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Q9H7X7

- IFT22_HUMAN

UniProt

Q9H7X7 - IFT22_HUMAN

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Protein

Intraflagellar transport protein 22 homolog

Gene
IFT22, RABL5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Small GTPase-like component of the intraflagellar transport (IFT) complex B By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178GTP By similarity
Nucleotide bindingi63 – 675GTP By similarity
Nucleotide bindingi123 – 1264GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 22 homolog
Alternative name(s):
Rab-like protein 5
Gene namesi
Name:IFT22
Synonyms:RABL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:21895. IFT22.

Subcellular locationi

Cell projectioncilium By similarity

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134871769.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Intraflagellar transport protein 22 homologPRO_0000253733Add
BLAST

Proteomic databases

MaxQBiQ9H7X7.
PaxDbiQ9H7X7.
PRIDEiQ9H7X7.

PTM databases

PhosphoSiteiQ9H7X7.

Expressioni

Gene expression databases

ArrayExpressiQ9H7X7.
BgeeiQ9H7X7.
CleanExiHS_RABL5.
GenevestigatoriQ9H7X7.

Organism-specific databases

HPAiHPA042930.

Interactioni

Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88 By similarity.

Protein-protein interaction databases

BioGridi122300. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9H7X7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG87073.
HOGENOMiHOG000232131.
HOVERGENiHBG083943.
InParanoidiQ9H7X7.
KOiK07935.
OMAiLQDTQCL.
OrthoDBiEOG7FBRJZ.
PhylomeDBiQ9H7X7.
TreeFamiTF313208.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H7X7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLKAKILFVG PCESGKTVLA NFLTESSDIT EYSPTQGVRI LEFENPHVTS    50
NNKGTGCEFE LWDCGGDAKF ESCWPALMKD AHGVVIVFNA DIPSHRKEME 100
MWYSCFVQQP SLQDTQCMLI AHHKPGSGDD KGSLSLSPPL NKLKLVHSNL 150
EDDPEEIRME FIKYLKSIIN SMSESRDREE MSIMT 185
Length:185
Mass (Da):20,835
Last modified:March 1, 2001 - v1
Checksum:i993D2ECEFE14A673
GO
Isoform 2 (identifier: Q9H7X7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-69: Missing.

Show »
Length:155
Mass (Da):17,541
Checksum:iEB372AFB4478E72E
GO
Isoform 3 (identifier: Q9H7X7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.

Show »
Length:108
Mass (Da):12,393
Checksum:i534B53C72D506620
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7777Missing in isoform 3. VSP_045182Add
BLAST
Alternative sequencei40 – 6930Missing in isoform 2. VSP_021112Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK023287 mRNA. Translation: BAG51181.1.
AK024179 mRNA. Translation: BAB14846.1.
AK298888 mRNA. Translation: BAH12896.1.
AC006329 Genomic DNA. No translation available.
CH471197 Genomic DNA. Translation: EAW50217.1.
BC004522 mRNA. Translation: AAH04522.1.
BC009823 mRNA. Translation: AAH09823.1.
BC038668 mRNA. Translation: AAH38668.1.
AL157469 mRNA. Translation: CAH10693.1.
CCDSiCCDS47670.1. [Q9H7X7-2]
CCDS47671.1. [Q9H7X7-3]
CCDS5719.1. [Q9H7X7-1]
RefSeqiNP_001124292.1. NM_001130820.2. [Q9H7X7-2]
NP_001124293.1. NM_001130821.2. [Q9H7X7-3]
NP_001124294.1. NM_001130822.2. [Q9H7X7-3]
NP_001274454.1. NM_001287525.1. [Q9H7X7-3]
NP_001274455.1. NM_001287526.1. [Q9H7X7-3]
NP_073614.1. NM_022777.3. [Q9H7X7-1]
UniGeneiHs.389104.

