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Protein

Zinc finger protein 696

Gene

ZNF696

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri125 – 14723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri153 – 17523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri181 – 20323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri209 – 23123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri237 – 25923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri265 – 28723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri293 – 31523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri321 – 34323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 696
Gene namesi
Name:ZNF696
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:25872. ZNF696.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670494.

Polymorphism and mutation databases

BioMutaiZNF696.
DMDMi212276484.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Zinc finger protein 696PRO_0000233278Add
BLAST

Proteomic databases

EPDiQ9H7X3.
MaxQBiQ9H7X3.
PaxDbiQ9H7X3.
PRIDEiQ9H7X3.

PTM databases

iPTMnetiQ9H7X3.

Expressioni

Gene expression databases

BgeeiQ9H7X3.
CleanExiHS_ZNF696.
ExpressionAtlasiQ9H7X3. baseline and differential.
GenevisibleiQ9H7X3. HS.

Organism-specific databases

HPAiHPA057855.

Interactioni

Protein-protein interaction databases

BioGridi123015. 16 interactions.
IntActiQ9H7X3. 1 interaction.
STRINGi9606.ENSP00000328515.

Structurei

3D structure databases

ProteinModelPortaliQ9H7X3.
SMRiQ9H7X3. Positions 123-373.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri125 – 14723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri153 – 17523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri181 – 20323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri209 – 23123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri237 – 25923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri265 – 28723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri293 – 31523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri321 – 34323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129696.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9H7X3.
OMAiKGRPYQC.
PhylomeDBiQ9H7X3.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H7X3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGGEPTGA KESSTLMESL AAVKAAFLAQ APSGSRSAEV QAAQSTEPAA
60 70 80 90 100
EAGAPEGEGH RGGPPRALGS LGLCENQEAR ERPGGSPRGP VTSEKTGGQS
110 120 130 140 150
GLESDVPPNA GPGAEGGGSW KGRPFPCGAC GRSFKCSSDA AKHRSIHSGE
160 170 180 190 200
KPYECSDCGK AFIHSSHVVR HQRAHSGERP YACAECGKAF GQSFNLLRHQ
210 220 230 240 250
RVHTGEKPYA CADCGKAFGQ RSDAAKHRRT HTGERLYACG ECGKRFLHSS
260 270 280 290 300
NVVRHRRTHH GENPYECREC GQAFSQSSNL LQHQRVHTGE RPFACQDCGR
310 320 330 340 350
AFSRSSFLRE HRRIHTGEKP HQCGHCGRAF RALSGFFRHQ RLHTGEKPFR
360 370
CTECGRAFRL SFHLIQHRRV HGAE
Length:374
Mass (Da):40,575
Last modified:November 4, 2008 - v2
Checksum:i68AE7E35A33FD6FE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti312 – 3121R → C in BAB14850 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024191 mRNA. Translation: BAB14850.1.
CH471162 Genomic DNA. Translation: EAW82267.1.
BC126317 mRNA. Translation: AAI26318.1.
CCDSiCCDS6399.1.
RefSeqiNP_112157.2. NM_030895.2.
UniGeneiHs.512740.

Genome annotation databases

EnsembliENST00000330143; ENSP00000328515; ENSG00000185730.
GeneIDi79943.
KEGGihsa:79943.
UCSCiuc003yxy.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024191 mRNA. Translation: BAB14850.1.
CH471162 Genomic DNA. Translation: EAW82267.1.
BC126317 mRNA. Translation: AAI26318.1.
CCDSiCCDS6399.1.
RefSeqiNP_112157.2. NM_030895.2.
UniGeneiHs.512740.

3D structure databases

ProteinModelPortaliQ9H7X3.
SMRiQ9H7X3. Positions 123-373.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123015. 16 interactions.
IntActiQ9H7X3. 1 interaction.
STRINGi9606.ENSP00000328515.

PTM databases

iPTMnetiQ9H7X3.

Polymorphism and mutation databases

BioMutaiZNF696.
DMDMi212276484.

Proteomic databases

EPDiQ9H7X3.
MaxQBiQ9H7X3.
PaxDbiQ9H7X3.
PRIDEiQ9H7X3.

Protocols and materials databases

DNASUi79943.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330143; ENSP00000328515; ENSG00000185730.
GeneIDi79943.
KEGGihsa:79943.
UCSCiuc003yxy.5. human.

Organism-specific databases

CTDi79943.
GeneCardsiZNF696.
HGNCiHGNC:25872. ZNF696.
HPAiHPA057855.
neXtProtiNX_Q9H7X3.
PharmGKBiPA142670494.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129696.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9H7X3.
OMAiKGRPYQC.
PhylomeDBiQ9H7X3.
TreeFamiTF337055.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF696. human.
GenomeRNAii79943.
PROiQ9H7X3.

Gene expression databases

BgeeiQ9H7X3.
CleanExiHS_ZNF696.
ExpressionAtlasiQ9H7X3. baseline and differential.
GenevisibleiQ9H7X3. HS.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiZN696_HUMAN
AccessioniPrimary (citable) accession number: Q9H7X3
Secondary accession number(s): A0AVE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 4, 2008
Last modified: June 8, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.