##gff-version 3 Q9H816 UniProtKB Chain 1 532 . . . ID=PRO_0000209119;Note=5' exonuclease Apollo Q9H816 UniProtKB Region 350 392 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H816 UniProtKB Region 453 482 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H816 UniProtKB Motif 496 511 . . . Note=TBM Q9H816 UniProtKB Compositional bias 361 392 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H816 UniProtKB Cross-link 333 333 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9H816 UniProtKB Natural variant 46 46 . . . ID=VAR_023292;Note=R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs28381069 Q9H816 UniProtKB Natural variant 61 61 . . . ID=VAR_023293;Note=H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs11552449 Q9H816 UniProtKB Natural variant 122 532 . . . ID=VAR_087866;Note=In DKCB8. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35007328;Dbxref=PMID:35007328 Q9H816 UniProtKB Natural variant 142 142 . . . ID=VAR_087867;Note=In DKCB8%3B decreased interaction with TERF2. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35007328;Dbxref=PMID:35007328 Q9H816 UniProtKB Natural variant 142 142 . . . ID=VAR_087868;Note=In DKCB8%3B decreased interaction with TERF2. L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35007328;Dbxref=dbSNP:rs763252884,PMID:35007328 Q9H816 UniProtKB Natural variant 158 532 . . . ID=VAR_087869;Note=In DKCB8. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:35007328;Dbxref=PMID:35007328 Q9H816 UniProtKB Natural variant 462 462 . . . ID=VAR_023294;Note=D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.2;Dbxref=dbSNP:rs28381079 Q9H816 UniProtKB Natural variant 510 510 . . . ID=VAR_048891;Note=N->Y;Dbxref=dbSNP:rs35397235 Q9H816 UniProtKB Mutagenesis 14 14 . . . Note=In Apm3%3B abolishes exonuclease activity and function on telomere maintenance. Impairs interaction with SPAG5. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19197158,ECO:0000269|PubMed:20655466;Dbxref=PMID:19197158,PMID:20655466 Q9H816 UniProtKB Mutagenesis 33 33 . . . Note=In Apm1%3B abolishes exonuclease activity and function on telomere maintenance%3B when associated with N-35. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20655466;Dbxref=PMID:20655466 Q9H816 UniProtKB Mutagenesis 35 35 . . . Note=In Apm2%3B abolishes exonuclease activity and function on telomere maintenance. In Apm1%3B abolishes exonuclease activity and function on telomere maintenance%3B when associated with A-33. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20655466;Dbxref=PMID:20655466 Q9H816 UniProtKB Mutagenesis 276 276 . . . Note=Slightly affects interaction with SPAG5. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19197158;Dbxref=PMID:19197158 Q9H816 UniProtKB Mutagenesis 504 504 . . . Note=Abolishes interaction with TERF2. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18202258;Dbxref=PMID:18202258 Q9H816 UniProtKB Mutagenesis 506 506 . . . Note=Abolishes interaction with TERF2. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18202258;Dbxref=PMID:18202258 Q9H816 UniProtKB Mutagenesis 508 508 . . . Note=Abolishes interaction with TERF2. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18202258;Dbxref=PMID:18202258 Q9H816 UniProtKB Sequence conflict 237 237 . . . Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9H816 UniProtKB Beta strand 4 6 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5AHO Q9H816 UniProtKB Beta strand 9 14 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Helix 18 20 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Beta strand 26 28 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Helix 34 36 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Beta strand 48 50 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Helix 52 62 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Helix 66 68 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Beta strand 69 71 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Beta strand 76 86 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Beta strand 89 96 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Beta strand 98 100 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Beta strand 104 110 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Beta strand 113 117 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Helix 125 128 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Helix 131 133 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Beta strand 140 144 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Helix 147 149 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B9B Q9H816 UniProtKB Beta strand 150 152 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7B9B Q9H816 UniProtKB Helix 158 170 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Beta strand 175 181 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Beta strand 183 185 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5AHO Q9H816 UniProtKB Helix 187 196 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Helix 205 211 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Turn 212 215 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Beta strand 220 222 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5AHO Q9H816 UniProtKB Beta strand 226 233 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Helix 234 236 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Helix 239 245 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Turn 246 248 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Beta strand 251 256 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Beta strand 268 271 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Helix 279 289 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Beta strand 292 297 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Helix 307 309 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Helix 321 327 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Helix 330 332 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7A1F Q9H816 UniProtKB Helix 500 503 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3BUA