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Protein

Zinc finger protein 703

Gene

ZNF703

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri456 – 484C2H2-typePROSITE-ProRule annotationAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-30859-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 703
Alternative name(s):
Zinc finger elbow-related proline domain protein 1
Gene namesi
Name:ZNF703
Synonyms:ZEPPO1, ZPO1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:25883. ZNF703.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nuclear matrix Source: UniProtKB
  • nucleus Source: UniProtKB
  • protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Luminal B breast cancers are the clinically more aggressive estrogen receptor-positive tumors. Amplification of a distal 8p12 locus occurs in around one third of the cases and ZNF703 is the single gene within the minimal amplicon. Amplification of the gene correlates with its protein expression in tumor cells. ZNF703 is a classical breast cancer oncogene since it is able to transform non-malignant cells and increase cellular proliferation.

Organism-specific databases

DisGeNETi80139.
OpenTargetsiENSG00000183779.
PharmGKBiPA142670500.

Polymorphism and mutation databases

BioMutaiZNF703.
DMDMi74761508.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000477022 – 590Zinc finger protein 703Add BLAST589

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei252PhosphoserineCombined sources1
Modified residuei580Omega-N-methylarginineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9H7S9.
MaxQBiQ9H7S9.
PaxDbiQ9H7S9.
PeptideAtlasiQ9H7S9.
PRIDEiQ9H7S9.

PTM databases

iPTMnetiQ9H7S9.
PhosphoSitePlusiQ9H7S9.

Expressioni

Tissue specificityi

Expressed in mammary epithelium.1 Publication

Inductioni

Up-regulated by 17-beta-estradiol.1 Publication

Gene expression databases

BgeeiENSG00000183779.
CleanExiHS_ZNF703.
GenevisibleiQ9H7S9. HS.

Organism-specific databases

HPAiCAB068249.
HPA023930.

Interactioni

Subunit structurei

Interacts with TLE4; increases transcriptional repression (By similarity). Interacts with DCAF7 and PHB2. May interact with HSPD1.By similarity1 Publication

Protein-protein interaction databases

BioGridi123134. 29 interactors.
IntActiQ9H7S9. 4 interactors.
STRINGi9606.ENSP00000332325.

Structurei

3D structure databases

ProteinModelPortaliQ9H7S9.
SMRiQ9H7S9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 24Poly-Gly8
Compositional biasi114 – 117Poly-Ala4
Compositional biasi133 – 139Poly-Ala7
Compositional biasi152 – 229Ser-richAdd BLAST78
Compositional biasi219 – 393Gly-richAdd BLAST175
Compositional biasi506 – 514Poly-Ala9

Sequence similaritiesi

Belongs to the Elbow/Noc family.Curated
Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri456 – 484C2H2-typePROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IH04. Eukaryota.
ENOG4111EZY. LUCA.
GeneTreeiENSGT00390000014618.
HOGENOMiHOG000043108.
HOVERGENiHBG054325.
InParanoidiQ9H7S9.
OMAiYHGASHL.
OrthoDBiEOG091G09NU.
PhylomeDBiQ9H7S9.
TreeFamiTF324968.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR022129. Tscrpt_rep_NocA-like.
IPR007087. Znf_C2H2.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF12402. nlz1. 1 hit.
[Graphical view]
PROSITEiPS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H7S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSPAGSNP RTPESSGSGS GGGGKRPAVP AAVSLLPPAD PLRQANRLPI
60 70 80 90 100
RVLKMLSAHT GHLLHPEYLQ PLSSTPVSPI ELDAKKSPLA LLAQTCSQIG
110 120 130 140 150
KPDPPPSSKL NSVAAAANGL GAEKDPGRSA PGAASAAAAL KQLGDSPAED
160 170 180 190 200
KSSFKPYSKG SGGGDSRKDS GSSSVSSTSS SSSSSPGDKA GFRVPSAACP
210 220 230 240 250
PFPPHGAPVS ASSSSSSPGG SRGGSPHHSD CKNGGGVGGG ELDKKDQEPK
260 270 280 290 300
PSPEPAAVSR GGGGEPGAHG GAESGASGRK SEPPSALVGA GHVAPVSPYK
310 320 330 340 350
PGHSVFPLPP SSIGYHGSIV GAYAGYPSQF VPGLDPSKSG LVGGQLSGGL
360 370 380 390 400
GLPPGKPPSS SPLTGASPPS FLQGLCRDPY CLGGYHGASH LGGSSCSTCS
410 420 430 440 450
AHDPAGPSLK AGGYPLVYPG HPLQPAALSS SAAQAALPGH PLYTYGFMLQ
460 470 480 490 500
NEPLPHSCNW VAASGPCDKR FATSEELLSH LRTHTALPGA EKLLAAYPGA
510 520 530 540 550
SGLGSAAAAA AAAASCHLHL PPPAAPGSPG SLSLRNPHTL GLSRYHPYGK
560 570 580 590
SHLSTAGGLA VPSLPTAGPY YSPYALYGQR LASASALGYQ
Length:590
Mass (Da):58,222
Last modified:March 1, 2001 - v1
Checksum:i713243279114EF46
GO

