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Q9H832

- UBE2Z_HUMAN

UniProt

Q9H832 - UBE2Z_HUMAN

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Protein

Ubiquitin-conjugating enzyme E2 Z

Gene
UBE2Z, HOYS7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins By similarity. Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation.2 Publications

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei188 – 1881Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. protein binding Source: IntAct

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Apoptosis, Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkiQ9H832.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 Z (EC:6.3.2.19)
Alternative name(s):
Uba6-specific E2 conjugating enzyme 1
Short name:
Use1
Ubiquitin carrier protein Z
Ubiquitin-protein ligase Z
Gene namesi
Name:UBE2Z
ORF Names:HOYS7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:25847. UBE2Z.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670659.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Ubiquitin-conjugating enzyme E2 ZPRO_0000280515Add
BLAST

Proteomic databases

MaxQBiQ9H832.
PaxDbiQ9H832.
PRIDEiQ9H832.

PTM databases

PhosphoSiteiQ9H832.

Expressioni

Tissue specificityi

Widely expressed. Highly in placenta, pancreas, spleen and testis.2 Publications

Gene expression databases

ArrayExpressiQ9H832.
BgeeiQ9H832.
CleanExiHS_UBE2Z.
GenevestigatoriQ9H832.

Organism-specific databases

HPAiHPA007922.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
UBDO152052EBI-720977,EBI-6657186

Protein-protein interaction databases

BioGridi122419. 29 interactions.
IntActiQ9H832. 30 interactions.
MINTiMINT-1388629.
STRINGi9606.ENSP00000354201.

Structurei

3D structure databases

ProteinModelPortaliQ9H832.
SMRiQ9H832. Positions 93-334.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5078.
HOGENOMiHOG000233451.
HOVERGENiHBG083204.
InParanoidiQ9H832.
KOiK10585.
OMAiAVMANMS.
OrthoDBiEOG7MSMP5.
PhylomeDBiQ9H832.
TreeFamiTF354204.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H832-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAESPTEEAA TAGAGAAGPG ASSVAGVVGV SGSGGGFGPP FLPDVWAAAA    50
AAGGAGGPGS GLAPLPGLPP SAAAHGAALL SHWDPTLSSD WDGERTAPQC 100
LLRIKRDIMS IYKEPPPGMF VVPDTVDMTK IHALITGPFD TPYEGGFFLF 150
VFRCPPDYPI HPPRVKLMTT GNNTVRFNPN FYRNGKVCLS ILGTWTGPAW 200
SPAQSISSVL ISIQSLMTEN PYHNEPGFEQ ERHPGDSKNY NECIRHETIR 250
VAVCDMMEGK CPCPEPLRGV MEKSFLEYYD FYEVACKDRL HLQGQTMQDP 300
FGEKRGHFDY QSLLMRLGLI RQKVLERLHN ENAEMDSDSS SSGTETDLHG 350
SLRV 354
Length:354
Mass (Da):38,210
Last modified:March 20, 2007 - v2
Checksum:i5AFC148BD8D31356
GO
Isoform 2 (identifier: Q9H832-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.

Note: No experimental confirmation available.

Show »
Length:246
Mass (Da):28,075
Checksum:iA0AE68FB9430ACDB
GO

Sequence cautioni

The sequence AAH15890.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB14724.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 108108Missing in isoform 2. VSP_023747Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF623992 mRNA. Translation: ABR25252.1.
AK023917 mRNA. Translation: BAB14724.1. Different initiation.
AK024030 mRNA. Translation: BAB14789.1.
AC091133 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94703.1.
BC015169 mRNA. Translation: AAH15169.2.
BC015890 mRNA. Translation: AAH15890.1. Different initiation.
AB025426 mRNA. Translation: BAB87810.1.
CR457322 mRNA. Translation: CAG33603.1.
AL713782 mRNA. Translation: CAD28542.1.
CCDSiCCDS11540.2. [Q9H832-1]
RefSeqiNP_075567.2. NM_023079.4. [Q9H832-1]
UniGeneiHs.514297.

