Q9H7T0 (CTSRB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cation channel sperm-associated protein subunit beta
Short name=CatSper-beta

Gene names

Name:	CATSPERB
Synonyms:	C14orf161

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1116 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization By similarity.
Subunit structure	Component of the CatSper complex By similarity.
Subcellular location	Membrane; Multi-pass membrane protein By similarity.

Ontologies

Keywords
Biological process	Differentiation Spermatogenesis
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	Developmental protein
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW spermatogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	CatSper complex Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H7T0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H7T0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-478: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1116	1116	Cation channel sperm-associated protein subunit beta		PRO_0000089953
Regions
	Transmembrane	4 – 24	21	Helical; Potential
	Transmembrane	193 – 213	21	Helical; Potential
	Transmembrane	244 – 264	21	Helical; Potential
	Transmembrane	1058 – 1078	21	Helical; Potential
Amino acid modifications
	Glycosylation	90	1	N-linked (GlcNAc...) Potential
	Glycosylation	100	1	N-linked (GlcNAc...) Potential
	Glycosylation	118	1	N-linked (GlcNAc...) Potential
	Glycosylation	226	1	N-linked (GlcNAc...) Potential
	Glycosylation	321	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 478	478	Missing in isoform 2.		VSP_027008
	Natural variant	318	1	F → Y. Corresponds to variant rs57706558 [ dbSNP | Ensembl ].		VAR_061634

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 24, 2007. Version 2. Checksum: 3A5DB4D5E2C1C81E	FASTA	1,116	126,924
	10 20 30 40 50 60 MESPLIYVSV LLLNIFEFSS GIVYNKDDTE KRFACSNKGF PQENEIIKLY LFLENLKIQC 70 80 90 100 110 120 FFQTENEIAS KAMLSVFTSG GLAPSLGIMN STYNGIFHFN LTLFSDRILW LVDIPRENIT 130 140 150 160 170 180 QSTDIAAVEE WLVRITLHHG LNIYATEGTL LDVIREPILQ WTPGDVIPES EISKLYPHVV 190 200 210 220 230 240 DLKVTKCPCA NDVALLGFIV DTIVDGVYIG ITFGGFWHDY DTTWFNMTQT IYSQLQEEYE 250 260 270 280 290 300 DLSLVDMVLT NHFLVILTSL GLFVSEDLRY PSRHSLSFSR ADFCGFERVD YVKGKLWYNE 310 320 330 340 350 360 RCFANREHFE VDYVTVTFER NRTLSESSSC FYSQEPFLEW VPCLPHIFKG IKIFPTVLTF 370 380 390 400 410 420 LVDQERGTGV YLFYNKVRKT AIASVSTLRN NEPNSQSKFP IFRFPSSFSS PVGMVFHPRS 430 440 450 460 470 480 HFLYAYGNQI WLSVDGGNTF QLIANFHDDI IKKTFHSFYT SAITFVSQRG KVYSTKAGMG 490 500 510 520 530 540 RYSAVGSVTE RIFTLYYDHL GFLHKLTLGR FEASGPPTAF GNSRNLFGQP PDMGFETALA 550 560 570 580 590 600 PQHTSLDEII FFAYVPENEP QETIYSKKFG NIHYGKVIHS GKTGRAYIRK VLQHTTPKGF 610 620 630 640 650 660 LSSVIAEMKE PFGLEEVNES SCLSSSLLIN KAGNVYKLTL DSQVVQALFE DTDIEKTVVL 670 680 690 700 710 720 PGYSSFLITS ILDNKNALAI ATMPESAPNN MTFLKSTWFL YNFGQRNGRT WKIYSKPCNY 730 740 750 760 770 780 WFQHDDSPSL NIVKYIDLGN SYVLKAKVIR NAKGFRMLEI PLLTVFVGNP NLLEVTAEVT 790 800 810 820 830 840 FDDTDSYVIT ISAASKVLHQ GSTSLAFIMW SASTECFVTT MVPTLKSSCS YLRSMHHIPS 850 860 870 880 890 900 KFIPFEDWIS GVHKDSQGFN LIKTLPINYR PPSNMGIAIP LTDNFYHADP SKPIPRNMFH 910 920 930 940 950 960 MSKKTGKFKQ CANVSTREEC NCTKDQKFSH AVAFSDCREK VPRFKFPITQ YPVSLEIINE 970 980 990 1000 1010 1020 DGRVPLQSPY LVTVTEVNMR HNWKLKHTVP ENIKRMKQLV EPILGAAVYN PSGLNLSIKG 1030 1040 1050 1060 1070 1080 SELFHFRVTV ISGVTFCNLI EEFQIYVDEA PLPFPGHTLI AVATAVVLGG LIFIAFMFQL 1090 1100 1110 QGIHPWRTFQ RWIRRNQEKF SSISLSELIH RSKSEE
	Isoform 2 [UniParc]. Checksum: 45396A81ACEBC7AC	FASTA	638	72,092
	10 20 30 40 50 60 MGRYSAVGSV TERIFTLYYD HLGFLHKLTL GRFEASGPPT AFGNSRNLFG QPPDMGFETA 70 80 90 100 110 120 LAPQHTSLDE IIFFAYVPEN EPQETIYSKK FGNIHYGKVI HSGKTGRAYI RKVLQHTTPK 130 140 150 160 170 180 GFLSSVIAEM KEPFGLEEVN ESSCLSSSLL INKAGNVYKL TLDSQVVQAL FEDTDIEKTV 190 200 210 220 230 240 VLPGYSSFLI TSILDNKNAL AIATMPESAP NNMTFLKSTW FLYNFGQRNG RTWKIYSKPC 250 260 270 280 290 300 NYWFQHDDSP SLNIVKYIDL GNSYVLKAKV IRNAKGFRML EIPLLTVFVG NPNLLEVTAE 310 320 330 340 350 360 VTFDDTDSYV ITISAASKVL HQGSTSLAFI MWSASTECFV TTMVPTLKSS CSYLRSMHHI 370 380 390 400 410 420 PSKFIPFEDW ISGVHKDSQG FNLIKTLPIN YRPPSNMGIA IPLTDNFYHA DPSKPIPRNM 430 440 450 460 470 480 FHMSKKTGKF KQCANVSTRE ECNCTKDQKF SHAVAFSDCR EKVPRFKFPI TQYPVSLEII 490 500 510 520 530 540 NEDGRVPLQS PYLVTVTEVN MRHNWKLKHT VPENIKRMKQ LVEPILGAAV YNPSGLNLSI 550 560 570 580 590 600 KGSELFHFRV TVISGVTFCN LIEEFQIYVD EAPLPFPGHT LIAVATAVVL GGLIFIAFMF 610 620 630 QLQGIHPWRT FQRWIRRNQE KFSSISLSEL IHRSKSEE

