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Protein

N-alpha-acetyltransferase 60

Gene

NAA60

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 'Lys-20'(H4K20ac), 'Lys-79'(H4K79ac) and 'Lys-91' (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase.2 Publications

Catalytic activityi

Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.1 Publication
Acetyl-CoA + [histone] = CoA + acetyl-[histone].1 Publication

GO - Molecular functioni

  1. H4 histone acetyltransferase activity Source: UniProtKB
  2. peptide alpha-N-acetyltransferase activity Source: UniProtKB

GO - Biological processi

  1. cell proliferation Source: UniProtKB
  2. chromosome segregation Source: UniProtKB
  3. histone H4 acetylation Source: UniProtKB
  4. N-terminal peptidyl-methionine acetylation Source: UniProtKB
  5. nucleosome assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Chromosome partition

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 60 (EC:2.3.1.48, EC:2.3.1.88)
Alternative name(s):
Histone acetyltransferase type B protein 4
Short name:
HAT4
N-acetyltransferase 15
NatF catalytic subunit
Gene namesi
Name:NAA60
Synonyms:HAT4, NAT15
ORF Names:UNQ2771/PRO7155
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:25875. NAA60.

Subcellular locationi

Golgi apparatus membrane 1 Publication

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi79 – 791K → R: Decreased histone acetyltransferase activity; when associated with R-105, R-109, R-121 and R-156. 1 Publication
Mutagenesisi105 – 1051K → R: Decreased histone acetyltransferase activity; when associated with R-79, R-109, R-121 and R-156. 1 Publication
Mutagenesisi109 – 1091K → R: Decreased histone acetyltransferase activity; when associated with R-79, R-105, R-121 and R-156. 1 Publication
Mutagenesisi111 – 1111G → A: Abolishes histone acetyltransferase activity. 1 Publication
Mutagenesisi121 – 1211K → R: Decreased histone acetyltransferase activity; when associated with R-79, R-105, R-109 and R-156. 1 Publication
Mutagenesisi156 – 1561K → R: Decreased histone acetyltransferase activity; when associated with R-79, R-105, R-109 and R-121. 1 Publication

Organism-specific databases

PharmGKBiPA164723438.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242N-alpha-acetyltransferase 60PRO_0000321566Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei79 – 791N6-acetyllysine; by autocatalysis1 Publication
Modified residuei105 – 1051N6-acetyllysine; by autocatalysis1 Publication
Modified residuei109 – 1091N6-acetyllysine; by autocatalysis1 Publication
Modified residuei121 – 1211N6-acetyllysine; by autocatalysis1 Publication
Modified residuei156 – 1561N6-acetyllysine; by autocatalysis1 Publication

Post-translational modificationi

Acetylated: autoacetylation is required for optimal acetyltransferase activity.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9H7X0.
PaxDbiQ9H7X0.
PRIDEiQ9H7X0.

PTM databases

PhosphoSiteiQ9H7X0.

Expressioni

Inductioni

Isoform 2 is imprinted. Promoter methylation of the paternal allele may restrict expression to the maternal allele in placenta and leukocytes. Isoform 1 is biallelically expressed.1 Publication

Gene expression databases

BgeeiQ9H7X0.
CleanExiHS_NAT15.
ExpressionAtlasiQ9H7X0. baseline and differential.
GenevestigatoriQ9H7X0.

Organism-specific databases

HPAiHPA040916.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000385903.

