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Q9H7M9

- GI24_HUMAN

UniProt

Q9H7M9 - GI24_HUMAN

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Protein

Platelet receptor Gi24

Gene
C10orf54, SISP1, PP2135, UNQ730/PRO1412
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May stimulate MMP14-mediated MMP2 activation.1 Publication

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet receptor Gi24
Alternative name(s):
Stress-induced secreted protein-1
Short name:
Sisp-1
Gene namesi
Synonyms:SISP1
ORF Names:PP2135, UNQ730/PRO1412
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:30085. C10orf54.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 194162Extracellular Reviewed predictionAdd
BLAST
Transmembranei195 – 21521Helical; Reviewed predictionAdd
BLAST
Topological domaini216 – 31196Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672307.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 32321 PublicationAdd
BLAST
Chaini33 – 311279Platelet receptor Gi24PRO_0000014765Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi49 – 491N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi54 ↔ 146 By similarity
Glycosylationi91 – 911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi128 – 1281N-linked (GlcNAc...) Reviewed prediction
Modified residuei235 – 2351Phosphoserine1 Publication
Modified residuei248 – 2481Phosphoserine2 Publications

Post-translational modificationi

At the cell surface, may be cleaved by MMP14.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9H7M9.
PRIDEiQ9H7M9.

PTM databases

PhosphoSiteiQ9H7M9.

Expressioni

Gene expression databases

BgeeiQ9H7M9.
CleanExiHS_C10orf54.
GenevestigatoriQ9H7M9.

Organism-specific databases

HPAiHPA007968.

Interactioni

Protein-protein interaction databases

BioGridi122071. 3 interactions.
IntActiQ9H7M9. 2 interactions.
MINTiMINT-1190465.

Structurei

3D structure databases

ProteinModelPortaliQ9H7M9.
SMRiQ9H7M9. Positions 42-150.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 162130Ig-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44794.
HOGENOMiHOG000015315.
HOVERGENiHBG051732.
OMAiMELQVQR.
OrthoDBiEOG7NW6BG.
PhylomeDBiQ9H7M9.
TreeFamiTF332066.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H7M9-1 [UniParc]FASTAAdd to Basket

« Hide

MGVPTALEAG SWRWGSLLFA LFLAASLGPV AAFKVATPYS LYVCPEGQNV    50
TLTCRLLGPV DKGHDVTFYK TWYRSSRGEV QTCSERRPIR NLTFQDLHLH 100
HGGHQAANTS HDLAQRHGLE SASDHHGNFS ITMRNLTLLD SGLYCCLVVE 150
IRHHHSEHRV HGAMELQVQT GKDAPSNCVV YPSSSQDSEN ITAAALATGA 200
CIVGILCLPL ILLLVYKQRQ AASNRRAQEL VRMDSNIQGI ENPGFEASPP 250
AQGIPEAKVR HPLSYVAQRQ PSESGRHLLS EPSTPLSPPG PGDVFFPSLD 300
PVPDSPNFEV I 311
Length:311
Mass (Da):33,908
Last modified:November 2, 2010 - v3
Checksum:i321862EC650623CD
GO

Sequence cautioni

The sequence AAL55778.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.
The sequence BAB15739.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence AAL55778.1 differs from that shown. Reason: Erroneous termination at position 84. Translated as Ser.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti187 – 1871D → E.5 Publications
Corresponds to variant rs3747869 [ dbSNP | Ensembl ].
VAR_028036

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331F → L in AAL55778. 1 Publication
Sequence conflicti85 – 851E → K in AAL55778. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY265805 mRNA. Translation: AAP03084.1.
EF506490 mRNA. Translation: ABP88253.1.
AF289594 mRNA. Translation: AAL55778.1. Sequence problems.
AK024449 mRNA. Translation: BAB15739.1. Different initiation.
AY358379 mRNA. Translation: AAQ88745.1.
AL731541 Genomic DNA. Translation: CAI40842.1.
BC020568 mRNA. Translation: AAH20568.1.
BC127257 mRNA. Translation: AAI27258.1.
CCDSiCCDS31218.1.
RefSeqiNP_071436.1. NM_022153.1.
UniGeneiHs.47382.

Genome annotation databases

EnsembliENST00000394957; ENSP00000378409; ENSG00000107738.
GeneIDi64115.
KEGGihsa:64115.
UCSCiuc001jsd.3. human.

Polymorphism databases

DMDMi311033449.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY265805 mRNA. Translation: AAP03084.1 .
EF506490 mRNA. Translation: ABP88253.1 .
AF289594 mRNA. Translation: AAL55778.1 . Sequence problems.
AK024449 mRNA. Translation: BAB15739.1 . Different initiation.
AY358379 mRNA. Translation: AAQ88745.1 .
AL731541 Genomic DNA. Translation: CAI40842.1 .
BC020568 mRNA. Translation: AAH20568.1 .
BC127257 mRNA. Translation: AAI27258.1 .
CCDSi CCDS31218.1.
RefSeqi NP_071436.1. NM_022153.1.
UniGenei Hs.47382.

3D structure databases

ProteinModelPortali Q9H7M9.
SMRi Q9H7M9. Positions 42-150.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122071. 3 interactions.
IntActi Q9H7M9. 2 interactions.
MINTi MINT-1190465.

PTM databases

PhosphoSitei Q9H7M9.

Polymorphism databases

DMDMi 311033449.

Proteomic databases

PaxDbi Q9H7M9.
PRIDEi Q9H7M9.

Protocols and materials databases

DNASUi 64115.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000394957 ; ENSP00000378409 ; ENSG00000107738 .
GeneIDi 64115.
KEGGi hsa:64115.
UCSCi uc001jsd.3. human.

Organism-specific databases

CTDi 64115.
GeneCardsi GC10M073507.
H-InvDB HIX0008907.
HGNCi HGNC:30085. C10orf54.
HPAi HPA007968.
MIMi 615608. gene.
neXtProti NX_Q9H7M9.
PharmGKBi PA142672307.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44794.
HOGENOMi HOG000015315.
HOVERGENi HBG051732.
OMAi MELQVQR.
OrthoDBi EOG7NW6BG.
PhylomeDBi Q9H7M9.
TreeFami TF332066.

Miscellaneous databases

GeneWikii C10orf54.
GenomeRNAii 64115.
NextBioi 35460482.
SOURCEi Search...

Gene expression databases

Bgeei Q9H7M9.
CleanExi HS_C10orf54.
Genevestigatori Q9H7M9.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gi24, a novel platelet receptor."
    Sachs U.J., Eva O., Clemetson K.J., Santoso S.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-187.
  2. "SISP1, a novel P53 target gene."
    Yang Y.-S., Seo Y.-S.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-187.
  3. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-187.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-187.
    Tissue: Spleen.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-187.
  6. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 33-47.
  9. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
    Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.
    J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: T-cell.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-248, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-235 AND SER-248, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase."
    Sakr M.A., Takino T., Domoto T., Nakano H., Wong R.W., Sasaki M., Nakanuma Y., Sato H.
    Cancer Sci. 101:2368-2374(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, CLEAVAGE BY MMP14.
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiGI24_HUMAN
AccessioniPrimary (citable) accession number: Q9H7M9
Secondary accession number(s): A1L0X9
, A4ZYV1, A8MVH5, Q6UXF3, Q8WUG3, Q8WYZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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