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Protein

Intraflagellar transport protein 22 homolog

Gene

IFT22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Small GTPase-like component of the intraflagellar transport (IFT) complex B.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178GTPBy similarity
Nucleotide bindingi63 – 675GTPBy similarity
Nucleotide bindingi123 – 1264GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: GO_Central
  2. GTPase activity Source: GO_Central
  3. GTP binding Source: GO_Central

GO - Biological processi

  1. GTP catabolic process Source: GO_Central
  2. intracellular protein transport Source: GO_Central
  3. Rab protein signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 22 homolog
Alternative name(s):
Rab-like protein 5
Gene namesi
Name:IFT22
Synonyms:RABL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:21895. IFT22.

Subcellular locationi

Cell projectioncilium By similarity

GO - Cellular componenti

  1. centrosome Source: Ensembl
  2. cilium Source: UniProtKB-SubCell
  3. endomembrane system Source: GO_Central
  4. intraciliary transport particle B Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134871769.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Intraflagellar transport protein 22 homologPRO_0000253733Add
BLAST

Proteomic databases

MaxQBiQ9H7X7.
PaxDbiQ9H7X7.
PRIDEiQ9H7X7.

PTM databases

PhosphoSiteiQ9H7X7.

Expressioni

Gene expression databases

BgeeiQ9H7X7.
CleanExiHS_RABL5.
ExpressionAtlasiQ9H7X7. baseline and differential.
GenevestigatoriQ9H7X7.

Organism-specific databases

HPAiHPA042930.

Interactioni

Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88 (By similarity).By similarity

Protein-protein interaction databases

BioGridi122300. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9H7X7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiNOG87073.
GeneTreeiENSGT00390000013187.
HOGENOMiHOG000232131.
HOVERGENiHBG083943.
InParanoidiQ9H7X7.
KOiK07935.
OMAiLQDTQCL.
OrthoDBiEOG7FBRJZ.
PhylomeDBiQ9H7X7.
TreeFamiTF313208.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H7X7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKAKILFVG PCESGKTVLA NFLTESSDIT EYSPTQGVRI LEFENPHVTS
60 70 80 90 100
NNKGTGCEFE LWDCGGDAKF ESCWPALMKD AHGVVIVFNA DIPSHRKEME
110 120 130 140 150
MWYSCFVQQP SLQDTQCMLI AHHKPGSGDD KGSLSLSPPL NKLKLVHSNL
160 170 180
EDDPEEIRME FIKYLKSIIN SMSESRDREE MSIMT
Length:185
Mass (Da):20,835
Last modified:March 1, 2001 - v1
Checksum:i993D2ECEFE14A673
GO
Isoform 2 (identifier: Q9H7X7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-69: Missing.

Show »
Length:155
Mass (Da):17,541
Checksum:iEB372AFB4478E72E
GO
Isoform 3 (identifier: Q9H7X7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.

Show »
Length:108
Mass (Da):12,393
Checksum:i534B53C72D506620
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7777Missing in isoform 3. 2 PublicationsVSP_045182Add
BLAST
Alternative sequencei40 – 6930Missing in isoform 2. 1 PublicationVSP_021112Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023287 mRNA. Translation: BAG51181.1.
AK024179 mRNA. Translation: BAB14846.1.
AK298888 mRNA. Translation: BAH12896.1.
AC006329 Genomic DNA. No translation available.
CH471197 Genomic DNA. Translation: EAW50217.1.
BC004522 mRNA. Translation: AAH04522.1.
BC009823 mRNA. Translation: AAH09823.1.
BC038668 mRNA. Translation: AAH38668.1.
AL157469 mRNA. Translation: CAH10693.1.
CCDSiCCDS47670.1. [Q9H7X7-2]
CCDS47671.1. [Q9H7X7-3]
CCDS5719.1. [Q9H7X7-1]
RefSeqiNP_001124292.1. NM_001130820.2. [Q9H7X7-2]
NP_001124293.1. NM_001130821.2. [Q9H7X7-3]
NP_001124294.1. NM_001130822.2. [Q9H7X7-3]
NP_001274454.1. NM_001287525.1. [Q9H7X7-3]
NP_001274455.1. NM_001287526.1. [Q9H7X7-3]
NP_073614.1. NM_022777.3. [Q9H7X7-1]
UniGeneiHs.389104.