Structurei

3D structure databases

ProteinModelPortaliQ9H7X0.
SMRiQ9H7X0. Positions 12-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 182170N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG276305.
GeneTreeiENSGT00390000008314.
HOGENOMiHOG000280717.
HOVERGENiHBG061680.
InParanoidiQ9H7X0.
OMAiTVKQLCG.
OrthoDBiEOG7M0NT7.
PhylomeDBiQ9H7X0.
TreeFamiTF323980.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H7X0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTEVVPSSAL SEVSLRLLCH DDIDTVKHLC GDWFPIEYPD SWYRDITSNK
60 70 80 90 100
KFFSLAATYR GAIVGMIVAE IKNRTKIHKE DGDILASNFS VDTQVAYILS
110 120 130 140 150
LGVVKEFRKH GIGSLLLESL KDHISTTAQD HCKAIYLHVL TTNNTAINFY
160 170 180 190 200
ENRDFKQHHY LPYYYSIRGV LKDGFTYVLY INGGHPPWTI LDYIQHLGSA
210 220 230 240
LASLSPCSIP HRVYRQAHSL LCSFLPWSGI SSKSGIEYSR TM
Length:242
Mass (Da):27,451
Last modified:February 28, 2001 - v1
Checksum:i11234F2C51DF55DE
GO
Isoform 2 (identifier: Q9H7X0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MTEVVPSSAL...KHLCGDWFPI → MFPRRRTERR...ASLSWEKSSR

Note: In placenta and leukocytes, expressed from the maternal allele, due to imprinting of the paternal allele.

Show »
Length:249
Mass (Da):28,375
Checksum:iE049FDCDA8FD6ECC
GO
Isoform 3 (identifier: Q9H7X0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.

Show »
Length:177
Mass (Da):20,103
Checksum:i32C31E8C2E777D5D
GO
Isoform 4 (identifier: Q9H7X0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-242: GSLLLESLKD...KSGIEYSRTM → ESTARPTACS...SVFCKELPAI

Note: Produced by alternative splicing. No experimental confirmation available.

Show »
Length:179
Mass (Da):19,493
Checksum:i806EE0412C45F54C
GO
Isoform 5 (identifier: Q9H7X0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-242: GSLLLESLKD...KSGIEYSRTM → EPHGLHPAPG...PPAEPAFLSI

Note: Produced by alternative splicing.Curated No experimental confirmation available.Curated

Show »
Length:190
Mass (Da):20,911
Checksum:iC82D743C3A3F0776
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti87 – 871S → T in AAQ88907 (PubMed:12975309).Curated
Sequence conflicti242 – 2421M → I in CAG33605 (Ref. 3) Curated
Isoform 5 (identifier: Q9H7X0-5)
Sequence conflicti180 – 1801R → Q in BAG60760 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti218 – 2181H → Q.
Corresponds to variant rs34464545 [ dbSNP | Ensembl ].
VAR_060995

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6565Missing in isoform 3. 1 PublicationVSP_044122Add
BLAST
Alternative sequencei1 – 3636MTEVV…DWFPI → MFPRRRTERRLGDTGTRKKI AYRKAVPGGRKCGASLSWEK SSR in isoform 2. 1 PublicationVSP_044123Add
BLAST
Alternative sequencei113 – 242130GSLLL…YSRTM → ESTARPTACSAASCHGRASL PRVASSTAGPCDVGWAAATR PHPSAARRARLPVHLTPSVF CKELPAI in isoform 4. 1 PublicationVSP_044124Add
BLAST
Alternative sequencei113 – 242130GSLLL…YSRTM → EPHGLHPAPGLCTSQPEPLL HSAQSLPPGPQPALQLPAMV GHLFQEWHRVQPDHVMSAGQ PPPGPTLRPPAEPAFLSI in isoform 5. 1 PublicationVSP_044125Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358543 mRNA. Translation: AAQ88907.1.
AK024216 mRNA. Translation: BAB14853.1.
AK092005 mRNA. Translation: BAG52462.1.
AK297219 mRNA. Translation: BAG59702.1.
AK298566 mRNA. Translation: BAG60760.1.
AK302361 mRNA. Translation: BAG63686.1.
CR457324 mRNA. Translation: CAG33605.1.
AC004224 Genomic DNA. No translation available.
AC025283 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85358.1.
CH471112 Genomic DNA. Translation: EAW85359.1.
CH471112 Genomic DNA. Translation: EAW85360.1.
CH471112 Genomic DNA. Translation: EAW85361.1.
CH471112 Genomic DNA. Translation: EAW85362.1.
CH471112 Genomic DNA. Translation: EAW85363.1.
CH471112 Genomic DNA. Translation: EAW85364.1.
BC011267 mRNA. Translation: AAH11267.1.
CCDSiCCDS45396.1. [Q9H7X0-1]
RefSeqiNP_001077069.1. NM_001083600.1. [Q9H7X0-1]
NP_001077070.1. NM_001083601.1. [Q9H7X0-1]
NP_079121.1. NM_024845.2. [Q9H7X0-1]
XP_006721012.1. XM_006720949.1. [Q9H7X0-1]
XP_006721013.1. XM_006720950.1. [Q9H7X0-1]
XP_006721014.1. XM_006720951.1. [Q9H7X0-1]
XP_006721015.1. XM_006720952.1. [Q9H7X0-1]
UniGeneiHs.513296.

