Q9H7M6 (ZSWM4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger SWIM domain-containing protein 4

Gene names

Name:

ZSWIM4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	989 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 1 SWIM-type zinc finger.
Sequence caution	The sequence BAB15742.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Domain	Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 989	989	Zinc finger SWIM domain-containing protein 4		PRO_0000223101
Regions
	Zinc finger	139 – 176	38	SWIM-type
Amino acid modifications
	Modified residue	640	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	629	1	T → M in BAB15742. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9H7M6 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 1BFDAF8291131A2D	FASTA	989	110,138
	10 20 30 40 50 60 MEPPAAKRSR GCPAGPEERD AGAGAARGRG RPEALLDLSA KRVAESWAFE QVEERFSRVP 70 80 90 100 110 120 EPVQKRIVFW SFPRSEREIC MYSSLGYPPP EGEHDARVPF TRGLHLLQSG AVDRVLQVGF 130 140 150 160 170 180 HLSGNIREPG SPGEPERLYH VSISFDRCKI TSVSCGCDNR DLFYCAHVVA LSLYRIRHAH 190 200 210 220 230 240 QVELRLPISE TLSQMNRDQL QKFVQYLISA HHTEVLPTAQ RLADEILLLG SEINLVNGAP 250 260 270 280 290 300 DPTAGAGIED ANCWHLDEEQ IQEQVKQLLS NGGYYGASQQ LRSMFSKVRE MLRMRDSNGA 310 320 330 340 350 360 RMLILMTEQF LQDTRLALWR QQGAGMTDKC RQLWDELGAL WVCVVLSPHC KPEERAGWLQ 370 380 390 400 410 420 LLSRWDKLDV CPLEEGNYSF DGPSLQPTMA PAPELLQKGS TCITNTEGWV GHPLDPIGCL 430 440 450 460 470 480 CRALLEACRL EEETLTLYPD SGPEKRKVAY QHVPVPGSPG ESYLVLALEV ALLGLGQQRA 490 500 510 520 530 540 LPEGLYAQDK VVRNEEQLLA LLEEVELDER LVQVLRKQAG LLLEGGPFSG FGEVLFRESV 550 560 570 580 590 600 PMHTCARYLF TALLPHDPDL AYRLALRAMR LPILETAFPA GEPHPSPLDS IMSNRFPRWF 610 620 630 640 650 660 ILGHLETRQC ELASTMLTAA KGDPKWLHTV LGSIQQNIHS PALLFKLAQD ACKTATPVSA 670 680 690 700 710 720 PPDTTLLGIA LELGLQVMRM TLNVMTWRRR EMVRWLVSCA TEIGPQALMN IMQNWYSLFT 730 740 750 760 770 780 PVEAATIVAV TGTTHATLLR LQLDTSRREE LWACARTLAL QCAMKDPQNC ALPALTLCEK 790 800 810 820 830 840 NHSAFEAAYQ IVLDAAAGGL GHAHLFTVAR YMEHRGLPLR AYKLATLALA QLSIAFNQDS 850 860 870 880 890 900 HPAVNDVLWA CSLSHSLGRH ELSAIVPLII RSIHCAPMLS DILRRWTLSA PGLGPLGARR 910 920 930 940 950 960 AAKPLGADRA PLCQLLDAAV TAYITTSHSR LTHISPRHYG DFIEFLGKAR ETFLLAPDGH 970 980 LQFSQFLENL KQTYKGKKKL MLLVRERFG

References

[1]

"Characterization of long cDNA clones from human adult spleen." Hattori A., Okumura K., Nagase T., Kikuno R., Hirosawa M., Ohara O. DNA Res. 7:357-366(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen.

[2]

"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK024452 mRNA. Translation: BAB15742.1. Different initiation. AC020916 Genomic DNA. No translation available.
IPI	IPI00303331.
RefSeq	NP_075560.2. NM_023072.2.
UniGene	Hs.466015.
3D structure databases
ProteinModelPortal	Q9H7M6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000254323.
PTM databases
PhosphoSite	Q9H7M6.
Polymorphism databases
DMDM	296453063.
Proteomic databases
PaxDb	Q9H7M6.
PRIDE	Q9H7M6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000254323; ENSP00000254323; ENSG00000132003.
GeneID	65249.
KEGG	hsa:65249.
UCSC	uc002mxh.1. human.
Organism-specific databases
CTD	65249.
GeneCards	GC19P013906.
HGNC	HGNC:25704. ZSWIM4.
HPA	HPA042084.
neXtProt	NX_Q9H7M6.
PharmGKB	PA134975055.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG322060.
HOGENOM	HOG000231419.
HOVERGEN	HBG058098.
InParanoid	Q9H7M6.
OrthoDB	EOG405S08.
Gene expression databases
ArrayExpress	Q9H7M6.
Bgee	Q9H7M6.
CleanEx	HS_ZSWIM4.
Genevestigator	Q9H7M6.
GermOnline	ENSG00000132003. Homo sapiens.
Family and domain databases
InterPro	IPR007527. Znf_SWIM. [Graphical view]
PROSITE	PS50966. ZF_SWIM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	65249.
NextBio	67367.

Entry information

Entry name

ZSWM4_HUMAN

Accession

Primary (citable) accession number: Q9H7M6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	May 18, 2010
Last modified:	April 3, 2013
This is version 73 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.