Q9H7P9 (PKHG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pleckstrin homology domain-containing family G member 2
Short name=PH domain-containing family G member 2

Gene names

Name:

PLEKHG2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1386 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be a transforming oncogene with exchange activity for CDC42 By similarity. May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein). Ref.5
Sequence similarities	Contains 1 DH (DBL-homology) domain. Contains 1 PH domain.
Sequence caution	The sequence BAB15364.1 differs from that shown. Reason: Frameshift at position 84. The sequence BAB15719.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Tumor suppressor
Molecular function	Guanine-nucleotide releasing factor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Traceable author statement. Source: Reactome nerve growth factor receptor signaling pathway Traceable author statement. Source: Reactome regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro regulation of small GTPase mediated signal transduction Traceable author statement. Source: Reactome small GTPase mediated signal transduction Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome
Molecular_function	Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H7P9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H7P9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     560-1368: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9H7P9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     468-496: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1386	1386	Pleckstrin homology domain-containing family G member 2		PRO_0000306861
Regions
	Domain	102 – 283	182	DH
	Domain	313 – 411	99	PH
	Compositional bias	593 – 600	8	Poly-Glu
	Compositional bias	1067 – 1184	118	Pro-rich
	Compositional bias	1319 – 1328	10	Poly-Pro
	Compositional bias	1344 – 1347	4	Poly-Gly
Amino acid modifications
	Modified residue	445	1	Phosphothreonine Ref.6
	Modified residue	450	1	Phosphoserine Ref.6
	Modified residue	1257	1	Phosphothreonine Ref.7
Natural variations
	Alternative sequence	468 – 496	29	Missing in isoform 3.		VSP_028529
	Alternative sequence	560 – 1368	809	Missing in isoform 2.		VSP_028530
	Natural variant	540	1	T → I. Corresponds to variant rs35904695 [ dbSNP | Ensembl ].		VAR_035324
	Natural variant	622	1	I → V. Corresponds to variant rs16973407 [ dbSNP | Ensembl ].		VAR_035325
	Natural variant	647	1	R → H. Ref.4 Corresponds to variant rs10407035 [ dbSNP | Ensembl ].		VAR_035326
	Natural variant	992	1	R → K. Ref.1 Ref.4 Corresponds to variant rs31726 [ dbSNP | Ensembl ].		VAR_035327
	Natural variant	1302	1	A → T. Corresponds to variant rs34603507 [ dbSNP | Ensembl ].		VAR_035328
	Natural variant	1329	1	P → A. Ref.1 Ref.4 Corresponds to variant rs31728 [ dbSNP | Ensembl ].		VAR_035329

