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Protein

Zinc finger protein 696

Gene

ZNF696

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri125 – 147C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri153 – 175C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri181 – 203C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri209 – 231C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri237 – 259C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri265 – 287C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri293 – 315C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri321 – 343C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri349 – 371C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 696
Gene namesi
Name:ZNF696
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000185730.7
HGNCiHGNC:25872 ZNF696
neXtProtiNX_Q9H7X3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185730
PharmGKBiPA142670494

Polymorphism and mutation databases

BioMutaiZNF696
DMDMi212276484

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002332781 – 374Zinc finger protein 696Add BLAST374

Proteomic databases

EPDiQ9H7X3
MaxQBiQ9H7X3
PaxDbiQ9H7X3
PeptideAtlasiQ9H7X3
PRIDEiQ9H7X3

PTM databases

iPTMnetiQ9H7X3
PhosphoSitePlusiQ9H7X3

Expressioni

Gene expression databases

BgeeiENSG00000185730
CleanExiHS_ZNF696
ExpressionAtlasiQ9H7X3 baseline and differential
GenevisibleiQ9H7X3 HS

Organism-specific databases

HPAiHPA057855
HPA072473

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123015, 23 interactors
IntActiQ9H7X3, 30 interactors
STRINGi9606.ENSP00000328515

Structurei

3D structure databases

ProteinModelPortaliQ9H7X3
SMRiQ9H7X3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri125 – 147C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri153 – 175C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri181 – 203C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri209 – 231C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri237 – 259C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri265 – 287C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri293 – 315C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri321 – 343C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri349 – 371C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144244
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9H7X3
OMAiKGRPYQC
OrthoDBiEOG091G02KC
PhylomeDBiQ9H7X3
TreeFamiTF337055

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequencei

Sequence statusi: Complete.

Q9H7X3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGGEPTGA KESSTLMESL AAVKAAFLAQ APSGSRSAEV QAAQSTEPAA
60 70 80 90 100
EAGAPEGEGH RGGPPRALGS LGLCENQEAR ERPGGSPRGP VTSEKTGGQS
110 120 130 140 150
GLESDVPPNA GPGAEGGGSW KGRPFPCGAC GRSFKCSSDA AKHRSIHSGE
160 170 180 190 200
KPYECSDCGK AFIHSSHVVR HQRAHSGERP YACAECGKAF GQSFNLLRHQ
210 220 230 240 250
RVHTGEKPYA CADCGKAFGQ RSDAAKHRRT HTGERLYACG ECGKRFLHSS
260 270 280 290 300
NVVRHRRTHH GENPYECREC GQAFSQSSNL LQHQRVHTGE RPFACQDCGR
310 320 330 340 350
AFSRSSFLRE HRRIHTGEKP HQCGHCGRAF RALSGFFRHQ RLHTGEKPFR
360 370
CTECGRAFRL SFHLIQHRRV HGAE
Length:374
Mass (Da):40,575
Last modified:November 4, 2008 - v2
Checksum:i68AE7E35A33FD6FE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti312R → C in BAB14850 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024191 mRNA Translation: BAB14850.1
CH471162 Genomic DNA Translation: EAW82267.1
BC126317 mRNA Translation: AAI26318.1
CCDSiCCDS6399.1
RefSeqiNP_112157.2, NM_030895.2
UniGeneiHs.512740

Genome annotation databases

EnsembliENST00000330143; ENSP00000328515; ENSG00000185730
GeneIDi79943
KEGGihsa:79943
UCSCiuc003yxy.5 human

Similar proteinsi

Entry informationi

Entry nameiZN696_HUMAN
AccessioniPrimary (citable) accession number: Q9H7X3
Secondary accession number(s): A0AVE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 4, 2008
Last modified: May 23, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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