Genome annotation databases

EnsembliENST00000360862; ENSP00000354108; ENSG00000122390. [Q9H7X0-3]
ENST00000407558; ENSP00000385903; ENSG00000122390. [Q9H7X0-1]
ENST00000414063; ENSP00000393224; ENSG00000122390. [Q9H7X0-1]
ENST00000421765; ENSP00000405873; ENSG00000122390. [Q9H7X0-5]
ENST00000424546; ENSP00000401237; ENSG00000122390. [Q9H7X0-2]
ENST00000570819; ENSP00000460763; ENSG00000122390. [Q9H7X0-4]
ENST00000572584; ENSP00000459057; ENSG00000122390. [Q9H7X0-1]
ENST00000572942; ENSP00000461730; ENSG00000122390. [Q9H7X0-4]
ENST00000573580; ENSP00000459055; ENSG00000122390. [Q9H7X0-3]
ENST00000575076; ENSP00000458667; ENSG00000122390. [Q9H7X0-1]
GeneIDi79903.
KEGGihsa:79903.
UCSCiuc002cvg.2. human. [Q9H7X0-1]
uc010uxb.1. human. [Q9H7X0-2]

Polymorphism databases

DMDMi74733721.

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358543 mRNA. Translation: AAQ88907.1.
AK024216 mRNA. Translation: BAB14853.1.
AK092005 mRNA. Translation: BAG52462.1.
AK297219 mRNA. Translation: BAG59702.1.
AK298566 mRNA. Translation: BAG60760.1.
AK302361 mRNA. Translation: BAG63686.1.
CR457324 mRNA. Translation: CAG33605.1.
AC004224 Genomic DNA. No translation available.
AC025283 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85358.1.
CH471112 Genomic DNA. Translation: EAW85359.1.
CH471112 Genomic DNA. Translation: EAW85360.1.
CH471112 Genomic DNA. Translation: EAW85361.1.
CH471112 Genomic DNA. Translation: EAW85362.1.
CH471112 Genomic DNA. Translation: EAW85363.1.
CH471112 Genomic DNA. Translation: EAW85364.1.
BC011267 mRNA. Translation: AAH11267.1.
CCDSiCCDS45396.1. [Q9H7X0-1]
RefSeqiNP_001077069.1. NM_001083600.1. [Q9H7X0-1]
NP_001077070.1. NM_001083601.1. [Q9H7X0-1]
NP_079121.1. NM_024845.2. [Q9H7X0-1]
XP_006721012.1. XM_006720949.1. [Q9H7X0-1]
XP_006721013.1. XM_006720950.1. [Q9H7X0-1]
XP_006721014.1. XM_006720951.1. [Q9H7X0-1]
XP_006721015.1. XM_006720952.1. [Q9H7X0-1]
UniGeneiHs.513296.

3D structure databases

ProteinModelPortaliQ9H7X0.
SMRiQ9H7X0. Positions 12-181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000385903.

PTM databases

PhosphoSiteiQ9H7X0.

Polymorphism databases

DMDMi74733721.

