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Protein

Sin3 histone deacetylase corepressor complex component SDS3

Gene

SUDS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.2 Publications

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • histone deacetylase activity Source: Reactome
  • histone deacetylase binding Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • histone deacetylation Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • positive regulation of apoptotic process Source: UniProtKB
  • substantia nigra development Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111707-MONOMER.
ReactomeiR-HSA-3214815. HDACs deacetylate histones.
R-HSA-427413. NoRC negatively regulates rRNA expression.
R-HSA-5689880. Ub-specific processing proteases.

Names & Taxonomyi

Protein namesi
Recommended name:
Sin3 histone deacetylase corepressor complex component SDS3
Alternative name(s):
45 kDa Sin3-associated polypeptide
Suppressor of defective silencing 3 protein homolog
Gene namesi
Name:SUDS3
Synonyms:SAP45, SDS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:29545. SUDS3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
  • Sin3 complex Source: UniProtKB
  • Sin3-type complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64426.
OpenTargetsiENSG00000111707.
PharmGKBiPA143485626.

Polymorphism and mutation databases

BioMutaiSUDS3.
DMDMi68053233.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000976522 – 328Sin3 histone deacetylase corepressor complex component SDS3Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei32PhosphoserineCombined sources1
Modified residuei45PhosphoserineCombined sources1
Modified residuei49PhosphothreonineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Cross-linki69Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei228PhosphoserineCombined sources1
Modified residuei234PhosphoserineCombined sources1
Modified residuei237PhosphoserineCombined sources1
Modified residuei244PhosphothreonineCombined sources1

Post-translational modificationi

Polyubiquitinated. 'Lys-63'-polyubiquitinated SUDS3 positively regulates histone deacetylation. Regulated through deubiquitination by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9H7L9.
MaxQBiQ9H7L9.
PaxDbiQ9H7L9.
PeptideAtlasiQ9H7L9.
PRIDEiQ9H7L9.

PTM databases

iPTMnetiQ9H7L9.
PhosphoSitePlusiQ9H7L9.

Expressioni

Tissue specificityi

Expressed in various cancer cell ines.1 Publication

Gene expression databases

BgeeiENSG00000111707.
CleanExiHS_SUDS3.
GenevisibleiQ9H7L9. HS.

Organism-specific databases

HPAiHPA040402.
HPA041972.

Interactioni

Subunit structurei

Homodimer. Component of the SIN3 histone deacetylase (HDAC) corepressor complex. Interacts with SIN3A. Interaction with SIN3B enhances the interaction between SIN3B and HDAC1 to form a complex (By similarity). Interacts with HCFC1. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Interacts with USP17L2; the interaction is direct. Interacts with FOXK2 (PubMed:25805136).By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BRMS1Q9HCU92EBI-540496,EBI-714781
HCFC1P516102EBI-540496,EBI-396176

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • histone deacetylase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi122174. 28 interactors.
IntActiQ9H7L9. 15 interactors.
STRINGi9606.ENSP00000443988.

Structurei

3D structure databases

ProteinModelPortaliQ9H7L9.
SMRiQ9H7L9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 170Mediates interaction with USP17L21 PublicationAdd BLAST169
Regioni188 – 226Sin3 interaction domain (SID)By similarityAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili66 – 171Sequence analysisAdd BLAST106

Domaini

The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms.

Sequence similaritiesi

Belongs to the SDS3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4466. Eukaryota.
ENOG410Y9N9. LUCA.
GeneTreeiENSGT00530000063177.
HOGENOMiHOG000007054.
HOVERGENiHBG108465.
InParanoidiQ9H7L9.
KOiK19201.
OMAiIYKEYMR.
OrthoDBiEOG091G0MS7.
PhylomeDBiQ9H7L9.
TreeFamiTF323740.

