Reviewed, UniProtKB/Swiss-Prot Q9H7J1 (PPR3E_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein phosphatase 1 regulatory subunit 3E

Gene names

Name:

PPP1R3E

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Acts as a glycogen-targeting subunit for PP1. PP1 is involved in glycogen metabolism and contributes to the activation of glycogen synthase leading to an increase in glycogen synthesis. Ref.1
Tissue specificity	Expressed in skeletal muscle and heart with barely detectable levels in liver. Ref.1
Domain	The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes.
Sequence similarities	Contains 1 CBM21 (carbohydrate binding type-21) domain.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glycogen metabolism
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycogen metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 279	279	Protein phosphatase 1 regulatory subunit 3E		PRO_0000338638
Regions
	Domain	154 – 259	106	CBM21
	Region	176 – 198	23	Glycogen-binding motif
	Region	248 – 256	9	Substrate-binding motif
	Motif	87 – 90	4	PP1-binding motif

Sequences

	Sequence		Length	Mass (Da)
	Q9H7J1-1 [UniParc]. Last modified June 10, 2008. Version 2. Checksum: E1FC0BEE683C97DC	FASTA	279	30,644
	10 20 30 40 50 60 MSRERPPGTD IPRNLSFIAA LTERAYYRSQ RPSLEEEPEE EPGEGGTRFG ARSRAHAPSR 70 80 90 100 110 120 GRRARSAPAG GGGARAPRSR SPDTRKRVRF ADALGLELAV VRRFRPGELP RVPRHVQIQL 130 140 150 160 170 180 QRDALRHFAP CQPRARGLQE ARAALEPASE PGFAARLLTQ RICLERAEAG PLGVAGSARV 190 200 210 220 230 240 VDLAYEKRVS VRWSADGWRS QREAPAAYAG PAPPPPRADR FAFRLPAPPI GGALLFALRY 250 260 270 RVTGHEFWDN NGGRDYALRG PEHPGSGGAP EPQGWIHFI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel glycogen-targeting subunit of protein phosphatase 1 that is regulated by insulin and shows differential tissue distribution in humans and rodents." Munro S., Ceulemans H., Bollen M., Diplexcito J., Cohen P.T.W. FEBS J. 272:1478-1489(2005) [PubMed: 15752363] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], MOTIF, REGIONS, FUNCTION, TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK024489 mRNA. Translation: BAB15779.1. Different initiation.
IPI	IPI00642162.
UniGene	Hs.601513
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	CBM21. Carbohydrate-Binding Module Family 21.
Proteomic databases
PRIDE	Q9H7J1.
Genome annotation databases
Ensembl	ENSG00000100829. Homo sapiens. [Contig view]
Organism-specific databases
GeneCards	GC14M022834. GC14M022835.
HGNC	HGNC:14943. PPP1R3E.
PharmGKB	PA33655.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9H7J1.
Gene expression databases
ArrayExpress	Q9H7J1.
Bgee	Q9H7J1.
CleanEx	HS_PPP1R3E.
Family and domain databases
InterPro	IPR005036. CBM_21. [Graphical view]
Pfam	PF03370. CBM_21. 1 hit. [Graphical view]
PROSITE	PS51159. CBM21. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPR3E_HUMAN

Accession

Primary (citable) accession number: Q9H7J1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	July 7, 2009
This is version 32 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)