Genome annotation databases

EnsembliENST00000315322; ENSP00000320359; ENSG00000128581. [Q9H7X7-1]
ENST00000422177; ENSP00000392087; ENSG00000128581. [Q9H7X7-1]
ENST00000437644; ENSP00000390770; ENSG00000128581. [Q9H7X7-2]
ENST00000498704; ENSP00000429648; ENSG00000128581. [Q9H7X7-3]
ENST00000517481; ENSP00000429202; ENSG00000128581. [Q9H7X7-3]
ENST00000621899; ENSP00000478948; ENSG00000128581. [Q9H7X7-3]
GeneIDi64792.
KEGGihsa:64792.
UCSCiuc003uyl.3. human. [Q9H7X7-1]
uc003uym.3. human. [Q9H7X7-2]

Polymorphism databases

DMDMi74733725.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023287 mRNA. Translation: BAG51181.1.
AK024179 mRNA. Translation: BAB14846.1.
AK298888 mRNA. Translation: BAH12896.1.
AC006329 Genomic DNA. No translation available.
CH471197 Genomic DNA. Translation: EAW50217.1.
BC004522 mRNA. Translation: AAH04522.1.
BC009823 mRNA. Translation: AAH09823.1.
BC038668 mRNA. Translation: AAH38668.1.
AL157469 mRNA. Translation: CAH10693.1.
CCDSiCCDS47670.1. [Q9H7X7-2]
CCDS47671.1. [Q9H7X7-3]
CCDS5719.1. [Q9H7X7-1]
RefSeqiNP_001124292.1. NM_001130820.2. [Q9H7X7-2]
NP_001124293.1. NM_001130821.2. [Q9H7X7-3]
NP_001124294.1. NM_001130822.2. [Q9H7X7-3]
NP_001274454.1. NM_001287525.1. [Q9H7X7-3]
NP_001274455.1. NM_001287526.1. [Q9H7X7-3]
NP_073614.1. NM_022777.3. [Q9H7X7-1]
UniGeneiHs.389104.

3D structure databases

ProteinModelPortaliQ9H7X7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122300. 5 interactions.

PTM databases

PhosphoSiteiQ9H7X7.

Polymorphism databases

DMDMi74733725.

Proteomic databases

MaxQBiQ9H7X7.
PaxDbiQ9H7X7.
PRIDEiQ9H7X7.

Protocols and materials databases

DNASUi64792.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315322; ENSP00000320359; ENSG00000128581. [Q9H7X7-1]
ENST00000422177; ENSP00000392087; ENSG00000128581. [Q9H7X7-1]
ENST00000437644; ENSP00000390770; ENSG00000128581. [Q9H7X7-2]
ENST00000498704; ENSP00000429648; ENSG00000128581. [Q9H7X7-3]
ENST00000517481; ENSP00000429202; ENSG00000128581. [Q9H7X7-3]
ENST00000621899; ENSP00000478948; ENSG00000128581. [Q9H7X7-3]
GeneIDi64792.
KEGGihsa:64792.
UCSCiuc003uyl.3. human. [Q9H7X7-1]
uc003uym.3. human. [Q9H7X7-2]

Organism-specific databases

CTDi64792.
GeneCardsiGC07M100961.
HGNCiHGNC:21895. IFT22.
HPAiHPA042930.
neXtProtiNX_Q9H7X7.
PharmGKBiPA134871769.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG87073.
GeneTreeiENSGT00390000013187.
HOGENOMiHOG000232131.
HOVERGENiHBG083943.
InParanoidiQ9H7X7.
KOiK07935.
OMAiLQDTQCL.
OrthoDBiEOG7FBRJZ.
PhylomeDBiQ9H7X7.
TreeFamiTF313208.

Miscellaneous databases

GenomeRNAii64792.
NextBioi66854.
PROiQ9H7X7.

Gene expression databases

BgeeiQ9H7X7.
CleanExiHS_RABL5.
ExpressionAtlasiQ9H7X7. baseline and differential.
GenevestigatoriQ9H7X7.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Mammary gland and Ovary.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Brain and Lung.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 93-185 (ISOFORMS 1/2/3).
    Tissue: Amygdala.

Entry informationi

Entry nameiIFT22_HUMAN
AccessioniPrimary (citable) accession number: Q9H7X7
Secondary accession number(s): Q49AG1, Q69YV5, Q9BSW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 1, 2001
Last modified: February 4, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.