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Protein

Probable cation-transporting ATPase 13A3

Gene

ATP13A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4984-aspartylphosphate intermediateBy similarity1
Metal bindingi883MagnesiumBy similarity1
Metal bindingi887MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133657-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cation-transporting ATPase 13A3 (EC:3.6.3.-)
Alternative name(s):
ATPase family homolog up-regulated in senescence cells 1
Gene namesi
Name:ATP13A3
Synonyms:AFURS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24113. ATP13A3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei410 – 430HelicalSequence analysisAdd BLAST21
Transmembranei449 – 469HelicalSequence analysisAdd BLAST21
Transmembranei941 – 961HelicalSequence analysisAdd BLAST21
Transmembranei963 – 983HelicalSequence analysisAdd BLAST21
Transmembranei1000 – 1020HelicalSequence analysisAdd BLAST21
Transmembranei1074 – 1094HelicalSequence analysisAdd BLAST21
Transmembranei1106 – 1126HelicalSequence analysisAdd BLAST21
Transmembranei1144 – 1164HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79572.
OpenTargetsiENSG00000133657.
PharmGKBiPA134971145.

Polymorphism and mutation databases

BioMutaiATP13A3.
DMDMi223590262.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000464251 – 1226Probable cation-transporting ATPase 13A3Add BLAST1226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei98PhosphoserineCombined sources1
Modified residuei817PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H7F0.
MaxQBiQ9H7F0.
PaxDbiQ9H7F0.
PeptideAtlasiQ9H7F0.
PRIDEiQ9H7F0.

PTM databases

iPTMnetiQ9H7F0.
PhosphoSitePlusiQ9H7F0.
SwissPalmiQ9H7F0.

Expressioni

Gene expression databases

BgeeiENSG00000133657.
CleanExiHS_ATP13A3.
ExpressionAtlasiQ9H7F0. baseline and differential.
GenevisibleiQ9H7F0. HS.

Organism-specific databases

HPAiHPA029471.

Interactioni

Protein-protein interaction databases

BioGridi122719. 11 interactors.
IntActiQ9H7F0. 4 interactors.
STRINGi9606.ENSP00000256031.

Structurei

3D structure databases

ProteinModelPortaliQ9H7F0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi231 – 234Poly-Tyr4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.
GeneTreeiENSGT00530000063001.
HOGENOMiHOG000171813.
HOVERGENiHBG065757.
InParanoidiQ9H7F0.
KOiK14951.
OMAiENRHRIS.
OrthoDBiEOG091G01IL.
PhylomeDBiQ9H7F0.
TreeFamiTF300331.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF12409. P5-ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01494. ATPase_P-type. 3 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H7F0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDREERKTIN QGQEDEMEIY GYNLSRWKLA IVSLGVICSG GFLLLLLYWM
60 70 80 90 100
PEWRVKATCV RAAIKDCEVV LLRTTDEFKM WFCAKIRVLS LETYPVSSPK
110 120 130 140 150
SMSNKLSNGH AVCLIENPTE ENRHRISKYS QTESQQIRYF THHSVKYFWN
160 170 180 190 200
DTIHNFDFLK GLDEGVSCTS IYEKHSAGLT KGMHAYRKLL YGVNEIAVKV
210 220 230 240 250
PSVFKLLIKE VLNPFYIFQL FSVILWSTDE YYYYALAIVV MSIVSIVSSL
260 270 280 290 300
YSIRKQYVML HDMVATHSTV RVSVCRVNEE IEEIFSTDLV PGDVMVIPLN
310 320 330 340 350
GTIMPCDAVL INGTCIVNES MLTGESVPVT KTNLPNPSVD VKGIGDELYN
360 370 380 390 400
PETHKRHTLF CGTTVIQTRF YTGELVKAIV VRTGFSTSKG QLVRSILYPK
410 420 430 440 450
PTDFKLYRDA YLFLLCLVAV AGIGFIYTII NSILNEVQVG VIIIESLDII
460 470 480 490 500
TITVPPALPA AMTAGIVYAQ RRLKKIGIFC ISPQRINICG QLNLVCFDKT
510 520 530 540 550
GTLTEDGLDL WGIQRVENAR FLSPEENVCN EMLVKSQFVA CMATCHSLTK
560 570 580 590 600
IEGVLSGDPL DLKMFEAIGW ILEEATEEET ALHNRIMPTV VRPPKQLLPE
610 620 630 640 650
STPAGNQEME LFELPATYEI GIVRQFPFSS ALQRMSVVAR VLGDRKMDAY
660 670 680 690 700
MKGAPEAIAG LCKPETVPVD FQNVLEDFTK QGFRVIALAH RKLESKLTWH
710 720 730 740 750
KVQNISRDAI ENNMDFMGLI IMQNKLKQET PAVLEDLHKA NIRTVMVTGD
760 770 780 790 800
SMLTAVSVAR DCGMILPQDK VIIAEALPPK DGKVAKINWH YADSLTQCSH
810 820 830 840 850
PSAIDPEAIP VKLVHDSLED LQMTRYHFAM NGKSFSVILE HFQDLVPKLM
860 870 880 890 900
LHGTVFARMA PDQKTQLIEA LQNVDYFVGM CGDGANDCGA LKRAHGGISL
910 920 930 940 950
SELEASVASP FTSKTPSISC VPNLIREGRA ALITSFCVFK FMALYSIIQY
960 970 980 990 1000
FSVTLLYSIL SNLGDFQFLF IDLAIILVVV FTMSLNPAWK ELVAQRPPSG
1010 1020 1030 1040 1050
LISGALLFSV LSQIIICIGF QSLGFFWVKQ QPWYEVWHPK SDACNTTGSG
1060 1070 1080 1090 1100
FWNSSHVDNE TELDEHNIQN YENTTVFFIS SFQYLIVAIA FSKGKPFRQP
1110 1120 1130 1140 1150
CYKNYFFVFS VIFLYIFILF IMLYPVASVD QVLQIVCVPY QWRVTMLIIV
1160 1170 1180 1190 1200
LVNAFVSITV EESVDRWGKC CLPWALGCRK KTPKAKYMYL AQELLVDPEW
1210 1220
PPKPQTTTEA KALVKENGSC QIITIT
Length:1,226
Mass (Da):138,043
Last modified:February 10, 2009 - v4
Checksum:i8DD1C0451223C7AB
GO
Isoform 2 (identifier: Q9H7F0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-277: Missing.
     278-279: NE → MS
     936-978: FCVFKFMALY...LFIDLAIILV → SCELALFSIV...FHNCAFYSLV
     979-1226: Missing.

