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Protein

Splicing factor, arginine/serine-rich 19

Gene

SCAF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function in pre-mRNA splicing.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126461-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Splicing factor, arginine/serine-rich 19
Alternative name(s):
SR-related and CTD-associated factor 1
SR-related-CTD-associated factor
Short name:
SCAF
Serine arginine-rich pre-mRNA splicing factor SR-A1
Short name:
SR-A1
Gene namesi
Name:SCAF1
Synonyms:SFRS19, SRA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30403. SCAF1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi58506.
OpenTargetsiENSG00000126461.
PharmGKBiPA162402459.

Polymorphism and mutation databases

BioMutaiSCAF1.
DMDMi296452955.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002994061 – 1312Splicing factor, arginine/serine-rich 19Add BLAST1312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei239PhosphoserineCombined sources1
Modified residuei335PhosphothreonineCombined sources1
Modified residuei448PhosphoserineCombined sources1
Modified residuei453PhosphoserineCombined sources1
Modified residuei498PhosphoserineCombined sources1
Modified residuei500PhosphoserineCombined sources1
Modified residuei526PhosphoserineCombined sources1
Modified residuei548PhosphoserineCombined sources1
Modified residuei612PhosphoserineCombined sources1
Modified residuei614PhosphoserineCombined sources1
Modified residuei706PhosphothreonineCombined sources1
Modified residuei719PhosphoserineCombined sources1
Modified residuei725PhosphoserineCombined sources1
Modified residuei732PhosphotyrosineCombined sources1
Modified residuei734PhosphoserineCombined sources1
Modified residuei738PhosphoserineCombined sources1
Modified residuei872PhosphoserineCombined sources1
Modified residuei874PhosphoserineCombined sources1
Modified residuei929PhosphoserineCombined sources1
Modified residuei936PhosphoserineCombined sources1
Modified residuei963PhosphoserineBy similarity1
Modified residuei965PhosphoserineCombined sources1
Modified residuei976PhosphothreonineCombined sources1
Modified residuei989PhosphothreonineCombined sources1
Modified residuei992PhosphoserineBy similarity1
Modified residuei1001PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H7N4.
MaxQBiQ9H7N4.
PaxDbiQ9H7N4.
PeptideAtlasiQ9H7N4.
PRIDEiQ9H7N4.

PTM databases

iPTMnetiQ9H7N4.
PhosphoSitePlusiQ9H7N4.
SwissPalmiQ9H7N4.

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in fetal brain and liver, poorly expressed in salivary gland, heart, skin and ovary. Expressed in colorectal carcinomas and ovarian cancers. Overexpressed in colorectal carcinomas as compared to normal colonic mucosa.4 Publications

Inductioni

Up-regulated by estrogens, androgens and glucocorticoids.1 Publication

Gene expression databases

BgeeiENSG00000126461.
CleanExiHS_SCAF1.
HS_SRA1.
ExpressionAtlasiQ9H7N4. baseline and differential.
GenevisibleiQ9H7N4. HS.

Organism-specific databases

HPAiHPA046828.
HPA054593.

Interactioni

Subunit structurei

Interacts with POLR2A.1 Publication

Protein-protein interaction databases

BioGridi121834. 22 interactors.
IntActiQ9H7N4. 12 interactors.
MINTiMINT-2875509.
STRINGi9606.ENSP00000353769.

Structurei

3D structure databases

ProteinModelPortaliQ9H7N4.
SMRiQ9H7N4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1187 – 1312Necessary for interaction with the CTD domain of POLR2AAdd BLAST126

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi184 – 267Pro-richAdd BLAST84
Compositional biasi191 – 207Ser-richAdd BLAST17
Compositional biasi268 – 288Glu-richAdd BLAST21
Compositional biasi380 – 441Pro-richAdd BLAST62
Compositional biasi534 – 828Ser-richAdd BLAST295
Compositional biasi556 – 654Arg-richAdd BLAST99
Compositional biasi896 – 926Lys-richAdd BLAST31
Compositional biasi1009 – 1039Glu-richAdd BLAST31
Compositional biasi1284 – 1311Pro-richAdd BLAST28

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0825. Eukaryota.
ENOG410YF5K. LUCA.
GeneTreeiENSGT00530000063661.
HOGENOMiHOG000168227.
HOVERGENiHBG097942.
InParanoidiQ9H7N4.
OMAiPDSWISS.
OrthoDBiEOG091G05JH.
PhylomeDBiQ9H7N4.
TreeFamiTF332183.

