Q9H7H0 (MET17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Methyltransferase-like protein 17, mitochondrial
EC=2.1.1.-

Alternative name(s):
False p73 target gene protein
Methyltransferase 11 domain-containing protein 1
Protein RSM22 homolog, mitochondrial

Gene names

Name:	METTL17
Synonyms:	METT11D1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	456 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be a component of the mitochondrial small ribosomal subunit By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the methyltransferase superfamily. Rsm22 family.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transit peptide
Molecular function	Methyltransferase Ribonucleoprotein Ribosomal protein Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ATXN1	P54253	5	EBI-749353,EBI-930964

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H7H0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H7H0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     422-430: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9H7H0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     423-456: DLYRCARVSSWGDLLPVLTPSAFPPSTAQDPSES → YGGCDQNQWD...VSSIYGSGSL

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 19	19	Mitochondrion Potential
	Chain	20 – 456	437	Methyltransferase-like protein 17, mitochondrial		PRO_0000312163
Natural variations
	Alternative sequence	422 – 430	9	Missing in isoform 2.		VSP_029720
	Alternative sequence	423 – 456	34	DLYRC…DPSES → YGGCDQNQWDVAGSCSPRQH LFPQGFVSLCPCQLLGRSFT CAYSVCVSSIYGSGSL in isoform 3.		VSP_029721
	Natural variant	289	1	G → A. Corresponds to variant rs2297717 [ dbSNP | Ensembl ].		VAR_037422
	Natural variant	346	1	A → P. Ref.2 Corresponds to variant rs2771350 [ dbSNP | Ensembl ].		VAR_037423
Experimental info
	Sequence conflict	53	1	P → S in AAK08200. Ref.1
	Sequence conflict	318	1	E → G in AAK08200. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: A23E9EF33C4BD3A1	FASTA	456	50,734
	10 20 30 40 50 60 MAAALKCLLT LGRWCPGLGV APQARALAAL VPGVTQVDNK SGFLQKRPHR QHPGILKLPH 70 80 90 100 110 120 VRLPQALANG AQLLLLGSAG PTMENQVQTL TSYLWSRHLP VEPEELQRRA RHLEKKFLEN 130 140 150 160 170 180 PDLSQTEEKL RGAVLHALRK TTYHWQELSY TEGLSLVYMA ARLDGGFAAV SRAFHEIRAR 190 200 210 220 230 240 NPAFQPQTLM DFGSGTGSVT WAAHSIWGQS LREYMCVDRS AAMLVLAEKL LKGGSESGEP 250 260 270 280 290 300 YIPGVFFRQF LPVSPKVQFD VVVSAFSLSE LPSKADRTEV VQTLWRKTGH FLVLVENGTK 310 320 330 340 350 360 AGHSLLMDAR DLVLKGKEKS PLDPRPGFVF APCPHELPCP QLTNLACSFS QAYHPIPFSW 370 380 390 400 410 420 NKKPKEEKFS MVILARGSPE EAHRWPRITQ PVLKRPRHVH CHLCCPDGHM QHAVLTARRH 430 440 450 GRDLYRCARV SSWGDLLPVL TPSAFPPSTA QDPSES
	Isoform 2 [UniParc]. Checksum: C96AB962BFA9A69D	FASTA	447	49,600
	10 20 30 40 50 60 MAAALKCLLT LGRWCPGLGV APQARALAAL VPGVTQVDNK SGFLQKRPHR QHPGILKLPH 70 80 90 100 110 120 VRLPQALANG AQLLLLGSAG PTMENQVQTL TSYLWSRHLP VEPEELQRRA RHLEKKFLEN 130 140 150 160 170 180 PDLSQTEEKL RGAVLHALRK TTYHWQELSY TEGLSLVYMA ARLDGGFAAV SRAFHEIRAR 190 200 210 220 230 240 NPAFQPQTLM DFGSGTGSVT WAAHSIWGQS LREYMCVDRS AAMLVLAEKL LKGGSESGEP 250 260 270 280 290 300 YIPGVFFRQF LPVSPKVQFD VVVSAFSLSE LPSKADRTEV VQTLWRKTGH FLVLVENGTK 310 320 330 340 350 360 AGHSLLMDAR DLVLKGKEKS PLDPRPGFVF APCPHELPCP QLTNLACSFS QAYHPIPFSW 370 380 390 400 410 420 NKKPKEEKFS MVILARGSPE EAHRWPRITQ PVLKRPRHVH CHLCCPDGHM QHAVLTARRH 430 440 GSSWGDLLPV LTPSAFPPST AQDPSES
