Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pleckstrin homology domain-containing family G member 2

Gene

PLEKHG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-HSA-193648. NRAGE signals death through JNK.
R-HSA-194840. Rho GTPase cycle.
R-HSA-416482. G alpha (12/13) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family G member 2
Short name:
PH domain-containing family G member 2
Gene namesi
Name:PLEKHG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29515. PLEKHG2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA134893492.

Polymorphism and mutation databases

BioMutaiPLEKHG2.
DMDMi296439273.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13861386Pleckstrin homology domain-containing family G member 2PRO_0000306861Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei90 – 901PhosphoserineCombined sources
Modified residuei445 – 4451PhosphothreonineCombined sources
Modified residuei450 – 4501PhosphoserineCombined sources
Modified residuei469 – 4691PhosphoserineCombined sources
Modified residuei911 – 9111PhosphoserineCombined sources
Modified residuei1049 – 10491PhosphoserineCombined sources
Modified residuei1257 – 12571PhosphothreonineCombined sources
Modified residuei1261 – 12611PhosphoserineCombined sources
Modified residuei1310 – 13101PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H7P9.
MaxQBiQ9H7P9.
PaxDbiQ9H7P9.
PeptideAtlasiQ9H7P9.
PRIDEiQ9H7P9.

PTM databases

iPTMnetiQ9H7P9.
PhosphoSiteiQ9H7P9.

Expressioni

Gene expression databases

BgeeiQ9H7P9.
CleanExiHS_PLEKHG2.
ExpressionAtlasiQ9H7P9. baseline and differential.
GenevisibleiQ9H7P9. HS.

Organism-specific databases

HPAiHPA017973.
HPA048054.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
B2R8Y43EBI-10175686,EBI-10175581

Protein-protein interaction databases

BioGridi122330. 9 interactions.
IntActiQ9H7P9. 4 interactions.
STRINGi9606.ENSP00000386733.

Structurei

3D structure databases

ProteinModelPortaliQ9H7P9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini102 – 283182DHPROSITE-ProRule annotationAdd
BLAST
Domaini313 – 41199PHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi593 – 6008Poly-Glu
Compositional biasi1067 – 1184118Pro-richAdd
BLAST
Compositional biasi1319 – 132810Poly-Pro
Compositional biasi1344 – 13474Poly-Gly

