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Protein

Intraflagellar transport protein 22 homolog

Gene

IFT22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Small GTPase-like component of the intraflagellar transport (IFT) complex B.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTPBy similarity8
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi123 – 126GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-5620924 Intraflagellar transport

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 22 homolog
Alternative name(s):
Rab-like protein 5
Gene namesi
Name:IFT22
Synonyms:RABL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000128581.15
HGNCiHGNC:21895 IFT22
neXtProtiNX_Q9H7X7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000128581
PharmGKBiPA134871769

Polymorphism and mutation databases

DMDMi74733725

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002537331 – 185Intraflagellar transport protein 22 homologAdd BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei137PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H7X7
MaxQBiQ9H7X7
PaxDbiQ9H7X7
PeptideAtlasiQ9H7X7
PRIDEiQ9H7X7
ProteomicsDBi81155
81156 [Q9H7X7-2]

PTM databases

iPTMnetiQ9H7X7
PhosphoSitePlusiQ9H7X7

Expressioni

Gene expression databases

BgeeiENSG00000128581
CleanExiHS_RABL5
ExpressionAtlasiQ9H7X7 baseline and differential
GenevisibleiQ9H7X7 HS

Organism-specific databases

HPAiHPA042930

Interactioni

Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88 (By similarity).By similarity

Protein-protein interaction databases

BioGridi122300, 40 interactors
CORUMiQ9H7X7
IntActiQ9H7X7, 19 interactors
STRINGi9606.ENSP00000320359

Structurei

3D structure databases

ProteinModelPortaliQ9H7X7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiENOG410IVWX Eukaryota
ENOG4111FYS LUCA
GeneTreeiENSGT00390000013187
HOGENOMiHOG000232131
HOVERGENiHBG083943
InParanoidiQ9H7X7
KOiK07935
OMAiLQDTQCL
OrthoDBiEOG091G0MTH
PhylomeDBiQ9H7X7
TreeFamiTF313208

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
SUPFAMiSSF52540 SSF52540, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H7X7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKAKILFVG PCESGKTVLA NFLTESSDIT EYSPTQGVRI LEFENPHVTS
60 70 80 90 100
NNKGTGCEFE LWDCGGDAKF ESCWPALMKD AHGVVIVFNA DIPSHRKEME
110 120 130 140 150
MWYSCFVQQP SLQDTQCMLI AHHKPGSGDD KGSLSLSPPL NKLKLVHSNL
160 170 180
EDDPEEIRME FIKYLKSIIN SMSESRDREE MSIMT
Length:185
Mass (Da):20,835
Last modified:March 1, 2001 - v1
Checksum:i993D2ECEFE14A673
GO
Isoform 2 (identifier: Q9H7X7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-69: Missing.

Show »
Length:155
Mass (Da):17,541
Checksum:iEB372AFB4478E72E
GO
Isoform 3 (identifier: Q9H7X7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.

Show »
Length:108
Mass (Da):12,393
Checksum:i534B53C72D506620
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0451821 – 77Missing in isoform 3. 2 PublicationsAdd BLAST77
Alternative sequenceiVSP_02111240 – 69Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023287 mRNA Translation: BAG51181.1
AK024179 mRNA Translation: BAB14846.1
AK298888 mRNA Translation: BAH12896.1
AC006329 Genomic DNA No translation available.
CH471197 Genomic DNA Translation: EAW50217.1
BC004522 mRNA Translation: AAH04522.1
BC009823 mRNA Translation: AAH09823.1
BC038668 mRNA Translation: AAH38668.1
AL157469 mRNA Translation: CAH10693.1
CCDSiCCDS47670.1 [Q9H7X7-2]
CCDS47671.1 [Q9H7X7-3]
CCDS5719.1 [Q9H7X7-1]
RefSeqiNP_001124292.1, NM_001130820.2 [Q9H7X7-2]
NP_001124293.1, NM_001130821.2 [Q9H7X7-3]
NP_001124294.1, NM_001130822.2 [Q9H7X7-3]
NP_001274454.1, NM_001287525.1 [Q9H7X7-3]
NP_001274455.1, NM_001287526.1 [Q9H7X7-3]
NP_073614.1, NM_022777.3 [Q9H7X7-1]
UniGeneiHs.389104

Genome annotation databases

EnsembliENST00000315322; ENSP00000320359; ENSG00000128581 [Q9H7X7-1]
ENST00000422177; ENSP00000392087; ENSG00000128581 [Q9H7X7-1]
ENST00000437644; ENSP00000390770; ENSG00000128581 [Q9H7X7-2]
ENST00000498704; ENSP00000429648; ENSG00000128581 [Q9H7X7-3]
ENST00000517481; ENSP00000429202; ENSG00000128581 [Q9H7X7-3]
ENST00000621899; ENSP00000478948; ENSG00000128581 [Q9H7X7-3]
GeneIDi64792
KEGGihsa:64792
UCSCiuc003uyl.5 human [Q9H7X7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiIFT22_HUMAN
AccessioniPrimary (citable) accession number: Q9H7X7
Secondary accession number(s): Q49AG1, Q69YV5, Q9BSW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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