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Q9H7T0

- CTSRB_HUMAN

UniProt

Q9H7T0 - CTSRB_HUMAN

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Protein

Cation channel sperm-associated protein subunit beta

Gene

CATSPERB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization (By similarity).By similarity

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
  3. multicellular organism reproduction Source: Reactome
  4. single fertilization Source: Reactome
  5. spermatogenesis Source: UniProtKB-KW
  6. sperm-egg recognition Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Enzyme and pathway databases

ReactomeiREACT_163875. Sperm Motility And Taxes.

Protein family/group databases

TCDBi1.A.1.19.1. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cation channel sperm-associated protein subunit beta
Short name:
CatSper-beta
Gene namesi
Name:CATSPERB
Synonyms:C14orf161
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20500. CATSPERB.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. CatSper complex Source: UniProtKB
  2. cilium Source: Ensembl
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162381112.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11161116Cation channel sperm-associated protein subunit betaPRO_0000089953Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9H7T0.
PRIDEiQ9H7T0.

PTM databases

PhosphoSiteiQ9H7T0.

Expressioni

Gene expression databases

BgeeiQ9H7T0.
CleanExiHS_CATSPERB.
ExpressionAtlasiQ9H7T0. baseline and differential.
GenevestigatoriQ9H7T0.

Organism-specific databases

HPAiHPA035134.

Interactioni

Subunit structurei

Component of the CatSper complex.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000256343.

Structurei

3D structure databases

ProteinModelPortaliQ9H7T0.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalSequence AnalysisAdd
BLAST
Transmembranei193 – 21321HelicalSequence AnalysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence AnalysisAdd
BLAST
Transmembranei1058 – 107821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG28354.
GeneTreeiENSGT00390000008198.
HOGENOMiHOG000112054.
HOVERGENiHBG101990.
InParanoidiQ9H7T0.
KOiK16893.
OMAiVTEVNMR.
OrthoDBiEOG7CZK4R.
PhylomeDBiQ9H7T0.
TreeFamiTF328432.

Family and domain databases

InterProiIPR028748. CATSPERB.
[Graphical view]
PANTHERiPTHR14705. PTHR14705. 1 hit.
PfamiPF15149. CATSPERB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H7T0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESPLIYVSV LLLNIFEFSS GIVYNKDDTE KRFACSNKGF PQENEIIKLY
60 70 80 90 100
LFLENLKIQC FFQTENEIAS KAMLSVFTSG GLAPSLGIMN STYNGIFHFN
110 120 130 140 150
LTLFSDRILW LVDIPRENIT QSTDIAAVEE WLVRITLHHG LNIYATEGTL
160 170 180 190 200
LDVIREPILQ WTPGDVIPES EISKLYPHVV DLKVTKCPCA NDVALLGFIV
210 220 230 240 250
DTIVDGVYIG ITFGGFWHDY DTTWFNMTQT IYSQLQEEYE DLSLVDMVLT
260 270 280 290 300
NHFLVILTSL GLFVSEDLRY PSRHSLSFSR ADFCGFERVD YVKGKLWYNE
310 320 330 340 350
RCFANREHFE VDYVTVTFER NRTLSESSSC FYSQEPFLEW VPCLPHIFKG
360 370 380 390 400
IKIFPTVLTF LVDQERGTGV YLFYNKVRKT AIASVSTLRN NEPNSQSKFP
410 420 430 440 450
IFRFPSSFSS PVGMVFHPRS HFLYAYGNQI WLSVDGGNTF QLIANFHDDI
460 470 480 490 500
IKKTFHSFYT SAITFVSQRG KVYSTKAGMG RYSAVGSVTE RIFTLYYDHL
510 520 530 540 550
GFLHKLTLGR FEASGPPTAF GNSRNLFGQP PDMGFETALA PQHTSLDEII
560 570 580 590 600
FFAYVPENEP QETIYSKKFG NIHYGKVIHS GKTGRAYIRK VLQHTTPKGF
610 620 630 640 650
LSSVIAEMKE PFGLEEVNES SCLSSSLLIN KAGNVYKLTL DSQVVQALFE
660 670 680 690 700
DTDIEKTVVL PGYSSFLITS ILDNKNALAI ATMPESAPNN MTFLKSTWFL
710 720 730 740 750
YNFGQRNGRT WKIYSKPCNY WFQHDDSPSL NIVKYIDLGN SYVLKAKVIR
760 770 780 790 800
NAKGFRMLEI PLLTVFVGNP NLLEVTAEVT FDDTDSYVIT ISAASKVLHQ
810 820 830 840 850
GSTSLAFIMW SASTECFVTT MVPTLKSSCS YLRSMHHIPS KFIPFEDWIS
860 870 880 890 900
GVHKDSQGFN LIKTLPINYR PPSNMGIAIP LTDNFYHADP SKPIPRNMFH
910 920 930 940 950
MSKKTGKFKQ CANVSTREEC NCTKDQKFSH AVAFSDCREK VPRFKFPITQ
960 970 980 990 1000
YPVSLEIINE DGRVPLQSPY LVTVTEVNMR HNWKLKHTVP ENIKRMKQLV
1010 1020 1030 1040 1050
EPILGAAVYN PSGLNLSIKG SELFHFRVTV ISGVTFCNLI EEFQIYVDEA
1060 1070 1080 1090 1100
PLPFPGHTLI AVATAVVLGG LIFIAFMFQL QGIHPWRTFQ RWIRRNQEKF
1110
SSISLSELIH RSKSEE
Length:1,116
Mass (Da):126,924
Last modified:July 24, 2007 - v2
Checksum:i3A5DB4D5E2C1C81E
GO
Isoform 2 (identifier: Q9H7T0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-478: Missing.

