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Protein

V-type immunoglobulin domain-containing suppressor of T-cell activation

Gene

VSIR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).By similarity2 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
V-type immunoglobulin domain-containing suppressor of T-cell activation1 Publication
Alternative name(s):
Platelet receptor Gi241 Publication
Stress-induced secreted protein-11 Publication
Short name:
Sisp-11 Publication
V-set domain-containing immunoregulatory receptorBy similarity
V-set immunoregulatory receptorImported
Gene namesi
Name:VSIRImported
Synonyms:C10orf54, SISP11 Publication, VISTA
ORF Names:PP2135, UNQ730/PRO1412
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000107738.19.
HGNCiHGNC:30085. VSIR.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 194ExtracellularBy similarityAdd BLAST162
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 311CytoplasmicBy similarityAdd BLAST96

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64115.
OpenTargetsiENSG00000107738.
PharmGKBiPA142672307.

Polymorphism and mutation databases

BioMutaiC10orf54.
DMDMi311033449.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 321 PublicationAdd BLAST32
ChainiPRO_000001476533 – 311V-type immunoglobulin domain-containing suppressor of T-cell activationAdd BLAST279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi54 ↔ 146PROSITE-ProRule annotation
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei235PhosphoserineCombined sources1
Modified residuei248PhosphoserineCombined sources1

Post-translational modificationi

At the cell surface, may be cleaved by MMP14.1 Publication
N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9H7M9.
PaxDbiQ9H7M9.
PeptideAtlasiQ9H7M9.
PRIDEiQ9H7M9.

PTM databases

iPTMnetiQ9H7M9.
PhosphoSitePlusiQ9H7M9.

Expressioni

Tissue specificityi

Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta, spleen, plasma blood leukocytes, and lung. Expressed at moderate levels in lymph node, bone marrow, fat, uterus, and trachea. Has low expression levels in other tissues.1 Publication

Gene expression databases

BgeeiENSG00000107738.
CleanExiHS_C10orf54.
ExpressionAtlasiQ9H7M9. baseline and differential.
GenevisibleiQ9H7M9. HS.

Organism-specific databases

HPAiHPA007968.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-744988,EBI-744988

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi122071. 2 interactors.
DIPiDIP-57562N.
IntActiQ9H7M9. 2 interactors.
MINTiMINT-1190465.
STRINGi9606.ENSP00000378409.

Structurei

3D structure databases

ProteinModelPortaliQ9H7M9.
SMRiQ9H7M9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 168Ig-like V-typePROSITE-ProRule annotationAdd BLAST136

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IES7. Eukaryota.
ENOG4111QW8. LUCA.
GeneTreeiENSGT00390000005486.
HOGENOMiHOG000015315.
HOVERGENiHBG051732.
InParanoidiQ9H7M9.
OMAiQGHENPV.
OrthoDBiEOG091G0BXH.
PhylomeDBiQ9H7M9.
TreeFamiTF332066.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
PfamiView protein in Pfam
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H7M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVPTALEAG SWRWGSLLFA LFLAASLGPV AAFKVATPYS LYVCPEGQNV
60 70 80 90 100
TLTCRLLGPV DKGHDVTFYK TWYRSSRGEV QTCSERRPIR NLTFQDLHLH
110 120 130 140 150
HGGHQAANTS HDLAQRHGLE SASDHHGNFS ITMRNLTLLD SGLYCCLVVE
160 170 180 190 200
IRHHHSEHRV HGAMELQVQT GKDAPSNCVV YPSSSQDSEN ITAAALATGA
210 220 230 240 250
CIVGILCLPL ILLLVYKQRQ AASNRRAQEL VRMDSNIQGI ENPGFEASPP
260 270 280 290 300
AQGIPEAKVR HPLSYVAQRQ PSESGRHLLS EPSTPLSPPG PGDVFFPSLD
310
PVPDSPNFEV I
Length:311
Mass (Da):33,908
Last modified:November 2, 2010 - v3
Checksum:i321862EC650623CD
GO

Sequence cautioni

Q9H7M9: The sequence AAL55778 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
Q9H7M9: The sequence AAL55778 differs from that shown. Reason: Erroneous termination at position 84. Translated as Ser.Curated
Q9H7M9: The sequence BAB15739 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33F → L in AAL55778 (PubMed:15498874).Curated1
Sequence conflicti85E → K in AAL55778 (PubMed:15498874).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028036187D → E5 PublicationsCorresponds to variant dbSNP:rs3747869Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY265805 mRNA. Translation: AAP03084.1.
EF506490 mRNA. Translation: ABP88253.1.
AF289594 mRNA. Translation: AAL55778.1. Sequence problems.
AK024449 mRNA. Translation: BAB15739.1. Different initiation.
AY358379 mRNA. Translation: AAQ88745.1.
AL731541 Genomic DNA. No translation available.
BC020568 mRNA. Translation: AAH20568.1.
BC127257 mRNA. Translation: AAI27258.1.
CCDSiCCDS31218.1.
RefSeqiNP_071436.1. NM_022153.1.
UniGeneiHs.47382.

Genome annotation databases

EnsembliENST00000394957; ENSP00000378409; ENSG00000107738.
GeneIDi64115.
KEGGihsa:64115.
UCSCiuc001jsd.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiVISTA_HUMAN
AccessioniPrimary (citable) accession number: Q9H7M9
Secondary accession number(s): A1L0X9
, A4ZYV1, A8MVH5, Q6UXF3, Q8WUG3, Q8WYZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: November 2, 2010
Last modified: October 25, 2017
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot