Reviewed, UniProtKB/Swiss-Prot Q9H7E9 (CH033_HUMAN)

Names and origin

Protein names

Recommended name:
    UPF0488 protein C8orf33

Gene names

Name:

C8orf33

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the UPF0488 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H7E9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H7E9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     106-106: Q → QARAGFGREGWNPR

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 229	228	UPF0488 protein C8orf33		PRO_0000304982
Amino acid modifications
	Modified residue	2	1	N-acetylalanine
Natural variations
	Alternative sequence	106	1	Q → QARAGFGREGWNPR in isoform 2.		VSP_028169

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: EFAFCF3ED552AC45	FASTA	229	24,993
	10 20 30 40 50 60 MAALGHLAGE AAAAPGPGTP CASRGARLPG PVSSARNPST VCLCPEQPTC SNADSRAHPL 70 80 90 100 110 120 GDEGGTASKK QKNKKKTRNR ASVANGGEKA SEKLAPEEVP LSAEAQAQQL AQELAWCVEQ 130 140 150 160 170 180 LELGLKRQKP TPKQKEQAIG AIRTLRSKRT PLPRKRQLMH SLFGDYRAQM EAEWREALRA 190 200 210 220 LRAAAYSAQV QPVDGATRKK SQRVCRPRSI WRAKATLDMP DEEFRFNFF
	Isoform 2. Checksum: EA75900805D43331	FASTA	242	26,448
	10 20 30 40 50 60 MAALGHLAGE AAAAPGPGTP CASRGARLPG PVSSARNPST VCLCPEQPTC SNADSRAHPL 70 80 90 100 110 120 GDEGGTASKK QKNKKKTRNR ASVANGGEKA SEKLAPEEVP LSAEAQARAG FGREGWNPRA 130 140 150 160 170 180 QQLAQELAWC VEQLELGLKR QKPTPKQKEQ AIGAIRTLRS KRTPLPRKRQ LMHSLFGDYR 190 200 210 220 230 240 AQMEAEWREA LRALRAAAYS AQVQPVDGAT RKKSQRVCRP RSIWRAKATL DMPDEEFRFN FF

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Endothelial cell.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed: 16421571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 76-229 (ISOFORM 2). Tissue: Brain and Uterus.
[6]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[7]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK024642 mRNA. Translation: BAB14943.1. CR457330 mRNA. Translation: CAG33611.1. AC139103 Genomic DNA. No translation available. CH471162 Genomic DNA. Translation: EAW82023.1. BC010001 mRNA. Translation: AAH10001.1. BC015181 mRNA. Translation: AAH15181.1.
IPI	IPI00011997. IPI00867735.
RefSeq	NP_075568.1.
UniGene	Hs.169615
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H7E9. 4 interactions.
STRING	Q9H7E9.
Proteomic databases
PRIDE	Q9H7E9.
Genome annotation databases
Ensembl	ENST00000331434; ENSP00000330361; ENSG00000182307; Homo sapiens. [Genome view]
GeneID	65265.
KEGG	hsa:65265.
UCSC	uc003zfc.2. human.
Organism-specific databases
CTD	65265.
GeneCards	GC08P146249.
HGNC	HGNC:26104. C8orf33.
PharmGKB	PA142672352.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9H7E9.
OMA	SVANGGE
OrthoDB	EOG9CG2VN
Gene expression databases
ArrayExpress	Q9H7E9.
Bgee	Q9H7E9.
CleanEx	HS_C8orf33.
Genevestigator	Q9H7E9.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	67394.

Entry information

Entry name

CH033_HUMAN

Accession

Primary (citable) accession number: Q9H7E9
Secondary accession number(s): A6NGC0, Q96BT8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	March 1, 2001
Last modified:	November 24, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.