IFT22

Functionⁱ

Small GTPase-like component of the intraflagellar transport (IFT) complex B.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	10 – 17	GTPBy similarity	8
Nucleotide bindingⁱ	63 – 67	GTPBy similarity	5
Nucleotide bindingⁱ	123 – 126	GTPBy similarity	4

GO - Molecular functionⁱ

GTP binding Source: UniProtKB-KW

Complete GO annotation...

GO - Biological processⁱ

intraciliary transport involved in cilium assembly Source: Reactome
small GTPase mediated signal transduction Source: InterPro

Complete GO annotation...

Keywordsⁱ

Ligand	GTP-binding, Nucleotide-binding

Ligand

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5620924. Intraflagellar transport.

Reactomeⁱ

R-HSA-5620924. Intraflagellar transport.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Intraflagellar transport protein 22 homolog Alternative name(s): Rab-like protein 5
Gene namesⁱ	Name:IFT22 Synonyms:RABL5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21895. IFT22.

HGNCⁱ

HGNC:21895. IFT22.

Subcellular locationⁱ

Cell projection › cilium By similarity

GO - Cellular componentⁱ

centrosome Source: Ensembl
ciliary tip Source: Reactome
cilium Source: Reactome
intraciliary transport particle B Source: UniProtKB

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell projection, Cilium

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000128581.
PharmGKBⁱ	PA134871769.

Polymorphism and mutation databases

DMDMⁱ	74733725.

DMDMⁱ

74733725.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000253733	1 – 185	Intraflagellar transport protein 22 homologAdd BLAST		185

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	137	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9H7X7.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H7X7.
PaxDbⁱ	Q9H7X7.
PeptideAtlas More...PeptideAtlasⁱ	Q9H7X7.
PRIDEⁱ	Q9H7X7.

PTM databases

iPTMnetⁱ	Q9H7X7.
PhosphoSitePlusⁱ	Q9H7X7.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000128581.
CleanExⁱ	HS_RABL5.
ExpressionAtlasⁱ	Q9H7X7. baseline and differential.
Genevisibleⁱ	Q9H7X7. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA042930.

HPAⁱ

HPA042930.

Interactionⁱ

Subunit structureⁱ

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88 (By similarity).By similarity

Protein-protein interaction databases

BioGridⁱ	122300. 15 interactors.
IntActⁱ	Q9H7X7. 19 interactors.
STRINGⁱ	9606.ENSP00000320359.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9H7X7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IVWX. Eukaryota. ENOG4111FYS. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013187.
HOGENOMⁱ	HOG000232131.
HOVERGENⁱ	HBG083943.
InParanoidⁱ	Q9H7X7.
KEGG Orthology (KO) More...KOⁱ	K07935.
OMAⁱ	LQDTQCL.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MTH.
PhylomeDBⁱ	Q9H7X7.
TreeFamⁱ	TF313208.

Family and domain databases

InterProⁱ	View protein in InterPro IPR013684. MIRO-like. IPR027417. P-loop_NTPase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08477. Roc. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q9H7X7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKAKILFVG PCESGKTVLA NFLTESSDIT EYSPTQGVRI LEFENPHVTS 
        60         70         80         90        100
NNKGTGCEFE LWDCGGDAKF ESCWPALMKD AHGVVIVFNA DIPSHRKEME 
       110        120        130        140        150
MWYSCFVQQP SLQDTQCMLI AHHKPGSGDD KGSLSLSPPL NKLKLVHSNL 
       160        170        180 
EDDPEEIRME FIKYLKSIIN SMSESRDREE MSIMT

Length:185

Mass (Da):20,835

Last modified:March 1, 2001 - v1

Checksum:ⁱ993D2ECEFE14A673

GO

Isoform 2 (identifier: Q9H7X7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
40-69: Missing.

« Hide

        10         20         30         40         50
MLKAKILFVG PCESGKTVLA NFLTESSDIT EYSPTQGVRF ESCWPALMKD 
        60         70         80         90        100
AHGVVIVFNA DIPSHRKEME MWYSCFVQQP SLQDTQCMLI AHHKPGSGDD 
       110        120        130        140        150
KGSLSLSPPL NKLKLVHSNL EDDPEEIRME FIKYLKSIIN SMSESRDREE 

MSIMT

Show »

Length:155

Mass (Da):17,541

Checksum:ⁱEB372AFB4478E72E

GO

Isoform 3 (identifier: Q9H7X7-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-77: Missing.

« Hide

        10         20         30         40         50
MKDAHGVVIV FNADIPSHRK EMEMWYSCFV QQPSLQDTQC MLIAHHKPGS 
        60         70         80         90        100
GDDKGSLSLS PPLNKLKLVH SNLEDDPEEI RMEFIKYLKS IINSMSESRD 

REEMSIMT

Show »

Length:108

Mass (Da):12,393

Checksum:ⁱ534B53C72D506620

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045182	1 – 77	Missing in isoform 3. 2 PublicationsAdd BLAST		77
Alternative sequenceⁱVSP_021112	40 – 69	Missing in isoform 2. 1 PublicationAdd BLAST		30

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK023287 mRNA. Translation: BAG51181.1. AK024179 mRNA. Translation: BAB14846.1. AK298888 mRNA. Translation: BAH12896.1. AC006329 Genomic DNA. No translation available. CH471197 Genomic DNA. Translation: EAW50217.1. BC004522 mRNA. Translation: AAH04522.1. BC009823 mRNA. Translation: AAH09823.1. BC038668 mRNA. Translation: AAH38668.1. AL157469 mRNA. Translation: CAH10693.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47670.1. [Q9H7X7-2] CCDS47671.1. [Q9H7X7-3] CCDS5719.1. [Q9H7X7-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001124292.1. NM_001130820.2. [Q9H7X7-2] NP_001124293.1. NM_001130821.2. [Q9H7X7-3] NP_001124294.1. NM_001130822.2. [Q9H7X7-3] NP_001274454.1. NM_001287525.1. [Q9H7X7-3] NP_001274455.1. NM_001287526.1. [Q9H7X7-3] NP_073614.1. NM_022777.3. [Q9H7X7-1]
UniGeneⁱ	Hs.389104.

