ID CH033_HUMAN Reviewed; 229 AA. AC Q9H7E9; A6NGC0; Q96BT8; DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2001, sequence version 1. DT 27-MAR-2024, entry version 155. DE RecName: Full=UPF0488 protein C8orf33; GN Name=C8orf33; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Endothelial cell; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16421571; DOI=10.1038/nature04406; RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., RA Platzer M., Shimizu N., Lander E.S.; RT "DNA sequence and analysis of human chromosome 8."; RL Nature 439:331-335(2006). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE RP [LARGE SCALE MRNA] OF 76-229 (ISOFORM 2). RC TISSUE=Brain, and Uterus; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY RP [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a RT refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [7] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.; RT "Quantitative phosphoproteomics reveals widespread full phosphorylation RT site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [9] RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-27, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Colon carcinoma; RX PubMed=24129315; DOI=10.1074/mcp.o113.027870; RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M., RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V., RA Bedford M.T., Comb M.J.; RT "Immunoaffinity enrichment and mass spectrometry analysis of protein RT methylation."; RL Mol. Cell. Proteomics 13:372-387(2014). RN [10] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; DOI=10.1002/pmic.201400617; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D., RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- INTERACTION: CC Q9H7E9; Q8NHQ1: CEP70; NbExp=5; IntAct=EBI-715389, EBI-739624; CC Q9H7E9; P13569: CFTR; NbExp=5; IntAct=EBI-715389, EBI-349854; CC Q9H7E9; Q9NRI5-2: DISC1; NbExp=3; IntAct=EBI-715389, EBI-11988027; CC Q9H7E9; Q8IZU0: FAM9B; NbExp=3; IntAct=EBI-715389, EBI-10175124; CC Q9H7E9; Q6NT76: HMBOX1; NbExp=6; IntAct=EBI-715389, EBI-2549423; CC Q9H7E9; Q13422: IKZF1; NbExp=3; IntAct=EBI-715389, EBI-745305; CC Q9H7E9; Q13422-7: IKZF1; NbExp=3; IntAct=EBI-715389, EBI-11522367; CC Q9H7E9; Q8NC69: KCTD6; NbExp=3; IntAct=EBI-715389, EBI-2511344; CC Q9H7E9; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-715389, EBI-10172290; CC Q9H7E9; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-715389, EBI-741037; CC Q9H7E9; P23508: MCC; NbExp=3; IntAct=EBI-715389, EBI-307531; CC Q9H7E9; Q99750: MDFI; NbExp=5; IntAct=EBI-715389, EBI-724076; CC Q9H7E9; Q96RE7: NACC1; NbExp=3; IntAct=EBI-715389, EBI-7950997; CC Q9H7E9; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-715389, EBI-79165; CC Q9H7E9; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-715389, EBI-302345; CC Q9H7E9; Q15025: TNIP1; NbExp=3; IntAct=EBI-715389, EBI-357849; CC Q9H7E9; P36406: TRIM23; NbExp=3; IntAct=EBI-715389, EBI-740098; CC Q9H7E9; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-715389, EBI-725997; CC Q9H7E9; Q8TF50: ZNF526; NbExp=3; IntAct=EBI-715389, EBI-11035148; CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q9H7E9-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9H7E9-2; Sequence=VSP_028169; CC -!