	Isoform 3 [UniParc]. Checksum: 014BF85E346BF3F4	FASTA	478	53,051
	10 20 30 40 50 60 MAAALKCLLT LGRWCPGLGV APQARALAAL VPGVTQVDNK SGFLQKRPHR QHPGILKLPH 70 80 90 100 110 120 VRLPQALANG AQLLLLGSAG PTMENQVQTL TSYLWSRHLP VEPEELQRRA RHLEKKFLEN 130 140 150 160 170 180 PDLSQTEEKL RGAVLHALRK TTYHWQELSY TEGLSLVYMA ARLDGGFAAV SRAFHEIRAR 190 200 210 220 230 240 NPAFQPQTLM DFGSGTGSVT WAAHSIWGQS LREYMCVDRS AAMLVLAEKL LKGGSESGEP 250 260 270 280 290 300 YIPGVFFRQF LPVSPKVQFD VVVSAFSLSE LPSKADRTEV VQTLWRKTGH FLVLVENGTK 310 320 330 340 350 360 AGHSLLMDAR DLVLKGKEKS PLDPRPGFVF APCPHELPCP QLTNLACSFS QAYHPIPFSW 370 380 390 400 410 420 NKKPKEEKFS MVILARGSPE EAHRWPRITQ PVLKRPRHVH CHLCCPDGHM QHAVLTARRH 430 440 450 460 470 GRYGGCDQNQ WDVAGSCSPR QHLFPQGFVS LCPCQLLGRS FTCAYSVCVS SIYGSGSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human genomic sequence of a false p73 target gene." Zheng X., Chen X. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 3). Tissue: Mammary cancer.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PRO-346. Tissue: Adipose tissue.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Lung.
[5]	"Identification of 12 new yeast mitochondrial ribosomal proteins including 6 that have no prokaryotic homologues." Saveanu C., Fromont-Racine M., Harington A., Ricard F., Namane A., Jacquier A. J. Biol. Chem. 276:15861-15867(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF321002 mRNA. Translation: AAK08200.1. AF321003 Genomic DNA. Translation: AAK08201.1. AK024512 mRNA. Translation: BAB14919.1. CH471078 Genomic DNA. Translation: EAW66433.1. CH471078 Genomic DNA. Translation: EAW66434.1. BC005053 mRNA. Translation: AAH05053.1.
IPI	IPI00289084. IPI00329663. IPI00876996.
RefSeq	NP_001025162.1. NM_001029991.1. NP_073571.1. NM_022734.2.
UniGene	Hs.512693.
3D structure databases
ProteinModelPortal	Q9H7H0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H7H0. 2 interactions.
MINT	MINT-2875825.
STRING	9606.ENSP00000372445.
PTM databases
PhosphoSite	Q9H7H0.
Polymorphism databases
DMDM	74718673.
Proteomic databases
PaxDb	Q9H7H0.
PRIDE	Q9H7H0.
Protocols and materials databases
DNASU	64745.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000339374; ENSP00000343041; ENSG00000165792. ENST00000382985; ENSP00000372445; ENSG00000165792.
GeneID	64745.
KEGG	hsa:64745.
UCSC	uc001vym.3. human. uc001vyn.3. human. uc001vyo.3. human.
Organism-specific databases
CTD	64745.
GeneCards	GC14P021458.
H-InvDB	HIX0011497.
HGNC	HGNC:19280. METTL17.
HPA	HPA002955.
neXtProt	NX_Q9H7H0.
PharmGKB	PA145008140.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5459.
HOVERGEN	HBG061595.
OMA	NRWPRIT.
OrthoDB	EOG4RJG1K.
PhylomeDB	Q9H7H0.
Gene expression databases
ArrayExpress	Q9H7H0.
Bgee	Q9H7H0.
CleanEx	HS_METT11D1.
Genevestigator	Q9H7H0.
Family and domain databases
InterPro	IPR007533. Cyt_c_oxidase_assmbl_CtaG. IPR015324. Ribosomal_Rsm22_bac-type. [Graphical view]
PANTHER	PTHR21320. PTHR21320. 1 hit.
Pfam	PF09243. Rsm22. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	METTL17. human.
GenomeRNAi	64745.
NextBio	66691.

Entry information

Entry name

MET17_HUMAN

Accession

Primary (citable) accession number: Q9H7H0
Secondary accession number(s): Q9BSH1, Q9BZH2, Q9BZH3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.