Genome annotation databases

Ensemblⁱ	ENST00000315322; ENSP00000320359; ENSG00000128581. [Q9H7X7-1] ENST00000422177; ENSP00000392087; ENSG00000128581. [Q9H7X7-1] ENST00000437644; ENSP00000390770; ENSG00000128581. [Q9H7X7-2] ENST00000498704; ENSP00000429648; ENSG00000128581. [Q9H7X7-3] ENST00000517481; ENSP00000429202; ENSG00000128581. [Q9H7X7-3] ENST00000621899; ENSP00000478948; ENSG00000128581. [Q9H7X7-3]
GeneIDⁱ	64792.
KEGGⁱ	hsa:64792.
UCSC genome browser More...UCSCⁱ	uc003uyl.5. human. [Q9H7X7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK023287 mRNA. Translation: BAG51181.1. AK024179 mRNA. Translation: BAB14846.1. AK298888 mRNA. Translation: BAH12896.1. AC006329 Genomic DNA. No translation available. CH471197 Genomic DNA. Translation: EAW50217.1. BC004522 mRNA. Translation: AAH04522.1. BC009823 mRNA. Translation: AAH09823.1. BC038668 mRNA. Translation: AAH38668.1. AL157469 mRNA. Translation: CAH10693.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47670.1. [Q9H7X7-2] CCDS47671.1. [Q9H7X7-3] CCDS5719.1. [Q9H7X7-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001124292.1. NM_001130820.2. [Q9H7X7-2] NP_001124293.1. NM_001130821.2. [Q9H7X7-3] NP_001124294.1. NM_001130822.2. [Q9H7X7-3] NP_001274454.1. NM_001287525.1. [Q9H7X7-3] NP_001274455.1. NM_001287526.1. [Q9H7X7-3] NP_073614.1. NM_022777.3. [Q9H7X7-1]
UniGeneⁱ	Hs.389104.

3D structure databases

ProteinModelPortalⁱ	Q9H7X7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122300. 15 interactors.
IntActⁱ	Q9H7X7. 19 interactors.
STRINGⁱ	9606.ENSP00000320359.

PTM databases

iPTMnetⁱ	Q9H7X7.
PhosphoSitePlusⁱ	Q9H7X7.

Polymorphism and mutation databases

DMDMⁱ	74733725.

DMDMⁱ

74733725.

Proteomic databases

EPDⁱ	Q9H7X7.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H7X7.
PaxDbⁱ	Q9H7X7.
PeptideAtlas More...PeptideAtlasⁱ	Q9H7X7.
PRIDEⁱ	Q9H7X7.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	64792.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000315322; ENSP00000320359; ENSG00000128581. [Q9H7X7-1] ENST00000422177; ENSP00000392087; ENSG00000128581. [Q9H7X7-1] ENST00000437644; ENSP00000390770; ENSG00000128581. [Q9H7X7-2] ENST00000498704; ENSP00000429648; ENSG00000128581. [Q9H7X7-3] ENST00000517481; ENSP00000429202; ENSG00000128581. [Q9H7X7-3] ENST00000621899; ENSP00000478948; ENSG00000128581. [Q9H7X7-3]
GeneIDⁱ	64792.
KEGGⁱ	hsa:64792.
UCSC genome browser More...UCSCⁱ	uc003uyl.5. human. [Q9H7X7-1]

Organism-specific databases

CTDⁱ	64792.
GeneCardsⁱ	IFT22.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21895. IFT22.
Human Protein Atlas More...HPAⁱ	HPA042930.
neXtProtⁱ	NX_Q9H7X7.
Open Targets More...OpenTargetsⁱ	ENSG00000128581.
PharmGKBⁱ	PA134871769.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IVWX. Eukaryota. ENOG4111FYS. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013187.
HOGENOMⁱ	HOG000232131.
HOVERGENⁱ	HBG083943.
InParanoidⁱ	Q9H7X7.
KEGG Orthology (KO) More...KOⁱ	K07935.
OMAⁱ	LQDTQCL.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MTH.
PhylomeDBⁱ	Q9H7X7.
TreeFamⁱ	TF313208.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5620924. Intraflagellar transport.

Reactomeⁱ

R-HSA-5620924. Intraflagellar transport.

Miscellaneous databases

GenomeRNAiⁱ	64792.
Protein Ontology More...PROⁱ	PR:Q9H7X7.

Gene expression databases

Bgeeⁱ	ENSG00000128581.
CleanExⁱ	HS_RABL5.
ExpressionAtlasⁱ	Q9H7X7. baseline and differential.
Genevisibleⁱ	Q9H7X7. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR013684. MIRO-like. IPR027417. P-loop_NTPase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08477. Roc. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IFT22_HUMAN
Accessionⁱ	Q9H7X7Primary (citable) accession number: Q9H7X7 Secondary accession number(s): Q49AG1, Q69YV5, Q9BSW4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
	Last sequence update:	March 1, 2001
	Last modified:	April 12, 2017
	This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9H7X7 (IFT22_HUMAN)

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Intraflagellar transport protein 22 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (3)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