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Protein

Syncoilin

Gene

SYNC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins.By similarity

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. intermediate filament-based process Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Syncoilin
Alternative name(s):
Syncoilin intermediate filament 1
Syncoilin-1
Gene namesi
Name:SYNC
Synonyms:SYNC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28897. SYNC.

Subcellular locationi

Cytoplasmperinuclear region By similarity
Note: In skeletal muscle, colocalizes with DES and DTNA, and is localized at the myotendinous and neuromuscular junctions, sarcolemma and Z-lines. In myotubes, detected in a punctate cytoplasmic pattern (By similarity).By similarity

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. intermediate filament Source: UniProtKB-KW
  3. neuromuscular junction Source: Ensembl
  4. perinuclear region of cytoplasm Source: UniProtKB-SubCell
  5. sarcolemma Source: Ensembl
  6. Z disc Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Intermediate filament

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164726395.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 482482SyncoilinPRO_0000306180Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei325 – 3251Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H7C4.
PaxDbiQ9H7C4.
PRIDEiQ9H7C4.

PTM databases

PhosphoSiteiQ9H7C4.

Expressioni

Inductioni

Up-regulated at the sarcolemma in individuals with various forms of neuromuscular disease.1 Publication

Gene expression databases

BgeeiQ9H7C4.
CleanExiHS_SYNC.
ExpressionAtlasiQ9H7C4. baseline and differential.
GenevestigatoriQ9H7C4.

Organism-specific databases

HPAiHPA028311.

Interactioni

Subunit structurei

May link the dystrophin-associated glycoprotein complex (DAPC) to intracellular desmin (DES) filaments. Interacts with DES and DTNA.By similarity

Protein-protein interaction databases

BioGridi123502. 1 interaction.
STRINGi9606.ENSP00000386439.

Structurei

3D structure databases

ProteinModelPortaliQ9H7C4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 161161HeadAdd
BLAST
Regioni162 – 1698Rod
Regioni170 – 20435Coil 1AAdd
BLAST
Regioni205 – 23127Linker 1Add
BLAST
Regioni232 – 30978Coil 1bAdd
BLAST
Regioni310 – 34940Linker 2Add
BLAST
Regioni350 – 458109Coil 2Add
BLAST
Regioni459 – 48224TailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence Analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG79532.
GeneTreeiENSGT00390000018108.
HOGENOMiHOG000010275.
HOVERGENiHBG108528.
InParanoidiQ9H7C4.
KOiK10377.
OMAiECVAYQY.
OrthoDBiEOG7MH102.
PhylomeDBiQ9H7C4.

Family and domain databases

InterProiIPR001664. IF.
IPR027702. Syncoilin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PTHR23239:SF100. PTHR23239:SF100. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H7C4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASPEPRRGG DGAAQAARKT RVEANSPLPK NSGSLNEAEA LNPEVTLSSE
60 70 80 90 100
GSLNLEDILY LEDTGDLDET LYVQETEKAE EALYIEEAMQ PDEALHVEEP
110 120 130 140 150
GNPEETVCVE ETTEPDRIQF VEGPVEPGKP TSPEHVVYEG ETVTRAEKSN
160 170 180 190 200
PEESLRAEQS PSMEENLSIE DLELLEGRFQ QCVQAVAQLE EERDQLIHEL
210 220 230 240 250
VLLREPALQE VQQVHQDILA AYKLHAQAEL ERDGLREEIR LVKQKLFKVT
260 270 280 290 300
KECVAYQYQL ECRQQDVAQF ADFREVLTTR ATQLSEELAQ LRDAYQKQKE
310 320 330 340 350
QLRQQLEAPP SQRDGHFLQE SRRLSAQFEN LMAESRQDLE EEYEPQFLRL
360 370 380 390 400
LERKEAGTKA LQRTQAEIQE MKEALRPLQA EARQLRLQNR NLEDQIALVR
410 420 430 440 450
QKRDEEVQQY REQLEEMEER QRQLRNGVQL QQQKNKEMEQ LRLSLAEELS
460 470 480
TYKAMLLPKS LEQADAPTSQ AGGMETQSQG AV
Length:482
Mass (Da):55,299
Last modified:July 13, 2010 - v3
Checksum:i969F2DA9C48C858B
GO
Isoform 2 (identifier: Q9H7C4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     454-482: AMLLPKSLEQADAPTSQAGGMETQSQGAV → GCLEIYGQICNPETAKNFLAKDH