Family and domain databases

InterProiIPR013907. Sds3.
[Graphical view]
PfamiPF08598. Sds3. 1 hit.
[Graphical view]
SMARTiSM01401. Sds3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H7L9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAGLLAPA PAQAGAPPAP EYYPEEDEEL ESAEDDERSC RGRESDEDTE
60 70 80 90 100
DASETDLAKH DEEDYVEMKE QMYQDKLASL KRQLQQLQEG TLQEYQKRMK
110 120 130 140 150
KLDQQYKERI RNAELFLQLE TEQVERNYIK EKKAAVKEFE DKKVELKENL
160 170 180 190 200
IAELEEKKKM IENEKLTMEL TGDSMEVKPI MTRKLRRRPN DPVPIPDKRR
210 220 230 240 250
KPAPAQLNYL LTDEQIMEDL RTLNKLKSPK RPASPSSPEH LPATPAESPA
260 270 280 290 300
QRFEARIEDG KLYYDKRWYH KSQAIYLESK DNQKLSCVIS SVGANEIWVR
310 320
KTSDSTKMRI YLGQLQRGLF VIRRRSAA
Length:328
Mass (Da):38,136
Last modified:June 21, 2005 - v2
Checksum:i10A7393B607117EB
GO

Sequence cautioni

The sequence BAB14685 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15750 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti164 – 171EKLTMELT → HASAHASA in AAH30252 (PubMed:12724404).Curated8
Sequence conflicti286S → R in BAB14685 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024460 mRNA. Translation: BAB15750.1. Different initiation.
BC030252 mRNA. Translation: AAH30252.1.
BC098404 mRNA. Translation: AAH98404.1.
AK023801 mRNA. Translation: BAB14685.1. Different initiation.
CCDSiCCDS44993.1.
RefSeqiNP_071936.2. NM_022491.2.
UniGeneiHs.416630.
Hs.602312.

Genome annotation databases

EnsembliENST00000543473; ENSP00000443988; ENSG00000111707.
GeneIDi64426.
KEGGihsa:64426.
UCSCiuc001twz.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024460 mRNA. Translation: BAB15750.1. Different initiation.
BC030252 mRNA. Translation: AAH30252.1.
BC098404 mRNA. Translation: AAH98404.1.
AK023801 mRNA. Translation: BAB14685.1. Different initiation.
CCDSiCCDS44993.1.
RefSeqiNP_071936.2. NM_022491.2.
UniGeneiHs.416630.
Hs.602312.

3D structure databases

ProteinModelPortaliQ9H7L9.
SMRiQ9H7L9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122174. 28 interactors.
IntActiQ9H7L9. 15 interactors.
STRINGi9606.ENSP00000443988.

PTM databases

iPTMnetiQ9H7L9.
PhosphoSitePlusiQ9H7L9.

Polymorphism and mutation databases

BioMutaiSUDS3.
DMDMi68053233.

Proteomic databases

EPDiQ9H7L9.
MaxQBiQ9H7L9.
PaxDbiQ9H7L9.
PeptideAtlasiQ9H7L9.
PRIDEiQ9H7L9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000543473; ENSP00000443988; ENSG00000111707.
GeneIDi64426.
KEGGihsa:64426.
UCSCiuc001twz.4. human.

Organism-specific databases

CTDi64426.
DisGeNETi64426.
GeneCardsiSUDS3.
HGNCiHGNC:29545. SUDS3.
HPAiHPA040402.
HPA041972.
MIMi608250. gene.
neXtProtiNX_Q9H7L9.
OpenTargetsiENSG00000111707.
PharmGKBiPA143485626.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4466. Eukaryota.
ENOG410Y9N9. LUCA.
GeneTreeiENSGT00530000063177.
HOGENOMiHOG000007054.
HOVERGENiHBG108465.
InParanoidiQ9H7L9.
KOiK19201.
OMAiIYKEYMR.
OrthoDBiEOG091G0MS7.
PhylomeDBiQ9H7L9.
TreeFamiTF323740.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111707-MONOMER.
ReactomeiR-HSA-3214815. HDACs deacetylate histones.
R-HSA-427413. NoRC negatively regulates rRNA expression.
R-HSA-5689880. Ub-specific processing proteases.

Miscellaneous databases

ChiTaRSiSUDS3. human.
GeneWikiiSUDS3.
GenomeRNAii64426.
PROiQ9H7L9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111707.
CleanExiHS_SUDS3.
GenevisibleiQ9H7L9. HS.

Family and domain databases

InterProiIPR013907. Sds3.
[Graphical view]
PfamiPF08598. Sds3. 1 hit.
[Graphical view]
SMARTiSM01401. Sds3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSDS3_HUMAN
AccessioniPrimary (citable) accession number: Q9H7L9
Secondary accession number(s): Q4KMQ5, Q8N6H0, Q9H8D2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: November 30, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.