Proteomic databases

MaxQBiQ9H7X0.
PaxDbiQ9H7X0.
PRIDEiQ9H7X0.

Protocols and materials databases

DNASUi79903.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360862; ENSP00000354108; ENSG00000122390. [Q9H7X0-3]
ENST00000407558; ENSP00000385903; ENSG00000122390. [Q9H7X0-1]
ENST00000414063; ENSP00000393224; ENSG00000122390. [Q9H7X0-1]
ENST00000421765; ENSP00000405873; ENSG00000122390. [Q9H7X0-5]
ENST00000424546; ENSP00000401237; ENSG00000122390. [Q9H7X0-2]
ENST00000570819; ENSP00000460763; ENSG00000122390. [Q9H7X0-4]
ENST00000572584; ENSP00000459057; ENSG00000122390. [Q9H7X0-1]
ENST00000572942; ENSP00000461730; ENSG00000122390. [Q9H7X0-4]
ENST00000573580; ENSP00000459055; ENSG00000122390. [Q9H7X0-3]
ENST00000575076; ENSP00000458667; ENSG00000122390. [Q9H7X0-1]
GeneIDi79903.
KEGGihsa:79903.
UCSCiuc002cvg.2. human. [Q9H7X0-1]
uc010uxb.1. human. [Q9H7X0-2]

Organism-specific databases

CTDi79903.
GeneCardsiGC16P003495.
H-InvDBHIX0012768.
HIX0173265.
HGNCiHGNC:25875. NAA60.
HPAiHPA040916.
MIMi614246. gene.
neXtProtiNX_Q9H7X0.
PharmGKBiPA164723438.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG276305.
GeneTreeiENSGT00390000008314.
HOGENOMiHOG000280717.
HOVERGENiHBG061680.
InParanoidiQ9H7X0.
OMAiTVKQLCG.
OrthoDBiEOG7M0NT7.
PhylomeDBiQ9H7X0.
TreeFamiTF323980.

Miscellaneous databases

ChiTaRSiNAA60. human.
GenomeRNAii79903.
NextBioi69755.
PROiQ9H7X0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H7X0.
CleanExiHS_NAT15.
ExpressionAtlasiQ9H7X0. baseline and differential.
GenevestigatoriQ9H7X0.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3; 4 AND 5).
    Tissue: Fetal brain, Mesangial cell, Teratocarcinoma and Testis.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. "Methylation screening of reciprocal genome-wide UPDs identifies novel human-specific imprinted genes."
    Nakabayashi K., Trujillo A.M., Tayama C., Camprubi C., Yoshida W., Lapunzina P., Sanchez A., Soejima H., Aburatani H., Nagae G., Ogata T., Hata K., Monk D.
    Hum. Mol. Genet. 20:3188-3197(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IMPRINTING, INDUCTION.
  8. "HAT4, a Golgi apparatus-anchored B-type histone acetyltransferase, acetylates free histone H4 and facilitates chromatin assembly."
    Yang X., Yu W., Shi L., Sun L., Liang J., Yi X., Li Q., Zhang Y., Yang F., Han X., Zhang D., Yang J., Yao Z., Shang Y.
    Mol. Cell 44:39-50(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, ACETYLATION AT LYS-79; LYS-105; LYS-109; LYS-121 AND LYS-156, MUTAGENESIS OF LYS-79; LYS-105; LYS-109; GLY-111; LYS-121 AND LYS-156.
  9. "NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation."
    Van Damme P., Hole K., Pimenta-Marques A., Helsens K., Vandekerckhove J., Martinho R.G., Gevaert K., Arnesen T.
    PLoS Genet. 7:E1002169-E1002169(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNAA60_HUMAN
AccessioniPrimary (citable) accession number: Q9H7X0
Secondary accession number(s): B3KRQ0
, B4DLZ0, B4DPZ8, B4DYC4, D3DUC2, E7EQ65, Q6IA31, Q6UX26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 25, 2008
Last sequence update: February 28, 2001
Last modified: January 6, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.