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Q9H7X0

- NAA60_HUMAN

UniProt

Q9H7X0 - NAA60_HUMAN

Protein

N-alpha-acetyltransferase 60

Gene

NAA60

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 'Lys-20'(H4K20ac), 'Lys-79'(H4K79ac) and 'Lys-91' (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase.2 Publications

    Catalytic activityi

    Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.1 Publication
    Acetyl-CoA + [histone] = CoA + acetyl-[histone].1 Publication

    GO - Molecular functioni

    1. H4 histone acetyltransferase activity Source: UniProtKB
    2. peptide alpha-N-acetyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. cell proliferation Source: UniProtKB
    2. chromosome segregation Source: UniProtKB
    3. histone H4 acetylation Source: UniProtKB
    4. N-terminal peptidyl-methionine acetylation Source: UniProtKB
    5. nucleosome assembly Source: UniProtKB

    Keywords - Molecular functioni

    Acyltransferase, Chromatin regulator, Transferase

    Keywords - Biological processi

    Chromosome partition

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-alpha-acetyltransferase 60 (EC:2.3.1.48, EC:2.3.1.88)
    Alternative name(s):
    Histone acetyltransferase type B protein 4
    Short name:
    HAT4
    N-acetyltransferase 15
    NatF catalytic subunit
    Gene namesi
    Name:NAA60
    Synonyms:HAT4, NAT15
    ORF Names:UNQ2771/PRO7155
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:25875. NAA60.

    Subcellular locationi

    Golgi apparatus membrane 1 Publication

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi79 – 791K → R: Decreased histone acetyltransferase activity; when associated with R-105, R-109, R-121 and R-156. 1 Publication
    Mutagenesisi105 – 1051K → R: Decreased histone acetyltransferase activity; when associated with R-79, R-109, R-121 and R-156. 1 Publication
    Mutagenesisi109 – 1091K → R: Decreased histone acetyltransferase activity; when associated with R-79, R-105, R-121 and R-156. 1 Publication
    Mutagenesisi111 – 1111G → A: Abolishes histone acetyltransferase activity. 1 Publication
    Mutagenesisi121 – 1211K → R: Decreased histone acetyltransferase activity; when associated with R-79, R-105, R-109 and R-156. 1 Publication
    Mutagenesisi156 – 1561K → R: Decreased histone acetyltransferase activity; when associated with R-79, R-105, R-109 and R-121. 1 Publication

    Organism-specific databases

    PharmGKBiPA164723438.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 242242N-alpha-acetyltransferase 60PRO_0000321566Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei79 – 791N6-acetyllysine; by autocatalysis1 Publication
    Modified residuei105 – 1051N6-acetyllysine; by autocatalysis1 Publication
    Modified residuei109 – 1091N6-acetyllysine; by autocatalysis1 Publication
    Modified residuei121 – 1211N6-acetyllysine; by autocatalysis1 Publication
    Modified residuei156 – 1561N6-acetyllysine; by autocatalysis1 Publication

    Post-translational modificationi

    Acetylated: autoacetylation is required for optimal acetyltransferase activity.1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9H7X0.
    PaxDbiQ9H7X0.
    PRIDEiQ9H7X0.

    PTM databases

    PhosphoSiteiQ9H7X0.

    Expressioni

    Inductioni

    Isoform 2 is imprinted. Promoter methylation of the paternal allele may restrict expression to the maternal allele in placenta and leukocytes. Isoform 1 is biallelically expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ9H7X0.
    BgeeiQ9H7X0.
    CleanExiHS_NAT15.
    GenevestigatoriQ9H7X0.

    Organism-specific databases

    HPAiHPA040916.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000385903.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H7X0.
    SMRiQ9H7X0. Positions 12-181.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 182170N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG276305.
    HOGENOMiHOG000280717.
    HOVERGENiHBG061680.
    InParanoidiQ9H7X0.
    OMAiMTERMAQ.
    OrthoDBiEOG7M0NT7.
    PhylomeDBiQ9H7X0.
    TreeFamiTF323980.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view]
    PfamiPF00583. Acetyltransf_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative promoter usage and alternative splicing. Align

