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Protein

Serine-rich coiled-coil domain-containing protein 2

Gene

CCSER2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-rich coiled-coil domain-containing protein 2
Alternative name(s):
Coiled-coil serine-rich protein 2
Protein GCAP14 homolog
Gene namesi
Name:CCSER2
Synonyms:FAM190B, KIAA1128
ORF Names:NPD012
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:29197. CCSER2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165548597.

Polymorphism and mutation databases

BioMutaiCCSER2.
DMDMi160386966.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 834834Serine-rich coiled-coil domain-containing protein 2PRO_0000309461Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei452 – 4521PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H7U1.
MaxQBiQ9H7U1.
PaxDbiQ9H7U1.
PRIDEiQ9H7U1.

PTM databases

iPTMnetiQ9H7U1.
PhosphoSiteiQ9H7U1.

Expressioni

Gene expression databases

BgeeiQ9H7U1.
CleanExiHS_KIAA1128.
GenevisibleiQ9H7U1. HS.

Organism-specific databases

HPAiHPA037481.
HPA037482.

Interactioni

Protein-protein interaction databases

BioGridi119968. 18 interactions.
IntActiQ9H7U1. 17 interactions.
MINTiMINT-1400475.
STRINGi9606.ENSP00000224756.

Structurei

3D structure databases

ProteinModelPortaliQ9H7U1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili712 – 74938Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi604 – 61613His-richAdd
BLAST

Sequence similaritiesi

Belongs to the CCSER family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGH2. Eukaryota.
ENOG410XT5P. LUCA.
GeneTreeiENSGT00730000111195.
InParanoidiQ9H7U1.
OMAiPLENVEC.
OrthoDBiEOG77WWBV.
PhylomeDBiQ9H7U1.
TreeFamiTF331021.

Family and domain databases

InterProiIPR029627. CCSER.
IPR029629. CCSER2.
[Graphical view]
PANTHERiPTHR22461. PTHR22461. 1 hit.
PTHR22461:SF2. PTHR22461:SF2. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H7U1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEKTQIKTF LGSKLPKYGT KSVRSTLQPM PNGTPVNLLG TSKNSNVKSY
60 70 80 90 100
IKNNGSDCPS SHSFNWRKAN KYQLCAQGVE EPNNTQNSHD KIIDPEKRVP
110 120 130 140 150
TQGMFDKNGI KGGLKSVSLF TSKLAKPSTM FVSSTEELNQ KSFSGPSNLG
160 170 180 190 200
KFTKGTLLGR TSYSSINTPK SQLNGFYGNR SAGSMQRPRA NSCATRSSSG
210 220 230 240 250
ESLAQSPDSS KSINCEKMVR SQSFSHSIQN SFLPPSSITR SHSFNRAVDL
260 270 280 290 300
TKPYQNQQLS IRVPLRSSML TRNSRQPEVL NGNEHLGYGF NRPYAAGGKK
310 320 330 340 350
LALPNGPGVT STLGYRMVHP SLLKSSRSPF SGTMTVDGNK NSPADTCVEE
360 370 380 390 400
DATVLAKDRA ANKDQELIEN ESYRTKNNQT MKHDAKMRYL SDDVDDISLS
410 420 430 440 450
SLSSSDKNDL SEDFSDDFID IEDSNRTRIT PEEMSLKEEK HENGPPQDMF
460 470 480 490 500
DSPKENEKAF SKTDEWIDIS VSDRSECTKH TSGNNLVSPD TDYRAGSSFE
510 520 530 540 550
LSPSDSSDGT YMWDEEGLEP IGNVHPVGSY ESSEMNSIDI LNNLESCDLE
560 570 580 590 600
DDDLMLDVDL PEDAPLENVE CDNMNRFDRP DRNVRQPQEG FWKRPPQRWS
610 620 630 640 650
GQEHYHLSHP DHYHHHGKSD LSRGSPYRES PLGHFESYGG MPFFQAQKMF
660 670 680 690 700
VDVPENTVIL DEMTLRHMVQ DCTAVKTQLL KLKRLLHQHD GSGSLHDIQL
710 720 730 740 750
SLPSSPEPED GDKVYKNEDL LNEIKQLKDE IKKKDEKIQL LELQLATQHI
760 770 780 790 800
CHQKCKEEKC TYADKYTQTP WRRIPGGYSA PSFSPWQGSF QGIPRTVPPH
810 820 830
RRQTSSTTAF QQPSQTHRSH PGKTNKATTY RGPQ
Length:834
Mass (Da):93,548
Last modified:November 13, 2007 - v2
Checksum:i036713F1975242A3
GO
Isoform 2 (identifier: Q9H7U1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     539-567: DILNNLESCDLEDDDLMLDVDLPEDAPLE → VCMDLYTLGIFCLPYYRETCDMIDFVKNL
     568-834: Missing.