Genome annotation databases

EnsembliENST00000360943; ENSP00000354201; ENSG00000159202. [Q9H832-1]
GeneIDi65264.
KEGGihsa:65264.
UCSCiuc002ioi.3. human. [Q9H832-1]

Polymorphism databases

DMDMi134035344.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF623992 mRNA. Translation: ABR25252.1 .
AK023917 mRNA. Translation: BAB14724.1 . Different initiation.
AK024030 mRNA. Translation: BAB14789.1 .
AC091133 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94703.1 .
BC015169 mRNA. Translation: AAH15169.2 .
BC015890 mRNA. Translation: AAH15890.1 . Different initiation.
AB025426 mRNA. Translation: BAB87810.1 .
CR457322 mRNA. Translation: CAG33603.1 .
AL713782 mRNA. Translation: CAD28542.1 .
CCDSi CCDS11540.2. [Q9H832-1 ]
RefSeqi NP_075567.2. NM_023079.4. [Q9H832-1 ]
UniGenei Hs.514297.

3D structure databases

ProteinModelPortali Q9H832.
SMRi Q9H832. Positions 93-334.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122419. 29 interactions.
IntActi Q9H832. 30 interactions.
MINTi MINT-1388629.
STRINGi 9606.ENSP00000354201.

PTM databases

PhosphoSitei Q9H832.

Polymorphism databases

DMDMi 134035344.

Proteomic databases

MaxQBi Q9H832.
PaxDbi Q9H832.
PRIDEi Q9H832.

Protocols and materials databases

DNASUi 65264.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360943 ; ENSP00000354201 ; ENSG00000159202 . [Q9H832-1 ]
GeneIDi 65264.
KEGGi hsa:65264.
UCSCi uc002ioi.3. human. [Q9H832-1 ]

Organism-specific databases

CTDi 65264.
GeneCardsi GC17P046985.
HGNCi HGNC:25847. UBE2Z.
HPAi HPA007922.
MIMi 611362. gene.
neXtProti NX_Q9H832.
PharmGKBi PA142670659.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5078.
HOGENOMi HOG000233451.
HOVERGENi HBG083204.
InParanoidi Q9H832.
KOi K10585.
OMAi AVMANMS.
OrthoDBi EOG7MSMP5.
PhylomeDBi Q9H832.
TreeFami TF354204.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinki Q9H832.

Miscellaneous databases

GenomeRNAii 65264.
NextBioi 67390.
PROi Q9H832.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9H832.
Bgeei Q9H832.
CleanExi HS_UBE2Z.
Genevestigatori Q9H832.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging."
    Jin J., Li X., Gygi S.P., Harper J.W.
    Nature 447:1135-1138(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Retinoblastoma and Thyroid.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  6. "Molecular cloning of an osteocyte derived gene."
    Ikeda A., Turitani K.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 109-354.
  7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 109-354.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 238-354.
    Tissue: Brain and Pancreas.
  9. "Cloning and characterization of a gene encoding the human putative ubiquitin conjugating enzyme E2Z (UBE2Z)."
    Gu X., Zhao F., Zheng M., Fei X., Chen X., Huang S., Xie Y., Mao Y.
    Mol. Biol. Rep. 34:183-188(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  10. "Identification of novel regulators of apoptosis using a high-throughput cell-based screen."
    Park K.M., Kang E., Jeon Y.-J., Kim N., Kim N.-S., Yoo H.-S., Yeom Y.I., Kim S.J.
    Mol. Cells 23:170-174(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUBE2Z_HUMAN
AccessioniPrimary (citable) accession number: Q9H832
Secondary accession number(s): A6N8M6
, A6NC60, Q7L354, Q8TCM4, Q9H893
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: September 3, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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