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Protein

V-type immunoglobulin domain-containing suppressor of T-cell activation

Gene

VSIR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).By similarity2 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
V-type immunoglobulin domain-containing suppressor of T-cell activation1 Publication
Alternative name(s):
Platelet receptor Gi241 Publication
Stress-induced secreted protein-11 Publication
Short name:
Sisp-11 Publication
V-set domain-containing immunoregulatory receptorBy similarity
V-set immunoregulatory receptorImported
Gene namesi
Name:VSIRImported
Synonyms:C10orf54, SISP11 Publication, VISTA
ORF Names:PP2135, UNQ730/PRO1412
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000107738.19
HGNCiHGNC:30085 VSIR
MIMi615608 gene
neXtProtiNX_Q9H7M9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 194ExtracellularBy similarityAdd BLAST162
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 311CytoplasmicBy similarityAdd BLAST96

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64115
OpenTargetsiENSG00000107738
PharmGKBiPA142672307

Polymorphism and mutation databases

BioMutaiC10orf54
DMDMi311033449

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 321 PublicationAdd BLAST32
ChainiPRO_000001476533 – 311V-type immunoglobulin domain-containing suppressor of T-cell activationAdd BLAST279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi54 ↔ 146PROSITE-ProRule annotation
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei235PhosphoserineCombined sources1
Modified residuei248PhosphoserineCombined sources1

Post-translational modificationi

At the cell surface, may be cleaved by MMP14.1 Publication
N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9H7M9
PaxDbiQ9H7M9
PeptideAtlasiQ9H7M9
PRIDEiQ9H7M9

PTM databases

iPTMnetiQ9H7M9
PhosphoSitePlusiQ9H7M9

Expressioni

Tissue specificityi

Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta, spleen, plasma blood leukocytes, and lung. Expressed at moderate levels in lymph node, bone marrow, fat, uterus, and trachea. Has low expression levels in other tissues.1 Publication

Gene expression databases

BgeeiENSG00000107738
CleanExiHS_C10orf54
ExpressionAtlasiQ9H7M9 baseline and differential
GenevisibleiQ9H7M9 HS

Organism-specific databases

HPAiHPA007968

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-744988,EBI-744988

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi122071, 2 interactors
DIPiDIP-57562N
IntActiQ9H7M9, 2 interactors
MINTiQ9H7M9
STRINGi9606.ENSP00000378409

Structurei

3D structure databases

ProteinModelPortaliQ9H7M9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 168Ig-like V-typePROSITE-ProRule annotationAdd BLAST136

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IES7 Eukaryota
ENOG4111QW8 LUCA
GeneTreeiENSGT00390000005486
HOGENOMiHOG000015315
HOVERGENiHBG051732
InParanoidiQ9H7M9
OMAiQGHENPV
OrthoDBiEOG091G0BXH
PhylomeDBiQ9H7M9
TreeFamiTF332066

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H7M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVPTALEAG SWRWGSLLFA LFLAASLGPV AAFKVATPYS LYVCPEGQNV
60 70 80 90 100
TLTCRLLGPV DKGHDVTFYK TWYRSSRGEV QTCSERRPIR NLTFQDLHLH
110 120 130 140 150
HGGHQAANTS HDLAQRHGLE SASDHHGNFS ITMRNLTLLD SGLYCCLVVE
160 170 180 190 200
IRHHHSEHRV HGAMELQVQT GKDAPSNCVV YPSSSQDSEN ITAAALATGA
210 220 230 240 250
CIVGILCLPL ILLLVYKQRQ AASNRRAQEL VRMDSNIQGI ENPGFEASPP
260 270 280 290 300
AQGIPEAKVR HPLSYVAQRQ PSESGRHLLS EPSTPLSPPG PGDVFFPSLD
310
PVPDSPNFEV I
Length:311
Mass (Da):33,908
Last modified:November 2, 2010 - v3
Checksum:i321862EC650623CD
GO

Sequence cautioni

The sequence AAL55778 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAL55778 differs from that shown. Reason: Erroneous termination at position 84. Translated as Ser.Curated
The sequence BAB15739 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33F → L in AAL55778 (PubMed:15498874).Curated1
Sequence conflicti85E → K in AAL55778 (PubMed:15498874).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028036187D → E5 PublicationsCorresponds to variant dbSNP:rs3747869Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY265805 mRNA Translation: AAP03084.1
EF506490 mRNA Translation: ABP88253.1
AF289594 mRNA Translation: AAL55778.1 Sequence problems.
AK024449 mRNA Translation: BAB15739.1 Different initiation.
AY358379 mRNA Translation: AAQ88745.1
AL731541 Genomic DNA No translation available.
BC020568 mRNA Translation: AAH20568.1
BC127257 mRNA Translation: AAI27258.1
CCDSiCCDS31218.1
RefSeqiNP_071436.1, NM_022153.1
UniGeneiHs.47382

Genome annotation databases

EnsembliENST00000394957; ENSP00000378409; ENSG00000107738
GeneIDi64115
KEGGihsa:64115
UCSCiuc001jsd.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiVISTA_HUMAN
AccessioniPrimary (citable) accession number: Q9H7M9
Secondary accession number(s): A1L0X9
, A4ZYV1, A8MVH5, Q6UXF3, Q8WUG3, Q8WYZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: November 2, 2010
Last modified: May 23, 2018
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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