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Protein

Dedicator of cytokinesis protein 5

Gene

DOCK5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of vascular smooth muscle contraction Source: BHF-UCL
  • positive regulation of epithelial cell migration Source: UniProtKB
  • positive regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
  • positive regulation of vascular associated smooth muscle cell migration Source: BHF-UCL
  • small GTPase mediated signal transduction Source: InterPro

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-HSA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Dedicator of cytokinesis protein 5
Gene namesi
Name:DOCK5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147459.17
HGNCiHGNC:23476 DOCK5
MIMi616904 gene
neXtProtiNX_Q9H7D0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi80005
OpenTargetsiENSG00000147459
PharmGKBiPA134932307

Polymorphism and mutation databases

BioMutaiDOCK5
DMDMi119370380

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001899921 – 1870Dedicator of cytokinesis protein 5Add BLAST1870

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei365PhosphoserineCombined sources1
Modified residuei818N6-acetyllysineCombined sources1
Modified residuei1756PhosphoserineCombined sources1
Modified residuei1766PhosphoserineCombined sources1
Modified residuei1785PhosphoserineBy similarity1
Modified residuei1789PhosphoserineCombined sources1
Modified residuei1794PhosphothreonineCombined sources1
Modified residuei1814PhosphothreonineCombined sources1
Modified residuei1834PhosphoserineCombined sources1
Modified residuei1869PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H7D0
MaxQBiQ9H7D0
PaxDbiQ9H7D0
PeptideAtlasiQ9H7D0
PRIDEiQ9H7D0

PTM databases

iPTMnetiQ9H7D0
PhosphoSitePlusiQ9H7D0

Expressioni

Gene expression databases

BgeeiENSG00000147459
CleanExiHS_DOCK5
ExpressionAtlasiQ9H7D0 baseline and differential
GenevisibleiQ9H7D0 HS

Organism-specific databases

HPAiHPA017719
HPA056837

Interactioni

Subunit structurei

Interacts with CRK and CRKL.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123062, 63 interactors
ELMiQ9H7D0
IntActiQ9H7D0, 24 interactors
MINTiQ9H7D0
STRINGi9606.ENSP00000276440

Structurei

3D structure databases

ProteinModelPortaliQ9H7D0
SMRiQ9H7D0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 69SH3PROSITE-ProRule annotationAdd BLAST62
Domaini443 – 627DHR-1PROSITE-ProRule annotationAdd BLAST185
Domaini1231 – 1642DHR-2PROSITE-ProRule annotationAdd BLAST412

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1782 – 1855Pro-richAdd BLAST74

Domaini

The DHR-2 domain may mediate some GEF activity.By similarity

Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG1998 Eukaryota
ENOG410XQH7 LUCA
GeneTreeiENSGT00610000085806
HOGENOMiHOG000006631
HOVERGENiHBG051389
InParanoidiQ9H7D0
KOiK17707
OMAiNTLMDRP
OrthoDBiEOG091G007D
PhylomeDBiQ9H7D0
TreeFamiTF300423