    Isoform 1 (identifier: Q9H7X0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTEVVPSSAL SEVSLRLLCH DDIDTVKHLC GDWFPIEYPD SWYRDITSNK    50
    KFFSLAATYR GAIVGMIVAE IKNRTKIHKE DGDILASNFS VDTQVAYILS 100
    LGVVKEFRKH GIGSLLLESL KDHISTTAQD HCKAIYLHVL TTNNTAINFY 150
    ENRDFKQHHY LPYYYSIRGV LKDGFTYVLY INGGHPPWTI LDYIQHLGSA 200
    LASLSPCSIP HRVYRQAHSL LCSFLPWSGI SSKSGIEYSR TM 242
    Length:242
    Mass (Da):27,451
    Last modified:March 1, 2001 - v1
    Checksum:i11234F2C51DF55DE
    GO
    Isoform 2 (identifier: Q9H7X0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-36: MTEVVPSSAL...KHLCGDWFPI → MFPRRRTERR...ASLSWEKSSR

    Note: In placenta and leukocytes, expressed from the maternal allele, due to imprinting of the paternal allele.

    Show »
    Length:249
    Mass (Da):28,375
    Checksum:iE049FDCDA8FD6ECC
    GO
    Isoform 3 (identifier: Q9H7X0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-65: Missing.

    Note: Produced by alternative splicing. No experimental confirmation available.

    Show »
    Length:177
    Mass (Da):20,103
    Checksum:i32C31E8C2E777D5D
    GO
    Isoform 4 (identifier: Q9H7X0-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         113-242: GSLLLESLKD...KSGIEYSRTM → ESTARPTACS...SVFCKELPAI

    Note: Produced by alternative splicing. No experimental confirmation available.

    Show »
    Length:179
    Mass (Da):19,493
    Checksum:i806EE0412C45F54C
    GO
    Isoform 5 (identifier: Q9H7X0-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         113-242: GSLLLESLKD...KSGIEYSRTM → EPHGLHPAPG...PPAEPAFLSI

    Note: Produced by alternative splicing.Curated No experimental confirmation available.Curated

    Show »
    Length:190
    Mass (Da):20,911
    Checksum:iC82D743C3A3F0776
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti87 – 871S → T in AAQ88907. (PubMed:12975309)Curated
    Sequence conflicti242 – 2421M → I in CAG33605. 1 PublicationCurated
    Isoform 5 (identifier: Q9H7X0-5)
    Sequence conflicti180 – 1801R → Q in BAG60760. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti218 – 2181H → Q.
    Corresponds to variant rs34464545 [ dbSNP | Ensembl ].
    VAR_060995

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6565Missing in isoform 3. 1 PublicationVSP_044122Add
    BLAST
    Alternative sequencei1 – 3636MTEVV…DWFPI → MFPRRRTERRLGDTGTRKKI AYRKAVPGGRKCGASLSWEK SSR in isoform 2. 1 PublicationVSP_044123Add
    BLAST
    Alternative sequencei113 – 242130GSLLL…YSRTM → ESTARPTACSAASCHGRASL PRVASSTAGPCDVGWAAATR PHPSAARRARLPVHLTPSVF CKELPAI in isoform 4. 1 PublicationVSP_044124Add
    BLAST
    Alternative sequencei113 – 242130GSLLL…YSRTM → EPHGLHPAPGLCTSQPEPLL HSAQSLPPGPQPALQLPAMV GHLFQEWHRVQPDHVMSAGQ PPPGPTLRPPAEPAFLSI in isoform 5. 1 PublicationVSP_044125Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358543 mRNA. Translation: AAQ88907.1.
    AK024216 mRNA. Translation: BAB14853.1.
    AK092005 mRNA. Translation: BAG52462.1.
    AK297219 mRNA. Translation: BAG59702.1.
    AK298566 mRNA. Translation: BAG60760.1.
    AK302361 mRNA. Translation: BAG63686.1.
    CR457324 mRNA. Translation: CAG33605.1.
    AC004224 Genomic DNA. No translation available.
    AC025283 Genomic DNA. No translation available.
    CH471112 Genomic DNA. Translation: EAW85358.1.
    CH471112 Genomic DNA. Translation: EAW85359.1.
    CH471112 Genomic DNA. Translation: EAW85360.1.
    CH471112 Genomic DNA. Translation: EAW85361.1.
    CH471112 Genomic DNA. Translation: EAW85362.1.
    CH471112 Genomic DNA. Translation: EAW85363.1.
    CH471112 Genomic DNA. Translation: EAW85364.1.
    BC011267 mRNA. Translation: AAH11267.1.
    CCDSiCCDS45396.1. [Q9H7X0-1]
    RefSeqiNP_001077069.1. NM_001083600.1. [Q9H7X0-1]
    NP_001077070.1. NM_001083601.1. [Q9H7X0-1]
    NP_079121.1. NM_024845.2. [Q9H7X0-1]
    XP_006721012.1. XM_006720949.1. [Q9H7X0-1]
    XP_006721013.1. XM_006720950.1. [Q9H7X0-1]
    XP_006721014.1. XM_006720951.1. [Q9H7X0-1]
    XP_006721015.1. XM_006720952.1. [Q9H7X0-1]
    UniGeneiHs.513296.

