Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

WD repeat-containing protein 26

Gene

WDR26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in MAPK pathways.1 Publication

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162923-MONOMER.
SignaLinkiQ9H7D7.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 26
Alternative name(s):
CUL4- and DDB1-associated WDR protein 2
Myocardial ischemic preconditioning up-regulated protein 2
Gene namesi
Name:WDR26
Synonyms:CDW2, MIP2
ORF Names:PRO0852
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:21208. WDR26.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi80232.
OpenTargetsiENSG00000162923.
PharmGKBiPA134907873.

Polymorphism and mutation databases

BioMutaiWDR26.
DMDMi134047967.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513731 – 661WD repeat-containing protein 26Add BLAST661

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei121PhosphoserineCombined sources1
Modified residuei123PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H7D7.
MaxQBiQ9H7D7.
PaxDbiQ9H7D7.
PeptideAtlasiQ9H7D7.
PRIDEiQ9H7D7.

PTM databases

iPTMnetiQ9H7D7.
PhosphoSitePlusiQ9H7D7.

Expressioni

Tissue specificityi

Broadly expressed, with highest levels in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000162923.
CleanExiHS_WDR26.
ExpressionAtlasiQ9H7D7. baseline and differential.
GenevisibleiQ9H7D7. HS.

Organism-specific databases

HPAiHPA028539.
HPA061094.

Interactioni

Subunit structurei

Interacts with DDB1-CUL4A/B E3 ligase complexes.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AXIN1O151694EBI-1046864,EBI-710484

Protein-protein interaction databases

BioGridi123195. 64 interactors.
IntActiQ9H7D7. 35 interactors.
MINTiMINT-4830971.
STRINGi9606.ENSP00000408108.

Structurei

3D structure databases

ProteinModelPortaliQ9H7D7.
SMRiQ9H7D7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 155LisHPROSITE-ProRule annotationAdd BLAST33
Domaini156 – 231CTLHPROSITE-ProRule annotationAdd BLAST76
Repeati353 – 392WD 1Add BLAST40
Repeati399 – 438WD 2Add BLAST40
Repeati444 – 484WD 3Add BLAST41
Repeati524 – 563WD 4Add BLAST40
Repeati566 – 608WD 5Add BLAST43
Repeati611 – 651WD 6Add BLAST41

Sequence similaritiesi

Contains 1 CTLH domain.PROSITE-ProRule annotation
Contains 1 LisH domain.PROSITE-ProRule annotation
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0293. Eukaryota.
ENOG410XQ2U. LUCA.
GeneTreeiENSGT00730000111021.
HOVERGENiHBG083958.
InParanoidiQ9H7D7.
OMAiLLMCPPE.
OrthoDBiEOG091G05NI.
PhylomeDBiQ9H7D7.
TreeFamiTF314869.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR006595. CTLH_C.
IPR006594. LisH.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM00668. CTLH. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H7D7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQANGAGGGG GGGGGGGGGG GGGGGQGQTP ELACLSAQNG ESSPSSSSSA
60 70 80 90 100
GDLAHANGLL PSAPSAASNN SNSLNVNNGV PGGAAAASSA TVAAASATTA
110 120 130 140 150
ASSSLATPEL GSSLKKKKRL SQSDEDVIRL IGQHLNGLGL NQTVDLLMQE
160 170 180 190 200
SGCRLEHPSA TKFRNHVMEG DWDKAENDLN ELKPLVHSPH AIVVRGALEI
210 220 230 240 250
SQTLLGIIVR MKFLLLQQKY LEYLEDGKVL EALQVLRCEL TPLKYNTERI
260 270 280 290 300
HVLSGYLMCS HAEDLRAKAE WEGKGTASRS KLLDKLQTYL PPSVMLPPRR
310 320 330 340 350
LQTLLRQAVE LQRDRCLYHN TKLDNNLDSV SLLIDHVCSR RQFPCYTQQI
360 370 380 390 400
LTEHCNEVWF CKFSNDGTKL ATGSKDTTVI IWQVDPDTHL LKLLKTLEGH
410 420 430 440 450
AYGVSYIAWS PDDNYLVACG PDDCSELWLW NVQTGELRTK MSQSHEDSLT
460 470 480 490 500
SVAWNPDGKR FVTGGQRGQF YQCDLDGNLL DSWEGVRVQC LWCLSDGKTV
510 520 530 540 550
LASDTHQRIR GYNFEDLTDR NIVQEDHPIM SFTISKNGRL ALLNVATQGV
560 570 580 590 600
HLWDLQDRVL VRKYQGVTQG FYTIHSCFGG HNEDFIASGS EDHKVYIWHK
610 620 630 640 650
RSELPIAELT GHTRTVNCVS WNPQIPSMMA SASDDGTVRI WGPAPFIDHQ
660
NIEEECSSMD S
Length:661
Mass (Da):72,124
Last modified:March 20, 2007 - v3
Checksum:iE0B8AAFF44CB7DF7
GO
Isoform 2 (identifier: Q9H7D7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-207: Missing.

Note: No experimental confirmation available.
Show »
Length:645
Mass (Da):70,460
Checksum:i664C8EA291526315
GO
Isoform 3 (identifier: Q9H7D7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     194-216: VRGALEISQTLLGIIVRMKFLLL → AQTFSETSINFFPLTAAFCHVRG
     217-661: Missing.

Note: No experimental confirmation available.
Show »
Length:216
Mass (Da):21,314
Checksum:i0CA772E9A8A59012
GO
Isoform 4 (identifier: Q9H7D7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-223: RMKFLLLQQKYLEY → VNTLLFLVSHLCLF
     224-661: Missing.

