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Protein

Methyltransferase-like protein 8

Gene

METTL8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable methyltransferase.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 8 (EC:2.1.1.-)
Gene namesi
Name:METTL8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25856. METTL8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi160410001.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291Methyltransferase-like protein 8PRO_0000311291Add
BLAST

Proteomic databases

EPDiQ9H825.
MaxQBiQ9H825.
PaxDbiQ9H825.
PeptideAtlasiQ9H825.
PRIDEiQ9H825.

PTM databases

iPTMnetiQ9H825.

Expressioni

Gene expression databases

BgeeiQ9H825.
CleanExiHS_METTL8.
ExpressionAtlasiQ9H825. baseline and differential.
GenevisibleiQ9H825. HS.

Organism-specific databases

HPAiHPA035421.

Interactioni

Subunit structurei

Interacts with EP300.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000364407.

Structurei

3D structure databases

ProteinModelPortaliQ9H825.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2361. Eukaryota.
ENOG410YAN4. LUCA.
GeneTreeiENSGT00520000055554.
HOGENOMiHOG000182278.
HOVERGENiHBG075344.
InParanoidiQ9H825.
OrthoDBiEOG7VX8ZJ.
PhylomeDBiQ9H825.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR026113. MeTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR22809. PTHR22809. 2 hits.
SUPFAMiSSF53335. SSF53335. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H825-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNMIWRNSIS CLRLGKVPHR YQSGYHPVAP LGSRILTDPA KVFEHNMWDH
60 70 80 90 100
MQWSKEEEAA ARKKVKENSA VRVLLEEQVK YEREASKYWD TFYKIHKNKF
110 120 130 140 150
FKDRNWLLRE FPEILPVDQK PEEKARESSW DHVKTSATNR FSRMHCPTVP
160 170 180 190 200
DEKNHYEKSS GSSEGQSKTE SDFSNLDSEK HKKGPMETGL FPGSNATFRI
210 220 230 240 250
LEVGCGAGNS VFPILNTLEN SPESFLYCCD FASGAVELVK SHSSYRATQC
260 270 280 290
FAFVHDVCDD GLPYPFPDGI LDVILLVFVL SSIHPDRTLF I
Length:291
Mass (Da):33,387
Last modified:November 13, 2007 - v2
Checksum:i0F239034FC81A9AF
GO
Isoform 2 (identifier: Q9H825-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.

Show »
Length:241
Mass (Da):27,544
Checksum:iF9D9104F3CBD6699
GO

Sequence cautioni

The sequence AAH25250.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAX93077.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5050Missing in isoform 2. 1 PublicationVSP_029514Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024046 mRNA. Translation: BAB14797.1.
AC008065 Genomic DNA. Translation: AAX93077.1. Sequence problems.
AC007739 Genomic DNA. Translation: AAX93284.1.
CH471058 Genomic DNA. Translation: EAX11215.1.
BC025250 mRNA. Translation: AAH25250.1. Different initiation.
RefSeqiNP_001308083.1. NM_001321154.1.
NP_001308084.1. NM_001321155.1.
NP_001308085.1. NM_001321156.1.
NP_001308086.1. NM_001321157.1.
NP_001308088.1. NM_001321159.1.
NP_001308089.1. NM_001321160.1. [Q9H825-1]
NP_001308091.1. NM_001321162.1. [Q9H825-2]
UniGeneiHs.135146.
Hs.560775.

Genome annotation databases

EnsembliENST00000392604; ENSP00000376382; ENSG00000123600. [Q9H825-1]
ENST00000447486; ENSP00000409025; ENSG00000123600. [Q9H825-2]
GeneIDi79828.
UCSCiuc002ugs.5. human. [Q9H825-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024046 mRNA. Translation: BAB14797.1.
AC008065 Genomic DNA. Translation: AAX93077.1. Sequence problems.
AC007739 Genomic DNA. Translation: AAX93284.1.
CH471058 Genomic DNA. Translation: EAX11215.1.
BC025250 mRNA. Translation: AAH25250.1. Different initiation.
RefSeqiNP_001308083.1. NM_001321154.1.
NP_001308084.1. NM_001321155.1.
NP_001308085.1. NM_001321156.1.
NP_001308086.1. NM_001321157.1.
NP_001308088.1. NM_001321159.1.
NP_001308089.1. NM_001321160.1. [Q9H825-1]
NP_001308091.1. NM_001321162.1. [Q9H825-2]
UniGeneiHs.135146.
Hs.560775.

3D structure databases

ProteinModelPortaliQ9H825.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000364407.

PTM databases

iPTMnetiQ9H825.

Polymorphism and mutation databases

DMDMi160410001.

Proteomic databases

EPDiQ9H825.
MaxQBiQ9H825.
PaxDbiQ9H825.
PeptideAtlasiQ9H825.
PRIDEiQ9H825.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392604; ENSP00000376382; ENSG00000123600. [Q9H825-1]
ENST00000447486; ENSP00000409025; ENSG00000123600. [Q9H825-2]
GeneIDi79828.
UCSCiuc002ugs.5. human. [Q9H825-1]

Organism-specific databases

GeneCardsiMETTL8.
HGNCiHGNC:25856. METTL8.
HPAiHPA035421.
MIMi609525. gene.
neXtProtiNX_Q9H825.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2361. Eukaryota.
ENOG410YAN4. LUCA.
GeneTreeiENSGT00520000055554.
HOGENOMiHOG000182278.
HOVERGENiHBG075344.
InParanoidiQ9H825.
OrthoDBiEOG7VX8ZJ.
PhylomeDBiQ9H825.

Miscellaneous databases

ChiTaRSiMETTL8. human.
PROiQ9H825.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H825.
CleanExiHS_METTL8.
ExpressionAtlasiQ9H825. baseline and differential.
GenevisibleiQ9H825. HS.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR026113. MeTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR22809. PTHR22809. 2 hits.
SUPFAMiSSF53335. SSF53335. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Liver.

Entry informationi

Entry nameiMETL8_HUMAN
AccessioniPrimary (citable) accession number: Q9H825
Secondary accession number(s): Q53TM9, Q53TQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: July 6, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.