Show »
Length:567
Mass (Da):62,760
Checksum:i5326DD577A85F838
GO
Isoform 3 (identifier: Q9H7U1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     776-834: GGYSAPSFSP...NKATTYRGPQ → PQVLQPSSSL...YSRLPKPKIH

Show »
Length:1,047
Mass (Da):116,913
Checksum:iE7C0A74671809440
GO
Isoform 4 (identifier: Q9H7U1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-573: Missing.

Note: No experimental confirmation available.
Show »
Length:261
Mass (Da):30,337
Checksum:i2AFAD6F347B4F273
GO

Sequence cautioni

The sequence AAG44473.1 differs from that shown. Reason: Frameshift at positions 187, 240 and 244. Curated
The sequence AAH30528.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI40902.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti155 – 1551G → C in AAG44473 (Ref. 5) Curated
Sequence conflicti215 – 2151C → Y in BAB14884 (PubMed:15489334).Curated
Sequence conflicti457 – 4571E → G in BAB14884 (PubMed:15489334).Curated
Sequence conflicti524 – 5241V → A in BAG61061 (PubMed:14702039).Curated
Sequence conflicti540 – 5401I → V in BAG61061 (PubMed:14702039).Curated
Sequence conflicti667 – 6671H → R in BAG61061 (PubMed:14702039).Curated
Isoform 3 (identifier: Q9H7U1-3)
Sequence conflicti782 – 7821S → F in BAG61061 (PubMed:14702039).Curated
Sequence conflicti881 – 8811M → I in BAG61061 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti84 – 841N → S.
Corresponds to variant rs3814205 [ dbSNP | Ensembl ].
VAR_036952
Natural varianti755 – 7551C → Y.
Corresponds to variant rs11201058 [ dbSNP | Ensembl ].
VAR_036953
Natural varianti819 – 8191S → P.
Corresponds to variant rs11557865 [ dbSNP | Ensembl ].
VAR_036954
Natural varianti821 – 8211P → S.
Corresponds to variant rs12569751 [ dbSNP | Ensembl ].
VAR_036955

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 573573Missing in isoform 4. 1 PublicationVSP_054560Add
BLAST
Alternative sequencei539 – 56729DILNN…DAPLE → VCMDLYTLGIFCLPYYRETC DMIDFVKNL in isoform 2. 1 PublicationVSP_029180Add
BLAST
Alternative sequencei568 – 834267Missing in isoform 2. 1 PublicationVSP_029181Add
BLAST
Alternative sequencei776 – 83459GGYSA…YRGPQ → PQVLQPSSSLPRPTDHTQGK LIKPQRIEARSECSIQDMHQ GGAHPEESFTHVLHQESNYG LEEQPFSSGPQLTMDVAKST PSEANLNITVNAQEPYHLAN NQISDMQFIPTSLQTPPESS TVDQAKRVGRNQSPPVGYMS QPKSLQLLKPSILSSLVPPP VSESSPSRTPTCKKSPIITT CNSAKLQPTSSQTNLANNQN LKASKLRPPSGSFKQKQTNS PQLEPQSFQAKTSIPRPLTQ RKEIMQNPNGNLHSGDCLAS NRYSRLPKPKIH in isoform 3. 1 PublicationVSP_040287Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024324 mRNA. Translation: BAB14884.1.
AK294321 mRNA. Translation: BAG57595.1.
AK298966 mRNA. Translation: BAG61061.1.
DC366088 mRNA. No translation available.
AL356115, AC074321 Genomic DNA. Translation: CAI40902.1. Sequence problems.
CH471142 Genomic DNA. Translation: EAW80350.1.
CH471142 Genomic DNA. Translation: EAW80352.1.
BC030528 mRNA. Translation: AAH30528.1. Different initiation.
AF241785 mRNA. Translation: AAG44473.1. Frameshift.
AB032954 mRNA. Translation: BAA86442.1.
CCDSiCCDS31235.1. [Q9H7U1-1]
CCDS60582.1. [Q9H7U1-3]
CCDS60583.1. [Q9H7U1-4]
CCDS73159.1. [Q9H7U1-2]
RefSeqiNP_001271169.1. NM_001284240.1. [Q9H7U1-3]
NP_001271170.1. NM_001284241.1. [Q9H7U1-2]
NP_001271171.1. NM_001284242.1.
NP_001271172.1. NM_001284243.1. [Q9H7U1-4]
NP_061872.2. NM_018999.3. [Q9H7U1-1]
UniGeneiHs.461988.