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 57D35431FCEBDAFA	FASTA	1,386	147,969
	10 20 30 40 50 60 MPEGAQGLSL SKPSPSLGCG RRGEVCDCGT VCETRTAPAA PTMASPRGSG SSTSLSTVGS 70 80 90 100 110 120 EGDPAPGPTP ACSASRPEPL PGPPIRLHLS PVGIPGSARP SRLERVAREI VETERAYVRD 130 140 150 160 170 180 LRSIVEDYLG PLLDGGVLGL SVEQVGTLFA NIEDIYEFSS ELLEDLENSS SAGGIAECFV 190 200 210 220 230 240 QRSEDFDIYT LYCMNYPSSL ALLRELSLSP PAALWLQERQ AQLRHSLPLQ SFLLKPVQRI 250 260 270 280 290 300 LKYHLLLQEL GKHWAEGPGT GGREMVEEAI VSMTAVAWYI NDMKRKQEHA ARLQEVQRRL 310 320 330 340 350 360 GGWTGPELSA FGELVLEGAF RGGGGGGPRL RGGERLLFLF SRMLLVAKRR GLEYTYKGHI 370 380 390 400 410 420 FCCNLSVSES PRDPLGFKVS DLTIPKHRHL LQAKNQEEKR LWIHCLQRLF FENHPASIPA 430 440 450 460 470 480 KAKQVLLENS LHCAPKSKPV LEPLTPPLGS PRPRDARSFT PGRRNTAPSP GPSVIRRGRR 490 500 510 520 530 540 QSEPVKDPYV MFPQNAKPGF KHAGSEGELY PPESQPPVSG SAPPEDLEDA GPPTLDPSGT 550 560 570 580 590 600 SITEEILELL NQRGLRDPGP STHDIPKFPG DSQVPGDSET LTFQALPSRD SSEEEEEEEE 610 620 630 640 650 660 GLEMDERGPS PLHVLEGLES SIAAEMPSIP CLTKIPDVPN LPEIPSRCEI PEGSRLPSLS 670 680 690 700 710 720 DISDVFEMPC LPAIPSVPNT PSLSSTPTLS CDSWLQGPLQ EPAEAPATRR ELFSGSNPGK 730 740 750 760 770 780 LGEPPSGGKA GPEEDEEGVS FTDFQPQDVT QHQGFPDELA FRSCSEIRSA WQALEQGQLA 790 800 810 820 830 840 RPGFPEPLLI LEDSDLGGDS GSGKAGAPSS ERTASRVREL ARLYSERIQQ MQRAETRASA 850 860 870 880 890 900 NAPRRRPRVL AQPQPSPCLP QEQAEPGLLP AFGHVLVCEL AFPLTCAQES VPLGPAVWVQ 910 920 930 940 950 960 AAIPLSKQGG SPDGQGLHVS NLPKQDLPGI HVSAATLLPE QGGSRHVQAP AATPLPKQEG 970 980 990 1000 1010 1020 PLHLQVPALT TFSDQGHPEI QVPATTPLPE HRSHMVIPAP STAFCPEQGH CADIHVPTTP 1030 1040 1050 1060 1070 1080 ALPKEICSDF TVSVTTPVPK QEGHLDSESP TNIPLTKQGG SRDVQGPDPV CSQPIQPLSW 1090 1100 1110 1120 1130 1140 HGSSLDPQGP GDTLPPLPCH LPDLQIPGTS PLPAHGSHLD HRIPANAPLS LSQELPDTQV 1150 1160 1170 1180 1190 1200 PATTPLPLPQ VLTDIWVQAL PTSPKQGSLP DIQGPAAAPP LPEPSLTDTQ VQKLTPSLEQ 1210 1220 1230 1240 1250 1260 KSLIDAHVPA ATPLPERGGS LDIQGLSPTP VQTTMVLSKP GGSLASHVAR LESSDLTPPH 1270 1280 1290 1300 1310 1320 SPPPSSRQLL GPNAAALSRY LAASYISQSL ARRQGPGGGA PAASRGSWSS APTSRASSPP 1330 1340 1350 1360 1370 1380 PQPQPPPPPA RRLSYATTVN IHVGGGGRLR PAKAQVRLNH PALLASTQES MGLHRAQGAP DAPFHM
	Isoform 2 [UniParc]. Checksum: 4499E73ED0C1F527	FASTA	577	62,851
	10 20 30 40 50 60 MPEGAQGLSL SKPSPSLGCG RRGEVCDCGT VCETRTAPAA PTMASPRGSG SSTSLSTVGS 70 80 90 100 110 120 EGDPAPGPTP ACSASRPEPL PGPPIRLHLS PVGIPGSARP SRLERVAREI VETERAYVRD 130 140 150 160 170 180 LRSIVEDYLG PLLDGGVLGL SVEQVGTLFA NIEDIYEFSS ELLEDLENSS SAGGIAECFV 190 200 210 220 230 240 QRSEDFDIYT LYCMNYPSSL ALLRELSLSP PAALWLQERQ AQLRHSLPLQ SFLLKPVQRI 250 260 270 280 290 300 LKYHLLLQEL GKHWAEGPGT GGREMVEEAI VSMTAVAWYI NDMKRKQEHA ARLQEVQRRL 310 320 330 340 350 360 GGWTGPELSA FGELVLEGAF RGGGGGGPRL RGGERLLFLF SRMLLVAKRR GLEYTYKGHI 370 380 390 400 410 420 FCCNLSVSES PRDPLGFKVS DLTIPKHRHL LQAKNQEEKR LWIHCLQRLF FENHPASIPA 430 440 450 460 470 480 KAKQVLLENS LHCAPKSKPV LEPLTPPLGS PRPRDARSFT PGRRNTAPSP GPSVIRRGRR 490 500 510 520 530 540 QSEPVKDPYV MFPQNAKPGF KHAGSEGELY PPESQPPVSG SAPPEDLEDA GPPTLDPSGT 550 560 570 SITEEILELL NQRGLRDPGE SMGLHRAQGA PDAPFHM