Note: No experimental confirmation available.
Show »
Length:223
Mass (Da):22,052
Checksum:i7880CBDF91D06DA0
GO

Sequence cautioni

The sequence AAG35477 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH52301 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH63817 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAO67709 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAQ74770 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence ABK41102 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14955 differs from that shown. Reason: Erroneous termination at position 274. Translated as Lys.Curated
The sequence BAD93124 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8G → A in AAH34498 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023895192 – 207Missing in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_023896194 – 216VRGAL…KFLLL → AQTFSETSINFFPLTAAFCH VRG in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_023897210 – 223RMKFL…KYLEY → VNTLLFLVSHLCLF in isoform 4. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_023898217 – 661Missing in isoform 3. 1 PublicationAdd BLAST445
Alternative sequenceiVSP_023899224 – 661Missing in isoform 4. 1 PublicationAdd BLAST438

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209887 mRNA. Translation: BAD93124.1. Different initiation.
AC099790 Genomic DNA. No translation available.
BC031471 mRNA. Translation: AAH31471.2.
BC034498 mRNA. Translation: AAH34498.1.
BC052301 mRNA. Translation: AAH52301.2. Different initiation.
BC063817 mRNA. Translation: AAH63817.2. Different initiation.
AY221751 mRNA. Translation: AAO67709.1. Different initiation.
AY304473 mRNA. Translation: AAQ74770.1. Different initiation.
AF130049 mRNA. Translation: AAG35477.1. Different initiation.
EF011612 mRNA. Translation: ABK41102.1. Different initiation.
AK024669 mRNA. Translation: BAB14955.1. Sequence problems.
CCDSiCCDS31037.2. [Q9H7D7-1]
RefSeqiNP_001108585.2. NM_001115113.2. [Q9H7D7-2]
NP_079436.4. NM_025160.6. [Q9H7D7-1]
UniGeneiHs.497873.
Hs.729289.

Genome annotation databases

EnsembliENST00000414423; ENSP00000408108; ENSG00000162923. [Q9H7D7-1]
GeneIDi80232.
KEGGihsa:80232.
UCSCiuc001hop.4. human. [Q9H7D7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209887 mRNA. Translation: BAD93124.1. Different initiation.
AC099790 Genomic DNA. No translation available.
BC031471 mRNA. Translation: AAH31471.2.
BC034498 mRNA. Translation: AAH34498.1.
BC052301 mRNA. Translation: AAH52301.2. Different initiation.
BC063817 mRNA. Translation: AAH63817.2. Different initiation.
AY221751 mRNA. Translation: AAO67709.1. Different initiation.
AY304473 mRNA. Translation: AAQ74770.1. Different initiation.
AF130049 mRNA. Translation: AAG35477.1. Different initiation.
EF011612 mRNA. Translation: ABK41102.1. Different initiation.
AK024669 mRNA. Translation: BAB14955.1. Sequence problems.
CCDSiCCDS31037.2. [Q9H7D7-1]
RefSeqiNP_001108585.2. NM_001115113.2. [Q9H7D7-2]
NP_079436.4. NM_025160.6. [Q9H7D7-1]
UniGeneiHs.497873.
Hs.729289.

3D structure databases

ProteinModelPortaliQ9H7D7.
SMRiQ9H7D7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123195. 64 interactors.
IntActiQ9H7D7. 35 interactors.
MINTiMINT-4830971.
STRINGi9606.ENSP00000408108.

PTM databases

iPTMnetiQ9H7D7.
PhosphoSitePlusiQ9H7D7.

Polymorphism and mutation databases

BioMutaiWDR26.
DMDMi134047967.

Proteomic databases

EPDiQ9H7D7.
MaxQBiQ9H7D7.
PaxDbiQ9H7D7.
PeptideAtlasiQ9H7D7.
PRIDEiQ9H7D7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000414423; ENSP00000408108; ENSG00000162923. [Q9H7D7-1]
GeneIDi80232.
KEGGihsa:80232.
UCSCiuc001hop.4. human. [Q9H7D7-1]

Organism-specific databases

CTDi80232.
DisGeNETi80232.
GeneCardsiWDR26.
HGNCiHGNC:21208. WDR26.
HPAiHPA028539.
HPA061094.
neXtProtiNX_Q9H7D7.
OpenTargetsiENSG00000162923.
PharmGKBiPA134907873.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0293. Eukaryota.
ENOG410XQ2U. LUCA.
GeneTreeiENSGT00730000111021.
HOVERGENiHBG083958.
InParanoidiQ9H7D7.
OMAiLLMCPPE.
OrthoDBiEOG091G05NI.
PhylomeDBiQ9H7D7.
TreeFamiTF314869.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162923-MONOMER.
SignaLinkiQ9H7D7.

Miscellaneous databases

ChiTaRSiWDR26. human.
GeneWikiiWDR26.
GenomeRNAii80232.
PROiQ9H7D7.

Gene expression databases

BgeeiENSG00000162923.
CleanExiHS_WDR26.
ExpressionAtlasiQ9H7D7. baseline and differential.
GenevisibleiQ9H7D7. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR006595. CTLH_C.
IPR006594. LisH.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
SMARTiSM00668. CTLH. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR26_HUMAN
AccessioniPrimary (citable) accession number: Q9H7D7
Secondary accession number(s): A0MNN3
, Q4G100, Q59EC4, Q5GLZ9, Q86UY4, Q9H3C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: March 20, 2007
Last modified: November 30, 2016
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.