Note: Dubious isoform produced through aberrant splice sites.
Show »
Length:701
Mass (Da):77,310
Checksum:i7927AFFE8413247F
GO

Sequence cautioni

The sequence BAB14942 differs from that shown. Reason: Frameshift at position 1065.Curated
The sequence BAB14942 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC11398 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti347E → Q in CAC84902 (PubMed:11867234).Curated1
Sequence conflicti730T → P in CAC84902 (PubMed:11867234).Curated1
Sequence conflicti784V → F in BAC11398 (PubMed:14702039).Curated1
Sequence conflicti807E → G in BAC11398 (PubMed:14702039).Curated1
Sequence conflicti964G → R in BAC11398 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0073141 – 277Missing in isoform 2. 1 PublicationAdd BLAST277
Alternative sequenceiVSP_036300278 – 279NE → MS in isoform 2. 1 Publication2
Alternative sequenceiVSP_007315936 – 978FCVFK…AIILV → SCELALFSIVTYSLDHFIIS ILISSMLVLFFSDFHNCAFY SLV in isoform 2. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_007316979 – 1226Missing in isoform 2. 1 PublicationAdd BLAST248

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306929 mRNA. Translation: CAC84902.1.
AC108676 Genomic DNA. No translation available.
AC125362 Genomic DNA. No translation available.
AK024639 mRNA. Translation: BAB14942.1. Sequence problems.
AK075094 mRNA. Translation: BAC11398.1. Different initiation.
CCDSiCCDS43187.1. [Q9H7F0-1]
RefSeqiNP_078800.3. NM_024524.3. [Q9H7F0-1]
XP_011511425.1. XM_011513123.2. [Q9H7F0-1]
UniGeneiHs.529609.

Genome annotation databases

EnsembliENST00000256031; ENSP00000256031; ENSG00000133657. [Q9H7F0-1]
ENST00000439040; ENSP00000416508; ENSG00000133657. [Q9H7F0-1]
GeneIDi79572.
KEGGihsa:79572.
UCSCiuc003fty.5. human. [Q9H7F0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306929 mRNA. Translation: CAC84902.1.
AC108676 Genomic DNA. No translation available.
AC125362 Genomic DNA. No translation available.
AK024639 mRNA. Translation: BAB14942.1. Sequence problems.
AK075094 mRNA. Translation: BAC11398.1. Different initiation.
CCDSiCCDS43187.1. [Q9H7F0-1]
RefSeqiNP_078800.3. NM_024524.3. [Q9H7F0-1]
XP_011511425.1. XM_011513123.2. [Q9H7F0-1]
UniGeneiHs.529609.

3D structure databases

ProteinModelPortaliQ9H7F0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122719. 11 interactors.
IntActiQ9H7F0. 4 interactors.
STRINGi9606.ENSP00000256031.

PTM databases

iPTMnetiQ9H7F0.
PhosphoSitePlusiQ9H7F0.
SwissPalmiQ9H7F0.

Polymorphism and mutation databases

BioMutaiATP13A3.
DMDMi223590262.

Proteomic databases

EPDiQ9H7F0.
MaxQBiQ9H7F0.
PaxDbiQ9H7F0.
PeptideAtlasiQ9H7F0.
PRIDEiQ9H7F0.

Protocols and materials databases

DNASUi79572.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256031; ENSP00000256031; ENSG00000133657. [Q9H7F0-1]
ENST00000439040; ENSP00000416508; ENSG00000133657. [Q9H7F0-1]
GeneIDi79572.
KEGGihsa:79572.
UCSCiuc003fty.5. human. [Q9H7F0-1]

Organism-specific databases

CTDi79572.
DisGeNETi79572.
GeneCardsiATP13A3.
HGNCiHGNC:24113. ATP13A3.
HPAiHPA029471.
MIMi610232. gene.
neXtProtiNX_Q9H7F0.
OpenTargetsiENSG00000133657.
PharmGKBiPA134971145.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.
GeneTreeiENSGT00530000063001.
HOGENOMiHOG000171813.
HOVERGENiHBG065757.
InParanoidiQ9H7F0.
KOiK14951.
OMAiENRHRIS.
OrthoDBiEOG091G01IL.
PhylomeDBiQ9H7F0.
TreeFamiTF300331.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133657-MONOMER.

Miscellaneous databases

ChiTaRSiATP13A3. human.
GeneWikiiATP13A3.
GenomeRNAii79572.
PROiQ9H7F0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133657.
CleanExiHS_ATP13A3.
ExpressionAtlasiQ9H7F0. baseline and differential.
GenevisibleiQ9H7F0. HS.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF12409. P5-ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01494. ATPase_P-type. 3 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT133_HUMAN
AccessioniPrimary (citable) accession number: Q9H7F0
Secondary accession number(s): Q8NC11, Q96KS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: February 10, 2009
Last modified: November 2, 2016
This is version 136 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.