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR010703 DOCK_C
IPR032376 DOCK_N
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR23317 PTHR23317, 1 hit
PfamiView protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF16172 DOCK_N, 1 hit
PF00018 SH3_1, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit
PS50002 SH3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H7D0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARWIPTKRQ KYGVAIYNYN ASQDVELSLQ IGDTVHILEM YEGWYRGYTL
60 70 80 90 100
QNKSKKGIFP ETYIHLKEAT VEDLGQHETV IPGELPLVQE LTSTLREWAV
110 120 130 140 150
IWRKLYVNNK LTLFRQLQQM TYSLIEWRSQ ILSGTLPKDE LAELKKKVTA
160 170 180 190 200
KIDHGNRMLG LDLVVRDDNG NILDPDETST IALFKAHEVA SKRIEEKIQE
210 220 230 240 250
EKSILQNLDL RGQSIFSTIH TYGLYVNFKN FVCNIGEDAE LFMALYDPDQ
260 270 280 290 300
STFISENYLI RWGSNGMPKE IEKLNNLQAV FTDLSSMDLI RPRVSLVCQI
310 320 330 340 350
VRVGHMELKE GKKHTCGLRR PFGVAVMDIT DIIHGKVDDE EKQHFIPFQQ
360 370 380 390 400
IAMETYIRQR QLIMSPLITS HVIGENEPLT SVLNKVIAAK EVNHKGQGLW
410 420 430 440 450
VSLKLLPGDL TQVQKNFSHL VDRSTAIARK MGFPEIILPG DVRNDIYVTL
460 470 480 490 500
IHGEFDKGKK KTPKNVEVTM SVHDEEGKLL EKAIHPGAGY EGISEYKSVV
510 520 530 540 550
YYQVKQPCWY ETVKVSIAIE EVTRCHIRFT FRHRSSQETR DKSERAFGVA
560 570 580 590 600
FVKLMNPDGT TLQDGRHDLV VYKGDNKKME DAKFYLTLPG TKMEMEEKEL
610 620 630 640 650
QASKNLVTFT PSKDSTKDSF QIATLICSTK LTQNVDLLGL LNWRSNSQNI
660 670 680 690 700
KHNLKKLMEV DGGEIVKFLQ DTLDALFNIM MEMSDSETYD FLVFDALVFI
710 720 730 740 750
ISLIGDIKFQ HFNPVLETYI YKHFSATLAY VKLSKVLNFY VANADDSSKT
760 770 780 790 800
ELLFAALKAL KYLFRFIIQS RVLYLRFYGQ SKDGDEFNNS IRQLFLAFNM
810 820 830 840 850
LMDRPLEEAV KIKGAALKYL PSIINDVKLV FDPVELSVLF CKFIQSIPDN
860 870 880 890 900
QLVRQKLNCM TKIVESTLFR QSECREVLLP LLTDQLSGQL DDNSNKPDHE
910 920 930 940 950
ASSQLLSNIL EVLDRKDVGA TAVHIQLIME RLLRRINRTV IGMNRQSPHI
960 970 980 990 1000
GSFVACMIAL LQQMDDSHYS HYISTFKTRQ DIIDFLMETF IMFKDLIGKN
1010 1020 1030 1040 1050
VYAKDWMVMN MTQNRVFLRA INQFAEVLTR FFMDQASFEL QLWNNYFHLA
1060 1070 1080 1090 1100
VAFLTHESLQ LETFSQAKRN KIVKKYGDMR KEIGFRIRDM WYNLGPHKIK
1110 1120 1130 1140 1150
FIPSMVGPIL EVTLTPEVEL RKATIPIFFD MMQCEFNFSG NGNFHMFENE
1160 1170 1180 1190 1200
LITKLDQEVE GGRGDEQYKV LLEKLLLEHC RKHKYLSSSG EVFALLVSSL
1210 1220 1230 1240 1250
LENLLDYRTI IMQDESKENR MSCTVNVLNF YKEKKREDIY IRYLYKLRDL
1260 1270 1280 1290 1300
HRDCENYTEA AYTLLLHAEL LQWSDKPCVP HLLQKDSYYV YTQQELKEKL
1310 1320 1330 1340 1350
YQEIISYFDK GKMWEKAIKL SKELAETYES KVFDYEGLGN LLKKRASFYE
1360 1370 1380 1390 1400
NIIKAMRPQP EYFAVGYYGQ GFPSFLRNKI FIYRGKEYER REDFSLRLLT
1410 1420 1430 1440 1450
QFPNAEKMTS TTPPGEDIKS SPKQYMQCFT VKPVMSLPPS YKDKPVPEQI
1460 1470 1480 1490 1500
LNYYRANEVQ QFRYSRPFRK GEKDPDNEFA TMWIERTTYT TAYTFPGILK
1510 1520 1530 1540 1550
WFEVKQISTE EISPLENAIE TMELTNERIS NCVQQHAWDR SLSVHPLSML
1560 1570 1580 1590 1600
LSGIVDPAVM GGFSNYEKAF FTEKYLQEHP EDQEKVELLK RLIALQMPLL
1610 1620 1630 1640 1650
TEGIRIHGEK LTEQLKPLHE RLSSCFRELK EKVEKHYGVI TLPPNLTERK
1660 1670 1680 1690 1700
QSRTGSIVLP YIMSSTLRRL SITSVTSSVV STSSNSSDNA PSRPGSDGSI
1710 1720 1730 1740 1750
LEPLLERRAS SGARVEDLSL REENSENRIS KFKRKDWSLS KSQVIAEKAP
1760 1770 1780 1790 1800
EPDLMSPTRK AQRPKSLQLM DNRLSPFHGS SPPQSTPLSP PPLTPKATRT
1810 1820 1830 1840 1850
LSSPSLQTDG IAATPVPPPP PPKSKPYEGS QRNSTELAPP LPVRREAKAP
1860 1870
PPPPPKARKS GIPTSEPGSQ
Length:1,870
Mass (Da):215,309
Last modified:December 12, 2006 - v3
Checksum:i947A3DC1190EF7A9
GO
Isoform 2 (identifier: Q9H7D0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-1870: Missing.

Show »
Length:350
Mass (Da):40,421
Checksum:iCFC696403289D76F
GO

Sequence cautioni

The sequence BAB14962 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC86503 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti987M → L in BAC86503 (PubMed:14702039).Curated1
Sequence conflicti1161G → E in BAC86503 (PubMed:14702039).Curated1
Sequence conflicti1548S → Y in CAH10503 (PubMed:17974005).Curated1
Sequence conflicti1833N → S in BAC86503 (PubMed:14702039).Curated1
Sequence conflicti1842P → S in CAH10503 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033886250Q → R. Corresponds to variant dbSNP:rs17053341Ensembl.1
Natural variantiVAR_0530651023Q → R. Corresponds to variant dbSNP:rs2271111Ensembl.1
Natural variantiVAR_0530661285K → R2 PublicationsCorresponds to variant dbSNP:rs2659585Ensembl.1
Natural variantiVAR_0338871836E → K. Corresponds to variant dbSNP:rs35688737Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021868351 – 1870Missing in isoform 2. 1 PublicationAdd BLAST1520

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC041005 Genomic DNA No translation available.
AC091185 Genomic DNA No translation available.
BC011877 mRNA Translation: AAH11877.1
BC041761 mRNA Translation: AAH41761.2
BC137175 mRNA Translation: AAI37176.1
BC137176 mRNA Translation: AAI37177.1
AK024687 mRNA Translation: BAB14962.1 Different initiation.
AK126249 mRNA Translation: BAC86503.1 Different initiation.
CR627414 mRNA Translation: CAH10503.1
CCDSiCCDS6047.1 [Q9H7D0-1]
RefSeqiNP_079216.4, NM_024940.7 [Q9H7D0-1]
UniGeneiHs.195403

Genome annotation databases

EnsembliENST00000276440; ENSP00000276440; ENSG00000147459 [Q9H7D0-1]
ENST00000481100; ENSP00000429737; ENSG00000147459 [Q9H7D0-2]
GeneIDi80005
KEGGihsa:80005
UCSCiuc003xef.4 human [Q9H7D0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDOCK5_HUMAN
AccessioniPrimary (citable) accession number: Q9H7D0
Secondary accession number(s): B2RNY0
, Q5XKD5, Q6AI11, Q6PJS6, Q6ZTS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: December 12, 2006
Last modified: March 28, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health