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Q9H7M6

- ZSWM4_HUMAN

UniProt

Q9H7M6 - ZSWM4_HUMAN

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Protein

Zinc finger SWIM domain-containing protein 4

Gene

ZSWIM4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri139 – 17638SWIM-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger SWIM domain-containing protein 4
Gene namesi
Name:ZSWIM4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:25704. ZSWIM4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134975055.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 989989Zinc finger SWIM domain-containing protein 4PRO_0000223101Add
BLAST

Proteomic databases

PaxDbiQ9H7M6.
PRIDEiQ9H7M6.

PTM databases

PhosphoSiteiQ9H7M6.

Expressioni

Gene expression databases

BgeeiQ9H7M6.
CleanExiHS_ZSWIM4.
ExpressionAtlasiQ9H7M6. baseline.
GenevestigatoriQ9H7M6.

Organism-specific databases

HPAiHPA042084.

Interactioni

Protein-protein interaction databases

BioGridi122412. 1 interaction.
STRINGi9606.ENSP00000254323.

Structurei

3D structure databases

ProteinModelPortaliQ9H7M6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 SWIM-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri139 – 17638SWIM-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG322060.
GeneTreeiENSGT00390000012572.
HOGENOMiHOG000231419.
HOVERGENiHBG058098.
InParanoidiQ9H7M6.
OMAiLYHVSIS.
OrthoDBiEOG74J970.
PhylomeDBiQ9H7M6.
TreeFamiTF324881.

Family and domain databases

InterProiIPR007527. Znf_SWIM.
[Graphical view]
PROSITEiPS50966. ZF_SWIM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H7M6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPPAAKRSR GCPAGPEERD AGAGAARGRG RPEALLDLSA KRVAESWAFE
60 70 80 90 100
QVEERFSRVP EPVQKRIVFW SFPRSEREIC MYSSLGYPPP EGEHDARVPF
110 120 130 140 150
TRGLHLLQSG AVDRVLQVGF HLSGNIREPG SPGEPERLYH VSISFDRCKI
160 170 180 190 200
TSVSCGCDNR DLFYCAHVVA LSLYRIRHAH QVELRLPISE TLSQMNRDQL
210 220 230 240 250
QKFVQYLISA HHTEVLPTAQ RLADEILLLG SEINLVNGAP DPTAGAGIED
260 270 280 290 300
ANCWHLDEEQ IQEQVKQLLS NGGYYGASQQ LRSMFSKVRE MLRMRDSNGA
310 320 330 340 350
RMLILMTEQF LQDTRLALWR QQGAGMTDKC RQLWDELGAL WVCVVLSPHC
360 370 380 390 400
KPEERAGWLQ LLSRWDKLDV CPLEEGNYSF DGPSLQPTMA PAPELLQKGS
410 420 430 440 450
TCITNTEGWV GHPLDPIGCL CRALLEACRL EEETLTLYPD SGPEKRKVAY
460 470 480 490 500
QHVPVPGSPG ESYLVLALEV ALLGLGQQRA LPEGLYAQDK VVRNEEQLLA
510 520 530 540 550
LLEEVELDER LVQVLRKQAG LLLEGGPFSG FGEVLFRESV PMHTCARYLF
560 570 580 590 600
TALLPHDPDL AYRLALRAMR LPILETAFPA GEPHPSPLDS IMSNRFPRWF
610 620 630 640 650
ILGHLETRQC ELASTMLTAA KGDPKWLHTV LGSIQQNIHS PALLFKLAQD
660 670 680 690 700
ACKTATPVSA PPDTTLLGIA LELGLQVMRM TLNVMTWRRR EMVRWLVSCA
710 720 730 740 750
TEIGPQALMN IMQNWYSLFT PVEAATIVAV TGTTHATLLR LQLDTSRREE
760 770 780 790 800
LWACARTLAL QCAMKDPQNC ALPALTLCEK NHSAFEAAYQ IVLDAAAGGL
810 820 830 840 850
GHAHLFTVAR YMEHRGLPLR AYKLATLALA QLSIAFNQDS HPAVNDVLWA
860 870 880 890 900
CSLSHSLGRH ELSAIVPLII RSIHCAPMLS DILRRWTLSA PGLGPLGARR
910 920 930 940 950
AAKPLGADRA PLCQLLDAAV TAYITTSHSR LTHISPRHYG DFIEFLGKAR
960 970 980
ETFLLAPDGH LQFSQFLENL KQTYKGKKKL MLLVRERFG
Length:989
Mass (Da):110,138
Last modified:May 18, 2010 - v3
Checksum:i1BFDAF8291131A2D
GO

Sequence cautioni

The sequence BAB15742.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti629 – 6291T → M in BAB15742. (PubMed:11214971)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024452 mRNA. Translation: BAB15742.1. Different initiation.
AC020916 Genomic DNA. No translation available.
CCDSiCCDS32924.1.
RefSeqiNP_075560.2. NM_023072.2.
UniGeneiHs.466015.

Genome annotation databases

EnsembliENST00000254323; ENSP00000254323; ENSG00000132003.
GeneIDi65249.
KEGGihsa:65249.
UCSCiuc002mxh.1. human.

Polymorphism databases

DMDMi296453063.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024452 mRNA. Translation: BAB15742.1 . Different initiation.
AC020916 Genomic DNA. No translation available.
CCDSi CCDS32924.1.
RefSeqi NP_075560.2. NM_023072.2.
UniGenei Hs.466015.

3D structure databases

ProteinModelPortali Q9H7M6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122412. 1 interaction.
STRINGi 9606.ENSP00000254323.

PTM databases

PhosphoSitei Q9H7M6.

Polymorphism databases

DMDMi 296453063.

Proteomic databases

PaxDbi Q9H7M6.
PRIDEi Q9H7M6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000254323 ; ENSP00000254323 ; ENSG00000132003 .
GeneIDi 65249.
KEGGi hsa:65249.
UCSCi uc002mxh.1. human.

Organism-specific databases

CTDi 65249.
GeneCardsi GC19P013906.
HGNCi HGNC:25704. ZSWIM4.
HPAi HPA042084.
neXtProti NX_Q9H7M6.
PharmGKBi PA134975055.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG322060.
GeneTreei ENSGT00390000012572.
HOGENOMi HOG000231419.
HOVERGENi HBG058098.
InParanoidi Q9H7M6.
OMAi LYHVSIS.
OrthoDBi EOG74J970.
PhylomeDBi Q9H7M6.
TreeFami TF324881.

Miscellaneous databases

ChiTaRSi ZSWIM4. human.
GenomeRNAii 65249.
NextBioi 67367.
PROi Q9H7M6.

Gene expression databases

Bgeei Q9H7M6.
CleanExi HS_ZSWIM4.
ExpressionAtlasi Q9H7M6. baseline.
Genevestigatori Q9H7M6.

Family and domain databases

InterProi IPR007527. Znf_SWIM.
[Graphical view ]
PROSITEi PS50966. ZF_SWIM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of long cDNA clones from human adult spleen."
    Hattori A., Okumura K., Nagase T., Kikuno R., Hirosawa M., Ohara O.
    DNA Res. 7:357-366(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZSWM4_HUMAN
AccessioniPrimary (citable) accession number: Q9H7M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 18, 2010
Last modified: November 26, 2014
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3