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Q9H7T0

- CTSRB_HUMAN

UniProt

Q9H7T0 - CTSRB_HUMAN

Protein

Cation channel sperm-associated protein subunit beta

Gene

CATSPERB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization By similarity.By similarity

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. multicellular organismal development Source: UniProtKB-KW
    3. multicellular organism reproduction Source: Reactome
    4. single fertilization Source: Reactome
    5. spermatogenesis Source: UniProtKB-KW
    6. sperm-egg recognition Source: Reactome

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Spermatogenesis

    Enzyme and pathway databases

    ReactomeiREACT_163875. Sperm Motility And Taxes.

    Protein family/group databases

    TCDBi1.A.1.19.1. the voltage-gated ion channel (vic) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cation channel sperm-associated protein subunit beta
    Short name:
    CatSper-beta
    Gene namesi
    Name:CATSPERB
    Synonyms:C14orf161
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:20500. CATSPERB.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. CatSper complex Source: UniProtKB
    2. cilium Source: Ensembl
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162381112.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11161116Cation channel sperm-associated protein subunit betaPRO_0000089953Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9H7T0.
    PRIDEiQ9H7T0.

    PTM databases

    PhosphoSiteiQ9H7T0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H7T0.
    BgeeiQ9H7T0.
    CleanExiHS_CATSPERB.
    GenevestigatoriQ9H7T0.

    Organism-specific databases

    HPAiHPA035134.

    Interactioni

    Subunit structurei

    Component of the CatSper complex.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000256343.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H7T0.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei193 – 21321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei244 – 26421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1058 – 107821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG28354.
    HOGENOMiHOG000112054.
    HOVERGENiHBG101990.
    InParanoidiQ9H7T0.
    KOiK16893.
    OMAiVTEVNMR.
    OrthoDBiEOG7CZK4R.
    PhylomeDBiQ9H7T0.
    TreeFamiTF328432.

    Family and domain databases

    InterProiIPR028748. CATSPERB.
    [Graphical view]
    PANTHERiPTHR14705. PTHR14705. 1 hit.
    PfamiPF15149. CATSPERB. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H7T0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESPLIYVSV LLLNIFEFSS GIVYNKDDTE KRFACSNKGF PQENEIIKLY     50
    LFLENLKIQC FFQTENEIAS KAMLSVFTSG GLAPSLGIMN STYNGIFHFN 100
    LTLFSDRILW LVDIPRENIT QSTDIAAVEE WLVRITLHHG LNIYATEGTL 150
    LDVIREPILQ WTPGDVIPES EISKLYPHVV DLKVTKCPCA NDVALLGFIV 200
    DTIVDGVYIG ITFGGFWHDY DTTWFNMTQT IYSQLQEEYE DLSLVDMVLT 250
    NHFLVILTSL GLFVSEDLRY PSRHSLSFSR ADFCGFERVD YVKGKLWYNE 300
    RCFANREHFE VDYVTVTFER NRTLSESSSC FYSQEPFLEW VPCLPHIFKG 350
    IKIFPTVLTF LVDQERGTGV YLFYNKVRKT AIASVSTLRN NEPNSQSKFP 400
    IFRFPSSFSS PVGMVFHPRS HFLYAYGNQI WLSVDGGNTF QLIANFHDDI 450
    IKKTFHSFYT SAITFVSQRG KVYSTKAGMG RYSAVGSVTE RIFTLYYDHL 500
    GFLHKLTLGR FEASGPPTAF GNSRNLFGQP PDMGFETALA PQHTSLDEII 550
    FFAYVPENEP QETIYSKKFG NIHYGKVIHS GKTGRAYIRK VLQHTTPKGF 600
    LSSVIAEMKE PFGLEEVNES SCLSSSLLIN KAGNVYKLTL DSQVVQALFE 650
    DTDIEKTVVL PGYSSFLITS ILDNKNALAI ATMPESAPNN MTFLKSTWFL 700
    YNFGQRNGRT WKIYSKPCNY WFQHDDSPSL NIVKYIDLGN SYVLKAKVIR 750
    NAKGFRMLEI PLLTVFVGNP NLLEVTAEVT FDDTDSYVIT ISAASKVLHQ 800
    GSTSLAFIMW SASTECFVTT MVPTLKSSCS YLRSMHHIPS KFIPFEDWIS 850
    GVHKDSQGFN LIKTLPINYR PPSNMGIAIP LTDNFYHADP SKPIPRNMFH 900
    MSKKTGKFKQ CANVSTREEC NCTKDQKFSH AVAFSDCREK VPRFKFPITQ 950
    YPVSLEIINE DGRVPLQSPY LVTVTEVNMR HNWKLKHTVP ENIKRMKQLV 1000
    EPILGAAVYN PSGLNLSIKG SELFHFRVTV ISGVTFCNLI EEFQIYVDEA 1050
    PLPFPGHTLI AVATAVVLGG LIFIAFMFQL QGIHPWRTFQ RWIRRNQEKF 1100
    SSISLSELIH RSKSEE 1116
    Length:1,116
    Mass (Da):126,924
    Last modified:July 24, 2007 - v2
    Checksum:i3A5DB4D5E2C1C81E
    GO
    Isoform 2 (identifier: Q9H7T0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-478: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:638
    Mass (Da):72,092
    Checksum:i45396A81ACEBC7AC
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti318 – 3181F → Y.
    Corresponds to variant rs57706558 [ dbSNP | Ensembl ].
    VAR_061634