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3518. Eukaryota.
ENOG410XR81. LUCA.
GeneTreeiENSGT00760000118925.
HOVERGENiHBG107024.
InParanoidiQ9H7P9.
OMAiVFEMPCL.
OrthoDBiEOG7K9K2H.
PhylomeDBiQ9H7P9.
TreeFamiTF328565.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H7P9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPEGAQGLSL SKPSPSLGCG RRGEVCDCGT VCETRTAPAA PTMASPRGSG
60 70 80 90 100
SSTSLSTVGS EGDPAPGPTP ACSASRPEPL PGPPIRLHLS PVGIPGSARP
110 120 130 140 150
SRLERVAREI VETERAYVRD LRSIVEDYLG PLLDGGVLGL SVEQVGTLFA
160 170 180 190 200
NIEDIYEFSS ELLEDLENSS SAGGIAECFV QRSEDFDIYT LYCMNYPSSL
210 220 230 240 250
ALLRELSLSP PAALWLQERQ AQLRHSLPLQ SFLLKPVQRI LKYHLLLQEL
260 270 280 290 300
GKHWAEGPGT GGREMVEEAI VSMTAVAWYI NDMKRKQEHA ARLQEVQRRL
310 320 330 340 350
GGWTGPELSA FGELVLEGAF RGGGGGGPRL RGGERLLFLF SRMLLVAKRR
360 370 380 390 400
GLEYTYKGHI FCCNLSVSES PRDPLGFKVS DLTIPKHRHL LQAKNQEEKR
410 420 430 440 450
LWIHCLQRLF FENHPASIPA KAKQVLLENS LHCAPKSKPV LEPLTPPLGS
460 470 480 490 500
PRPRDARSFT PGRRNTAPSP GPSVIRRGRR QSEPVKDPYV MFPQNAKPGF
510 520 530 540 550
KHAGSEGELY PPESQPPVSG SAPPEDLEDA GPPTLDPSGT SITEEILELL
560 570 580 590 600
NQRGLRDPGP STHDIPKFPG DSQVPGDSET LTFQALPSRD SSEEEEEEEE
610 620 630 640 650
GLEMDERGPS PLHVLEGLES SIAAEMPSIP CLTKIPDVPN LPEIPSRCEI
660 670 680 690 700
PEGSRLPSLS DISDVFEMPC LPAIPSVPNT PSLSSTPTLS CDSWLQGPLQ
710 720 730 740 750
EPAEAPATRR ELFSGSNPGK LGEPPSGGKA GPEEDEEGVS FTDFQPQDVT
760 770 780 790 800
QHQGFPDELA FRSCSEIRSA WQALEQGQLA RPGFPEPLLI LEDSDLGGDS
810 820 830 840 850
GSGKAGAPSS ERTASRVREL ARLYSERIQQ MQRAETRASA NAPRRRPRVL
860 870 880 890 900
AQPQPSPCLP QEQAEPGLLP AFGHVLVCEL AFPLTCAQES VPLGPAVWVQ
910 920 930 940 950
AAIPLSKQGG SPDGQGLHVS NLPKQDLPGI HVSAATLLPE QGGSRHVQAP
960 970 980 990 1000
AATPLPKQEG PLHLQVPALT TFSDQGHPEI QVPATTPLPE HRSHMVIPAP
1010 1020 1030 1040 1050
STAFCPEQGH CADIHVPTTP ALPKEICSDF TVSVTTPVPK QEGHLDSESP
1060 1070 1080 1090 1100
TNIPLTKQGG SRDVQGPDPV CSQPIQPLSW HGSSLDPQGP GDTLPPLPCH
1110 1120 1130 1140 1150
LPDLQIPGTS PLPAHGSHLD HRIPANAPLS LSQELPDTQV PATTPLPLPQ
1160 1170 1180 1190 1200
VLTDIWVQAL PTSPKQGSLP DIQGPAAAPP LPEPSLTDTQ VQKLTPSLEQ
1210 1220 1230 1240 1250
KSLIDAHVPA ATPLPERGGS LDIQGLSPTP VQTTMVLSKP GGSLASHVAR
1260 1270 1280 1290 1300
LESSDLTPPH SPPPSSRQLL GPNAAALSRY LAASYISQSL ARRQGPGGGA
1310 1320 1330 1340 1350
PAASRGSWSS APTSRASSPP PQPQPPPPPA RRLSYATTVN IHVGGGGRLR
1360 1370 1380
PAKAQVRLNH PALLASTQES MGLHRAQGAP DAPFHM
Length:1,386
Mass (Da):147,969
Last modified:May 18, 2010 - v3
Checksum:i57D35431FCEBDAFA
GO
Isoform 2 (identifier: Q9H7P9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     560-1368: Missing.

Note: No experimental confirmation available.
Show »
Length:577
Mass (Da):62,851
Checksum:i4499E73ED0C1F527
GO
Isoform 3 (identifier: Q9H7P9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     468-496: Missing.

Note: No experimental confirmation available.
Show »
Length:1,357
Mass (Da):144,720
Checksum:i84392788E828CF6B
GO

Sequence cautioni

The sequence BAB15364.1 differs from that shown. Reason: Frameshift at position 84. Curated
The sequence BAB15719.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti540 – 5401T → I.
Corresponds to variant rs35904695 [ dbSNP | Ensembl ].
VAR_035324
Natural varianti622 – 6221I → V.
Corresponds to variant rs16973407 [ dbSNP | Ensembl ].
VAR_035325
Natural varianti647 – 6471R → H.1 Publication
Corresponds to variant rs10407035 [ dbSNP | Ensembl ].
VAR_035326
Natural varianti992 – 9921R → K.2 Publications
Corresponds to variant rs31726 [ dbSNP | Ensembl ].
VAR_035327
Natural varianti1302 – 13021A → T.
Corresponds to variant rs34603507 [ dbSNP | Ensembl ].
VAR_035328
Natural varianti1329 – 13291P → A.Combined sources2 Publications
Corresponds to variant rs31728 [ dbSNP | Ensembl ].
VAR_035329

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei468 – 49629Missing in isoform 3. 1 PublicationVSP_028529Add
BLAST
Alternative sequencei560 – 1368809Missing in isoform 2. 1 PublicationVSP_028530Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024429 mRNA. Translation: BAB15719.1. Different initiation.
AK026111 mRNA. Translation: BAB15364.1. Frameshift.
AC011500 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW56888.1.
BC013426 mRNA. Translation: AAH13426.2.
BC015174 mRNA. Translation: AAH15174.1.
BC075858 mRNA. Translation: AAH75858.1.
CCDSiCCDS33022.2. [Q9H7P9-1]
RefSeqiNP_073746.2. NM_022835.2. [Q9H7P9-1]
XP_005259220.1. XM_005259163.1. [Q9H7P9-1]
XP_006723396.1. XM_006723333.1. [Q9H7P9-1]
UniGeneiHs.631574.

