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Protein

Mth938 domain-containing protein

Gene

AAMDC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in preadipocyte differentiation and adipogenesis.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Mth938 domain-containing protein
Alternative name(s):
Adipogenesis associated Mth938 domain-containing protein
Gene namesi
Name:AAMDC
Synonyms:C11orf67
ORF Names:PTD015
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:30205. AAMDC.

Subcellular locationi

  • Cytoplasm By similarity

  • Note: Diffuse distribution with some highly concentrated spots around the nucleus.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596486.

Polymorphism and mutation databases

BioMutaiAAMDC.
DMDMi74733628.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 122122Mth938 domain-containing proteinPRO_0000239814Add
BLAST

Proteomic databases

EPDiQ9H7C9.
MaxQBiQ9H7C9.
PaxDbiQ9H7C9.
PeptideAtlasiQ9H7C9.
PRIDEiQ9H7C9.

PTM databases

iPTMnetiQ9H7C9.
PhosphoSiteiQ9H7C9.

Expressioni

Gene expression databases

BgeeiENSG00000087884.
CleanExiHS_C11orf67.
ExpressionAtlasiQ9H7C9. baseline and differential.
GenevisibleiQ9H7C9. HS.

Organism-specific databases

HPAiHPA037918.
HPA037919.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ACY3Q96HD93EBI-10308705,EBI-3916242
GORASP2Q9H8Y83EBI-10308705,EBI-739467

Protein-protein interaction databases

BioGridi118795. 6 interactions.
IntActiQ9H7C9. 2 interactions.
STRINGi9606.ENSP00000377078.

Structurei

Secondary structure

1
122
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 105Combined sources
Beta strandi13 – 164Combined sources
Beta strandi22 – 298Combined sources
Beta strandi32 – 365Combined sources
Helixi38 – 414Combined sources
Beta strandi45 – 473Combined sources
Helixi51 – 588Combined sources
Beta strandi63 – 697Combined sources
Helixi79 – 879Combined sources
Beta strandi91 – 955Combined sources
Helixi97 – 10913Combined sources
Beta strandi114 – 1196Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AB1X-ray2.59A/B2-122[»]
2Q4QX-ray2.59A/B2-122[»]
ProteinModelPortaliQ9H7C9.
SMRiQ9H7C9. Positions 2-122.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H7C9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni6 – 122117MTH138-like domainBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the AAMDC family.Curated

Phylogenomic databases

eggNOGiENOG410IXVS. Eukaryota.
ENOG41120BN. LUCA.
GeneTreeiENSGT00390000011958.
HOGENOMiHOG000223243.
HOVERGENiHBG081222.
InParanoidiQ9H7C9.
PhylomeDBiQ9H7C9.
TreeFamiTF332083.

Family and domain databases

Gene3Di3.40.1230.10. 1 hit.
InterProiIPR007523. NDUFAF3/AAMDC.
[Graphical view]
PfamiPF04430. DUF498. 1 hit.
[Graphical view]
SUPFAMiSSF64076. SSF64076. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H7C9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSPEIASLS WGQMKVKGSN TTYKDCKVWP GGSRTWDWRE TGTEHSPGVQ
60 70 80 90 100
PADVKEVVEK GVQTLVIGRG MSEALKVPSS TVEYLKKHGI DVRVLQTEQA
110 120
VKEYNALVAQ GVRVGGVFHS TC
Length:122
Mass (Da):13,332
Last modified:March 1, 2001 - v1
Checksum:iA0C88AD311E62C78
GO
Isoform 2 (identifier: Q9H7C9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-118: VPSSTVEYLK...AQGVRVGGVF → APTQQLPSGV...TGAGLTSNML
     119-122: Missing.

Show »
Length:118
Mass (Da):12,807
Checksum:i15D644B69E9DFFDD
GO
Isoform 3 (identifier: Q9H7C9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-88: VPSSTVEYLKKH → DGIQGAQLDLNC
     89-122: Missing.

Show »
Length:88
Mass (Da):9,564
Checksum:i2522364F087D260B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti92 – 921V → M.
Corresponds to variant rs2186564 [ dbSNP | Ensembl ].
VAR_052696

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei77 – 11842VPSST…VGGVF → APTQQLPSGVHVRAGVQFHL LQLHGTSFERCKTGAGLTSN ML in isoform 2. 1 PublicationVSP_019267Add
BLAST
Alternative sequencei77 – 8812VPSST…YLKKH → DGIQGAQLDLNC in isoform 3. 1 PublicationVSP_019266Add
BLAST
Alternative sequencei89 – 12234Missing in isoform 3. 1 PublicationVSP_019268Add
BLAST
Alternative sequencei119 – 1224Missing in isoform 2. 1 PublicationVSP_019269

