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Q9H7E9

- CH033_HUMAN

UniProt

Q9H7E9 - CH033_HUMAN

Protein

UPF0488 protein C8orf33

Gene

C8orf33

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UPF0488 protein C8orf33
    Gene namesi
    Name:C8orf33
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:26104. C8orf33.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672352.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 229228UPF0488 protein C8orf33PRO_0000304982Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei82 – 821Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9H7E9.
    PaxDbiQ9H7E9.
    PRIDEiQ9H7E9.

    PTM databases

    PhosphoSiteiQ9H7E9.

    Expressioni

    Gene expression databases

    BgeeiQ9H7E9.
    CleanExiHS_C8orf33.
    GenevestigatoriQ9H7E9.

    Organism-specific databases

    HPAiHPA024812.
    HPA026104.

    Interactioni

    Protein-protein interaction databases

    BioGridi122420. 37 interactions.
    IntActiQ9H7E9. 35 interactions.
    MINTiMINT-1396236.
    STRINGi9606.ENSP00000330361.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H7E9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UPF0488 family.Curated

    Phylogenomic databases

    eggNOGiNOG76812.
    HOGENOMiHOG000111613.
    HOVERGENiHBG097250.
    InParanoidiQ9H7E9.
    OMAiSQRVCRP.
    OrthoDBiEOG7RV9HN.
    PhylomeDBiQ9H7E9.
    TreeFamiTF326272.

    Family and domain databases

    InterProiIPR029274. DUF4615.
    [Graphical view]
    PfamiPF15393. DUF4615. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H7E9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAALGHLAGE AAAAPGPGTP CASRGARLPG PVSSARNPST VCLCPEQPTC    50
    SNADSRAHPL GDEGGTASKK QKNKKKTRNR ASVANGGEKA SEKLAPEEVP 100
    LSAEAQAQQL AQELAWCVEQ LELGLKRQKP TPKQKEQAIG AIRTLRSKRT 150
    PLPRKRQLMH SLFGDYRAQM EAEWREALRA LRAAAYSAQV QPVDGATRKK 200
    SQRVCRPRSI WRAKATLDMP DEEFRFNFF 229
    Length:229
    Mass (Da):24,993
    Last modified:March 1, 2001 - v1
    Checksum:iEFAFCF3ED552AC45
    GO
    Isoform 2 (identifier: Q9H7E9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         106-106: Q → QARAGFGREGWNPR

    Note: No experimental confirmation available.

    Show »
    Length:242
    Mass (Da):26,448
    Checksum:iEA75900805D43331
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei106 – 1061Q → QARAGFGREGWNPR in isoform 2. 1 PublicationVSP_028169

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK024642 mRNA. Translation: BAB14943.1.
    CR457330 mRNA. Translation: CAG33611.1.
    AC139103 Genomic DNA. No translation available.
    CH471162 Genomic DNA. Translation: EAW82023.1.
    BC010001 mRNA. Translation: AAH10001.1.
    BC015181 mRNA. Translation: AAH15181.1.
    CCDSiCCDS34974.1. [Q9H7E9-1]
    RefSeqiNP_075568.1. NM_023080.2. [Q9H7E9-1]
    UniGeneiHs.169615.

    Genome annotation databases

    EnsembliENST00000331434; ENSP00000330361; ENSG00000182307. [Q9H7E9-1]
    GeneIDi65265.
    KEGGihsa:65265.
    UCSCiuc003zfc.4. human. [Q9H7E9-1]

    Polymorphism databases

    DMDMi74733630.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK024642 mRNA. Translation: BAB14943.1 .
    CR457330 mRNA. Translation: CAG33611.1 .
    AC139103 Genomic DNA. No translation available.
    CH471162 Genomic DNA. Translation: EAW82023.1 .
    BC010001 mRNA. Translation: AAH10001.1 .
    BC015181 mRNA. Translation: AAH15181.1 .
    CCDSi CCDS34974.1. [Q9H7E9-1 ]
    RefSeqi NP_075568.1. NM_023080.2. [Q9H7E9-1 ]
    UniGenei Hs.169615.

    3D structure databases

    ProteinModelPortali Q9H7E9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122420. 37 interactions.
    IntActi Q9H7E9. 35 interactions.
    MINTi MINT-1396236.
    STRINGi 9606.ENSP00000330361.

    PTM databases

    PhosphoSitei Q9H7E9.

    Polymorphism databases

    DMDMi 74733630.

    Proteomic databases

    MaxQBi Q9H7E9.
    PaxDbi Q9H7E9.
    PRIDEi Q9H7E9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000331434 ; ENSP00000330361 ; ENSG00000182307 . [Q9H7E9-1 ]
    GeneIDi 65265.
    KEGGi hsa:65265.
    UCSCi uc003zfc.4. human. [Q9H7E9-1 ]

    Organism-specific databases

    CTDi 65265.
    GeneCardsi GC08P146249.
    H-InvDB HIX0019175.
    HGNCi HGNC:26104. C8orf33.
    HPAi HPA024812.
    HPA026104.
    neXtProti NX_Q9H7E9.
    PharmGKBi PA142672352.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG76812.
    HOGENOMi HOG000111613.
    HOVERGENi HBG097250.
    InParanoidi Q9H7E9.
    OMAi SQRVCRP.
    OrthoDBi EOG7RV9HN.
    PhylomeDBi Q9H7E9.
    TreeFami TF326272.

    Miscellaneous databases

    GenomeRNAii 65265.
    NextBioi 67394.

    Gene expression databases

    Bgeei Q9H7E9.
    CleanExi HS_C8orf33.
    Genevestigatori Q9H7E9.

    Family and domain databases

    InterProi IPR029274. DUF4615.
    [Graphical view ]
    Pfami PF15393. DUF4615. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Endothelial cell.
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 76-229 (ISOFORM 2).
      Tissue: Brain and Uterus.
    6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCH033_HUMAN
    AccessioniPrimary (citable) accession number: Q9H7E9
    Secondary accession number(s): A6NGC0, Q96BT8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3