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 478478Missing in isoform 2. 1 PublicationVSP_027008Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK024360 mRNA. Translation: BAB14896.1.
    BC126214 mRNA. Translation: AAI26215.1.
    BC126216 mRNA. Translation: AAI26217.1.
    CCDSiCCDS32142.1. [Q9H7T0-1]
    RefSeqiNP_079040.2. NM_024764.2. [Q9H7T0-1]
    UniGeneiHs.131755.

    Genome annotation databases

    EnsembliENST00000256343; ENSP00000256343; ENSG00000133962. [Q9H7T0-1]
    GeneIDi79820.
    KEGGihsa:79820.
    UCSCiuc001xzs.1. human. [Q9H7T0-1]

    Polymorphism databases

    DMDMi158519875.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK024360 mRNA. Translation: BAB14896.1 .
    BC126214 mRNA. Translation: AAI26215.1 .
    BC126216 mRNA. Translation: AAI26217.1 .
    CCDSi CCDS32142.1. [Q9H7T0-1 ]
    RefSeqi NP_079040.2. NM_024764.2. [Q9H7T0-1 ]
    UniGenei Hs.131755.

    3D structure databases

    ProteinModelPortali Q9H7T0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000256343.

    Protein family/group databases

    TCDBi 1.A.1.19.1. the voltage-gated ion channel (vic) superfamily.

    PTM databases

    PhosphoSitei Q9H7T0.

    Polymorphism databases

    DMDMi 158519875.

    Proteomic databases

    PaxDbi Q9H7T0.
    PRIDEi Q9H7T0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000256343 ; ENSP00000256343 ; ENSG00000133962 . [Q9H7T0-1 ]
    GeneIDi 79820.
    KEGGi hsa:79820.
    UCSCi uc001xzs.1. human. [Q9H7T0-1 ]

    Organism-specific databases

    CTDi 79820.
    GeneCardsi GC14M092047.
    H-InvDB HIX0011894.
    HGNCi HGNC:20500. CATSPERB.
    HPAi HPA035134.
    MIMi 611169. gene.
    neXtProti NX_Q9H7T0.
    PharmGKBi PA162381112.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG28354.
    HOGENOMi HOG000112054.
    HOVERGENi HBG101990.
    InParanoidi Q9H7T0.
    KOi K16893.
    OMAi VTEVNMR.
    OrthoDBi EOG7CZK4R.
    PhylomeDBi Q9H7T0.
    TreeFami TF328432.

    Enzyme and pathway databases

    Reactomei REACT_163875. Sperm Motility And Taxes.

    Miscellaneous databases

    GenomeRNAii 79820.
    NextBioi 69440.
    PROi Q9H7T0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H7T0.
    Bgeei Q9H7T0.
    CleanExi HS_CATSPERB.
    Genevestigatori Q9H7T0.

    Family and domain databases

    InterProi IPR028748. CATSPERB.
    [Graphical view ]
    PANTHERi PTHR14705. PTHR14705. 1 hit.
    Pfami PF15149. CATSPERB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Placenta.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

    Entry informationi

    Entry nameiCTSRB_HUMAN
    AccessioniPrimary (citable) accession number: Q9H7T0
    Secondary accession number(s): A0AV51
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3