Sequencei

Sequence statusi: Complete.

Q9H7N4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEEDESRGK TEESGEDRGD GPPDRDPTLS PSAFILRAIQ QAVGSSLQGD
60 70 80 90 100
LPNDKDGSRC HGLRWRRCRS PRSEPRSQES GGTDTATVLD MATDSFLAGL
110 120 130 140 150
VSVLDPPDTW VPSRLDLRPG ESEDMLELVA EVRIGDRDPI PLPVPSLLPR
160 170 180 190 200
LRAWRTGKTV SPQSNSSRPT CARHLTLGTG DGGPAPPPAP SSASSSPSPS
210 220 230 240 250
PSSSSPSPPP PPPPPAPPAP PAPRFDIYDP FHPTDEAYSP PPAPEQKYDP
260 270 280 290 300
FEPTGSNPSS SAGTPSPEEE EEEEEEEEEE EEDEEEEEGL SQSISRISET
310 320 330 340 350
LAGIYDDNSL SQDFPGDESP RPDAQPTQPT PAPGTPPQVD STRADGAMRR
360 370 380 390 400
RVFVVGTEAE ACREGKVSVE VVTAGGAALP PPLLPPGDSE IEEGEIVQPE
410 420 430 440 450
EEPRLALSLF RPGGRAARPT PAASATPTAQ PLPQPPAPRA PEGDDFLSLH
460 470 480 490 500
AESDGEGALQ VDLGEPAPAP PAADSRWGGL DLRRKILTQR RERYRQRSPS
510 520 530 540 550
PAPAPAPAAA AGPPTRKKSR RERKRSGEAK EAASSSSGTQ PAPPAPASPW
560 570 580 590 600
DSKKHRSRDR KPGSHASSSA RRRSRSRSRS RSTRRRSRST DRRRGGSRRS
610 620 630 640 650
RSREKRRRRR RSASPPPATS SSSSSRRERH RGKHRDGGGS KKKKKRSRSR
660 670 680 690 700
GEKRSGDGSE KAPAPAPPPS GSTSCGDRDS RRRGAVPPSI QDLTDHDLFA
710 720 730 740 750
IKRTITVGRL DKSDPRGPSP APASSPKREV LYDSEGLSGE ERGGKSSQKD
760 770 780 790 800
RRRSGAASSS SSSREKGSRR KALDGGDRDR DRDRDRDRDR SSKKARPPKE
810 820 830 840 850
SAPSSGPPPK PPVSSGSGSS SSSSSCSSRK VKLQSKVAVL IREGVSSTTP
860 870 880 890 900
AKDAASAGLG SIGVKFSRDR ESRSPFLKPD ERAPTEMAKA APGSTKPKKT
910 920 930 940 950
KVKAKAGAKK TKGTKGKTKP SKTRKKVRSG GGSGGSGGQV SLKKSKADSC
960 970 980 990 1000
SQAAGTKGAE ETSWSGEERA AKVPSTPPPK AAPPPPALTP DSQTVDSSCK
1010 1020 1030 1040 1050
TPEVSFLPEE ATEEAGVRGG AEEEEEEEEE EEEEEEEEEQ QPATTTATST
1060 1070 1080 1090 1100
AAAAPSTAPS AGSTAGDSGA EDGPASRVSQ LPTLPPPMPW NLPAGVDCTT
1110 1120 1130 1140 1150
SGVLALTALL FKMEEANLAS RAKAQELIQA TNQILSHRKP PSSLGMTPAP
1160 1170 1180 1190 1200
VPTSLGLPPG PSSYLLPGSL PLGGCGSTPP TPTGLAATSD KREGSSSSEG
1210 1220 1230 1240 1250
RGDTDKYLKK LHTQERAVEE VKLAIKPYYQ KKDITKEEYK DILRKAVHKI
1260 1270 1280 1290 1300
CHSKSGEINP VKVSNLVRAY VQRYRYFRKH GRKPGDPPGP PRPPKEPGPP
1310
DKGGPGLPLP PL
Length:1,312
Mass (Da):139,270
Last modified:May 18, 2010 - v3
Checksum:i0CB1C87C963C52BD
GO

