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Q9H841

- NPAL2_HUMAN

UniProt

Q9H841 - NPAL2_HUMAN

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Protein

NIPA-like protein 2

Gene
NIPAL2, NPAL2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. magnesium ion transmembrane transporter activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
NIPA-like protein 2
Gene namesi
Name:NIPAL2
Synonyms:NPAL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:25854. NIPAL2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei46 – 6621Helical; Reviewed predictionAdd
BLAST
Transmembranei88 – 10821Helical; Reviewed predictionAdd
BLAST
Transmembranei110 – 13021Helical; Reviewed predictionAdd
BLAST
Transmembranei144 – 16421Helical; Reviewed predictionAdd
BLAST
Transmembranei177 – 19721Helical; Reviewed predictionAdd
BLAST
Transmembranei209 – 22921Helical; Reviewed predictionAdd
BLAST
Transmembranei243 – 26321Helical; Reviewed predictionAdd
BLAST
Transmembranei278 – 29821Helical; Reviewed predictionAdd
BLAST
Transmembranei306 – 32621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164723926.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368NIPA-like protein 2PRO_0000242148Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi33 – 331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi274 – 2741N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9H841.
PRIDEiQ9H841.

Expressioni

Gene expression databases

ArrayExpressiQ9H841.
BgeeiQ9H841.
CleanExiHS_NPAL2.
GenevestigatoriQ9H841.

Structurei

3D structure databases

ProteinModelPortaliQ9H841.

Family & Domainsi

Sequence similaritiesi

Belongs to the NIPA family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249324.
HOGENOMiHOG000230865.
HOVERGENiHBG069791.
InParanoidiQ9H841.
PhylomeDBiQ9H841.
TreeFamiTF313214.

Family and domain databases

InterProiIPR008521. Mg_trans_NIPA.
[Graphical view]
PANTHERiPTHR12570. PTHR12570. 1 hit.
PfamiPF05653. Mg_trans_NIPA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H841-1 [UniParc]FASTAAdd to Basket

« Hide

MAAVAPAGPG DSASAALDEL SLNFTYGAPG AGNGSLSGDW YRRNQIHLFG    50
VLLAILGNLV ISISLNIQKY SHLQLAQQEH PRPYFKSVLW WGGVLLMAVG 100
ETGNFAAYGF APITLIAPLG CVSVTGSAII SVTFLKDNLR ASDLLGTTLA 150
FAGTYLLVNF APNITQAISA RTVQYYLVGW QFLIYVILEI LIFCILLYFY 200
KRKGMKHMVI LLTLVAILAS LTVISVKAVS GMITFSVMDK MQLTYPIFYI 250
MFIIMIASCV FQVKFLNQAT KLYNTTTVVP VNHIFFTISA IIAGIIFYQE 300
FLGAPFLTVF IYLFGCFLSF LGVFLVTRNR EKEHLQQSYI DFGNIPDTTP 350
ERKAWRETNV GQNTTRFT 368
Length:368
Mass (Da):40,785
Last modified:March 1, 2001 - v1
Checksum:i8221F45E85273782
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK024017 mRNA. Translation: BAB14779.1.
CCDSiCCDS6278.1.
RefSeqiNP_079035.1. NM_024759.1.
UniGeneiHs.309489.

Genome annotation databases

EnsembliENST00000341166; ENSP00000339256; ENSG00000104361.
GeneIDi79815.
KEGGihsa:79815.
UCSCiuc003yil.1. human.

Polymorphism databases

DMDMi74733759.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK024017 mRNA. Translation: BAB14779.1 .
CCDSi CCDS6278.1.
RefSeqi NP_079035.1. NM_024759.1.
UniGenei Hs.309489.

3D structure databases

ProteinModelPortali Q9H841.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 74733759.

Proteomic databases

PaxDbi Q9H841.
PRIDEi Q9H841.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000341166 ; ENSP00000339256 ; ENSG00000104361 .
GeneIDi 79815.
KEGGi hsa:79815.
UCSCi uc003yil.1. human.

Organism-specific databases

CTDi 79815.
GeneCardsi GC08M099278.
HGNCi HGNC:25854. NIPAL2.
neXtProti NX_Q9H841.
PharmGKBi PA164723926.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG249324.
HOGENOMi HOG000230865.
HOVERGENi HBG069791.
InParanoidi Q9H841.
PhylomeDBi Q9H841.
TreeFami TF313214.

Miscellaneous databases

GenomeRNAii 79815.
NextBioi 69418.
PROi Q9H841.

Gene expression databases

ArrayExpressi Q9H841.
Bgeei Q9H841.
CleanExi HS_NPAL2.
Genevestigatori Q9H841.

Family and domain databases

InterProi IPR008521. Mg_trans_NIPA.
[Graphical view ]
PANTHERi PTHR12570. PTHR12570. 1 hit.
Pfami PF05653. Mg_trans_NIPA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiNPAL2_HUMAN
AccessioniPrimary (citable) accession number: Q9H841
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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