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Q9H7T0 (CTSRB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cation channel sperm-associated protein subunit beta

Short name=CatSper-beta
Gene names
Name:CATSPERB
Synonyms:C14orf161
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1116 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization By similarity.

Subunit structure

Component of the CatSper complex By similarity.

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H7T0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H7T0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-478: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11161116Cation channel sperm-associated protein subunit beta
PRO_0000089953

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane193 – 21321Helical; Potential
Transmembrane244 – 26421Helical; Potential
Transmembrane1058 – 107821Helical; Potential

Amino acid modifications

Glycosylation901N-linked (GlcNAc...) Potential
Glycosylation1001N-linked (GlcNAc...) Potential
Glycosylation1181N-linked (GlcNAc...) Potential
Glycosylation2261N-linked (GlcNAc...) Potential
Glycosylation3211N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 478478Missing in isoform 2.
VSP_027008
Natural variant3181F → Y.
Corresponds to variant rs57706558 [ dbSNP | Ensembl ].
VAR_061634

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 24, 2007. Version 2.
Checksum: 3A5DB4D5E2C1C81E

FASTA1,116126,924
        10         20         30         40         50         60 
MESPLIYVSV LLLNIFEFSS GIVYNKDDTE KRFACSNKGF PQENEIIKLY LFLENLKIQC 

        70         80         90        100        110        120 
FFQTENEIAS KAMLSVFTSG GLAPSLGIMN STYNGIFHFN LTLFSDRILW LVDIPRENIT 

       130        140        150        160        170        180 
QSTDIAAVEE WLVRITLHHG LNIYATEGTL LDVIREPILQ WTPGDVIPES EISKLYPHVV 

       190        200        210        220        230        240 
DLKVTKCPCA NDVALLGFIV DTIVDGVYIG ITFGGFWHDY DTTWFNMTQT IYSQLQEEYE 

       250        260        270        280        290        300 
DLSLVDMVLT NHFLVILTSL GLFVSEDLRY PSRHSLSFSR ADFCGFERVD YVKGKLWYNE 

       310        320        330        340        350        360 
RCFANREHFE VDYVTVTFER NRTLSESSSC FYSQEPFLEW VPCLPHIFKG IKIFPTVLTF 

       370        380        390        400        410        420 
LVDQERGTGV YLFYNKVRKT AIASVSTLRN NEPNSQSKFP IFRFPSSFSS PVGMVFHPRS 

       430        440        450        460        470        480 
HFLYAYGNQI WLSVDGGNTF QLIANFHDDI IKKTFHSFYT SAITFVSQRG KVYSTKAGMG 

       490        500        510        520        530        540 
RYSAVGSVTE RIFTLYYDHL GFLHKLTLGR FEASGPPTAF GNSRNLFGQP PDMGFETALA 

       550        560        570        580        590        600 
PQHTSLDEII FFAYVPENEP QETIYSKKFG NIHYGKVIHS GKTGRAYIRK VLQHTTPKGF 

       610        620        630        640        650        660 
LSSVIAEMKE PFGLEEVNES SCLSSSLLIN KAGNVYKLTL DSQVVQALFE DTDIEKTVVL 

       670        680        690        700        710        720 
PGYSSFLITS ILDNKNALAI ATMPESAPNN MTFLKSTWFL YNFGQRNGRT WKIYSKPCNY 

       730        740        750        760        770        780 
WFQHDDSPSL NIVKYIDLGN SYVLKAKVIR NAKGFRMLEI PLLTVFVGNP NLLEVTAEVT 

       790        800        810        820        830        840 
FDDTDSYVIT ISAASKVLHQ GSTSLAFIMW SASTECFVTT MVPTLKSSCS YLRSMHHIPS 

       850        860        870        880        890        900 
KFIPFEDWIS GVHKDSQGFN LIKTLPINYR PPSNMGIAIP LTDNFYHADP SKPIPRNMFH 

       910        920        930        940        950        960 
MSKKTGKFKQ CANVSTREEC NCTKDQKFSH AVAFSDCREK VPRFKFPITQ YPVSLEIINE 

       970        980        990       1000       1010       1020 
DGRVPLQSPY LVTVTEVNMR HNWKLKHTVP ENIKRMKQLV EPILGAAVYN PSGLNLSIKG 

      1030       1040       1050       1060       1070       1080 
SELFHFRVTV ISGVTFCNLI EEFQIYVDEA PLPFPGHTLI AVATAVVLGG LIFIAFMFQL 

      1090       1100       1110 
QGIHPWRTFQ RWIRRNQEKF SSISLSELIH RSKSEE 

« Hide

Isoform 2 [UniParc].

Checksum: 45396A81ACEBC7AC
Show »

FASTA63872,092

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Placenta.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK024360 mRNA. Translation: BAB14896.1.
BC126214 mRNA. Translation: AAI26215.1.
BC126216 mRNA. Translation: AAI26217.1.
CCDSCCDS32142.1. [Q9H7T0-1]
RefSeqNP_079040.2. NM_024764.2. [Q9H7T0-1]
UniGeneHs.131755.

3D structure databases

ProteinModelPortalQ9H7T0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000256343.

Protein family/group databases

TCDB1.A.1.19.1. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSiteQ9H7T0.

Polymorphism databases

DMDM158519875.

Proteomic databases

PaxDbQ9H7T0.
PRIDEQ9H7T0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000256343; ENSP00000256343; ENSG00000133962. [Q9H7T0-1]
GeneID79820.
KEGGhsa:79820.
UCSCuc001xzs.1. human. [Q9H7T0-1]

Organism-specific databases

CTD79820.
GeneCardsGC14M092047.
H-InvDBHIX0011894.
HGNCHGNC:20500. CATSPERB.
HPAHPA035134.
MIM611169. gene.
neXtProtNX_Q9H7T0.
PharmGKBPA162381112.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG28354.
HOGENOMHOG000112054.
HOVERGENHBG101990.
InParanoidQ9H7T0.
KOK16893.
OMAVTEVNMR.
OrthoDBEOG7CZK4R.
PhylomeDBQ9H7T0.
TreeFamTF328432.

Enzyme and pathway databases

ReactomeREACT_163848. Reproduction.

Gene expression databases

ArrayExpressQ9H7T0.
BgeeQ9H7T0.
CleanExHS_CATSPERB.
GenevestigatorQ9H7T0.

Family and domain databases

InterProIPR028748. CATSPERB.
[Graphical view]
PANTHERPTHR14705. PTHR14705. 1 hit.
PfamPF15149. CATSPERB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi79820.
NextBio69440.
PROQ9H7T0.
SOURCESearch...

Entry information

Entry nameCTSRB_HUMAN
AccessionPrimary (citable) accession number: Q9H7T0
Secondary accession number(s): A0AV51
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 24, 2007
Last modified: July 9, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM