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Q9H7L9

- SDS3_HUMAN

UniProt

Q9H7L9 - SDS3_HUMAN

Protein

Sin3 histone deacetylase corepressor complex component SDS3

Gene

SUDS3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.2 Publications

    GO - Molecular functioni

    1. enzyme binding Source: UniProtKB
    2. histone deacetylase binding Source: UniProtKB
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. histone deacetylation Source: UniProtKB
    3. negative regulation of transcription, DNA-templated Source: UniProtKB
    4. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    5. positive regulation of apoptotic process Source: UniProtKB
    6. substantia nigra development Source: UniProt
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Repressor

    Keywords - Biological processi

    Apoptosis, Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_200856. NoRC negatively regulates rRNA expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sin3 histone deacetylase corepressor complex component SDS3
    Alternative name(s):
    45 kDa Sin3-associated polypeptide
    Suppressor of defective silencing 3 protein homolog
    Gene namesi
    Name:SUDS3
    Synonyms:SAP45, SDS3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:29545. SUDS3.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleus Source: UniProtKB
    3. plasma membrane Source: HPA
    4. Sin3 complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485626.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 328327Sin3 histone deacetylase corepressor complex component SDS3PRO_0000097652Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Modified residuei32 – 321Phosphoserine1 Publication
    Modified residuei45 – 451Phosphoserine5 Publications
    Modified residuei49 – 491Phosphothreonine4 Publications
    Modified residuei53 – 531Phosphoserine1 Publication
    Modified residuei228 – 2281Phosphoserine1 Publication
    Modified residuei234 – 2341Phosphoserine4 Publications
    Modified residuei237 – 2371PhosphoserineBy similarity
    Modified residuei244 – 2441Phosphothreonine1 Publication

    Post-translational modificationi

    Polyubiquitinated. 'Lys-63'-polyubiquitinated SUDS3 positively regulates histone deacetylation. Regulated through deubiquitination by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ9H7L9.
    PaxDbiQ9H7L9.
    PRIDEiQ9H7L9.

    PTM databases

    PhosphoSiteiQ9H7L9.

    Expressioni

    Tissue specificityi

    Expressed in various cancer cell ines.1 Publication

    Gene expression databases

    ArrayExpressiQ9H7L9.
    BgeeiQ9H7L9.
    CleanExiHS_SUDS3.
    GenevestigatoriQ9H7L9.

    Organism-specific databases

    HPAiHPA040402.
    HPA041972.

    Interactioni

    Subunit structurei

    Homodimer. Component of the SIN3 histone deacetylase (HDAC) corepressor complex. Interacts with SIN3A. Interaction with SIN3B enhances the interaction between SIN3B and HDAC1 to form a complex By similarity. Interacts with HCFC1. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Interacts with USP17L2; the interaction is direct.By similarity3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BRMS1Q9HCU92EBI-540496,EBI-714781
    HCFC1P516102EBI-540496,EBI-396176

    Protein-protein interaction databases

    BioGridi122174. 15 interactions.
    IntActiQ9H7L9. 8 interactions.
    STRINGi9606.ENSP00000380695.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H7L9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 170169Mediates interaction with USP17L2Add
    BLAST
    Regioni188 – 22639Sin3 interaction domain (SID)By similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili66 – 171106Sequence AnalysisAdd
    BLAST

    Domaini

    The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms.

    Sequence similaritiesi

    Belongs to the SDS3 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG311652.
    HOGENOMiHOG000007054.
    HOVERGENiHBG108465.
    InParanoidiQ9H7L9.
    OrthoDBiEOG7VQJFB.
    PhylomeDBiQ9H7L9.
    TreeFamiTF323740.

    Family and domain databases

    InterProiIPR013907. Sds3.
    [Graphical view]
    PfamiPF08598. Sds3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9H7L9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAAGLLAPA PAQAGAPPAP EYYPEEDEEL ESAEDDERSC RGRESDEDTE    50
    DASETDLAKH DEEDYVEMKE QMYQDKLASL KRQLQQLQEG TLQEYQKRMK 100
    KLDQQYKERI RNAELFLQLE TEQVERNYIK EKKAAVKEFE DKKVELKENL 150
    IAELEEKKKM IENEKLTMEL TGDSMEVKPI MTRKLRRRPN DPVPIPDKRR 200
    KPAPAQLNYL LTDEQIMEDL RTLNKLKSPK RPASPSSPEH LPATPAESPA 250
    QRFEARIEDG KLYYDKRWYH KSQAIYLESK DNQKLSCVIS SVGANEIWVR 300
    KTSDSTKMRI YLGQLQRGLF VIRRRSAA 328
    Length:328
    Mass (Da):38,136
    Last modified:June 21, 2005 - v2
    Checksum:i10A7393B607117EB
    GO

    Sequence cautioni

    The sequence BAB14685.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB15750.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti164 – 1718EKLTMELT → HASAHASA in AAH30252. (PubMed:12724404)Curated
    Sequence conflicti286 – 2861S → R in BAB14685. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK024460 mRNA. Translation: BAB15750.1. Different initiation.
    BC030252 mRNA. Translation: AAH30252.1.
    BC098404 mRNA. Translation: AAH98404.1.
    AK023801 mRNA. Translation: BAB14685.1. Different initiation.
    CCDSiCCDS44993.1.
    RefSeqiNP_071936.2. NM_022491.2.
    UniGeneiHs.416630.
    Hs.602312.

    Genome annotation databases

    EnsembliENST00000543473; ENSP00000443988; ENSG00000111707.
    GeneIDi64426.
    KEGGihsa:64426.
    UCSCiuc001twz.3. human.

    Polymorphism databases

    DMDMi68053233.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK024460 mRNA. Translation: BAB15750.1 . Different initiation.
    BC030252 mRNA. Translation: AAH30252.1 .
    BC098404 mRNA. Translation: AAH98404.1 .
    AK023801 mRNA. Translation: BAB14685.1 . Different initiation.
    CCDSi CCDS44993.1.
    RefSeqi NP_071936.2. NM_022491.2.
    UniGenei Hs.416630.
    Hs.602312.

    3D structure databases

    ProteinModelPortali Q9H7L9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122174. 15 interactions.
    IntActi Q9H7L9. 8 interactions.
    STRINGi 9606.ENSP00000380695.

    PTM databases

    PhosphoSitei Q9H7L9.

    Polymorphism databases

    DMDMi 68053233.

    Proteomic databases

    MaxQBi Q9H7L9.
    PaxDbi Q9H7L9.
    PRIDEi Q9H7L9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000543473 ; ENSP00000443988 ; ENSG00000111707 .
    GeneIDi 64426.
    KEGGi hsa:64426.
    UCSCi uc001twz.3. human.

    Organism-specific databases

    CTDi 64426.
    GeneCardsi GC12P118814.
    HGNCi HGNC:29545. SUDS3.
    HPAi HPA040402.
    HPA041972.
    MIMi 608250. gene.
    neXtProti NX_Q9H7L9.
    PharmGKBi PA143485626.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG311652.
    HOGENOMi HOG000007054.
    HOVERGENi HBG108465.
    InParanoidi Q9H7L9.
    OrthoDBi EOG7VQJFB.
    PhylomeDBi Q9H7L9.
    TreeFami TF323740.

    Enzyme and pathway databases

    Reactomei REACT_200856. NoRC negatively regulates rRNA expression.

    Miscellaneous databases

    ChiTaRSi SUDS3. human.
    GeneWikii SUDS3.
    GenomeRNAii 64426.
    NextBioi 66429.
    PROi Q9H7L9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H7L9.
    Bgeei Q9H7L9.
    CleanExi HS_SUDS3.
    Genevestigatori Q9H7L9.

    Family and domain databases

    InterProi IPR013907. Sds3.
    [Graphical view ]
    Pfami PF08598. Sds3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of long cDNA clones from human adult spleen."
      Hattori A., Okumura K., Nagase T., Kikuno R., Hirosawa M., Ohara O.
      DNA Res. 7:357-366(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.
    2. "Identification and characterization of three new components of the mSin3A corepressor complex."
      Fleischer T.C., Yun U.J., Ayer D.E.
      Mol. Cell. Biol. 23:3456-3467(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, IDENTIFICATION IN A MSIN3A COREPRESSOR COMPLEX WITH SIN3A; SAP130; SUDS3; ARID4B; HDAC1 AND HDAC2.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: LungImported and Placenta.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 130-328.
      Tissue: PlacentaImported and SpleenImported.
    5. "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1."
      Wysocka J., Myers M.P., Laherty C.D., Eisenman R.N., Herr W.
      Genes Dev. 17:896-911(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HCFC1.
    6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 AND THR-49, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45; THR-49; SER-53; SER-234 AND THR-244, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
      Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
      Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 AND THR-49, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-234, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45; THR-49 AND SER-234, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity."
      Ramakrishna S., Suresh B., Lee E.J., Lee H.J., Ahn W.S., Baek K.H.
      J. Biol. Chem. 286:10505-10514(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH USP17L2, SUBCELLULAR LOCATION, UBIQUITINATION, DEUBIQUITINATION BY USP17L2.
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32; SER-45; SER-228 AND SER-234, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSDS3_HUMAN
    AccessioniPrimary (citable) accession number: Q9H7L9
    Secondary accession number(s): Q4KMQ5, Q8N6H0, Q9H8D2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3