- SIMILARITY: Belongs to the UPF0488 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK024642; BAB14943.1; -; mRNA. DR EMBL; CR457330; CAG33611.1; -; mRNA. DR EMBL; AC139103; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471162; EAW82023.1; -; Genomic_DNA. DR EMBL; BC010001; AAH10001.1; -; mRNA. DR EMBL; BC015181; AAH15181.1; -; mRNA. DR CCDS; CCDS34974.1; -. [Q9H7E9-1] DR RefSeq; NP_075568.1; NM_023080.2. [Q9H7E9-1] DR AlphaFoldDB; Q9H7E9; -. DR SMR; Q9H7E9; -. DR BioGRID; 122420; 198. DR IntAct; Q9H7E9; 79. DR MINT; Q9H7E9; -. DR STRING; 9606.ENSP00000330361; -. DR GlyCosmos; Q9H7E9; 1 site, 1 glycan. DR GlyGen; Q9H7E9; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q9H7E9; -. DR PhosphoSitePlus; Q9H7E9; -. DR BioMuta; C8orf33; -. DR DMDM; 74733630; -. DR EPD; Q9H7E9; -. DR jPOST; Q9H7E9; -. DR MassIVE; Q9H7E9; -. DR MaxQB; Q9H7E9; -. DR PaxDb; 9606-ENSP00000330361; -. DR PeptideAtlas; Q9H7E9; -. DR ProteomicsDB; 81116; -. [Q9H7E9-1] DR ProteomicsDB; 81117; -. [Q9H7E9-2] DR Pumba; Q9H7E9; -. DR Antibodypedia; 28690; 84 antibodies from 13 providers. DR DNASU; 65265; -. DR Ensembl; ENST00000331434.7; ENSP00000330361.6; ENSG00000182307.14. [Q9H7E9-1] DR Ensembl; ENST00000707298.1; ENSP00000516830.1; ENSG00000291362.1. [Q9H7E9-1] DR GeneID; 65265; -. DR KEGG; hsa:65265; -. DR MANE-Select; ENST00000331434.7; ENSP00000330361.6; NM_023080.3; NP_075568.1. DR UCSC; uc003zfc.5; human. [Q9H7E9-1] DR AGR; HGNC:26104; -. DR CTD; 65265; -. DR DisGeNET; 65265; -. DR GeneCards; C8orf33; -. DR HGNC; HGNC:26104; C8orf33. DR HPA; ENSG00000182307; Low tissue specificity. DR neXtProt; NX_Q9H7E9; -. DR OpenTargets; ENSG00000182307; -. DR PharmGKB; PA142672352; -. DR VEuPathDB; HostDB:ENSG00000182307; -. DR eggNOG; ENOG502S1RU; Eukaryota. DR GeneTree; ENSGT00390000000306; -. DR HOGENOM; CLU_082144_1_1_1; -. DR InParanoid; Q9H7E9; -. DR OMA; CLCAGQP; -. DR OrthoDB; 3740726at2759; -. DR PhylomeDB; Q9H7E9; -. DR TreeFam; TF326272; -. DR PathwayCommons; Q9H7E9; -. DR SignaLink; Q9H7E9; -. DR BioGRID-ORCS; 65265; 103 hits in 1146 CRISPR screens. DR ChiTaRS; C8orf33; human. DR GenomeRNAi; 65265; -. DR Pharos; Q9H7E9; Tdark. DR PRO; PR:Q9H7E9; -. DR Proteomes; UP000005640; Chromosome 8. DR RNAct; Q9H7E9; Protein. DR Bgee; ENSG00000182307; Expressed in right adrenal gland cortex and 196 other cell types or tissues. DR ExpressionAtlas; Q9H7E9; baseline and differential. DR InterPro; IPR029274; DUF4615. DR PANTHER; PTHR13602; UNCHARACTERIZED; 1. DR PANTHER; PTHR13602:SF2; UPF0488 PROTEIN C8ORF33; 1. DR Pfam; PF15393; DUF4615; 1. DR Genevisible; Q9H7E9; HS. PE 1: Evidence at protein level; KW Acetylation; Alternative splicing; Methylation; Phosphoprotein; KW Reference proteome. FT INIT_MET 1 FT /note="Removed" FT /evidence="ECO:0007744|PubMed:19413330" FT CHAIN 2..229 FT /note="UPF0488 protein C8orf33" FT /id="PRO_0000304982" FT REGION 1..98 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 33..54 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 2 FT /note="N-acetylalanine" FT /evidence="ECO:0007744|PubMed:19413330" FT MOD_RES 27 FT /note="Omega-N-methylarginine" FT /evidence="ECO:0007744|PubMed:24129315" FT MOD_RES 82 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:20068231" FT VAR_SEQ 106 FT /note="Q -> QARAGFGREGWNPR (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_028169" SQ SEQUENCE 229 AA; 24993 MW; EFAFCF3ED552AC45 CRC64; MAALGHLAGE AAAAPGPGTP CASRGARLPG PVSSARNPST VCLCPEQPTC SNADSRAHPL GDEGGTASKK QKNKKKTRNR ASVANGGEKA SEKLAPEEVP LSAEAQAQQL AQELAWCVEQ LELGLKRQKP TPKQKEQAIG AIRTLRSKRT PLPRKRQLMH SLFGDYRAQM EAEWREALRA LRAAAYSAQV QPVDGATRKK SQRVCRPRSI WRAKATLDMP DEEFRFNFF //