    Genome annotation databases

    EnsembliENST00000360862; ENSP00000354108; ENSG00000122390. [Q9H7X0-3]
    ENST00000407558; ENSP00000385903; ENSG00000122390. [Q9H7X0-1]
    ENST00000414063; ENSP00000393224; ENSG00000122390. [Q9H7X0-1]
    ENST00000421765; ENSP00000405873; ENSG00000122390. [Q9H7X0-5]
    ENST00000424546; ENSP00000401237; ENSG00000122390. [Q9H7X0-2]
    ENST00000570819; ENSP00000460763; ENSG00000122390. [Q9H7X0-4]
    ENST00000572584; ENSP00000459057; ENSG00000122390. [Q9H7X0-1]
    ENST00000572942; ENSP00000461730; ENSG00000122390. [Q9H7X0-4]
    ENST00000573580; ENSP00000459055; ENSG00000122390. [Q9H7X0-3]
    ENST00000575076; ENSP00000458667; ENSG00000122390. [Q9H7X0-1]
    GeneIDi79903.
    KEGGihsa:79903.
    UCSCiuc002cvg.2. human. [Q9H7X0-1]
    uc010uxb.1. human. [Q9H7X0-2]

    Polymorphism databases

    DMDMi74733721.

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358543 mRNA. Translation: AAQ88907.1 .
    AK024216 mRNA. Translation: BAB14853.1 .
    AK092005 mRNA. Translation: BAG52462.1 .
    AK297219 mRNA. Translation: BAG59702.1 .
    AK298566 mRNA. Translation: BAG60760.1 .
    AK302361 mRNA. Translation: BAG63686.1 .
    CR457324 mRNA. Translation: CAG33605.1 .
    AC004224 Genomic DNA. No translation available.
    AC025283 Genomic DNA. No translation available.
    CH471112 Genomic DNA. Translation: EAW85358.1 .
    CH471112 Genomic DNA. Translation: EAW85359.1 .
    CH471112 Genomic DNA. Translation: EAW85360.1 .
    CH471112 Genomic DNA. Translation: EAW85361.1 .
    CH471112 Genomic DNA. Translation: EAW85362.1 .
    CH471112 Genomic DNA. Translation: EAW85363.1 .
    CH471112 Genomic DNA. Translation: EAW85364.1 .
    BC011267 mRNA. Translation: AAH11267.1 .
    CCDSi CCDS45396.1. [Q9H7X0-1 ]
    RefSeqi NP_001077069.1. NM_001083600.1. [Q9H7X0-1 ]
    NP_001077070.1. NM_001083601.1. [Q9H7X0-1 ]
    NP_079121.1. NM_024845.2. [Q9H7X0-1 ]
    XP_006721012.1. XM_006720949.1. [Q9H7X0-1 ]
    XP_006721013.1. XM_006720950.1. [Q9H7X0-1 ]
    XP_006721014.1. XM_006720951.1. [Q9H7X0-1 ]
    XP_006721015.1. XM_006720952.1. [Q9H7X0-1 ]
    UniGenei Hs.513296.

    3D structure databases

    ProteinModelPortali Q9H7X0.
    SMRi Q9H7X0. Positions 12-181.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000385903.

    PTM databases

    PhosphoSitei Q9H7X0.

    Polymorphism databases

    DMDMi 74733721.