Genome annotation databases

EnsembliENST00000315322; ENSP00000320359; ENSG00000128581. [Q9H7X7-1]
ENST00000422177; ENSP00000392087; ENSG00000128581. [Q9H7X7-1]
ENST00000437644; ENSP00000390770; ENSG00000128581. [Q9H7X7-2]
ENST00000498704; ENSP00000429648; ENSG00000128581. [Q9H7X7-3]
ENST00000517481; ENSP00000429202; ENSG00000128581. [Q9H7X7-3]
GeneIDi64792.
KEGGihsa:64792.
UCSCiuc003uyl.3. human. [Q9H7X7-1]
uc003uym.3. human. [Q9H7X7-2]

Polymorphism databases

DMDMi74733725.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK023287 mRNA. Translation: BAG51181.1 .
AK024179 mRNA. Translation: BAB14846.1 .
AK298888 mRNA. Translation: BAH12896.1 .
AC006329 Genomic DNA. No translation available.
CH471197 Genomic DNA. Translation: EAW50217.1 .
BC004522 mRNA. Translation: AAH04522.1 .
BC009823 mRNA. Translation: AAH09823.1 .
BC038668 mRNA. Translation: AAH38668.1 .
AL157469 mRNA. Translation: CAH10693.1 .
CCDSi CCDS47670.1. [Q9H7X7-2 ]
CCDS47671.1. [Q9H7X7-3 ]
CCDS5719.1. [Q9H7X7-1 ]
RefSeqi NP_001124292.1. NM_001130820.2. [Q9H7X7-2 ]
NP_001124293.1. NM_001130821.2. [Q9H7X7-3 ]
NP_001124294.1. NM_001130822.2. [Q9H7X7-3 ]
NP_001274454.1. NM_001287525.1. [Q9H7X7-3 ]
NP_001274455.1. NM_001287526.1. [Q9H7X7-3 ]
NP_073614.1. NM_022777.3. [Q9H7X7-1 ]
UniGenei Hs.389104.

3D structure databases

ProteinModelPortali Q9H7X7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122300. 2 interactions.

PTM databases

PhosphoSitei Q9H7X7.

Polymorphism databases

DMDMi 74733725.

Proteomic databases

MaxQBi Q9H7X7.
PaxDbi Q9H7X7.
PRIDEi Q9H7X7.

Protocols and materials databases

DNASUi 64792.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000315322 ; ENSP00000320359 ; ENSG00000128581 . [Q9H7X7-1 ]
ENST00000422177 ; ENSP00000392087 ; ENSG00000128581 . [Q9H7X7-1 ]
ENST00000437644 ; ENSP00000390770 ; ENSG00000128581 . [Q9H7X7-2 ]
ENST00000498704 ; ENSP00000429648 ; ENSG00000128581 . [Q9H7X7-3 ]
ENST00000517481 ; ENSP00000429202 ; ENSG00000128581 . [Q9H7X7-3 ]
GeneIDi 64792.
KEGGi hsa:64792.
UCSCi uc003uyl.3. human. [Q9H7X7-1 ]
uc003uym.3. human. [Q9H7X7-2 ]

Organism-specific databases

CTDi 64792.
GeneCardsi GC07M100956.
HGNCi HGNC:21895. IFT22.
HPAi HPA042930.
neXtProti NX_Q9H7X7.
PharmGKBi PA134871769.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG87073.
HOGENOMi HOG000232131.
HOVERGENi HBG083943.
InParanoidi Q9H7X7.
KOi K07935.
OMAi LQDTQCL.
OrthoDBi EOG7FBRJZ.
PhylomeDBi Q9H7X7.
TreeFami TF313208.

Miscellaneous databases

ChiTaRSi RABL5. human.
GenomeRNAii 64792.
NextBioi 66854.
PROi Q9H7X7.

Gene expression databases

ArrayExpressi Q9H7X7.
Bgeei Q9H7X7.
CleanExi HS_RABL5.
Genevestigatori Q9H7X7.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Mammary gland and Ovary.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Brain and Lung.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 93-185 (ISOFORMS 1/2/3).
    Tissue: Amygdala.

Entry informationi

Entry nameiIFT22_HUMAN
AccessioniPrimary (citable) accession number: Q9H7X7
Secondary accession number(s): Q49AG1, Q69YV5, Q9BSW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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