	Isoform 3 [UniParc]. Checksum: 84392788E828CF6B	FASTA	1,357	144,720
	10 20 30 40 50 60 MPEGAQGLSL SKPSPSLGCG RRGEVCDCGT VCETRTAPAA PTMASPRGSG SSTSLSTVGS 70 80 90 100 110 120 EGDPAPGPTP ACSASRPEPL PGPPIRLHLS PVGIPGSARP SRLERVAREI VETERAYVRD 130 140 150 160 170 180 LRSIVEDYLG PLLDGGVLGL SVEQVGTLFA NIEDIYEFSS ELLEDLENSS SAGGIAECFV 190 200 210 220 230 240 QRSEDFDIYT LYCMNYPSSL ALLRELSLSP PAALWLQERQ AQLRHSLPLQ SFLLKPVQRI 250 260 270 280 290 300 LKYHLLLQEL GKHWAEGPGT GGREMVEEAI VSMTAVAWYI NDMKRKQEHA ARLQEVQRRL 310 320 330 340 350 360 GGWTGPELSA FGELVLEGAF RGGGGGGPRL RGGERLLFLF SRMLLVAKRR GLEYTYKGHI 370 380 390 400 410 420 FCCNLSVSES PRDPLGFKVS DLTIPKHRHL LQAKNQEEKR LWIHCLQRLF FENHPASIPA 430 440 450 460 470 480 KAKQVLLENS LHCAPKSKPV LEPLTPPLGS PRPRDARSFT PGRRNTAKPG FKHAGSEGEL 490 500 510 520 530 540 YPPESQPPVS GSAPPEDLED AGPPTLDPSG TSITEEILEL LNQRGLRDPG PSTHDIPKFP 550 560 570 580 590 600 GDSQVPGDSE TLTFQALPSR DSSEEEEEEE EGLEMDERGP SPLHVLEGLE SSIAAEMPSI 610 620 630 640 650 660 PCLTKIPDVP NLPEIPSRCE IPEGSRLPSL SDISDVFEMP CLPAIPSVPN TPSLSSTPTL 670 680 690 700 710 720 SCDSWLQGPL QEPAEAPATR RELFSGSNPG KLGEPPSGGK AGPEEDEEGV SFTDFQPQDV 730 740 750 760 770 780 TQHQGFPDEL AFRSCSEIRS AWQALEQGQL ARPGFPEPLL ILEDSDLGGD SGSGKAGAPS 790 800 810 820 830 840 SERTASRVRE LARLYSERIQ QMQRAETRAS ANAPRRRPRV LAQPQPSPCL PQEQAEPGLL 850 860 870 880 890 900 PAFGHVLVCE LAFPLTCAQE SVPLGPAVWV QAAIPLSKQG GSPDGQGLHV SNLPKQDLPG 910 920 930 940 950 960 IHVSAATLLP EQGGSRHVQA PAATPLPKQE GPLHLQVPAL TTFSDQGHPE IQVPATTPLP 970 980 990 1000 1010 1020 EHRSHMVIPA PSTAFCPEQG HCADIHVPTT PALPKEICSD FTVSVTTPVP KQEGHLDSES 1030 1040 1050 1060 1070 1080 PTNIPLTKQG GSRDVQGPDP VCSQPIQPLS WHGSSLDPQG PGDTLPPLPC HLPDLQIPGT 1090 1100 1110 1120 1130 1140 SPLPAHGSHL DHRIPANAPL SLSQELPDTQ VPATTPLPLP QVLTDIWVQA LPTSPKQGSL 1150 1160 1170 1180 1190 1200 PDIQGPAAAP PLPEPSLTDT QVQKLTPSLE QKSLIDAHVP AATPLPERGG SLDIQGLSPT 1210 1220 1230 1240 1250 1260 PVQTTMVLSK PGGSLASHVA RLESSDLTPP HSPPPSSRQL LGPNAAALSR YLAASYISQS 1270 1280 1290 1300 1310 1320 LARRQGPGGG APAASRGSWS SAPTSRASSP PPQPQPPPPP ARRLSYATTV NIHVGGGGRL 1330 1340 1350 RPAKAQVRLN HPALLASTQE SMGLHRAQGA PDAPFHM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS LYS-992 AND ALA-1329. Tissue: Spleen.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 105-1386 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 396-1386 (ISOFORM 1), VARIANTS HIS-647; LYS-992 AND ALA-1329. Tissue: Pancreas.
