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Protein

Cation channel sperm-associated protein subunit beta

Gene

CATSPERB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Enzyme and pathway databases

ReactomeiR-HSA-1300642 Sperm Motility And Taxes

Protein family/group databases

TCDBi1.A.1.19.1 the voltage-gated ion channel (vic) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cation channel sperm-associated protein subunit beta
Short name:
CatSper-beta
Gene namesi
Name:CATSPERB
Synonyms:C14orf161
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000133962.7
HGNCiHGNC:20500 CATSPERB
MIMi611169 gene
neXtProtiNX_Q9H7T0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Transmembranei1058 – 1078HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000133962
PharmGKBiPA162381112

Polymorphism and mutation databases

BioMutaiCATSPERB
DMDMi158519875

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000899531 – 1116Cation channel sperm-associated protein subunit betaAdd BLAST1116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi226N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9H7T0
PaxDbiQ9H7T0
PeptideAtlasiQ9H7T0
PRIDEiQ9H7T0

PTM databases

iPTMnetiQ9H7T0
PhosphoSitePlusiQ9H7T0

Expressioni

Gene expression databases

BgeeiENSG00000133962
CleanExiHS_CATSPERB
ExpressionAtlasiQ9H7T0 baseline and differential
GenevisibleiQ9H7T0 HS

Organism-specific databases

HPAiHPA035134

Interactioni

Subunit structurei

Component of the CatSper complex.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000256343

Structurei

3D structure databases

ProteinModelPortaliQ9H7T0
SMRiQ9H7T0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH6R Eukaryota
ENOG4111J8A LUCA
GeneTreeiENSGT00390000008198
HOGENOMiHOG000112054
HOVERGENiHBG101990
InParanoidiQ9H7T0
KOiK16893
OMAiVTEVNMR
OrthoDBiEOG091G05B6
PhylomeDBiQ9H7T0
TreeFamiTF328432

Family and domain databases

InterProiView protein in InterPro
IPR028748 CATSPERB
PANTHERiPTHR14705 PTHR14705, 1 hit
PfamiView protein in Pfam
PF15149 CATSPERB, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H7T0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESPLIYVSV LLLNIFEFSS GIVYNKDDTE KRFACSNKGF PQENEIIKLY
60 70 80 90 100
LFLENLKIQC FFQTENEIAS KAMLSVFTSG GLAPSLGIMN STYNGIFHFN
110 120 130 140 150
LTLFSDRILW LVDIPRENIT QSTDIAAVEE WLVRITLHHG LNIYATEGTL
160 170 180 190 200
LDVIREPILQ WTPGDVIPES EISKLYPHVV DLKVTKCPCA NDVALLGFIV
210 220 230 240 250
DTIVDGVYIG ITFGGFWHDY DTTWFNMTQT IYSQLQEEYE DLSLVDMVLT
260 270 280 290 300
NHFLVILTSL GLFVSEDLRY PSRHSLSFSR ADFCGFERVD YVKGKLWYNE
310 320 330 340 350
RCFANREHFE VDYVTVTFER NRTLSESSSC FYSQEPFLEW VPCLPHIFKG
360 370 380 390 400
IKIFPTVLTF LVDQERGTGV YLFYNKVRKT AIASVSTLRN NEPNSQSKFP
410 420 430 440 450
IFRFPSSFSS PVGMVFHPRS HFLYAYGNQI WLSVDGGNTF QLIANFHDDI
460 470 480 490 500
IKKTFHSFYT SAITFVSQRG KVYSTKAGMG RYSAVGSVTE RIFTLYYDHL
510 520 530 540 550
GFLHKLTLGR FEASGPPTAF GNSRNLFGQP PDMGFETALA PQHTSLDEII
560 570 580 590 600
FFAYVPENEP QETIYSKKFG NIHYGKVIHS GKTGRAYIRK VLQHTTPKGF
610 620 630 640 650
LSSVIAEMKE PFGLEEVNES SCLSSSLLIN KAGNVYKLTL DSQVVQALFE
660 670 680 690 700
DTDIEKTVVL PGYSSFLITS ILDNKNALAI ATMPESAPNN MTFLKSTWFL
710 720 730 740 750
YNFGQRNGRT WKIYSKPCNY WFQHDDSPSL NIVKYIDLGN SYVLKAKVIR
760 770 780 790 800
NAKGFRMLEI PLLTVFVGNP NLLEVTAEVT FDDTDSYVIT ISAASKVLHQ
810 820 830 840 850
GSTSLAFIMW SASTECFVTT MVPTLKSSCS YLRSMHHIPS KFIPFEDWIS
860 870 880 890 900
GVHKDSQGFN LIKTLPINYR PPSNMGIAIP LTDNFYHADP SKPIPRNMFH
910 920 930 940 950
MSKKTGKFKQ CANVSTREEC NCTKDQKFSH AVAFSDCREK VPRFKFPITQ
960 970 980 990 1000
YPVSLEIINE DGRVPLQSPY LVTVTEVNMR HNWKLKHTVP ENIKRMKQLV
1010 1020 1030 1040 1050
EPILGAAVYN PSGLNLSIKG SELFHFRVTV ISGVTFCNLI EEFQIYVDEA
1060 1070 1080 1090 1100
PLPFPGHTLI AVATAVVLGG LIFIAFMFQL QGIHPWRTFQ RWIRRNQEKF
1110
SSISLSELIH RSKSEE
Length:1,116
Mass (Da):126,924
Last modified:July 24, 2007 - v2
Checksum:i3A5DB4D5E2C1C81E
GO
Isoform 2 (identifier: Q9H7T0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-478: Missing.

Note: No experimental confirmation available.
Show »
Length:638
Mass (Da):72,092
Checksum:i45396A81ACEBC7AC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061634318F → Y. Corresponds to variant dbSNP:rs57706558Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0270081 – 478Missing in isoform 2. 1 PublicationAdd BLAST478

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024360 mRNA Translation: BAB14896.1
BC126214 mRNA Translation: AAI26215.1
BC126216 mRNA Translation: AAI26217.1
CCDSiCCDS32142.1 [Q9H7T0-1]
RefSeqiNP_079040.2, NM_024764.3 [Q9H7T0-1]
UniGeneiHs.131755

Genome annotation databases

EnsembliENST00000256343; ENSP00000256343; ENSG00000133962 [Q9H7T0-1]
ENST00000619027; ENSP00000478546; ENSG00000274338 [Q9H7T0-1]
GeneIDi79820
KEGGihsa:79820
UCSCiuc001xzs.2 human [Q9H7T0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCTSRB_HUMAN
AccessioniPrimary (citable) accession number: Q9H7T0
Secondary accession number(s): A0AV51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 24, 2007
Last modified: May 23, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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