Q9H7D7 (WDR26_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD repeat-containing protein 26

Alternative name(s):
CUL4- and DDB1-associated WDR protein 2
Myocardial ischemic preconditioning up-regulated protein 2

Gene names

Name:	WDR26
Synonyms:	CDW2, MIP2
ORF Names:	PRO0852

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	661 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in MAPK pathways. Ref.5
Subunit structure	Interacts with DDB1-CUL4A/B E3 ligase complexes. Ref.7
Subcellular location	Cytoplasm Ref.5.
Tissue specificity	Broadly expressed, with highest levels in heart and skeletal muscle. Ref.5
Sequence similarities	Contains 1 CTLH domain. Contains 1 LisH domain. Contains 6 WD repeats.
Sequence caution	The sequence AAG35477.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH52301.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH63817.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAO67709.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAQ74770.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence ABK41102.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB14955.1 differs from that shown. Reason: Erroneous termination at position 274. Translated as Lys. The sequence BAD93124.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Domain	Repeat WD repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from direct assay Ref.5. Source: UniProtKB nucleus Inferred from direct assay. Source: HPA
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H7D7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H7D7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     192-207: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9H7D7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     194-216: VRGALEISQTLLGIIVRMKFLLL → AQTFSETSINFFPLTAAFCHVRG
     217-661: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9H7D7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     210-223: RMKFLLLQQKYLEY → VNTLLFLVSHLCLF
     224-661: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 661	661	WD repeat-containing protein 26		PRO_0000051373
Regions
	Domain	123 – 155	33	LisH
	Domain	156 – 231	76	CTLH
	Repeat	353 – 392	40	WD 1
	Repeat	399 – 438	40	WD 2
	Repeat	444 – 484	41	WD 3
	Repeat	524 – 563	40	WD 4
	Repeat	566 – 608	43	WD 5
	Repeat	611 – 651	41	WD 6
Amino acid modifications
	Modified residue	121	1	Phosphoserine Ref.9 Ref.10
Natural variations
	Alternative sequence	192 – 207	16	Missing in isoform 2.		VSP_023895
	Alternative sequence	194 – 216	23	VRGAL…KFLLL → AQTFSETSINFFPLTAAFCH VRG in isoform 3.		VSP_023896
	Alternative sequence	210 – 223	14	RMKFL…KYLEY → VNTLLFLVSHLCLF in isoform 4.		VSP_023897
	Alternative sequence	217 – 661	445	Missing in isoform 3.		VSP_023898
	Alternative sequence	224 – 661	438	Missing in isoform 4.		VSP_023899
Experimental info
	Sequence conflict	8	1	G → A in AAH34498. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 20, 2007. Version 3. Checksum: E0B8AAFF44CB7DF7	FASTA	661	72,124
