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Q9H7X7 (RABL5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rab-like protein 5
Gene names
Name:RABL5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length185 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   LigandGTP-binding
Nucleotide-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsmall GTPase mediated signal transduction

Inferred from electronic annotation. Source: InterPro

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H7X7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H7X7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     40-69: Missing.
Isoform 3 (identifier: Q9H7X7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 185185Rab-like protein 5
PRO_0000253733

Regions

Nucleotide binding10 – 178GTP By similarity
Nucleotide binding63 – 675GTP By similarity
Nucleotide binding123 – 1264GTP By similarity

Natural variations

Alternative sequence1 – 7777Missing in isoform 3.
VSP_045182
Alternative sequence40 – 6930Missing in isoform 2.
VSP_021112

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 993D2ECEFE14A673

FASTA18520,835
        10         20         30         40         50         60 
MLKAKILFVG PCESGKTVLA NFLTESSDIT EYSPTQGVRI LEFENPHVTS NNKGTGCEFE 

        70         80         90        100        110        120 
LWDCGGDAKF ESCWPALMKD AHGVVIVFNA DIPSHRKEME MWYSCFVQQP SLQDTQCMLI 

       130        140        150        160        170        180 
AHHKPGSGDD KGSLSLSPPL NKLKLVHSNL EDDPEEIRME FIKYLKSIIN SMSESRDREE 


MSIMT 

« Hide

Isoform 2 [UniParc].

Checksum: EB372AFB4478E72E
Show »

FASTA15517,541
Isoform 3 [UniParc].

Checksum: 534B53C72D506620
Show »

FASTA10812,393

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Mammary gland and Ovary.
[2]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Brain and Lung.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 93-185 (ISOFORMS 1/2/3).
Tissue: Amygdala.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK023287 mRNA. Translation: BAG51181.1.
AK024179 mRNA. Translation: BAB14846.1.
AK298888 mRNA. Translation: BAH12896.1.
AC006329 Genomic DNA. No translation available.
CH471197 Genomic DNA. Translation: EAW50217.1.
BC004522 mRNA. Translation: AAH04522.1.
BC009823 mRNA. Translation: AAH09823.1.
BC038668 mRNA. Translation: AAH38668.1.
AL157469 mRNA. Translation: CAH10693.1.
RefSeqNP_001124292.1. NM_001130820.2.
NP_001124293.1. NM_001130821.2.
NP_001124294.1. NM_001130822.2.
NP_001274454.1. NM_001287525.1.
NP_001274455.1. NM_001287526.1.
NP_073614.1. NM_022777.3.
UniGeneHs.389104.

3D structure databases

ProteinModelPortalQ9H7X7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122300. 2 interactions.

PTM databases

PhosphoSiteQ9H7X7.

Polymorphism databases

DMDM74733725.

Proteomic databases

PaxDbQ9H7X7.
PRIDEQ9H7X7.

Protocols and materials databases

DNASU64792.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000315322; ENSP00000320359; ENSG00000128581. [Q9H7X7-1]
ENST00000422177; ENSP00000392087; ENSG00000128581. [Q9H7X7-1]
ENST00000437644; ENSP00000390770; ENSG00000128581. [Q9H7X7-2]
ENST00000498704; ENSP00000429648; ENSG00000128581. [Q9H7X7-3]
ENST00000517481; ENSP00000429202; ENSG00000128581. [Q9H7X7-3]
GeneID64792.
KEGGhsa:64792.
UCSCuc003uyl.3. human. [Q9H7X7-1]
uc003uym.3. human. [Q9H7X7-2]

Organism-specific databases

CTD64792.
GeneCardsGC07M100956.
HGNCHGNC:21895. RABL5.
HPAHPA042930.
neXtProtNX_Q9H7X7.
PharmGKBPA134871769.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG87073.
HOGENOMHOG000232131.
HOVERGENHBG083943.
InParanoidQ9H7X7.
KOK07935.
OMALQDTQCL.
OrthoDBEOG7FBRJZ.
PhylomeDBQ9H7X7.
TreeFamTF313208.

Gene expression databases

ArrayExpressQ9H7X7.
BgeeQ9H7X7.
CleanExHS_RABL5.
GenevestigatorQ9H7X7.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Other

ChiTaRSRABL5. human.
GenomeRNAi64792.
NextBio66854.
PROQ9H7X7.

Entry information

Entry nameRABL5_HUMAN
AccessionPrimary (citable) accession number: Q9H7X7
Secondary accession number(s): Q49AG1, Q69YV5, Q9BSW4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM