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Protein

Sin3 histone deacetylase corepressor complex component SDS3

Gene

SUDS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.2 Publications

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • histone deacetylase activity Source: Reactome
  • histone deacetylase binding Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • histone deacetylation Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: BHF-UCL
  • positive regulation of apoptotic process Source: UniProtKB
  • protein deubiquitination Source: Reactome
  • substantia nigra development Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processApoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3214815 HDACs deacetylate histones
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-5689880 Ub-specific processing proteases

Names & Taxonomyi

Protein namesi
Recommended name:
Sin3 histone deacetylase corepressor complex component SDS3
Alternative name(s):
45 kDa Sin3-associated polypeptide
Suppressor of defective silencing 3 protein homolog
Gene namesi
Name:SUDS3
Synonyms:SAP45, SDS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111707.11
HGNCiHGNC:29545 SUDS3
MIMi608250 gene
neXtProtiNX_Q9H7L9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64426
OpenTargetsiENSG00000111707
PharmGKBiPA143485626

Polymorphism and mutation databases

BioMutaiSUDS3
DMDMi68053233

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000976522 – 328Sin3 histone deacetylase corepressor complex component SDS3Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei32PhosphoserineCombined sources1
Modified residuei45PhosphoserineCombined sources1
Modified residuei49PhosphothreonineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Cross-linki69Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki201Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei228PhosphoserineCombined sources1
Modified residuei234PhosphoserineCombined sources1
Modified residuei237PhosphoserineCombined sources1
Modified residuei244PhosphothreonineCombined sources1

Post-translational modificationi

Polyubiquitinated. 'Lys-63'-polyubiquitinated SUDS3 positively regulates histone deacetylation. Regulated through deubiquitination by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9H7L9
MaxQBiQ9H7L9
PaxDbiQ9H7L9
PeptideAtlasiQ9H7L9
PRIDEiQ9H7L9

PTM databases

iPTMnetiQ9H7L9
PhosphoSitePlusiQ9H7L9

Expressioni

Tissue specificityi

Expressed in various cancer cell ines.1 Publication

Gene expression databases

BgeeiENSG00000111707
CleanExiHS_SUDS3
GenevisibleiQ9H7L9 HS

Organism-specific databases

HPAiHPA040402
HPA041972

Interactioni

Subunit structurei

Homodimer. Component of the SIN3 histone deacetylase (HDAC) corepressor complex. Interacts with SIN3A. Interaction with SIN3B enhances the interaction between SIN3B and HDAC1 to form a complex (By similarity). Interacts with HCFC1. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Interacts with USP17L2; the interaction is direct. Interacts with FOXK2 (PubMed:25805136).By similarity4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • histone deacetylase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122174, 33 interactors
CORUMiQ9H7L9
IntActiQ9H7L9, 17 interactors
MINTiQ9H7L9
STRINGi9606.ENSP00000443988

Structurei

3D structure databases

ProteinModelPortaliQ9H7L9
SMRiQ9H7L9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 170Mediates interaction with USP17L21 PublicationAdd BLAST169
Regioni188 – 226Sin3 interaction domain (SID)By similarityAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili66 – 171Sequence analysisAdd BLAST106

Domaini

The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms.

Sequence similaritiesi

Belongs to the SDS3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4466 Eukaryota
ENOG410Y9N9 LUCA
GeneTreeiENSGT00910000144281
HOGENOMiHOG000007054
HOVERGENiHBG108465
InParanoidiQ9H7L9
KOiK19201
OMAiNDSMEIK
OrthoDBiEOG091G0MS7
PhylomeDBiQ9H7L9
TreeFamiTF323740

Family and domain databases

InterProiView protein in InterPro
IPR013907 Sds3
PANTHERiPTHR21964 PTHR21964, 1 hit
PfamiView protein in Pfam
PF08598 Sds3, 1 hit
SMARTiView protein in SMART
SM01401 Sds3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H7L9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAGLLAPA PAQAGAPPAP EYYPEEDEEL ESAEDDERSC RGRESDEDTE
60 70 80 90 100
DASETDLAKH DEEDYVEMKE QMYQDKLASL KRQLQQLQEG TLQEYQKRMK
110 120 130 140 150
KLDQQYKERI RNAELFLQLE TEQVERNYIK EKKAAVKEFE DKKVELKENL
160 170 180 190 200
IAELEEKKKM IENEKLTMEL TGDSMEVKPI MTRKLRRRPN DPVPIPDKRR
210 220 230 240 250
KPAPAQLNYL LTDEQIMEDL RTLNKLKSPK RPASPSSPEH LPATPAESPA
260 270 280 290 300
QRFEARIEDG KLYYDKRWYH KSQAIYLESK DNQKLSCVIS SVGANEIWVR
310 320
KTSDSTKMRI YLGQLQRGLF VIRRRSAA
Length:328
Mass (Da):38,136
Last modified:June 21, 2005 - v2
Checksum:i10A7393B607117EB
GO

Sequence cautioni

The sequence BAB14685 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15750 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti164 – 171EKLTMELT → HASAHASA in AAH30252 (PubMed:12724404).Curated8
Sequence conflicti286S → R in BAB14685 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024460 mRNA Translation: BAB15750.1 Different initiation.
BC030252 mRNA Translation: AAH30252.1
BC098404 mRNA Translation: AAH98404.1
AK023801 mRNA Translation: BAB14685.1 Different initiation.
CCDSiCCDS44993.1
RefSeqiNP_071936.2, NM_022491.2
UniGeneiHs.416630
Hs.602312

Genome annotation databases

EnsembliENST00000543473; ENSP00000443988; ENSG00000111707
GeneIDi64426
KEGGihsa:64426
UCSCiuc001twz.4 human

Similar proteinsi

Entry informationi

Entry nameiSDS3_HUMAN
AccessioniPrimary (citable) accession number: Q9H7L9
Secondary accession number(s): Q4KMQ5, Q8N6H0, Q9H8D2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: March 28, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health