Sequence cautioni

The sequence BAB15734 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti420T → P in BAB15734 (PubMed:14702039).Curated1
Sequence conflicti420T → P in AAH53992 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052235895T → A.Corresponds to variant rs3745470dbSNPEnsembl.1
Natural variantiVAR_0522361146M → T.Corresponds to variant rs2304208dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254411 Genomic DNA. Translation: AAF87552.1.
AK024444 mRNA. Translation: BAB15734.1. Different initiation.
BC018398 mRNA. Translation: AAH18398.1.
BC053992 mRNA. Translation: AAH53992.1.
CCDSiCCDS33074.1.
RefSeqiNP_067051.2. NM_021228.2.
XP_005259179.1. XM_005259122.4.
UniGeneiHs.103521.

Genome annotation databases

EnsembliENST00000360565; ENSP00000353769; ENSG00000126461.
GeneIDi58506.
KEGGihsa:58506.
UCSCiuc002poq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254411 Genomic DNA. Translation: AAF87552.1.
AK024444 mRNA. Translation: BAB15734.1. Different initiation.
BC018398 mRNA. Translation: AAH18398.1.
BC053992 mRNA. Translation: AAH53992.1.
CCDSiCCDS33074.1.
RefSeqiNP_067051.2. NM_021228.2.
XP_005259179.1. XM_005259122.4.
UniGeneiHs.103521.

3D structure databases

ProteinModelPortaliQ9H7N4.
SMRiQ9H7N4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121834. 22 interactors.
IntActiQ9H7N4. 12 interactors.
MINTiMINT-2875509.
STRINGi9606.ENSP00000353769.

PTM databases

iPTMnetiQ9H7N4.
PhosphoSitePlusiQ9H7N4.
SwissPalmiQ9H7N4.

Polymorphism and mutation databases

BioMutaiSCAF1.
DMDMi296452955.

Proteomic databases

EPDiQ9H7N4.
MaxQBiQ9H7N4.
PaxDbiQ9H7N4.
PeptideAtlasiQ9H7N4.
PRIDEiQ9H7N4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360565; ENSP00000353769; ENSG00000126461.
GeneIDi58506.
KEGGihsa:58506.
UCSCiuc002poq.4. human.

Organism-specific databases

CTDi58506.
DisGeNETi58506.
GeneCardsiSCAF1.
H-InvDBHIX0015337.
HGNCiHGNC:30403. SCAF1.
HPAiHPA046828.
HPA054593.
neXtProtiNX_Q9H7N4.
OpenTargetsiENSG00000126461.
PharmGKBiPA162402459.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0825. Eukaryota.
ENOG410YF5K. LUCA.
GeneTreeiENSGT00530000063661.
HOGENOMiHOG000168227.
HOVERGENiHBG097942.
InParanoidiQ9H7N4.
OMAiPDSWISS.
OrthoDBiEOG091G05JH.
PhylomeDBiQ9H7N4.
TreeFamiTF332183.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126461-MONOMER.

Miscellaneous databases

ChiTaRSiSCAF1. human.
GenomeRNAii58506.
PROiQ9H7N4.

Gene expression databases

BgeeiENSG00000126461.
CleanExiHS_SCAF1.
HS_SRA1.
ExpressionAtlasiQ9H7N4. baseline and differential.
GenevisibleiQ9H7N4. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiSFR19_HUMAN
AccessioniPrimary (citable) accession number: Q9H7N4
Secondary accession number(s): Q7Z5V7, Q8WVA1, Q9NR59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.