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Protein

Protein NRDE2 homolog

Gene

NRDE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NRDE2 homolog
Gene namesi
Name:NRDE2
Synonyms:C14orf102
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000119720.17
HGNCiHGNC:20186 NRDE2
neXtProtiNX_Q9H7Z3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi55051
OpenTargetsiENSG00000119720
PharmGKBiPA134926790

Polymorphism and mutation databases

BioMutaiNRDE2
DMDMi296439394

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000899072 – 1164Protein NRDE2 homologAdd BLAST1163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9H7Z3
MaxQBiQ9H7Z3
PaxDbiQ9H7Z3
PeptideAtlasiQ9H7Z3
PRIDEiQ9H7Z3

PTM databases

iPTMnetiQ9H7Z3
PhosphoSitePlusiQ9H7Z3

Expressioni

Gene expression databases

BgeeiENSG00000119720
CleanExiHS_C14orf102
ExpressionAtlasiQ9H7Z3 baseline and differential
GenevisibleiQ9H7Z3 HS

Organism-specific databases

HPAiHPA047050
HPA050583

Interactioni

Protein-protein interaction databases

BioGridi120373, 4 interactors
IntActiQ9H7Z3, 4 interactors
STRINGi9606.ENSP00000346335

Structurei

3D structure databases

ProteinModelPortaliQ9H7Z3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati305 – 337HAT 1Add BLAST33
Repeati395 – 427HAT 2Add BLAST33
Repeati758 – 792HAT 3Add BLAST35
Repeati978 – 1010HAT 4Add BLAST33
Repeati1067 – 1101HAT 5Add BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili61 – 383Sequence analysisAdd BLAST323

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi73 – 101Lys-richAdd BLAST29
Compositional biasi81 – 91Poly-LysAdd BLAST11
Compositional biasi105 – 110Poly-Ser6

Sequence similaritiesi

Belongs to the NRDE2 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1972 Eukaryota
ENOG410XPGD LUCA
GeneTreeiENSGT00390000005524
HOGENOMiHOG000069945
HOVERGENiHBG051018
InParanoidiQ9H7Z3
OMAiAMVDFTF
OrthoDBiEOG091G01S9
PhylomeDBiQ9H7Z3
TreeFamiTF323791

Family and domain databases

InterProiView protein in InterPro
IPR013633 NRDE-2
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF08424 NRDE-2, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H7Z3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALFPAFAGL SEAPDGGSSR KELDWLSNPS FCVGSITSLS QQTEAAPAHV
60 70 80 90 100
SEGLPLTRSH LKSESSDESD TNKKLKQTSR KKKKEKKKKR KHQHHKKTKR
110 120 130 140 150
KHGPSSSSRS ETDTDSEKDK PSRGVGGSKK ESEEPNQGNN AAADTGHRFV
160 170 180 190 200
WLEDIQAVTG ETFRTDKKPD PANWEYKSLY RGDIARYKRK GDSCLGINPK
210 220 230 240 250
KQCISWEGTS TEKKHSRKQV ERYFTKKSVG LMNIDGVAIS SKTEPPSSEP
260 270 280 290 300
ISFIPVKDLE DAAPVTTWLN PLGIYDQSTT HWLQGQGPPE QESKQPDAQP
310 320 330 340 350
DSESAALKAK VEEFNRRVRE NPRDTQLWMA FVAFQDEVMK SPGLYAIEEG
360 370 380 390 400
EQEKRKRSLK LILEKKLAIL ERAIESNQSS VDLKLAKLKL CTEFWEPSTL
410 420 430 440 450
VKEWQKLIFL HPNNTALWQK YLLFCQSQFS TFSISKIHSL YGKCLSTLSA
460 470 480 490 500
VKDGSILSHP ALPGTEEAMF ALFLQQCHFL RQAGHSEKAI SLFQAMVDFT
510 520 530 540 550
FFKPDSVKDL PTKGQVEFFE PFWDSGEPRA GEKGARGWKA WMHQQERGGW
560 570 580 590 600
VVINPDEDDD EPEEDDQEIK DKTLPRWQIW LAAERSRDQR HWRPWRPDKT
610 620 630 640 650
KKQTEEDCED PERQVLFDDI GQSLIRLSSH DLQFQLVEAF LQFLGVPSGF
660 670 680 690 700
TPPASCLYLA MDENSIFDNG LYDEKPLTFF NPLFSGASCV GRMDRLGYPR
710 720 730 740 750
WTRGQNREGE EFIRNVFHLV MPLFSGKEKS QLCFSWLQYE IAKVIWCLHT
760 770 780 790 800
KNKKRLKSQG KNCKKLAKNL LKEPENCNNF CLWKQYAHLE WLLGNTEDAR
810 820 830 840 850
KVFDTALGMA GSRELKDSDL CELSLLYAEL EVELSPEVRR AATARAVHIL
860 870 880 890 900
TKLTESSPYG PYTGQVLAVH ILKARKAYEH ALQDCLGDSC VSNPAPTDSC
910 920 930 940 950
SRLISLAKCF MLFQYLTIGI DAAVQIYEQV FAKLNSSVFP EGSGEGDSAS
960 970 980 990 1000
SQSWTSVLEA ITLMHTSLLR FHMKVSVYPL APLREALSQA LKLYPGNQVL
1010 1020 1030 1040 1050
WRSYVQIQNK SHSASKTRRF FDTITRSAKP LEPWLFAIEA EKLRKRLVET
1060 1070 1080 1090 1100
VQRLDGREIH ATIPETGLMH RIQALFENAM RSDSGSQCPL LWRMYLNFLV
1110 1120 1130 1140 1150
SLGNKERSKG VFYKALQNCP WAKVLYLDAV EYFPDEMQEI LDLMTEKELR
1160
VRLPLEELEL LLED
Length:1,164
Mass (Da):132,673
Last modified:May 18, 2010 - v3
Checksum:i343D0CF623AE2E83
GO

Sequence cautioni

The sequence BAB14830 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti117E → G in BAA91404 (PubMed:14702039).Curated1
Sequence conflicti357R → G in BAA91404 (PubMed:14702039).Curated1
Sequence conflicti694D → G in BAB14830 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05781332C → F. Corresponds to variant dbSNP:rs7140914Ensembl.1
Natural variantiVAR_062239928E → K. Corresponds to variant dbSNP:rs59039343Ensembl.1
Natural variantiVAR_0603431118N → S2 PublicationsCorresponds to variant dbSNP:rs3737035Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000870 mRNA Translation: BAA91404.1
AK024113 mRNA Translation: BAB14830.1 Different initiation.
AK294958 mRNA Translation: BAG58032.1
AL161662 Genomic DNA No translation available.
BC098568 mRNA Translation: AAH98568.1
CCDSiCCDS9890.1
RefSeqiNP_060440.2, NM_017970.3
UniGeneiHs.528131

Genome annotation databases

EnsembliENST00000354366; ENSP00000346335; ENSG00000119720
GeneIDi55051
KEGGihsa:55051
UCSCiuc001xyi.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNRDE2_HUMAN
AccessioniPrimary (citable) accession number: Q9H7Z3
Secondary accession number(s): B4DH71, Q4G0A7, Q9NWH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 132 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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