Reviewed,
UniProtKB/Swiss-Prot Q9H7J1 (PPR3E_HUMAN)
Last modified
July 7, 2009.
Version 32.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Protein phosphatase 1 regulatory subunit 3E | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 279 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Acts as a glycogen-targeting subunit for PP1. PP1 is involved in glycogen metabolism and contributes to the activation of glycogen synthase leading to an increase in glycogen synthesis. Ref.1 |
| Tissue specificity | Expressed in skeletal muscle and heart with barely detectable levels in liver. Ref.1 |
| Domain | The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes. |
| Sequence similarities | Contains 1 CBM21 (carbohydrate binding type-21) domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Carbohydrate metabolism Glycogen metabolism |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | glycogen metabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 279 | 279 | Protein phosphatase 1 regulatory subunit 3E | PRO_0000338638 | |||||
Regions | |||||||||
| Domain | 154 – 259 | 106 | CBM21 | ||||||
| Region | 176 – 198 | 23 | Glycogen-binding motif | ||||||
| Region | 248 – 256 | 9 | Substrate-binding motif | ||||||
| Motif | 87 – 90 | 4 | PP1-binding motif | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A novel glycogen-targeting subunit of protein phosphatase 1 that is regulated by insulin and shows differential tissue distribution in humans and rodents." Munro S., Ceulemans H., Bollen M., Diplexcito J., Cohen P.T.W. FEBS J. 272:1478-1489(2005) [PubMed: 15752363] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], MOTIF, REGIONS, FUNCTION, TISSUE SPECIFICITY. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen. |
Cross-references
Sequence databases | |
|---|---|
| AK024489 mRNA. Translation: BAB15779.1. Different initiation. | |
| IPI | IPI00642162. |
| UniGene | Hs.601513 |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| CAZy | CBM21. Carbohydrate-Binding Module Family 21. |
Proteomic databases | |
| PRIDE | Q9H7J1. |
Genome annotation databases | |
| Ensembl | ENSG00000100829. Homo sapiens. [Contig view] |
Organism-specific databases | |
| GeneCards | GC14M022834. GC14M022835. |
| HGNC | HGNC:14943. PPP1R3E. |
| PharmGKB | PA33655. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q9H7J1. |
Gene expression databases | |
| ArrayExpress | Q9H7J1. |
| Bgee | Q9H7J1. |
| CleanEx | HS_PPP1R3E. |
Family and domain databases | |
| InterPro | IPR005036. CBM_21. [Graphical view] |
| Pfam | PF03370. CBM_21. 1 hit. [Graphical view] |
| PROSITE | PS51159. CBM21. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PPR3E_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9H7J1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 14 Human chromosome 14: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

Clusters with