Show »
Length:476
Mass (Da):54,947
Checksum:i2B3ADA20445CCE58
GO

Sequence cautioni

The sequence AAI19701.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI19702.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14970.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581I → T in BAG60270 (PubMed:14702039).Curated
Sequence conflicti163 – 1631M → V in BAG63620 (PubMed:14702039).Curated
Sequence conflicti163 – 1631M → V in BAG60270 (PubMed:14702039).Curated
Sequence conflicti274 – 2741R → Q in BAG63620 (PubMed:14702039).Curated
Sequence conflicti274 – 2741R → Q in BAG60270 (PubMed:14702039).Curated
Sequence conflicti328 – 3281F → S in BAG60270 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei454 – 48229AMLLP…SQGAV → GCLEIYGQICNPETAKNFLA KDH in isoform 2. 1 PublicationVSP_039404Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024707 mRNA. Translation: BAB14970.1. Different initiation.
AK297958 mRNA. Translation: BAG60270.1.
AK302275 mRNA. Translation: BAG63620.1.
AC114489 Genomic DNA. No translation available.
BC119700 mRNA. Translation: AAI19701.1. Different initiation.
BC119701 mRNA. Translation: AAI19702.1. Different initiation.
CCDSiCCDS367.2. [Q9H7C4-1]
CCDS53294.1. [Q9H7C4-2]
RefSeqiNP_001155180.1. NM_001161708.1.
NP_110413.2. NM_030786.2.
UniGeneiHs.712631.

Genome annotation databases

EnsembliENST00000373484; ENSP00000362583; ENSG00000162520. [Q9H7C4-2]
ENST00000409190; ENSP00000386439; ENSG00000162520. [Q9H7C4-1]
GeneIDi81493.
KEGGihsa:81493.
UCSCiuc001bvt.2. human. [Q9H7C4-1]
uc010ohl.1. human. [Q9H7C4-2]

Polymorphism databases

DMDMi300669677.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024707 mRNA. Translation: BAB14970.1. Different initiation.
AK297958 mRNA. Translation: BAG60270.1.
AK302275 mRNA. Translation: BAG63620.1.
AC114489 Genomic DNA. No translation available.
BC119700 mRNA. Translation: AAI19701.1. Different initiation.
BC119701 mRNA. Translation: AAI19702.1. Different initiation.
CCDSiCCDS367.2. [Q9H7C4-1]
CCDS53294.1. [Q9H7C4-2]
RefSeqiNP_001155180.1. NM_001161708.1.
NP_110413.2. NM_030786.2.
UniGeneiHs.712631.

3D structure databases

ProteinModelPortaliQ9H7C4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123502. 1 interaction.
STRINGi9606.ENSP00000386439.

PTM databases

PhosphoSiteiQ9H7C4.

Polymorphism databases

DMDMi300669677.

Proteomic databases

MaxQBiQ9H7C4.
PaxDbiQ9H7C4.
PRIDEiQ9H7C4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373484; ENSP00000362583; ENSG00000162520. [Q9H7C4-2]
ENST00000409190; ENSP00000386439; ENSG00000162520. [Q9H7C4-1]
GeneIDi81493.
KEGGihsa:81493.
UCSCiuc001bvt.2. human. [Q9H7C4-1]
uc010ohl.1. human. [Q9H7C4-2]

Organism-specific databases

CTDi81493.
GeneCardsiGC01M033145.
H-InvDBHIX0000378.
HGNCiHGNC:28897. SYNC.
HPAiHPA028311.
MIMi611750. gene.
neXtProtiNX_Q9H7C4.
PharmGKBiPA164726395.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG79532.
GeneTreeiENSGT00390000018108.
HOGENOMiHOG000010275.
HOVERGENiHBG108528.
InParanoidiQ9H7C4.
KOiK10377.
OMAiECVAYQY.
OrthoDBiEOG7MH102.
PhylomeDBiQ9H7C4.

Miscellaneous databases

GenomeRNAii81493.
NextBioi71734.
PROiQ9H7C4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H7C4.
CleanExiHS_SYNC.
ExpressionAtlasiQ9H7C4. baseline and differential.
GenevestigatoriQ9H7C4.

Family and domain databases

InterProiIPR001664. IF.
IPR027702. Syncoilin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PTHR23239:SF100. PTHR23239:SF100. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 311-482 (ISOFORM 1).
  4. "Syncoilin upregulation in muscle of patients with neuromuscular disease."
    Brown S.C., Torelli S., Ugo I., De Biasia F., Howman E.V., Poon E., Britton J., Davies K.E., Muntoni F.
    Muscle Nerve 32:715-725(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-325, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiSYNCI_HUMAN
AccessioniPrimary (citable) accession number: Q9H7C4
Secondary accession number(s): B4DNK8, B4DY58, C9IY41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 13, 2010
Last modified: January 7, 2015
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.