Q9H7X7 (IFT22_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Intraflagellar transport protein 22 homolog

Alternative name(s):
Rab-like protein 5

Gene names

Name:	IFT22
Synonyms:	RABL5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Small GTPase-like component of the intraflagellar transport (IFT) complex B By similarity.
Subunit structure	Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88 By similarity.
Subcellular location	Cell projection › cilium By similarity.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Cellular component	Cell projection Cilium
Coding sequence diversity	Alternative splicing
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H7X7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H7X7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     40-69: Missing.

Isoform 3 (identifier: Q9H7X7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Intraflagellar transport protein 22 homolog		PRO_0000253733
Regions
	Nucleotide binding	10 – 17	8	GTP By similarity
	Nucleotide binding	63 – 67	5	GTP By similarity
	Nucleotide binding	123 – 126	4	GTP By similarity
Natural variations
	Alternative sequence	1 – 77	77	Missing in isoform 3.		VSP_045182
	Alternative sequence	40 – 69	30	Missing in isoform 2.		VSP_021112

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 993D2ECEFE14A673	FASTA	185	20,835
	10 20 30 40 50 60 MLKAKILFVG PCESGKTVLA NFLTESSDIT EYSPTQGVRI LEFENPHVTS NNKGTGCEFE 70 80 90 100 110 120 LWDCGGDAKF ESCWPALMKD AHGVVIVFNA DIPSHRKEME MWYSCFVQQP SLQDTQCMLI 130 140 150 160 170 180 AHHKPGSGDD KGSLSLSPPL NKLKLVHSNL EDDPEEIRME FIKYLKSIIN SMSESRDREE MSIMT
	Isoform 2 [UniParc]. Checksum: EB372AFB4478E72E	FASTA	155	17,541
	10 20 30 40 50 60 MLKAKILFVG PCESGKTVLA NFLTESSDIT EYSPTQGVRF ESCWPALMKD AHGVVIVFNA 70 80 90 100 110 120 DIPSHRKEME MWYSCFVQQP SLQDTQCMLI AHHKPGSGDD KGSLSLSPPL NKLKLVHSNL 130 140 150 EDDPEEIRME FIKYLKSIIN SMSESRDREE MSIMT
	Isoform 3 [UniParc]. Checksum: 534B53C72D506620	FASTA	108	12,393
	10 20 30 40 50 60 MKDAHGVVIV FNADIPSHRK EMEMWYSCFV QQPSLQDTQC MLIAHHKPGS GDDKGSLSLS 70 80 90 100 PPLNKLKLVH SNLEDDPEEI RMEFIKYLKS IINSMSESRD REEMSIMT

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Mammary gland and Ovary.
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Brain and Lung.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 93-185 (ISOFORMS 1/2/3). Tissue: Amygdala.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK023287 mRNA. Translation: BAG51181.1. AK024179 mRNA. Translation: BAB14846.1. AK298888 mRNA. Translation: BAH12896.1. AC006329 Genomic DNA. No translation available. CH471197 Genomic DNA. Translation: EAW50217.1. BC004522 mRNA. Translation: AAH04522.1. BC009823 mRNA. Translation: AAH09823.1. BC038668 mRNA. Translation: AAH38668.1. AL157469 mRNA. Translation: CAH10693.1.
CCDS	CCDS47670.1. [Q9H7X7-2] CCDS47671.1. [Q9H7X7-3] CCDS5719.1. [Q9H7X7-1]
RefSeq	NP_001124292.1. NM_001130820.2. [Q9H7X7-2] NP_001124293.1. NM_001130821.2. [Q9H7X7-3] NP_001124294.1. NM_001130822.2. [Q9H7X7-3] NP_001274454.1. NM_001287525.1. [Q9H7X7-3] NP_001274455.1. NM_001287526.1. [Q9H7X7-3] NP_073614.1. NM_022777.3. [Q9H7X7-1]
UniGene	Hs.389104.
3D structure databases
ProteinModelPortal	Q9H7X7.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
BioGrid	122300. 2 interactions.
PTM databases
PhosphoSite	Q9H7X7.
Polymorphism databases
DMDM	74733725.
Proteomic databases
MaxQB	Q9H7X7.
PaxDb	Q9H7X7.
PRIDE	Q9H7X7.
Protocols and materials databases
DNASU	64792.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000315322; ENSP00000320359; ENSG00000128581. [Q9H7X7-1] ENST00000422177; ENSP00000392087; ENSG00000128581. [Q9H7X7-1] ENST00000437644; ENSP00000390770; ENSG00000128581. [Q9H7X7-2] ENST00000498704; ENSP00000429648; ENSG00000128581. [Q9H7X7-3] ENST00000517481; ENSP00000429202; ENSG00000128581. [Q9H7X7-3]
GeneID	64792.
KEGG	hsa:64792.
UCSC	uc003uyl.3. human. [Q9H7X7-1] uc003uym.3. human. [Q9H7X7-2]
Organism-specific databases
CTD	64792.
GeneCards	GC07M100956.
HGNC	HGNC:21895. IFT22.
HPA	HPA042930.
neXtProt	NX_Q9H7X7.
PharmGKB	PA134871769.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG87073.
HOGENOM	HOG000232131.
HOVERGEN	HBG083943.
InParanoid	Q9H7X7.
KO	K07935.
OMA	LQDTQCL.
OrthoDB	EOG7FBRJZ.
PhylomeDB	Q9H7X7.
TreeFam	TF313208.
Gene expression databases
ArrayExpress	Q9H7X7.
Bgee	Q9H7X7.
CleanEx	HS_RABL5.
Genevestigator	Q9H7X7.
Family and domain databases
Gene3D	3.40.50.300. 1 hit.
InterPro	IPR027417. P-loop_NTPase. IPR001806. Small_GTPase. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	RABL5. human.
GenomeRNAi	64792.
NextBio	66854.
PRO	Q9H7X7.

Entry information

Entry name

IFT22_HUMAN

Accession

Primary (citable) accession number: Q9H7X7
Secondary accession number(s): Q49AG1, Q69YV5, Q9BSW4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	March 1, 2001
Last modified:	July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.