Q9H819 (DJC18_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DnaJ homolog subfamily C member 18

Gene names

Name:

DNAJC18

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Contains 1 J domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	heat shock protein binding Inferred from electronic annotation. Source: InterPro unfolded protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	DnaJ homolog subfamily C member 18		PRO_0000244085
Regions
	Transmembrane	228 – 248	21	Helical; Potential
	Domain	82 – 146	65	J
	Compositional bias	216 – 220	5	Poly-Glu

Sequences

	Sequence		Length	Mass (Da)
	Q9H819 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: BF8864DAB6D7695A	FASTA	358	41,551
	10 20 30 40 50 60 MAATLGSGER WTEAYIDAVR RNKYPEDTPP ESHDPCGCCN CMKAQKEKKS ENEWTQTRQG 70 80 90 100 110 120 EGNSTYSEEQ LLGVQRIKKC RNYYEILGVS RDASDEELKK AYRKLALKFH PDKNCAPGAT 130 140 150 160 170 180 DAFKAIGNAF AVLSNPDKRL RYDEYGDEQV TFTAPRARPY NYYRDFEADI TPEELFNVFF 190 200 210 220 230 240 GGHFPTGNIH MFSNVTDDTY YYRRRHRHER TQTQKEEEEE KPQTTYSAFI QLLPVLVIVI 250 260 270 280 290 300 ISVITQLLAT NPPYSLFYKS TLGYTISRET QNLQVPYFVD KNFDKAYRGA SLHDLEKTIE 310 320 330 340 350 KDYIDYIQTS CWKEKQQKSE LTNLAGLYRD ERLKQKAESL KLENCEKLSK LIGLRRGG

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK024054 mRNA. Translation: BAB14804.1. BC030162 mRNA. Translation: AAH30162.1.
IPI	IPI00025510.
RefSeq	NP_689899.1. NM_152686.3.
UniGene	Hs.483537.
3D structure databases
ProteinModelPortal	Q9H819.
SMR	Q9H819. Positions 80-176.
ModBase	Search...
PTM databases
PhosphoSite	Q9H819.
Polymorphism databases
DMDM	74733748.
Proteomic databases
PRIDE	Q9H819.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000302060; ENSP00000302843; ENSG00000170464.
GeneID	202052.
KEGG	hsa:202052.
UCSC	uc003len.1. human.
Organism-specific databases
CTD	202052.
GeneCards	GC05M138776.
HGNC	HGNC:28429. DNAJC18.
HPA	HPA036538.
neXtProt	NX_Q9H819.
PharmGKB	PA142671966.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG09729.
GeneTree	ENSGT00550000074587.
HOGENOM	HBG737361.
HOVERGEN	HBG051373.
InParanoid	Q9H819.
OMA	PRARPYN.
OrthoDB	EOG41G34F.
PhylomeDB	Q9H819.
Gene expression databases
ArrayExpress	Q9H819.
Bgee	Q9H819.
CleanEx	HS_DNAJC18.
Genevestigator	Q9H819.
GermOnline	ENSG00000170464. Homo sapiens.
Family and domain databases
InterPro	IPR001623. DnaJ_N. IPR015399. DUF1977_DnaJ-like. IPR018253. Heat_shock_DnaJ_CS. IPR003095. Hsp_DnaJ. [Graphical view]
Gene3D	G3DSA:1.10.287.110. DnaJ_N. 1 hit.
KO	K09538.
Pfam	PF00226. DnaJ. 1 hit. PF09320. DUF1977. 1 hit. [Graphical view]
PRINTS	PR00625. JDOMAIN.
SMART	SM00271. DnaJ. 1 hit. [Graphical view]
SUPFAM	SSF46565. DnaJ_N. 1 hit.
PROSITE	PS00636. DNAJ_1. 1 hit. PS50076. DNAJ_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	90244.

Entry information

Entry name

DJC18_HUMAN

Accession

Primary (citable) accession number: Q9H819

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	March 1, 2001
Last modified:	January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.