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Protein

Protein NRDE2 homolog

Gene

NRDE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NRDE2 homolog
Gene namesi
Name:NRDE2
Synonyms:C14orf102
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20186. NRDE2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134926790.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 11641163Protein NRDE2 homologPRO_0000089907Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9H7Z3.
PaxDbiQ9H7Z3.
PRIDEiQ9H7Z3.

PTM databases

PhosphoSiteiQ9H7Z3.

Expressioni

Gene expression databases

BgeeiQ9H7Z3.
CleanExiHS_C14orf102.
ExpressionAtlasiQ9H7Z3. baseline and differential.
GenevestigatoriQ9H7Z3.

Organism-specific databases

HPAiHPA047050.
HPA050583.

Interactioni

Protein-protein interaction databases

BioGridi120373. 3 interactions.
STRINGi9606.ENSP00000346335.

Structurei

3D structure databases

ProteinModelPortaliQ9H7Z3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati305 – 33733HAT 1Add
BLAST
Repeati395 – 42733HAT 2Add
BLAST
Repeati758 – 79235HAT 3Add
BLAST
Repeati978 – 101033HAT 4Add
BLAST
Repeati1067 – 110135HAT 5Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili61 – 383323Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi73 – 10129Lys-richAdd
BLAST
Compositional biasi81 – 9111Poly-LysAdd
BLAST
Compositional biasi105 – 1106Poly-Ser

Sequence similaritiesi

Belongs to the NRDE2 family.Curated
Contains 5 HAT repeats.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG315726.
GeneTreeiENSGT00390000005524.
HOGENOMiHOG000069945.
HOVERGENiHBG051018.
InParanoidiQ9H7Z3.
OMAiVTLMHTS.
OrthoDBiEOG75TMB3.
PhylomeDBiQ9H7Z3.
TreeFamiTF323791.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR013633. NRDE-2.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF08424. NRDE-2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H7Z3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALFPAFAGL SEAPDGGSSR KELDWLSNPS FCVGSITSLS QQTEAAPAHV
60 70 80 90 100
SEGLPLTRSH LKSESSDESD TNKKLKQTSR KKKKEKKKKR KHQHHKKTKR
110 120 130 140 150
KHGPSSSSRS ETDTDSEKDK PSRGVGGSKK ESEEPNQGNN AAADTGHRFV
160 170 180 190 200
WLEDIQAVTG ETFRTDKKPD PANWEYKSLY RGDIARYKRK GDSCLGINPK
210 220 230 240 250
KQCISWEGTS TEKKHSRKQV ERYFTKKSVG LMNIDGVAIS SKTEPPSSEP
260 270 280 290 300
ISFIPVKDLE DAAPVTTWLN PLGIYDQSTT HWLQGQGPPE QESKQPDAQP
310 320 330 340 350
DSESAALKAK VEEFNRRVRE NPRDTQLWMA FVAFQDEVMK SPGLYAIEEG
360 370 380 390 400
EQEKRKRSLK LILEKKLAIL ERAIESNQSS VDLKLAKLKL CTEFWEPSTL
410 420 430 440 450
VKEWQKLIFL HPNNTALWQK YLLFCQSQFS TFSISKIHSL YGKCLSTLSA
460 470 480 490 500
VKDGSILSHP ALPGTEEAMF ALFLQQCHFL RQAGHSEKAI SLFQAMVDFT
510 520 530 540 550
FFKPDSVKDL PTKGQVEFFE PFWDSGEPRA GEKGARGWKA WMHQQERGGW
560 570 580 590 600
VVINPDEDDD EPEEDDQEIK DKTLPRWQIW LAAERSRDQR HWRPWRPDKT
610 620 630 640 650
KKQTEEDCED PERQVLFDDI GQSLIRLSSH DLQFQLVEAF LQFLGVPSGF
660 670 680 690 700
TPPASCLYLA MDENSIFDNG LYDEKPLTFF NPLFSGASCV GRMDRLGYPR
710 720 730 740 750
WTRGQNREGE EFIRNVFHLV MPLFSGKEKS QLCFSWLQYE IAKVIWCLHT
760 770 780 790 800
KNKKRLKSQG KNCKKLAKNL LKEPENCNNF CLWKQYAHLE WLLGNTEDAR
810 820 830 840 850
KVFDTALGMA GSRELKDSDL CELSLLYAEL EVELSPEVRR AATARAVHIL
860 870 880 890 900
TKLTESSPYG PYTGQVLAVH ILKARKAYEH ALQDCLGDSC VSNPAPTDSC
910 920 930 940 950
SRLISLAKCF MLFQYLTIGI DAAVQIYEQV FAKLNSSVFP EGSGEGDSAS
960 970 980 990 1000
SQSWTSVLEA ITLMHTSLLR FHMKVSVYPL APLREALSQA LKLYPGNQVL
1010 1020 1030 1040 1050
WRSYVQIQNK SHSASKTRRF FDTITRSAKP LEPWLFAIEA EKLRKRLVET
1060 1070 1080 1090 1100
VQRLDGREIH ATIPETGLMH RIQALFENAM RSDSGSQCPL LWRMYLNFLV
1110 1120 1130 1140 1150
SLGNKERSKG VFYKALQNCP WAKVLYLDAV EYFPDEMQEI LDLMTEKELR
1160
VRLPLEELEL LLED
Length:1,164
Mass (Da):132,673
Last modified:May 18, 2010 - v3
Checksum:i343D0CF623AE2E83
GO

