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Protein

UPF0488 protein C8orf33

Gene

C8orf33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0488 protein C8orf33
Gene namesi
Name:C8orf33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:26104. C8orf33.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672352.

Polymorphism and mutation databases

BioMutaiC8orf33.
DMDMi74733630.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 229228UPF0488 protein C8orf33PRO_0000304982Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei82 – 821Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9H7E9.
PaxDbiQ9H7E9.
PRIDEiQ9H7E9.

PTM databases

PhosphoSiteiQ9H7E9.

Expressioni

Gene expression databases

BgeeiQ9H7E9.
CleanExiHS_C8orf33.
GenevestigatoriQ9H7E9.

Organism-specific databases

HPAiHPA024812.
HPA026104.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP70Q8NHQ14EBI-715389,EBI-739624
FAM9BQ8IZU03EBI-715389,EBI-10175124
HMBOX1Q6NT763EBI-715389,EBI-2549423
IKZF1Q134223EBI-715389,EBI-745305
KCTD6Q8NC693EBI-715389,EBI-2511344
KRTAP10-7P604093EBI-715389,EBI-10172290
LZTS2Q9BRK43EBI-715389,EBI-741037
PNMA1Q8ND903EBI-715389,EBI-302345
TRIM23P364063EBI-715389,EBI-740098

Protein-protein interaction databases

BioGridi122420. 53 interactions.
IntActiQ9H7E9. 44 interactions.
MINTiMINT-1396236.
STRINGi9606.ENSP00000330361.

Structurei

3D structure databases

ProteinModelPortaliQ9H7E9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0488 family.Curated

Phylogenomic databases

eggNOGiNOG76812.
GeneTreeiENSGT00390000000306.
HOGENOMiHOG000111613.
HOVERGENiHBG097250.
InParanoidiQ9H7E9.
OMAiSQRVCRP.
OrthoDBiEOG7RV9HN.
PhylomeDBiQ9H7E9.
TreeFamiTF326272.

Family and domain databases

InterProiIPR029274. DUF4615.
[Graphical view]
PfamiPF15393. DUF4615. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H7E9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALGHLAGE AAAAPGPGTP CASRGARLPG PVSSARNPST VCLCPEQPTC
60 70 80 90 100
SNADSRAHPL GDEGGTASKK QKNKKKTRNR ASVANGGEKA SEKLAPEEVP
110 120 130 140 150
LSAEAQAQQL AQELAWCVEQ LELGLKRQKP TPKQKEQAIG AIRTLRSKRT
160 170 180 190 200
PLPRKRQLMH SLFGDYRAQM EAEWREALRA LRAAAYSAQV QPVDGATRKK
210 220
SQRVCRPRSI WRAKATLDMP DEEFRFNFF
Length:229
Mass (Da):24,993
Last modified:March 1, 2001 - v1
Checksum:iEFAFCF3ED552AC45
GO
Isoform 2 (identifier: Q9H7E9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-106: Q → QARAGFGREGWNPR

Note: No experimental confirmation available.

Show »
Length:242
Mass (Da):26,448
Checksum:iEA75900805D43331
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei106 – 1061Q → QARAGFGREGWNPR in isoform 2. 1 PublicationVSP_028169

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024642 mRNA. Translation: BAB14943.1.
CR457330 mRNA. Translation: CAG33611.1.
AC139103 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82023.1.
BC010001 mRNA. Translation: AAH10001.1.
BC015181 mRNA. Translation: AAH15181.1.
CCDSiCCDS34974.1. [Q9H7E9-1]
RefSeqiNP_075568.1. NM_023080.2. [Q9H7E9-1]
UniGeneiHs.169615.

Genome annotation databases

EnsembliENST00000331434; ENSP00000330361; ENSG00000182307. [Q9H7E9-1]
GeneIDi65265.
KEGGihsa:65265.
UCSCiuc003zfc.4. human. [Q9H7E9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024642 mRNA. Translation: BAB14943.1.
CR457330 mRNA. Translation: CAG33611.1.
AC139103 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82023.1.
BC010001 mRNA. Translation: AAH10001.1.
BC015181 mRNA. Translation: AAH15181.1.
CCDSiCCDS34974.1. [Q9H7E9-1]
RefSeqiNP_075568.1. NM_023080.2. [Q9H7E9-1]
UniGeneiHs.169615.

3D structure databases

ProteinModelPortaliQ9H7E9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122420. 53 interactions.
IntActiQ9H7E9. 44 interactions.
MINTiMINT-1396236.
STRINGi9606.ENSP00000330361.

PTM databases

PhosphoSiteiQ9H7E9.

Polymorphism and mutation databases

BioMutaiC8orf33.
DMDMi74733630.

Proteomic databases

MaxQBiQ9H7E9.
PaxDbiQ9H7E9.
PRIDEiQ9H7E9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331434; ENSP00000330361; ENSG00000182307. [Q9H7E9-1]
GeneIDi65265.
KEGGihsa:65265.
UCSCiuc003zfc.4. human. [Q9H7E9-1]

Organism-specific databases

CTDi65265.
GeneCardsiGC08P146249.
H-InvDBHIX0019175.
HGNCiHGNC:26104. C8orf33.
HPAiHPA024812.
HPA026104.
neXtProtiNX_Q9H7E9.
PharmGKBiPA142672352.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG76812.
GeneTreeiENSGT00390000000306.
HOGENOMiHOG000111613.
HOVERGENiHBG097250.
InParanoidiQ9H7E9.
OMAiSQRVCRP.
OrthoDBiEOG7RV9HN.
PhylomeDBiQ9H7E9.
TreeFamiTF326272.

Miscellaneous databases

ChiTaRSiC8orf33. human.
GenomeRNAii65265.
NextBioi67394.
PROiQ9H7E9.

Gene expression databases

BgeeiQ9H7E9.
CleanExiHS_C8orf33.
GenevestigatoriQ9H7E9.

Family and domain databases

InterProiIPR029274. DUF4615.
[Graphical view]
PfamiPF15393. DUF4615. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Endothelial cell.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 76-229 (ISOFORM 2).
    Tissue: Brain and Uterus.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCH033_HUMAN
AccessioniPrimary (citable) accession number: Q9H7E9
Secondary accession number(s): A6NGC0, Q96BT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 1, 2001
Last modified: May 27, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.