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Protein

Zinc finger protein 442

Gene

ZNF442

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri181 – 20323C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri209 – 23123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri237 – 25923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri265 – 28723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri293 – 31523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri321 – 34323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 39923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri405 – 42723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri433 – 45523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri461 – 48222C2H2-type 11; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri488 – 51023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri516 – 53823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri544 – 56623C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri572 – 59423C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri600 – 62223C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 442
Gene namesi
Name:ZNF442
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20877. ZNF442.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134983440.

Polymorphism and mutation databases

BioMutaiZNF442.
DMDMi30580638.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 627627Zinc finger protein 442PRO_0000047591Add
BLAST

Proteomic databases

PaxDbiQ9H7R0.
PRIDEiQ9H7R0.

PTM databases

iPTMnetiQ9H7R0.
PhosphoSiteiQ9H7R0.

Expressioni

Gene expression databases

BgeeiQ9H7R0.
CleanExiHS_ZNF442.
ExpressionAtlasiQ9H7R0. baseline and differential.
GenevisibleiQ9H7R0. HS.

Organism-specific databases

HPAiHPA045738.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000242804.

Structurei

3D structure databases

ProteinModelPortaliQ9H7R0.
SMRiQ9H7R0. Positions 29-79, 149-622.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 11587KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri181 – 20323C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri209 – 23123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri237 – 25923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri265 – 28723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri293 – 31523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri321 – 34323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 39923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri405 – 42723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri433 – 45523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri461 – 48222C2H2-type 11; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri488 – 51023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri516 – 53823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri544 – 56623C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri572 – 59423C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri600 – 62223C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9H7R0.
KOiK09228.
OMAiMHECKEC.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9H7R0.
TreeFamiTF338854.

Family and domain databases

Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H7R0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIVFGGEDRS DLFLPDSQTN EERKQYDSVA FEDVAVNFTQ EEWALLGPSQ
60 70 80 90 100
KSLYRDVMWE TIRNLDCIGM KWEDTNIEDQ HRNPRRSLRC HIIERFSESR
110 120 130 140 150
QPDSTVNEKP PGVDPCKSSV CGEIMGCSFL NCYITFDAGH KPDECQEYGE
160 170 180 190 200
KPHTHKQCGT AFNYHHSFQT QERPHTGKKR YDCKECGKTF SSSGNLRRHI
210 220 230 240 250
IVQRGGGPYI CKLCGKAFFW PSLFRMHERT HTGEKPYECK QCCKAFPIYS
260 270 280 290 300
SYLRHERTHT GEKPYECKHC SKAFPDYSSY VRHERTHTGE KPYKCKRCGR
310 320 330 340 350
AFSVSSSLRI HERTHTGEKP YECKQCGKAF HHLGSFQRHM IRHTGDGPHK
360 370 380 390 400
CKICGKGFDC PSSLQSHERT HTGEKPYECK QCGKALSHHS SFRSHMIMHT
410 420 430 440 450
GDGPHKCKVC GKAFIYPSVF QGHERTHTGE KPYECKECGK AFRISSSLRR
460 470 480 490 500
HETTHTGEKP YKCKCGKAFI DFYSFQNHET THTGEKPYEC KECGKAFSCF
510 520 530 540 550
TYLSQHRRTH MAEKPYECKT CKKAFSHFGN LKVHERIHTG EKPYECKECR
560 570 580 590 600
KAFSWLTCLL RHERIHTGKK SYECQQCGKA FTRSRFLRGH EKTHTGEKMH
610 620
ECKECGKALS SLSSLHRHKR THWRDTL
Length:627
Mass (Da):72,863
Last modified:March 1, 2001 - v1
Checksum:iE95D75A75F807C68
GO
Isoform 2 (identifier: Q9H7R0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.

Note: No experimental confirmation available.
Show »
Length:558
Mass (Da):64,877
Checksum:iC857E9A833F3E1C2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti93 – 931I → V.
Corresponds to variant rs10423273 [ dbSNP | Ensembl ].
VAR_052830
Natural varianti110 – 1101P → T.
Corresponds to variant rs10415207 [ dbSNP | Ensembl ].
VAR_024217
Natural varianti152 – 1521P → S in a colorectal cancer sample; somatic mutation. 1 Publication
Corresponds to variant rs10414971 [ dbSNP | Ensembl ].
VAR_035581
Natural varianti243 – 2431C → S in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035582
Natural varianti422 – 4221G → R.
Corresponds to variant rs11085808 [ dbSNP | Ensembl ].
VAR_052831
Natural varianti443 – 4431R → C.
Corresponds to variant rs10500210 [ dbSNP | Ensembl ].
VAR_024218
Natural varianti590 – 5901H → L Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
VAR_064763

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6969Missing in isoform 2. 1 PublicationVSP_055953Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024418 mRNA. Translation: BAB14916.1.
AK295923 mRNA. Translation: BAG58710.1.
AC008758 Genomic DNA. No translation available.
CCDSiCCDS12271.1. [Q9H7R0-1]
RefSeqiNP_110451.1. NM_030824.2. [Q9H7R0-1]
UniGeneiHs.253193.

Genome annotation databases

EnsembliENST00000242804; ENSP00000242804; ENSG00000198342. [Q9H7R0-1]
ENST00000438182; ENSP00000388634; ENSG00000198342. [Q9H7R0-2]
ENST00000545749; ENSP00000440162; ENSG00000198342. [Q9H7R0-1]
GeneIDi79973.
KEGGihsa:79973.
UCSCiuc002mtr.2. human. [Q9H7R0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024418 mRNA. Translation: BAB14916.1.
AK295923 mRNA. Translation: BAG58710.1.
AC008758 Genomic DNA. No translation available.
CCDSiCCDS12271.1. [Q9H7R0-1]
RefSeqiNP_110451.1. NM_030824.2. [Q9H7R0-1]
UniGeneiHs.253193.

3D structure databases

ProteinModelPortaliQ9H7R0.
SMRiQ9H7R0. Positions 29-79, 149-622.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000242804.

PTM databases

iPTMnetiQ9H7R0.
PhosphoSiteiQ9H7R0.

Polymorphism and mutation databases

BioMutaiZNF442.
DMDMi30580638.

Proteomic databases

PaxDbiQ9H7R0.
PRIDEiQ9H7R0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242804; ENSP00000242804; ENSG00000198342. [Q9H7R0-1]
ENST00000438182; ENSP00000388634; ENSG00000198342. [Q9H7R0-2]
ENST00000545749; ENSP00000440162; ENSG00000198342. [Q9H7R0-1]
GeneIDi79973.
KEGGihsa:79973.
UCSCiuc002mtr.2. human. [Q9H7R0-1]

Organism-specific databases

CTDi79973.
GeneCardsiZNF442.
HGNCiHGNC:20877. ZNF442.
HPAiHPA045738.
neXtProtiNX_Q9H7R0.
PharmGKBiPA134983440.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9H7R0.
KOiK09228.
OMAiMHECKEC.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9H7R0.
TreeFamiTF338854.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii79973.
NextBioi35472437.
PROiQ9H7R0.

Gene expression databases

BgeeiQ9H7R0.
CleanExiHS_ZNF442.
ExpressionAtlasiQ9H7R0. baseline and differential.
GenevisibleiQ9H7R0. HS.

Family and domain databases

Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 4 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Substantia nigra.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-152 AND SER-243.
  4. Cited for: VARIANT LEU-590.

Entry informationi

Entry nameiZN442_HUMAN
AccessioniPrimary (citable) accession number: Q9H7R0
Secondary accession number(s): B4DJ48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: March 1, 2001
Last modified: March 16, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.