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092136 mRNA. Translation: AAD40378.1.
AK024688 mRNA. Translation: BAB14963.1.
CR457332 mRNA. Translation: CAG33613.1.
AP000580 Genomic DNA. No translation available.
AP002812 Genomic DNA. No translation available.
BC002752 mRNA. Translation: AAH02752.1.
BC016854 mRNA. Translation: AAH16854.1.
CCDSiCCDS8254.1. [Q9H7C9-1]
RefSeqiNP_001303886.1. NM_001316957.1.
NP_001303889.1. NM_001316960.1. [Q9H7C9-1]
NP_001303890.1. NM_001316961.1. [Q9H7C9-1]
NP_001303891.1. NM_001316962.1. [Q9H7C9-1]
NP_078960.1. NM_024684.3. [Q9H7C9-1]
XP_011543271.1. XM_011544969.2. [Q9H7C9-1]
UniGeneiHs.745040.

Genome annotation databases

EnsembliENST00000393427; ENSP00000377078; ENSG00000087884. [Q9H7C9-1]
ENST00000526415; ENSP00000431808; ENSG00000087884. [Q9H7C9-1]
ENST00000532481; ENSP00000433293; ENSG00000087884. [Q9H7C9-3]
GeneIDi28971.
KEGGihsa:28971.
UCSCiuc001oyp.4. human. [Q9H7C9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092136 mRNA. Translation: AAD40378.1.
AK024688 mRNA. Translation: BAB14963.1.
CR457332 mRNA. Translation: CAG33613.1.
AP000580 Genomic DNA. No translation available.
AP002812 Genomic DNA. No translation available.
BC002752 mRNA. Translation: AAH02752.1.
BC016854 mRNA. Translation: AAH16854.1.
CCDSiCCDS8254.1. [Q9H7C9-1]
RefSeqiNP_001303886.1. NM_001316957.1.
NP_001303889.1. NM_001316960.1. [Q9H7C9-1]
NP_001303890.1. NM_001316961.1. [Q9H7C9-1]
NP_001303891.1. NM_001316962.1. [Q9H7C9-1]
NP_078960.1. NM_024684.3. [Q9H7C9-1]
XP_011543271.1. XM_011544969.2. [Q9H7C9-1]
UniGeneiHs.745040.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AB1X-ray2.59A/B2-122[»]
2Q4QX-ray2.59A/B2-122[»]
ProteinModelPortaliQ9H7C9.
SMRiQ9H7C9. Positions 2-122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118795. 6 interactions.
IntActiQ9H7C9. 2 interactions.
STRINGi9606.ENSP00000377078.

PTM databases

iPTMnetiQ9H7C9.
PhosphoSiteiQ9H7C9.

Polymorphism and mutation databases

BioMutaiAAMDC.
DMDMi74733628.

Proteomic databases

EPDiQ9H7C9.
MaxQBiQ9H7C9.
PaxDbiQ9H7C9.
PeptideAtlasiQ9H7C9.
PRIDEiQ9H7C9.

Protocols and materials databases

DNASUi28971.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393427; ENSP00000377078; ENSG00000087884. [Q9H7C9-1]
ENST00000526415; ENSP00000431808; ENSG00000087884. [Q9H7C9-1]
ENST00000532481; ENSP00000433293; ENSG00000087884. [Q9H7C9-3]
GeneIDi28971.
KEGGihsa:28971.
UCSCiuc001oyp.4. human. [Q9H7C9-1]

Organism-specific databases

CTDi28971.
GeneCardsiAAMDC.
H-InvDBHIX0009970.
HGNCiHGNC:30205. AAMDC.
HPAiHPA037918.
HPA037919.
neXtProtiNX_Q9H7C9.
PharmGKBiPA144596486.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXVS. Eukaryota.
ENOG41120BN. LUCA.
GeneTreeiENSGT00390000011958.
HOGENOMiHOG000223243.
HOVERGENiHBG081222.
InParanoidiQ9H7C9.
PhylomeDBiQ9H7C9.
TreeFamiTF332083.

Miscellaneous databases

EvolutionaryTraceiQ9H7C9.
GenomeRNAii28971.
PROiQ9H7C9.

Gene expression databases

BgeeiENSG00000087884.
CleanExiHS_C11orf67.
ExpressionAtlasiQ9H7C9. baseline and differential.
GenevisibleiQ9H7C9. HS.

Family and domain databases

Gene3Di3.40.1230.10. 1 hit.
InterProiIPR007523. NDUFAF3/AAMDC.
[Graphical view]
PfamiPF04430. DUF498. 1 hit.
[Graphical view]
SUPFAMiSSF64076. SSF64076. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAAMDC_HUMAN
AccessioniPrimary (citable) accession number: Q9H7C9
Secondary accession number(s): Q96AQ4, Q9Y6B1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.