPAL2.
Genevestigator	Q9H841.
Family and domain databases
InterPro	IPR008521. Mg_trans_NIPA. [Graphical view]
PANTHER	PTHR12570. PTHR12570. 1 hit.
Pfam	PF05653. Mg_trans_NIPA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	79815.
NextBio	69418.

Entry information

Entry name

NPAL2_HUMAN

Accession

Primary (citable) accession number: Q9H841

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	March 1, 2001
Last modified:	April 3, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.