Sequence cautioni

The sequence AAH84581 differs from that shown. Aberrant splicing.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024361 mRNA. Translation: BAB14897.1.
AC137579 Genomic DNA. No translation available.
BC032534 mRNA. Translation: AAH32534.1.
BC084581 mRNA. Translation: AAH84581.1. Sequence problems.
CCDSiCCDS6094.1.
RefSeqiNP_079345.1. NM_025069.2.
UniGeneiHs.288042.
Hs.726062.
Hs.744591.

Genome annotation databases

EnsembliENST00000331569; ENSP00000332325; ENSG00000183779.
GeneIDi80139.
KEGGihsa:80139.
UCSCiuc003xjy.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024361 mRNA. Translation: BAB14897.1.
AC137579 Genomic DNA. No translation available.
BC032534 mRNA. Translation: AAH32534.1.
BC084581 mRNA. Translation: AAH84581.1. Sequence problems.
CCDSiCCDS6094.1.
RefSeqiNP_079345.1. NM_025069.2.
UniGeneiHs.288042.
Hs.726062.
Hs.744591.

3D structure databases

ProteinModelPortaliQ9H7S9.
SMRiQ9H7S9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123134. 29 interactors.
IntActiQ9H7S9. 4 interactors.
STRINGi9606.ENSP00000332325.

PTM databases

iPTMnetiQ9H7S9.
PhosphoSitePlusiQ9H7S9.

Polymorphism and mutation databases

BioMutaiZNF703.
DMDMi74761508.

Proteomic databases

EPDiQ9H7S9.
MaxQBiQ9H7S9.
PaxDbiQ9H7S9.
PeptideAtlasiQ9H7S9.
PRIDEiQ9H7S9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331569; ENSP00000332325; ENSG00000183779.
GeneIDi80139.
KEGGihsa:80139.
UCSCiuc003xjy.2. human.

Organism-specific databases

CTDi80139.
DisGeNETi80139.
GeneCardsiZNF703.
HGNCiHGNC:25883. ZNF703.
HPAiCAB068249.
HPA023930.
neXtProtiNX_Q9H7S9.
OpenTargetsiENSG00000183779.
PharmGKBiPA142670500.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH04. Eukaryota.
ENOG4111EZY. LUCA.
GeneTreeiENSGT00390000014618.
HOGENOMiHOG000043108.
HOVERGENiHBG054325.
InParanoidiQ9H7S9.
OMAiYHGASHL.
OrthoDBiEOG091G09NU.
PhylomeDBiQ9H7S9.
TreeFamiTF324968.

Enzyme and pathway databases

BioCyciZFISH:G66-30859-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF703. human.
GenomeRNAii80139.
PROiQ9H7S9.

Gene expression databases

BgeeiENSG00000183779.
CleanExiHS_ZNF703.
GenevisibleiQ9H7S9. HS.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR022129. Tscrpt_rep_NocA-like.
IPR007087. Znf_C2H2.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF12402. nlz1. 1 hit.
[Graphical view]
PROSITEiPS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN703_HUMAN
AccessioniPrimary (citable) accession number: Q9H7S9
Secondary accession number(s): Q5XG76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.