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Q9H7X7

- IFT22_HUMAN

UniProt

Q9H7X7 - IFT22_HUMAN

Protein

Intraflagellar transport protein 22 homolog

Gene

IFT22

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Small GTPase-like component of the intraflagellar transport (IFT) complex B.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 178GTPBy similarity
    Nucleotide bindingi63 – 675GTPBy similarity
    Nucleotide bindingi123 – 1264GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Intraflagellar transport protein 22 homolog
    Alternative name(s):
    Rab-like protein 5
    Gene namesi
    Name:IFT22
    Synonyms:RABL5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:21895. IFT22.

    Subcellular locationi

    Cell projectioncilium By similarity

    GO - Cellular componenti

    1. cilium Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell projection, Cilium

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134871769.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 185185Intraflagellar transport protein 22 homologPRO_0000253733Add
    BLAST

    Proteomic databases

    MaxQBiQ9H7X7.
    PaxDbiQ9H7X7.
    PRIDEiQ9H7X7.

    PTM databases

    PhosphoSiteiQ9H7X7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H7X7.
    BgeeiQ9H7X7.
    CleanExiHS_RABL5.
    GenevestigatoriQ9H7X7.

    Organism-specific databases

    HPAiHPA042930.

    Interactioni

    Subunit structurei

    Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi122300. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H7X7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiNOG87073.
    HOGENOMiHOG000232131.
    HOVERGENiHBG083943.
    InParanoidiQ9H7X7.
    KOiK07935.
    OMAiLQDTQCL.
    OrthoDBiEOG7FBRJZ.
    PhylomeDBiQ9H7X7.
    TreeFamiTF313208.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR001806. Small_GTPase.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H7X7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLKAKILFVG PCESGKTVLA NFLTESSDIT EYSPTQGVRI LEFENPHVTS    50
    NNKGTGCEFE LWDCGGDAKF ESCWPALMKD AHGVVIVFNA DIPSHRKEME 100
    MWYSCFVQQP SLQDTQCMLI AHHKPGSGDD KGSLSLSPPL NKLKLVHSNL 150
    EDDPEEIRME FIKYLKSIIN SMSESRDREE MSIMT 185
    Length:185
    Mass (Da):20,835
    Last modified:March 1, 2001 - v1
    Checksum:i993D2ECEFE14A673
    GO
    Isoform 2 (identifier: Q9H7X7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         40-69: Missing.

    Show »
    Length:155
    Mass (Da):17,541
    Checksum:iEB372AFB4478E72E
    GO
    Isoform 3 (identifier: Q9H7X7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-77: Missing.

    Show »
    Length:108
    Mass (Da):12,393
    Checksum:i534B53C72D506620
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7777Missing in isoform 3. 2 PublicationsVSP_045182Add
    BLAST
    Alternative sequencei40 – 6930Missing in isoform 2. 1 PublicationVSP_021112Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK023287 mRNA. Translation: BAG51181.1.
    AK024179 mRNA. Translation: BAB14846.1.
    AK298888 mRNA. Translation: BAH12896.1.
    AC006329 Genomic DNA. No translation available.
    CH471197 Genomic DNA. Translation: EAW50217.1.
    BC004522 mRNA. Translation: AAH04522.1.
    BC009823 mRNA. Translation: AAH09823.1.
    BC038668 mRNA. Translation: AAH38668.1.
    AL157469 mRNA. Translation: CAH10693.1.
    CCDSiCCDS47670.1. [Q9H7X7-2]
    CCDS47671.1. [Q9H7X7-3]
    CCDS5719.1. [Q9H7X7-1]
    RefSeqiNP_001124292.1. NM_001130820.2. [Q9H7X7-2]
    NP_001124293.1. NM_001130821.2. [Q9H7X7-3]
    NP_001124294.1. NM_001130822.2. [Q9H7X7-3]
    NP_001274454.1. NM_001287525.1. [Q9H7X7-3]
    NP_001274455.1. NM_001287526.1. [Q9H7X7-3]
    NP_073614.1. NM_022777.3. [Q9H7X7-1]
    UniGeneiHs.389104.