Genome annotation databases

EnsembliENST00000409797; ENSP00000386492; ENSG00000090924. [Q9H7P9-2]
ENST00000425673; ENSP00000392906; ENSG00000090924. [Q9H7P9-1]
GeneIDi64857.
KEGGihsa:64857.
UCSCiuc002olj.4. human. [Q9H7P9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024429 mRNA. Translation: BAB15719.1. Different initiation.
AK026111 mRNA. Translation: BAB15364.1. Frameshift.
AC011500 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW56888.1.
BC013426 mRNA. Translation: AAH13426.2.
BC015174 mRNA. Translation: AAH15174.1.
BC075858 mRNA. Translation: AAH75858.1.
CCDSiCCDS33022.2. [Q9H7P9-1]
RefSeqiNP_073746.2. NM_022835.2. [Q9H7P9-1]
XP_005259220.1. XM_005259163.1. [Q9H7P9-1]
XP_006723396.1. XM_006723333.1. [Q9H7P9-1]
UniGeneiHs.631574.

3D structure databases

ProteinModelPortaliQ9H7P9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122330. 9 interactions.
IntActiQ9H7P9. 4 interactions.
STRINGi9606.ENSP00000386733.

PTM databases

iPTMnetiQ9H7P9.
PhosphoSiteiQ9H7P9.

Polymorphism and mutation databases

BioMutaiPLEKHG2.
DMDMi296439273.

Proteomic databases

EPDiQ9H7P9.
MaxQBiQ9H7P9.
PaxDbiQ9H7P9.
PeptideAtlasiQ9H7P9.
PRIDEiQ9H7P9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409797; ENSP00000386492; ENSG00000090924. [Q9H7P9-2]
ENST00000425673; ENSP00000392906; ENSG00000090924. [Q9H7P9-1]
GeneIDi64857.
KEGGihsa:64857.
UCSCiuc002olj.4. human. [Q9H7P9-1]

Organism-specific databases

CTDi64857.
GeneCardsiPLEKHG2.
H-InvDBHIX0015119.
HGNCiHGNC:29515. PLEKHG2.
HPAiHPA017973.
HPA048054.
MIMi611893. gene.
neXtProtiNX_Q9H7P9.
PharmGKBiPA134893492.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3518. Eukaryota.
ENOG410XR81. LUCA.
GeneTreeiENSGT00760000118925.
HOVERGENiHBG107024.
InParanoidiQ9H7P9.
OMAiVFEMPCL.
OrthoDBiEOG7K9K2H.
PhylomeDBiQ9H7P9.
TreeFamiTF328565.

Enzyme and pathway databases

ReactomeiR-HSA-193648. NRAGE signals death through JNK.
R-HSA-194840. Rho GTPase cycle.
R-HSA-416482. G alpha (12/13) signalling events.

Miscellaneous databases

ChiTaRSiPLEKHG2. human.
GenomeRNAii64857.
PROiQ9H7P9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H7P9.
CleanExiHS_PLEKHG2.
ExpressionAtlasiQ9H7P9. baseline and differential.
GenevisibleiQ9H7P9. HS.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS LYS-992 AND ALA-1329.
    Tissue: Spleen.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 105-1386 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 396-1386 (ISOFORM 1), VARIANTS HIS-647; LYS-992 AND ALA-1329.
    Tissue: Pancreas.
  5. "Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42."
    Ueda H., Nagae R., Kozawa M., Morishita R., Kimura S., Nagase T., Ohara O., Yoshida S., Asano T.
    J. Biol. Chem. 283:1946-1953(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-445 AND SER-450, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1257, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90; THR-445; SER-469; SER-911; SER-1049; THR-1257; SER-1261 AND SER-1310, VARIANT [LARGE SCALE ANALYSIS] ALA-1329, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.

Entry informationi

Entry nameiPKHG2_HUMAN
AccessioniPrimary (citable) accession number: Q9H7P9
Secondary accession number(s): B8ZZK6
, C9J0Y4, Q6DHV6, Q96BU2, Q96D18, Q9H699
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.