	10 20 30 40 50 60 MQANGAGGGG GGGGGGGGGG GGGGGQGQTP ELACLSAQNG ESSPSSSSSA GDLAHANGLL 70 80 90 100 110 120 PSAPSAASNN SNSLNVNNGV PGGAAAASSA TVAAASATTA ASSSLATPEL GSSLKKKKRL 130 140 150 160 170 180 SQSDEDVIRL IGQHLNGLGL NQTVDLLMQE SGCRLEHPSA TKFRNHVMEG DWDKAENDLN 190 200 210 220 230 240 ELKPLVHSPH AIVVRGALEI SQTLLGIIVR MKFLLLQQKY LEYLEDGKVL EALQVLRCEL 250 260 270 280 290 300 TPLKYNTERI HVLSGYLMCS HAEDLRAKAE WEGKGTASRS KLLDKLQTYL PPSVMLPPRR 310 320 330 340 350 360 LQTLLRQAVE LQRDRCLYHN TKLDNNLDSV SLLIDHVCSR RQFPCYTQQI LTEHCNEVWF 370 380 390 400 410 420 CKFSNDGTKL ATGSKDTTVI IWQVDPDTHL LKLLKTLEGH AYGVSYIAWS PDDNYLVACG 430 440 450 460 470 480 PDDCSELWLW NVQTGELRTK MSQSHEDSLT SVAWNPDGKR FVTGGQRGQF YQCDLDGNLL 490 500 510 520 530 540 DSWEGVRVQC LWCLSDGKTV LASDTHQRIR GYNFEDLTDR NIVQEDHPIM SFTISKNGRL 550 560 570 580 590 600 ALLNVATQGV HLWDLQDRVL VRKYQGVTQG FYTIHSCFGG HNEDFIASGS EDHKVYIWHK 610 620 630 640 650 660 RSELPIAELT GHTRTVNCVS WNPQIPSMMA SASDDGTVRI WGPAPFIDHQ NIEEECSSMD S
	Isoform 2 [UniParc]. Checksum: 664C8EA291526315	FASTA	645	70,460
	10 20 30 40 50 60 MQANGAGGGG GGGGGGGGGG GGGGGQGQTP ELACLSAQNG ESSPSSSSSA GDLAHANGLL 70 80 90 100 110 120 PSAPSAASNN SNSLNVNNGV PGGAAAASSA TVAAASATTA ASSSLATPEL GSSLKKKKRL 130 140 150 160 170 180 SQSDEDVIRL IGQHLNGLGL NQTVDLLMQE SGCRLEHPSA TKFRNHVMEG DWDKAENDLN 190 200 210 220 230 240 ELKPLVHSPH AIVRMKFLLL QQKYLEYLED GKVLEALQVL RCELTPLKYN TERIHVLSGY 250 260 270 280 290 300 LMCSHAEDLR AKAEWEGKGT ASRSKLLDKL QTYLPPSVML PPRRLQTLLR QAVELQRDRC 310 320 330 340 350 360 LYHNTKLDNN LDSVSLLIDH VCSRRQFPCY TQQILTEHCN EVWFCKFSND GTKLATGSKD 370 380 390 400 410 420 TTVIIWQVDP DTHLLKLLKT LEGHAYGVSY IAWSPDDNYL VACGPDDCSE LWLWNVQTGE 430 440 450 460 470 480 LRTKMSQSHE DSLTSVAWNP DGKRFVTGGQ RGQFYQCDLD GNLLDSWEGV RVQCLWCLSD 490 500 510 520 530 540 GKTVLASDTH QRIRGYNFED LTDRNIVQED HPIMSFTISK NGRLALLNVA TQGVHLWDLQ 550 560 570 580 590 600 DRVLVRKYQG VTQGFYTIHS CFGGHNEDFI ASGSEDHKVY IWHKRSELPI AELTGHTRTV 610 620 630 640 NCVSWNPQIP SMMASASDDG TVRIWGPAPF IDHQNIEEEC SSMDS
	Isoform 3 [UniParc]. Checksum: 0CA772E9A8A59012	FASTA	216	21,314
	10 20 30 40 50 60 MQANGAGGGG GGGGGGGGGG GGGGGQGQTP ELACLSAQNG ESSPSSSSSA GDLAHANGLL 70 80 90 100 110 120 PSAPSAASNN SNSLNVNNGV PGGAAAASSA TVAAASATTA ASSSLATPEL GSSLKKKKRL 130 140 150 160 170 180 SQSDEDVIRL IGQHLNGLGL NQTVDLLMQE SGCRLEHPSA TKFRNHVMEG DWDKAENDLN 190 200 210 ELKPLVHSPH AIVAQTFSET SINFFPLTAA FCHVRG
	Isoform 4 [UniParc]. Checksum: 7880CBDF91D06DA0	FASTA	223	22,052
	10 20 30 40 50 60 MQANGAGGGG GGGGGGGGGG GGGGGQGQTP ELACLSAQNG ESSPSSSSSA GDLAHANGLL 70 80 90 100 110 120 PSAPSAASNN SNSLNVNNGV PGGAAAASSA TVAAASATTA ASSSLATPEL GSSLKKKKRL 130 140 150 160 170 180 SQSDEDVIRL IGQHLNGLGL NQTVDLLMQE SGCRLEHPSA TKFRNHVMEG DWDKAENDLN 190 200 210 220 ELKPLVHSPH AIVVRGALEI SQTLLGIIVV NTLLFLVSHL CLF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Endothelial cell.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-661 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 138-661 (ISOFORM 1). Tissue: Lung, Testis and Uterus.
[4]	"Human myocardial ischemic preconditioning upregulated gene 2." Yuan C., Xiao X., Zhang H. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-661 (ISOFORM 2).
[5]	"WDR26: a novel Gbeta-like protein, suppresses MAPK signaling pathway." Zhu Y., Wang Y., Xia C., Li D., Li Y., Zeng W., Yuan W., Liu H., Zhu C., Wu X., Liu M. J. Cell. Biochem. 93:579-587(2004) [PubMed: 15378603] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 84-661 (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION, SUBCELLULAR LOCATION. Tissue: Heart.
