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Protein

Aurora kinase A and ninein-interacting protein

Gene

AUNIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle.1 Publication

GO - Biological processi

  • spindle organization Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127423-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aurora kinase A and ninein-interacting protein
Short name:
AIBp
Gene namesi
Name:AUNIP
Synonyms:C1orf135
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28363. AUNIP.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: UniProtKB-KW
  • spindle pole Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000127423.
PharmGKBiPA142672453.

Polymorphism and mutation databases

DMDMi74733700.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002845721 – 357Aurora kinase A and ninein-interacting proteinAdd BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei267PhosphoserineCombined sources1
Modified residuei292PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H7T9.
PaxDbiQ9H7T9.
PeptideAtlasiQ9H7T9.
PRIDEiQ9H7T9.

PTM databases

iPTMnetiQ9H7T9.
PhosphoSitePlusiQ9H7T9.

Expressioni

Tissue specificityi

Expressed in heart, skeletal muscles, placenta and testis.

Inductioni

Overexpressed in brain tumors.1 Publication

Gene expression databases

BgeeiENSG00000127423.
CleanExiHS_C1orf135.
GenevisibleiQ9H7T9. HS.

Organism-specific databases

HPAiHPA028730.

Interactioni

Subunit structurei

Interacts (via C-terminus) with AURKA (via C-terminus). Interacts (via N-terminus) with NIN; this interaction blocks NIN phosphorylation by both AURKA and GSK3B. Identified in a complex with NIN and AURKA.1 Publication

Protein-protein interaction databases

BioGridi122471. 6 interactors.
IntActiQ9H7T9. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9H7T9.
SMRiQ9H7T9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni187 – 357Interaction with AURKA1 PublicationAdd BLAST171

Phylogenomic databases

eggNOGiENOG410IJFA. Eukaryota.
ENOG41113GP. LUCA.
GeneTreeiENSGT00390000003280.
HOGENOMiHOG000261642.
HOVERGENiHBG101165.
InParanoidiQ9H7T9.
KOiK16800.
OMAiEEACGVW.
OrthoDBiEOG091G08VG.
PhylomeDBiQ9H7T9.
TreeFamiTF337334.

Family and domain databases

InterProiIPR029286. AUNIP.
[Graphical view]
PfamiPF15334. AIB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H7T9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRTGPEEEA CGVWLDAAAL KRRKVQTHLI KPGTKMLTLL PGERKANIYF
60 70 80 90 100
TQRRAPSTGI HQRSIASFFT LQPGKTNGSD QKSVSSHTES QINKESKKNA
110 120 130 140 150
TQLDHLIPGL AHDCMASPLA TSTTADIQEA GLSPQSLQTS GHHRMKTPFS
160 170 180 190 200
TELSLLQPDT PDCAGDSHTP LAFSFTEDLE SSCLLDRKEE KGDSARKWEW
210 220 230 240 250
LHESKKNYQS MEKHTKLPGD KCCQPLGKTK LERKVSAKEN RQAPVLLQTY
260 270 280 290 300
RESWNGENIE SVKQSRSPVS VFSWDNEKND KDSWSQLFTE DSQGQRVIAH
310 320 330 340 350
NTRAPFQDVT NNWNWDLGPF PNSPWAQCQE DGPTQNLKPD LLFTQDSEGN

QVIRHQF
Length:357
Mass (Da):40,253
Last modified:March 1, 2001 - v1
Checksum:i8080DCF2E3CAB569
GO
Isoform 2 (identifier: Q9H7T9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     349-357: GNQVIRHQF → VQALACQQDCCRRSILKRQKHLR

Show »
Length:371
Mass (Da):41,909
Checksum:iF9A649D1518BABD9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03177682K → T.1 PublicationCorresponds to variant rs34449716dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044288349 – 357GNQVIRHQF → VQALACQQDCCRRSILKRQK HLR in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ844687 mRNA. Translation: ACV90488.1.
AK024326 mRNA. Translation: BAB14886.1.
AK223419 mRNA. Translation: BAD97139.1.
AL033528, AL020996 Genomic DNA. Translation: CAM12868.1.
BC000209 mRNA. Translation: AAH00209.1.
CCDSiCCDS266.1. [Q9H7T9-1]
CCDS72731.1. [Q9H7T9-2]
RefSeqiNP_001274419.1. NM_001287490.1. [Q9H7T9-2]
NP_076942.1. NM_024037.2. [Q9H7T9-1]
UniGeneiHs.149305.
Hs.725400.

Genome annotation databases

EnsembliENST00000374298; ENSP00000363416; ENSG00000127423. [Q9H7T9-1]
ENST00000538789; ENSP00000443647; ENSG00000127423. [Q9H7T9-2]
GeneIDi79000.
KEGGihsa:79000.
UCSCiuc001bkw.3. human. [Q9H7T9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ844687 mRNA. Translation: ACV90488.1.
AK024326 mRNA. Translation: BAB14886.1.
AK223419 mRNA. Translation: BAD97139.1.
AL033528, AL020996 Genomic DNA. Translation: CAM12868.1.
BC000209 mRNA. Translation: AAH00209.1.
CCDSiCCDS266.1. [Q9H7T9-1]
CCDS72731.1. [Q9H7T9-2]
RefSeqiNP_001274419.1. NM_001287490.1. [Q9H7T9-2]
NP_076942.1. NM_024037.2. [Q9H7T9-1]
UniGeneiHs.149305.
Hs.725400.

3D structure databases

ProteinModelPortaliQ9H7T9.
SMRiQ9H7T9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122471. 6 interactors.
IntActiQ9H7T9. 2 interactors.

PTM databases

iPTMnetiQ9H7T9.
PhosphoSitePlusiQ9H7T9.

Polymorphism and mutation databases

DMDMi74733700.

Proteomic databases

MaxQBiQ9H7T9.
PaxDbiQ9H7T9.
PeptideAtlasiQ9H7T9.
PRIDEiQ9H7T9.

Protocols and materials databases

DNASUi79000.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374298; ENSP00000363416; ENSG00000127423. [Q9H7T9-1]
ENST00000538789; ENSP00000443647; ENSG00000127423. [Q9H7T9-2]
GeneIDi79000.
KEGGihsa:79000.
UCSCiuc001bkw.3. human. [Q9H7T9-1]

Organism-specific databases

CTDi79000.
GeneCardsiAUNIP.
HGNCiHGNC:28363. AUNIP.
HPAiHPA028730.
neXtProtiNX_Q9H7T9.
OpenTargetsiENSG00000127423.
PharmGKBiPA142672453.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJFA. Eukaryota.
ENOG41113GP. LUCA.
GeneTreeiENSGT00390000003280.
HOGENOMiHOG000261642.
HOVERGENiHBG101165.
InParanoidiQ9H7T9.
KOiK16800.
OMAiEEACGVW.
OrthoDBiEOG091G08VG.
PhylomeDBiQ9H7T9.
TreeFamiTF337334.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127423-MONOMER.

Miscellaneous databases

GenomeRNAii79000.
PROiQ9H7T9.

Gene expression databases

BgeeiENSG00000127423.
CleanExiHS_C1orf135.
GenevisibleiQ9H7T9. HS.

Family and domain databases

InterProiIPR029286. AUNIP.
[Graphical view]
PfamiPF15334. AIB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAUNIP_HUMAN
AccessioniPrimary (citable) accession number: Q9H7T9
Secondary accession number(s): C9EI59, Q53F70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.