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Protein

Protein phosphatase 1 regulatory subunit 3E

Gene

PPP1R3E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a glycogen-targeting subunit for PP1. PP1 is involved in glycogen metabolism and contributes to the activation of glycogen synthase leading to an increase in glycogen synthesis.1 Publication

GO - Biological processi

Keywordsi

Biological processCarbohydrate metabolism, Glycogen metabolism

Protein family/group databases

CAZyiCBM21 Carbohydrate-Binding Module Family 21

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 3E
Gene namesi
Name:PPP1R3E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000235194.8
HGNCiHGNC:14943 PPP1R3E
neXtProtiNX_Q9H7J1

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000235194

Polymorphism and mutation databases

DMDMi190359980

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003386381 – 279Protein phosphatase 1 regulatory subunit 3EAdd BLAST279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Modified residuei33PhosphoserineCombined sources1
Modified residuei66PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H7J1
PaxDbiQ9H7J1
PeptideAtlasiQ9H7J1
PRIDEiQ9H7J1
TopDownProteomicsiQ9H7J1

PTM databases

iPTMnetiQ9H7J1
PhosphoSitePlusiQ9H7J1

Expressioni

Tissue specificityi

Expressed in skeletal muscle and heart with barely detectable levels in liver.1 Publication

Gene expression databases

BgeeiENSG00000235194
CleanExiHS_PPP1R3E
ExpressionAtlasiQ9H7J1 baseline and differential
GenevisibleiQ9H7J1 HS

Organism-specific databases

HPAiHPA061600

Interactioni

Protein-protein interaction databases

BioGridi124753, 1 interactor
IntActiQ9H7J1, 2 interactors
MINTiQ9H7J1
STRINGi9606.ENSP00000408288

Structurei

3D structure databases

ProteinModelPortaliQ9H7J1
SMRiQ9H7J1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini154 – 259CBM21PROSITE-ProRule annotationAdd BLAST106

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni176 – 198Glycogen-binding motifAdd BLAST23
Regioni248 – 256Substrate-binding motif9

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi87 – 90PP1-binding motif4

Domaini

The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes.

Phylogenomic databases

eggNOGiKOG3986 Eukaryota
ENOG4111FT1 LUCA
GeneTreeiENSGT00530000062978
HOGENOMiHOG000231580
HOVERGENiHBG108282
InParanoidiQ9H7J1
KOiK07189
OMAiWSADGWR
OrthoDBiEOG091G0PR9
PhylomeDBiQ9H7J1
TreeFamiTF105537

Family and domain databases

Gene3Di2.60.40.2440, 1 hit
InterProiView protein in InterPro
IPR005036 CBM21_dom
IPR038175 CBM21_dom_sf
PfamiView protein in Pfam
PF03370 CBM_21, 1 hit
PROSITEiView protein in PROSITE
PS51159 CBM21, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H7J1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRERPPGTD IPRNLSFIAA LTERAYYRSQ RPSLEEEPEE EPGEGGTRFG
60 70 80 90 100
ARSRAHAPSR GRRARSAPAG GGGARAPRSR SPDTRKRVRF ADALGLELAV
110 120 130 140 150
VRRFRPGELP RVPRHVQIQL QRDALRHFAP CQPRARGLQE ARAALEPASE
160 170 180 190 200
PGFAARLLTQ RICLERAEAG PLGVAGSARV VDLAYEKRVS VRWSADGWRS
210 220 230 240 250
QREAPAAYAG PAPPPPRADR FAFRLPAPPI GGALLFALRY RVTGHEFWDN
260 270
NGGRDYALRG PEHPGSGGAP EPQGWIHFI
Length:279
Mass (Da):30,644
Last modified:June 10, 2008 - v2
Checksum:iE1FC0BEE683C97DC
GO

Sequence cautioni

The sequence BAB15779 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024489 mRNA Translation: BAB15779.1 Different initiation.
CH471078 Genomic DNA Translation: EAW66170.1
CH471078 Genomic DNA Translation: EAW66172.1
CH471078 Genomic DNA Translation: EAW66173.1
CCDSiCCDS61403.1
RefSeqiNP_001263247.1, NM_001276318.1
UniGeneiHs.601513

Genome annotation databases

EnsembliENST00000452015; ENSP00000408288; ENSG00000235194
GeneIDi90673
KEGGihsa:90673
UCSCiuc031qns.2 human

Similar proteinsi

Entry informationi

Entry nameiPPR3E_HUMAN
AccessioniPrimary (citable) accession number: Q9H7J1
Secondary accession number(s): D3DS47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: March 28, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health