[6]	"Functional prediction of the coding sequences of 75 new genes deduced by analysis of cDNA clones from human fetal liver." Zhang C., Yu Y., Zhang S., Wei H., Bi J., Zhou G., Dong C., Zai Y., Xu W., Gao F., Liu M., He F. Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 86-661 (ISOFORM 4). Tissue: Fetal liver.
[7]	"CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation." Higa L.A., Wu M., Ye T., Kobayashi R., Sun H., Zhang H. Nat. Cell Biol. 8:1277-1283(2006) [PubMed: 17041588] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 138-661 (ISOFORM 1), INTERACTION WITH CUL4, IDENTIFICATION BY MASS SPECTROMETRY.
[8]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 265-661 (ISOFORM 1).
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-121, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-121, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB209887 mRNA. Translation: BAD93124.1. Different initiation. AC099790 Genomic DNA. No translation available. BC031471 mRNA. Translation: AAH31471.2. BC034498 mRNA. Translation: AAH34498.1. BC052301 mRNA. Translation: AAH52301.2. Different initiation. BC063817 mRNA. Translation: AAH63817.2. Different initiation. AY221751 mRNA. Translation: AAO67709.1. Different initiation. AY304473 mRNA. Translation: AAQ74770.1. Different initiation. AF130049 mRNA. Translation: AAG35477.1. Different initiation. EF011612 mRNA. Translation: ABK41102.1. Different initiation. AK024669 mRNA. Translation: BAB14955.1. Sequence problems.
IPI	IPI00414197. IPI00645819. IPI00646469. IPI00829602.
RefSeq	NP_001108585.2. NM_001115113.2. NP_079436.4. NM_025160.6.
UniGene	Hs.497873.
3D structure databases
ProteinModelPortal	Q9H7D7.
SMR	Q9H7D7. Positions 344-643.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H7D7. 10 interactions.
STRING	Q9H7D7.
PTM databases
PhosphoSite	Q9H7D7.
Polymorphism databases
DMDM	134047967.
Proteomic databases
PRIDE	Q9H7D7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000414423; ENSP00000408108; ENSG00000162923.
GeneID	80232.
KEGG	hsa:80232.
UCSC	uc001hop.2. human. uc001hoq.2. human.
Organism-specific databases
CTD	80232.
GeneCards	GC01M224573.
H-InvDB	HIX0001629.
HGNC	HGNC:21208. WDR26.
HPA	HPA028539.
neXtProt	NX_Q9H7D7.
PharmGKB	PA134907873.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17597.
GeneTree	ENSGT00530000063585.
HOVERGEN	HBG083958.
InParanoid	Q9H7D7.
OMA	PDTHQLK.
OrthoDB	EOG4GHZNV.
PhylomeDB	Q9H7D7.
Gene expression databases
ArrayExpress	Q9H7D7.
Bgee	Q9H7D7.
CleanEx	HS_WDR26.
Genevestigator	Q9H7D7.
GermOnline	ENSG00000162923. Homo sapiens.
Family and domain databases
InterPro	IPR006595. CTLH_C. IPR006594. LisH_dimerisation. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR017986. WD40_repeat_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00400. WD40. 5 hits. [Graphical view]
SMART	SM00668. CTLH. 1 hit. SM00667. LisH. 1 hit. SM00320. WD40. 5 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS50897. CTLH. 1 hit. PS50896. LISH. 1 hit. PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. 3 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	70673.

Entry information

Entry name

WDR26_HUMAN

Accession

Primary (citable) accession number: Q9H7D7
Secondary accession number(s): A0MNN3 , Q4G100, Q59EC4, Q5GLZ9, Q86UY4, Q9H3C2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	March 20, 2007
Last modified:	January 25, 2012
This is version 90 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.