[5]	"Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42." Ueda H., Nagae R., Kozawa M., Morishita R., Kimura S., Nagase T., Ohara O., Yoshida S., Asano T. J. Biol. Chem. 283:1946-1953(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-445 AND SER-450, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1257, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK024429 mRNA. Translation: BAB15719.1. Different initiation. AK026111 mRNA. Translation: BAB15364.1. Frameshift. AC011500 Genomic DNA. No translation available. CH471126 Genomic DNA. Translation: EAW56888.1. BC013426 mRNA. Translation: AAH13426.2. BC015174 mRNA. Translation: AAH15174.1. BC075858 mRNA. Translation: AAH75858.1.
IPI	IPI00303373. IPI00645390. IPI00867660.
RefSeq	NP_073746.2. NM_022835.2.
UniGene	Hs.631574.
3D structure databases
HSSP	HSSP built from PDB template 1KZ7 based on UniProtKB Q64096.
ProteinModelPortal	Q9H7P9.
SMR	Q9H7P9. Positions 91-407.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H7P9. 3 interactions.
STRING	9606.ENSP00000386733.
PTM databases
PhosphoSite	Q9H7P9.
Polymorphism databases
DMDM	296439273.
Proteomic databases
PaxDb	Q9H7P9.
PRIDE	Q9H7P9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000378550; ENSP00000367812; ENSG00000090924. ENST00000409794; ENSP00000386733; ENSG00000090924. ENST00000409797; ENSP00000386492; ENSG00000090924. ENST00000425673; ENSP00000392906; ENSG00000090924.
GeneID	64857.
KEGG	hsa:64857.
UCSC	uc002olj.3. human. uc010xuz.2. human. uc010xva.2. human.
Organism-specific databases
CTD	64857.
GeneCards	GC19P039903.
H-InvDB	HIX0015119.
HGNC	HGNC:29515. PLEKHG2.
HPA	HPA017973. HPA048054.
MIM	611893. gene.
neXtProt	NX_Q9H7P9.
PharmGKB	PA134893492.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG77237.
HOVERGEN	HBG107024.
InParanoid	Q9H7P9.
OMA	VEDYLGP.
OrthoDB	EOG42820S.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q9H7P9.
Bgee	Q9H7P9.
CleanEx	HS_PLEKHG2.
Genevestigator	Q9H7P9.
Family and domain databases
Gene3D	1.20.900.10. 1 hit. 2.30.29.30. 1 hit.
InterPro	IPR000219. DH-domain. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. [Graphical view]
Pfam	PF00621. RhoGEF. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit. [Graphical view]
SUPFAM	SSF48065. DH-domain. 1 hit.
PROSITE	PS00741. DH_1. False negative. PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	64857.
NextBio	67003.
SOURCE	Search...

Entry information

Entry name

PKHG2_HUMAN

Accession

Primary (citable) accession number: Q9H7P9
Secondary accession number(s): B8ZZK6 , C9J0Y4, Q6DHV6, Q96BU2, Q96D18, Q9H699

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 80 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.