Sequence cautioni

The sequence BAB14830.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti117 – 1171E → G in BAA91404. (PubMed:14702039)Curated
Sequence conflicti357 – 3571R → G in BAA91404. (PubMed:14702039)Curated
Sequence conflicti694 – 6941D → G in BAB14830. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti32 – 321C → F.
Corresponds to variant rs7140914 [ dbSNP | Ensembl ].
VAR_057813
Natural varianti928 – 9281E → K.
Corresponds to variant rs59039343 [ dbSNP | Ensembl ].
VAR_062239
Natural varianti1118 – 11181N → S.2 Publications
Corresponds to variant rs3737035 [ dbSNP | Ensembl ].
VAR_060343

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000870 mRNA. Translation: BAA91404.1.
AK024113 mRNA. Translation: BAB14830.1. Different initiation.
AK294958 mRNA. Translation: BAG58032.1.
AL161662 Genomic DNA. No translation available.
BC098568 mRNA. Translation: AAH98568.1.
CCDSiCCDS9890.1.
RefSeqiNP_060440.2. NM_017970.3.
UniGeneiHs.528131.

Genome annotation databases

EnsembliENST00000354366; ENSP00000346335; ENSG00000119720.
GeneIDi55051.
KEGGihsa:55051.
UCSCiuc001xyi.2. human.

Polymorphism databases

DMDMi296439394.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000870 mRNA. Translation: BAA91404.1.
AK024113 mRNA. Translation: BAB14830.1. Different initiation.
AK294958 mRNA. Translation: BAG58032.1.
AL161662 Genomic DNA. No translation available.
BC098568 mRNA. Translation: AAH98568.1.
CCDSiCCDS9890.1.
RefSeqiNP_060440.2. NM_017970.3.
UniGeneiHs.528131.

3D structure databases

ProteinModelPortaliQ9H7Z3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120373. 3 interactions.
STRINGi9606.ENSP00000346335.

PTM databases

PhosphoSiteiQ9H7Z3.

Polymorphism databases

DMDMi296439394.

Proteomic databases

MaxQBiQ9H7Z3.
PaxDbiQ9H7Z3.
PRIDEiQ9H7Z3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354366; ENSP00000346335; ENSG00000119720.
GeneIDi55051.
KEGGihsa:55051.
UCSCiuc001xyi.2. human.

Organism-specific databases

CTDi55051.
GeneCardsiGC14M090742.
H-InvDBHIX0011882.
HGNCiHGNC:20186. NRDE2.
HPAiHPA047050.
HPA050583.
neXtProtiNX_Q9H7Z3.
PharmGKBiPA134926790.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG315726.
GeneTreeiENSGT00390000005524.
HOGENOMiHOG000069945.
HOVERGENiHBG051018.
InParanoidiQ9H7Z3.
OMAiVTLMHTS.
OrthoDBiEOG75TMB3.
PhylomeDBiQ9H7Z3.
TreeFamiTF323791.

Miscellaneous databases

GenomeRNAii55051.
NextBioi58515.

Gene expression databases

BgeeiQ9H7Z3.
CleanExiHS_C14orf102.
ExpressionAtlasiQ9H7Z3. baseline and differential.
GenevestigatoriQ9H7Z3.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR013633. NRDE-2.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF08424. NRDE-2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-1118.
    Tissue: Brain and Embryo.
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-1118.
    Tissue: Chondrosarcoma.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNRDE2_HUMAN
AccessioniPrimary (citable) accession number: Q9H7Z3
Secondary accession number(s): B4DH71, Q4G0A7, Q9NWH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: May 18, 2010
Last modified: January 7, 2015
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.