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Placenta.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK024360 mRNA. Translation: BAB14896.1. BC126214 mRNA. Translation: AAI26215.1. BC126216 mRNA. Translation: AAI26217.1.
IPI	IPI00015553. IPI00854780.
RefSeq	NP_079040.2. NM_024764.2.
UniGene	Hs.131755.
3D structure databases
ProteinModelPortal	Q9H7T0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000256343.
Protein family/group databases
TCDB	1.A.1.19.1. voltage-gated ion channel (VIC) superfamily.
PTM databases
PhosphoSite	Q9H7T0.
Polymorphism databases
DMDM	158519875.
Proteomic databases
PaxDb	Q9H7T0.
PRIDE	Q9H7T0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000256343; ENSP00000256343; ENSG00000133962.
GeneID	79820.
KEGG	hsa:79820.
UCSC	uc001xzs.1. human.
Organism-specific databases
CTD	79820.
GeneCards	GC14M092047.
H-InvDB	HIX0011894.
HGNC	HGNC:20500. CATSPERB.
HPA	HPA035134.
MIM	611169. gene.
neXtProt	NX_Q9H7T0.
PharmGKB	PA162381112.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG28354.
HOGENOM	HOG000112054.
HOVERGEN	HBG101990.
InParanoid	Q9H7T0.
OMA	KVYLTKA.
OrthoDB	EOG4NVZJJ.
Gene expression databases
ArrayExpress	Q9H7T0.
Bgee	Q9H7T0.
CleanEx	HS_CATSPERB.
Genevestigator	Q9H7T0.
GermOnline	ENSG00000133962. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	79820.
NextBio	69440.
SOURCE	Search...

Entry information

Entry name

CTSRB_HUMAN

Accession

Primary (citable) accession number: Q9H7T0
Secondary accession number(s): A0AV51

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	July 24, 2007
Last modified:	April 3, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.