Genome annotation databases

EnsembliENST00000224756; ENSP00000224756; ENSG00000107771. [Q9H7U1-1]
ENST00000359979; ENSP00000353068; ENSG00000107771. [Q9H7U1-2]
ENST00000372088; ENSP00000361160; ENSG00000107771. [Q9H7U1-3]
ENST00000543283; ENSP00000439944; ENSG00000107771. [Q9H7U1-4]
GeneIDi54462.
KEGGihsa:54462.
UCSCiuc001kdg.3. human. [Q9H7U1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024324 mRNA. Translation: BAB14884.1.
AK294321 mRNA. Translation: BAG57595.1.
AK298966 mRNA. Translation: BAG61061.1.
DC366088 mRNA. No translation available.
AL356115, AC074321 Genomic DNA. Translation: CAI40902.1. Sequence problems.
CH471142 Genomic DNA. Translation: EAW80350.1.
CH471142 Genomic DNA. Translation: EAW80352.1.
BC030528 mRNA. Translation: AAH30528.1. Different initiation.
AF241785 mRNA. Translation: AAG44473.1. Frameshift.
AB032954 mRNA. Translation: BAA86442.1.
CCDSiCCDS31235.1. [Q9H7U1-1]
CCDS60582.1. [Q9H7U1-3]
CCDS60583.1. [Q9H7U1-4]
CCDS73159.1. [Q9H7U1-2]
RefSeqiNP_001271169.1. NM_001284240.1. [Q9H7U1-3]
NP_001271170.1. NM_001284241.1. [Q9H7U1-2]
NP_001271171.1. NM_001284242.1.
NP_001271172.1. NM_001284243.1. [Q9H7U1-4]
NP_061872.2. NM_018999.3. [Q9H7U1-1]
UniGeneiHs.461988.

3D structure databases

ProteinModelPortaliQ9H7U1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119968. 18 interactions.
IntActiQ9H7U1. 17 interactions.
MINTiMINT-1400475.
STRINGi9606.ENSP00000224756.

PTM databases

iPTMnetiQ9H7U1.
PhosphoSiteiQ9H7U1.

Polymorphism and mutation databases

BioMutaiCCSER2.
DMDMi160386966.

Proteomic databases

EPDiQ9H7U1.
MaxQBiQ9H7U1.
PaxDbiQ9H7U1.
PRIDEiQ9H7U1.

Protocols and materials databases

DNASUi54462.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000224756; ENSP00000224756; ENSG00000107771. [Q9H7U1-1]
ENST00000359979; ENSP00000353068; ENSG00000107771. [Q9H7U1-2]
ENST00000372088; ENSP00000361160; ENSG00000107771. [Q9H7U1-3]
ENST00000543283; ENSP00000439944; ENSG00000107771. [Q9H7U1-4]
GeneIDi54462.
KEGGihsa:54462.
UCSCiuc001kdg.3. human. [Q9H7U1-1]

Organism-specific databases

CTDi54462.
GeneCardsiCCSER2.
H-InvDBHIX0008990.
HGNCiHGNC:29197. CCSER2.
HPAiHPA037481.
HPA037482.
neXtProtiNX_Q9H7U1.
PharmGKBiPA165548597.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGH2. Eukaryota.
ENOG410XT5P. LUCA.
GeneTreeiENSGT00730000111195.
InParanoidiQ9H7U1.
OMAiPLENVEC.
OrthoDBiEOG77WWBV.
PhylomeDBiQ9H7U1.
TreeFamiTF331021.

Miscellaneous databases

GenomeRNAii54462.
PROiQ9H7U1.

Gene expression databases

BgeeiQ9H7U1.
CleanExiHS_KIAA1128.
GenevisibleiQ9H7U1. HS.

Family and domain databases

InterProiIPR029627. CCSER.
IPR029629. CCSER2.
[Graphical view]
PANTHERiPTHR22461. PTHR22461. 1 hit.
PTHR22461:SF2. PTHR22461:SF2. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-110 (ISOFORMS 1/2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-730 (ISOFORM 1).
    Tissue: Amygdala, Placenta and Teratocarcinoma.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung.
  5. Cheng Z., Gao G., Peng Y., Ren S., Chen Z., Han Z.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 85-834 (ISOFORM 1).
    Tissue: Pituitary.
  6. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 247-834 (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiCCSE2_HUMAN
AccessioniPrimary (citable) accession number: Q9H7U1
Secondary accession number(s): B4DFY4
, B4DQU9, B7WPE8, D3DWE2, Q8N6E9, Q9H2S0, Q9ULU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: June 8, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.