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Protein

Mth938 domain-containing protein

Gene

AAMDC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in preadipocyte differentiation and adipogenesis.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Mth938 domain-containing protein
Alternative name(s):
Adipogenesis associated Mth938 domain-containing protein
Gene namesi
Name:AAMDC
Synonyms:C11orf67
ORF Names:PTD015
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000087884.14
HGNCiHGNC:30205 AAMDC
neXtProtiNX_Q9H7C9

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000087884
PharmGKBiPA144596486

Polymorphism and mutation databases

BioMutaiAAMDC
DMDMi74733628

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002398141 – 122Mth938 domain-containing proteinAdd BLAST122

Proteomic databases

EPDiQ9H7C9
MaxQBiQ9H7C9
PaxDbiQ9H7C9
PeptideAtlasiQ9H7C9
PRIDEiQ9H7C9

PTM databases

iPTMnetiQ9H7C9
PhosphoSitePlusiQ9H7C9

Expressioni

Gene expression databases

BgeeiENSG00000087884
CleanExiHS_C11orf67
ExpressionAtlasiQ9H7C9 baseline and differential
GenevisibleiQ9H7C9 HS

Organism-specific databases

HPAiHPA037918
HPA037919

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi118795, 6 interactors
IntActiQ9H7C9, 4 interactors

Structurei

Secondary structure

1122
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 10Combined sources5
Beta strandi13 – 16Combined sources4
Beta strandi22 – 29Combined sources8
Beta strandi32 – 36Combined sources5
Helixi38 – 41Combined sources4
Beta strandi45 – 47Combined sources3
Helixi51 – 58Combined sources8
Beta strandi63 – 69Combined sources7
Helixi79 – 87Combined sources9
Beta strandi91 – 95Combined sources5
Helixi97 – 109Combined sources13
Beta strandi114 – 119Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AB1X-ray2.59A/B2-122[»]
2Q4QX-ray2.59A/B2-122[»]
ProteinModelPortaliQ9H7C9
SMRiQ9H7C9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H7C9

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni6 – 122MTH138-like domainBy similarityAdd BLAST117

Sequence similaritiesi

Belongs to the AAMDC family.Curated

Phylogenomic databases

eggNOGiENOG410IXVS Eukaryota
ENOG41120BN LUCA
GeneTreeiENSGT00390000011958
HOGENOMiHOG000223243
HOVERGENiHBG081222
InParanoidiQ9H7C9
PhylomeDBiQ9H7C9
TreeFamiTF332083

Family and domain databases

CDDicd05126 Mth938, 1 hit
Gene3Di3.40.1230.10, 1 hit
InterProiView protein in InterPro
IPR034096 AAMDC
IPR036748 MTH938-like_sf
IPR007523 NDUFAF3/AAMDC
PfamiView protein in Pfam
PF04430 DUF498, 1 hit
SUPFAMiSSF64076 SSF64076, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H7C9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSPEIASLS WGQMKVKGSN TTYKDCKVWP GGSRTWDWRE TGTEHSPGVQ
60 70 80 90 100
PADVKEVVEK GVQTLVIGRG MSEALKVPSS TVEYLKKHGI DVRVLQTEQA
110 120
VKEYNALVAQ GVRVGGVFHS TC
Length:122
Mass (Da):13,332
Last modified:March 1, 2001 - v1
Checksum:iA0C88AD311E62C78
GO
Isoform 2 (identifier: Q9H7C9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-118: VPSSTVEYLK...AQGVRVGGVF → APTQQLPSGV...TGAGLTSNML
     119-122: Missing.

Show »
Length:118
Mass (Da):12,807
Checksum:i15D644B69E9DFFDD
GO
Isoform 3 (identifier: Q9H7C9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-88: VPSSTVEYLKKH → DGIQGAQLDLNC
     89-122: Missing.

Show »
Length:88
Mass (Da):9,564
Checksum:i2522364F087D260B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05269692V → M. Corresponds to variant dbSNP:rs2186564Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01926777 – 118VPSST…VGGVF → APTQQLPSGVHVRAGVQFHL LQLHGTSFERCKTGAGLTSN ML in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_01926677 – 88VPSST…YLKKH → DGIQGAQLDLNC in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_01926889 – 122Missing in isoform 3. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_019269119 – 122Missing in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092136 mRNA Translation: AAD40378.1
AK024688 mRNA Translation: BAB14963.1
CR457332 mRNA Translation: CAG33613.1
AP000580 Genomic DNA No translation available.
AP002812 Genomic DNA No translation available.
BC002752 mRNA Translation: AAH02752.1
BC016854 mRNA Translation: AAH16854.1
CCDSiCCDS8254.1 [Q9H7C9-1]
RefSeqiNP_001303886.1, NM_001316957.1
NP_001303889.1, NM_001316960.1 [Q9H7C9-1]
NP_001303890.1, NM_001316961.1 [Q9H7C9-1]
NP_001303891.1, NM_001316962.1 [Q9H7C9-1]
NP_078960.1, NM_024684.3 [Q9H7C9-1]
XP_011543271.1, XM_011544969.2 [Q9H7C9-1]
UniGeneiHs.745040

Genome annotation databases

EnsembliENST00000393427; ENSP00000377078; ENSG00000087884 [Q9H7C9-1]
ENST00000526415; ENSP00000431808; ENSG00000087884 [Q9H7C9-1]
ENST00000532481; ENSP00000433293; ENSG00000087884 [Q9H7C9-3]
GeneIDi28971
KEGGihsa:28971
UCSCiuc001oyp.4 human [Q9H7C9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAAMDC_HUMAN
AccessioniPrimary (citable) accession number: Q9H7C9
Secondary accession number(s): Q96AQ4, Q9Y6B1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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