    Proteomic databases

    MaxQBi Q9H7X0.
    PaxDbi Q9H7X0.
    PRIDEi Q9H7X0.

    Protocols and materials databases

    DNASUi 79903.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360862 ; ENSP00000354108 ; ENSG00000122390 . [Q9H7X0-3 ]
    ENST00000407558 ; ENSP00000385903 ; ENSG00000122390 . [Q9H7X0-1 ]
    ENST00000414063 ; ENSP00000393224 ; ENSG00000122390 . [Q9H7X0-1 ]
    ENST00000421765 ; ENSP00000405873 ; ENSG00000122390 . [Q9H7X0-5 ]
    ENST00000424546 ; ENSP00000401237 ; ENSG00000122390 . [Q9H7X0-2 ]
    ENST00000570819 ; ENSP00000460763 ; ENSG00000122390 . [Q9H7X0-4 ]
    ENST00000572584 ; ENSP00000459057 ; ENSG00000122390 . [Q9H7X0-1 ]
    ENST00000572942 ; ENSP00000461730 ; ENSG00000122390 . [Q9H7X0-4 ]
    ENST00000573580 ; ENSP00000459055 ; ENSG00000122390 . [Q9H7X0-3 ]
    ENST00000575076 ; ENSP00000458667 ; ENSG00000122390 . [Q9H7X0-1 ]
    GeneIDi 79903.
    KEGGi hsa:79903.
    UCSCi uc002cvg.2. human. [Q9H7X0-1 ]
    uc010uxb.1. human. [Q9H7X0-2 ]

    Organism-specific databases

    CTDi 79903.
    GeneCardsi GC16P003495.
    H-InvDB HIX0012768.
    HIX0173265.
    HGNCi HGNC:25875. NAA60.
    HPAi HPA040916.
    MIMi 614246. gene.
    neXtProti NX_Q9H7X0.
    PharmGKBi PA164723438.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG276305.
    HOGENOMi HOG000280717.
    HOVERGENi HBG061680.
    InParanoidi Q9H7X0.
    OMAi MTERMAQ.
    OrthoDBi EOG7M0NT7.
    PhylomeDBi Q9H7X0.
    TreeFami TF323980.

    Miscellaneous databases

    ChiTaRSi NAA60. human.
    GenomeRNAii 79903.
    NextBioi 69755.
    PROi Q9H7X0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H7X0.
    Bgeei Q9H7X0.
    CleanExi HS_NAT15.
    Genevestigatori Q9H7X0.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view ]
    Pfami PF00583. Acetyltransf_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3; 4 AND 5).
      Tissue: Fetal brain, Mesangial cell, Teratocarcinoma and Testis.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    7. "Methylation screening of reciprocal genome-wide UPDs identifies novel human-specific imprinted genes."
      Nakabayashi K., Trujillo A.M., Tayama C., Camprubi C., Yoshida W., Lapunzina P., Sanchez A., Soejima H., Aburatani H., Nagae G., Ogata T., Hata K., Monk D.
      Hum. Mol. Genet. 20:3188-3197(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IMPRINTING, INDUCTION.
    8. "HAT4, a Golgi apparatus-anchored B-type histone acetyltransferase, acetylates free histone H4 and facilitates chromatin assembly."
      Yang X., Yu W., Shi L., Sun L., Liang J., Yi X., Li Q., Zhang Y., Yang F., Han X., Zhang D., Yang J., Yao Z., Shang Y.
      Mol. Cell 44:39-50(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, ACETYLATION AT LYS-79; LYS-105; LYS-109; LYS-121 AND LYS-156, MUTAGENESIS OF LYS-79; LYS-105; LYS-109; GLY-111; LYS-121 AND LYS-156.
    9. "NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation."
      Van Damme P., Hole K., Pimenta-Marques A., Helsens K., Vandekerckhove J., Martinho R.G., Gevaert K., Arnesen T.
      PLoS Genet. 7:E1002169-E1002169(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiNAA60_HUMAN
    AccessioniPrimary (citable) accession number: Q9H7X0
    Secondary accession number(s): B3KRQ0
    , B4DLZ0, B4DPZ8, B4DYC4, D3DUC2, E7EQ65, Q6IA31, Q6UX26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3