UniProtKB - Q9H7X7 (IFT22_HUMAN)
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Protein
Intraflagellar transport protein 22 homolog
Gene
IFT22
Organism
Homo sapiens (Human)
Status
Functioni
Small GTPase-like component of the intraflagellar transport (IFT) complex B.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 17 | GTPBy similarity | 8 | |
Nucleotide bindingi | 63 – 67 | GTPBy similarity | 5 | |
Nucleotide bindingi | 123 – 126 | GTPBy similarity | 4 |
GO - Molecular functioni
- GTP binding Source: UniProtKB-KW
GO - Biological processi
- intraciliary transport involved in cilium assembly Source: Reactome
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-HSA-5620924. Intraflagellar transport. |
Names & Taxonomyi
Protein namesi | Recommended name: Intraflagellar transport protein 22 homologAlternative name(s): Rab-like protein 5 |
Gene namesi | Name:IFT22 Synonyms:RABL5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000128581.15. |
HGNCi | HGNC:21895. IFT22. |
neXtProti | NX_Q9H7X7. |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000128581. |
PharmGKBi | PA134871769. |
Polymorphism and mutation databases
DMDMi | 74733725. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000253733 | 1 – 185 | Intraflagellar transport protein 22 homologAdd BLAST | 185 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 137 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9H7X7. |
MaxQBi | Q9H7X7. |
PaxDbi | Q9H7X7. |
PeptideAtlasi | Q9H7X7. |
PRIDEi | Q9H7X7. |
PTM databases
iPTMneti | Q9H7X7. |
PhosphoSitePlusi | Q9H7X7. |
Expressioni
Gene expression databases
Bgeei | ENSG00000128581. |
CleanExi | HS_RABL5. |
ExpressionAtlasi | Q9H7X7. baseline and differential. |
Genevisiblei | Q9H7X7. HS. |
Organism-specific databases
HPAi | HPA042930. |
Interactioni
Subunit structurei
Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88 (By similarity).By similarity
Binary interactionsi
Protein-protein interaction databases
BioGridi | 122300. 40 interactors. |
CORUMi | Q9H7X7. |
IntActi | Q9H7X7. 22 interactors. |
STRINGi | 9606.ENSP00000320359. |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG410IVWX. Eukaryota. ENOG4111FYS. LUCA. |
GeneTreei | ENSGT00390000013187. |
HOGENOMi | HOG000232131. |
HOVERGENi | HBG083943. |
InParanoidi | Q9H7X7. |
KOi | K07935. |
OMAi | LQDTQCL. |
OrthoDBi | EOG091G0MTH. |
PhylomeDBi | Q9H7X7. |
TreeFami | TF313208. |
Family and domain databases
InterProi | View protein in InterPro IPR027417. P-loop_NTPase. |
SUPFAMi | SSF52540. SSF52540. 1 hit. |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9H7X7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MLKAKILFVG PCESGKTVLA NFLTESSDIT EYSPTQGVRI LEFENPHVTS
60 70 80 90 100
NNKGTGCEFE LWDCGGDAKF ESCWPALMKD AHGVVIVFNA DIPSHRKEME
110 120 130 140 150
MWYSCFVQQP SLQDTQCMLI AHHKPGSGDD KGSLSLSPPL NKLKLVHSNL
160 170 180
EDDPEEIRME FIKYLKSIIN SMSESRDREE MSIMT
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045182 | 1 – 77 | Missing in isoform 3. 2 PublicationsAdd BLAST | 77 | |
Alternative sequenceiVSP_021112 | 40 – 69 | Missing in isoform 2. 1 PublicationAdd BLAST | 30 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK023287 mRNA. Translation: BAG51181.1. AK024179 mRNA. Translation: BAB14846.1. AK298888 mRNA. Translation: BAH12896.1. AC006329 Genomic DNA. No translation available. CH471197 Genomic DNA. Translation: EAW50217.1. BC004522 mRNA. Translation: AAH04522.1. BC009823 mRNA. Translation: AAH09823.1. BC038668 mRNA. Translation: AAH38668.1. AL157469 mRNA. Translation: CAH10693.1. |
CCDSi | CCDS47670.1. [Q9H7X7-2] CCDS47671.1. [Q9H7X7-3] CCDS5719.1. [Q9H7X7-1] |
RefSeqi | NP_001124292.1. NM_001130820.2. [Q9H7X7-2] NP_001124293.1. NM_001130821.2. [Q9H7X7-3] NP_001124294.1. NM_001130822.2. [Q9H7X7-3] NP_001274454.1. NM_001287525.1. [Q9H7X7-3] NP_001274455.1. NM_001287526.1. [Q9H7X7-3] NP_073614.1. NM_022777.3. [Q9H7X7-1] |
UniGenei | Hs.389104. |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | IFT22_HUMAN | |
Accessioni | Q9H7X7Primary (citable) accession number: Q9H7X7 Secondary accession number(s): Q49AG1, Q69YV5, Q9BSW4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 17, 2006 |
Last sequence update: | March 1, 2001 | |
Last modified: | March 28, 2018 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |