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Q9H7J1 (PPR3E_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein phosphatase 1 regulatory subunit 3E
Gene names
Name:PPP1R3E
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a glycogen-targeting subunit for PP1. PP1 is involved in glycogen metabolism and contributes to the activation of glycogen synthase leading to an increase in glycogen synthesis. Ref.1

Tissue specificity

Expressed in skeletal muscle and heart with barely detectable levels in liver. Ref.1

Domain

The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes.

Sequence similarities

Contains 1 CBM21 (carbohydrate binding type-21) domain.

Sequence caution

The sequence BAB15779.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glycogen metabolism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processglycogen metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 279279Protein phosphatase 1 regulatory subunit 3E
PRO_0000338638

Regions

Domain154 – 259106CBM21
Region176 – 19823Glycogen-binding motif
Region248 – 2569Substrate-binding motif
Motif87 – 904PP1-binding motif

Sequences

Sequence LengthMass (Da)Tools
Q9H7J1 [UniParc].

Last modified June 10, 2008. Version 2.
Checksum: E1FC0BEE683C97DC

FASTA27930,644
        10         20         30         40         50         60 
MSRERPPGTD IPRNLSFIAA LTERAYYRSQ RPSLEEEPEE EPGEGGTRFG ARSRAHAPSR 

        70         80         90        100        110        120 
GRRARSAPAG GGGARAPRSR SPDTRKRVRF ADALGLELAV VRRFRPGELP RVPRHVQIQL 

       130        140        150        160        170        180 
QRDALRHFAP CQPRARGLQE ARAALEPASE PGFAARLLTQ RICLERAEAG PLGVAGSARV 

       190        200        210        220        230        240 
VDLAYEKRVS VRWSADGWRS QREAPAAYAG PAPPPPRADR FAFRLPAPPI GGALLFALRY 

       250        260        270 
RVTGHEFWDN NGGRDYALRG PEHPGSGGAP EPQGWIHFI 

« Hide

References

« Hide 'large scale' references
[1]"A novel glycogen-targeting subunit of protein phosphatase 1 that is regulated by insulin and shows differential tissue distribution in humans and rodents."
Munro S., Ceulemans H., Bollen M., Diplexcito J., Cohen P.T.W.
FEBS J. 272:1478-1489(2005) [PubMed: 15752363] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], MOTIF, REGIONS, FUNCTION, TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Spleen.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK024489 mRNA. Translation: BAB15779.1. Different initiation.
CH471078 Genomic DNA. Translation: EAW66170.1.
CH471078 Genomic DNA. Translation: EAW66172.1.
CH471078 Genomic DNA. Translation: EAW66173.1.
IPIIPI00642162.
UniGeneHs.601513.

3D structure databases

ProteinModelPortalQ9H7J1.
SMRQ9H7J1. Positions 135-272.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9H7J1.

Protein family/group databases

CAZyCBM21. Carbohydrate-Binding Module Family 21.

PTM databases

PhosphoSiteQ9H7J1.

Polymorphism databases

DMDM190359980.

Proteomic databases

PRIDEQ9H7J1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000361215; ENSP00000354717; ENSG00000100829.

Organism-specific databases

GeneCardsGC14M023765.
HGNCHGNC:14943. PPP1R3E.
neXtProtNX_Q9H7J1.
GenAtlasSearch...

Phylogenomic databases

GeneTreeENSGT00530000062978.
HOGENOMHBG715688.
HOVERGENHBG108282.
InParanoidQ9H7J1.
OMAHVQIQLQ.
OrthoDBEOG4K0QP5.
PhylomeDBQ9H7J1.

Gene expression databases

ArrayExpressQ9H7J1.
BgeeQ9H7J1.
CleanExHS_PPP1R3E.
GenevestigatorQ9H7J1.

Family and domain databases

InterProIPR005036. CBM_21.
[Graphical view]
PfamPF03370. CBM_21. 1 hit.
[Graphical view]
PROSITEPS51159. CBM21. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePPR3E_HUMAN
AccessionPrimary (citable) accession number: Q9H7J1
Secondary accession number(s): D3DS47
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: January 25, 2012
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families