    Genome annotation databases

    EnsembliENST00000315322; ENSP00000320359; ENSG00000128581. [Q9H7X7-1]
    ENST00000422177; ENSP00000392087; ENSG00000128581. [Q9H7X7-1]
    ENST00000437644; ENSP00000390770; ENSG00000128581. [Q9H7X7-2]
    ENST00000498704; ENSP00000429648; ENSG00000128581. [Q9H7X7-3]
    ENST00000517481; ENSP00000429202; ENSG00000128581. [Q9H7X7-3]
    GeneIDi64792.
    KEGGihsa:64792.
    UCSCiuc003uyl.3. human. [Q9H7X7-1]
    uc003uym.3. human. [Q9H7X7-2]

    Polymorphism databases

    DMDMi74733725.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK023287 mRNA. Translation: BAG51181.1 .
    AK024179 mRNA. Translation: BAB14846.1 .
    AK298888 mRNA. Translation: BAH12896.1 .
    AC006329 Genomic DNA. No translation available.
    CH471197 Genomic DNA. Translation: EAW50217.1 .
    BC004522 mRNA. Translation: AAH04522.1 .
    BC009823 mRNA. Translation: AAH09823.1 .
    BC038668 mRNA. Translation: AAH38668.1 .
    AL157469 mRNA. Translation: CAH10693.1 .
    CCDSi CCDS47670.1. [Q9H7X7-2 ]
    CCDS47671.1. [Q9H7X7-3 ]
    CCDS5719.1. [Q9H7X7-1 ]
    RefSeqi NP_001124292.1. NM_001130820.2. [Q9H7X7-2 ]
    NP_001124293.1. NM_001130821.2. [Q9H7X7-3 ]
    NP_001124294.1. NM_001130822.2. [Q9H7X7-3 ]
    NP_001274454.1. NM_001287525.1. [Q9H7X7-3 ]
    NP_001274455.1. NM_001287526.1. [Q9H7X7-3 ]
    NP_073614.1. NM_022777.3. [Q9H7X7-1 ]
    UniGenei Hs.389104.

    3D structure databases

    ProteinModelPortali Q9H7X7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122300. 2 interactions.

    PTM databases

    PhosphoSitei Q9H7X7.

    Polymorphism databases

    DMDMi 74733725.

    Proteomic databases

    MaxQBi Q9H7X7.
    PaxDbi Q9H7X7.
    PRIDEi Q9H7X7.

    Protocols and materials databases

    DNASUi 64792.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000315322 ; ENSP00000320359 ; ENSG00000128581 . [Q9H7X7-1 ]
    ENST00000422177 ; ENSP00000392087 ; ENSG00000128581 . [Q9H7X7-1 ]
    ENST00000437644 ; ENSP00000390770 ; ENSG00000128581 . [Q9H7X7-2 ]
    ENST00000498704 ; ENSP00000429648 ; ENSG00000128581 . [Q9H7X7-3 ]
    ENST00000517481 ; ENSP00000429202 ; ENSG00000128581 . [Q9H7X7-3 ]
    GeneIDi 64792.
    KEGGi hsa:64792.
    UCSCi uc003uyl.3. human. [Q9H7X7-1 ]
    uc003uym.3. human. [Q9H7X7-2 ]

    Organism-specific databases

    CTDi 64792.
    GeneCardsi GC07M100956.
    HGNCi HGNC:21895. IFT22.
    HPAi HPA042930.
    neXtProti NX_Q9H7X7.
    PharmGKBi PA134871769.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG87073.
    HOGENOMi HOG000232131.
    HOVERGENi HBG083943.
    InParanoidi Q9H7X7.
    KOi K07935.
    OMAi LQDTQCL.
    OrthoDBi EOG7FBRJZ.
    PhylomeDBi Q9H7X7.
    TreeFami TF313208.

    Miscellaneous databases

    ChiTaRSi RABL5. human.
    GenomeRNAii 64792.
    NextBioi 66854.
    PROi Q9H7X7.

    Gene expression databases

    ArrayExpressi Q9H7X7.
    Bgeei Q9H7X7.
    CleanExi HS_RABL5.
    Genevestigatori Q9H7X7.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR001806. Small_GTPase.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Mammary gland and Ovary.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Brain and Lung.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 93-185 (ISOFORMS 1/2/3).
      Tissue: Amygdala.

    Entry informationi

    Entry nameiIFT22_HUMAN
    AccessioniPrimary (citable) accession number: Q9H7X7
    Secondary accession number(s): Q49AG1, Q69YV5, Q9BSW4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3