Note: No experimental confirmation available.

Show »
Length:638
Mass (Da):72,092
Checksum:i45396A81ACEBC7AC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti318 – 3181F → Y.
Corresponds to variant rs57706558 [ dbSNP | Ensembl ].
VAR_061634

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 478478Missing in isoform 2. 1 PublicationVSP_027008Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK024360 mRNA. Translation: BAB14896.1.
BC126214 mRNA. Translation: AAI26215.1.
BC126216 mRNA. Translation: AAI26217.1.
CCDSiCCDS32142.1. [Q9H7T0-1]
RefSeqiNP_079040.2. NM_024764.2. [Q9H7T0-1]
UniGeneiHs.131755.

Genome annotation databases

EnsembliENST00000256343; ENSP00000256343; ENSG00000133962. [Q9H7T0-1]
GeneIDi79820.
KEGGihsa:79820.
UCSCiuc001xzs.1. human. [Q9H7T0-1]

Polymorphism databases

DMDMi158519875.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK024360 mRNA. Translation: BAB14896.1 .
BC126214 mRNA. Translation: AAI26215.1 .
BC126216 mRNA. Translation: AAI26217.1 .
CCDSi CCDS32142.1. [Q9H7T0-1 ]
RefSeqi NP_079040.2. NM_024764.2. [Q9H7T0-1 ]
UniGenei Hs.131755.

3D structure databases

ProteinModelPortali Q9H7T0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000256343.

Protein family/group databases

TCDBi 1.A.1.19.1. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitei Q9H7T0.

Polymorphism databases

DMDMi 158519875.

Proteomic databases

PaxDbi Q9H7T0.
PRIDEi Q9H7T0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000256343 ; ENSP00000256343 ; ENSG00000133962 . [Q9H7T0-1 ]
GeneIDi 79820.
KEGGi hsa:79820.
UCSCi uc001xzs.1. human. [Q9H7T0-1 ]

Organism-specific databases

CTDi 79820.
GeneCardsi GC14M092047.
H-InvDB HIX0011894.
HGNCi HGNC:20500. CATSPERB.
HPAi HPA035134.
MIMi 611169. gene.
neXtProti NX_Q9H7T0.
PharmGKBi PA162381112.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG28354.
GeneTreei ENSGT00390000008198.
HOGENOMi HOG000112054.
HOVERGENi HBG101990.
InParanoidi Q9H7T0.
KOi K16893.
OMAi VTEVNMR.
OrthoDBi EOG7CZK4R.
PhylomeDBi Q9H7T0.
TreeFami TF328432.

Enzyme and pathway databases

Reactomei REACT_163875. Sperm Motility And Taxes.

Miscellaneous databases

GenomeRNAii 79820.
NextBioi 69440.
PROi Q9H7T0.
SOURCEi Search...

Gene expression databases

Bgeei Q9H7T0.
CleanExi HS_CATSPERB.
ExpressionAtlasi Q9H7T0. baseline and differential.
Genevestigatori Q9H7T0.

Family and domain databases

InterProi IPR028748. CATSPERB.
[Graphical view ]
PANTHERi PTHR14705. PTHR14705. 1 hit.
Pfami PF15149. CATSPERB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiCTSRB_HUMAN
AccessioniPrimary (citable) accession number: Q9H7T0
Secondary accession number(s): A0AV51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3