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Protein

Ribosome production factor 2 homolog

Gene

RPF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • rRNA binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome production factor 2 homolog
Alternative name(s):
Brix domain-containing protein 1
Ribosome biogenesis protein RPF2 homolog
Gene namesi
Name:RPF2
Synonyms:BXDC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20870. RPF2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165618192.

Polymorphism and mutation databases

BioMutaiRPF2.
DMDMi30581070.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Ribosome production factor 2 homologPRO_0000120223Add
BLAST

Proteomic databases

EPDiQ9H7B2.
MaxQBiQ9H7B2.
PaxDbiQ9H7B2.
PeptideAtlasiQ9H7B2.
PRIDEiQ9H7B2.

2D gel databases

SWISS-2DPAGEQ9H7B2.

PTM databases

iPTMnetiQ9H7B2.
PhosphoSiteiQ9H7B2.
SwissPalmiQ9H7B2.

Expressioni

Gene expression databases

BgeeiENSG00000197498.
CleanExiHS_BXDC1.
ExpressionAtlasiQ9H7B2. baseline and differential.
GenevisibleiQ9H7B2. HS.

Organism-specific databases

HPAiHPA035475.

Interactioni

Protein-protein interaction databases

BioGridi123917. 71 interactions.
IntActiQ9H7B2. 16 interactions.
MINTiMINT-3068834.
STRINGi9606.ENSP00000402338.

Structurei

3D structure databases

ProteinModelPortaliQ9H7B2.
SMRiQ9H7B2. Positions 22-242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 234204BrixPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RPF2 family.Curated
Contains 1 Brix domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3031. Eukaryota.
COG5106. LUCA.
GeneTreeiENSGT00390000007279.
HOGENOMiHOG000157782.
HOVERGENiHBG050749.
InParanoidiQ9H7B2.
KOiK14847.
OMAiSKKRPNC.
OrthoDBiEOG091G0EYG.
PhylomeDBiQ9H7B2.
TreeFamiTF314371.

Family and domain databases

InterProiIPR007109. Brix.
[Graphical view]
PfamiPF04427. Brix. 1 hit.
[Graphical view]
SMARTiSM00879. Brix. 1 hit.
[Graphical view]
PROSITEiPS50833. BRIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H7B2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTLDRVVKP KTKRAKRFLE KREPKLNENI KNAMLIKGGN ANATVTKVLK
60 70 80 90 100
DVYALKKPYG VLYKKKNITR PFEDQTSLEF FSKKSDCSLF MFGSHNKKRP
110 120 130 140 150
NNLVIGRMYD YHVLDMIELG IENFVSLKDI KNSKCPEGTK PMLIFAGDDF
160 170 180 190 200
DVTEDYRRLK SLLIDFFRGP TVSNIRLAGL EYVLHFTALN GKIYFRSYKL
210 220 230 240 250
LLKKSGCRTP RIELEEMGPS LDLVLRRTHL ASDDLYKLSM KMPKALKPKK
260 270 280 290 300
KKNISHDTFG TTYGRIHMQK QDLSKLQTRK MKGLKKRPAE RITEDHEKKS

KRIKKN
Length:306
Mass (Da):35,583
Last modified:May 9, 2003 - v2
Checksum:i377F53E1371A0BB1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti253 – 2531N → K in BAB14983 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti41 – 411A → G.
Corresponds to variant rs9320350 [ dbSNP | Ensembl ].
VAR_033639
Natural varianti60 – 601G → S.
Corresponds to variant rs6909298 [ dbSNP | Ensembl ].
VAR_033640

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL357515 Genomic DNA. Translation: CAH73394.1.
CH471051 Genomic DNA. Translation: EAW48303.1.
BC035314 mRNA. Translation: AAH35314.1.
AK024740 mRNA. Translation: BAB14983.1.
CCDSiCCDS5088.1.
RefSeqiNP_115570.1. NM_032194.2.
UniGeneiHs.372265.

Genome annotation databases

EnsembliENST00000441448; ENSP00000402338; ENSG00000197498.
GeneIDi84154.
KEGGihsa:84154.
UCSCiuc003pun.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL357515 Genomic DNA. Translation: CAH73394.1.
CH471051 Genomic DNA. Translation: EAW48303.1.
BC035314 mRNA. Translation: AAH35314.1.
AK024740 mRNA. Translation: BAB14983.1.
CCDSiCCDS5088.1.
RefSeqiNP_115570.1. NM_032194.2.
UniGeneiHs.372265.

3D structure databases

ProteinModelPortaliQ9H7B2.
SMRiQ9H7B2. Positions 22-242.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123917. 71 interactions.
IntActiQ9H7B2. 16 interactions.
MINTiMINT-3068834.
STRINGi9606.ENSP00000402338.

PTM databases

iPTMnetiQ9H7B2.
PhosphoSiteiQ9H7B2.
SwissPalmiQ9H7B2.

Polymorphism and mutation databases

BioMutaiRPF2.
DMDMi30581070.

2D gel databases

SWISS-2DPAGEQ9H7B2.

Proteomic databases

EPDiQ9H7B2.
MaxQBiQ9H7B2.
PaxDbiQ9H7B2.
PeptideAtlasiQ9H7B2.
PRIDEiQ9H7B2.

Protocols and materials databases

DNASUi84154.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000441448; ENSP00000402338; ENSG00000197498.
GeneIDi84154.
KEGGihsa:84154.
UCSCiuc003pun.5. human.

Organism-specific databases

CTDi84154.
GeneCardsiRPF2.
HGNCiHGNC:20870. RPF2.
HPAiHPA035475.
neXtProtiNX_Q9H7B2.
PharmGKBiPA165618192.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3031. Eukaryota.
COG5106. LUCA.
GeneTreeiENSGT00390000007279.
HOGENOMiHOG000157782.
HOVERGENiHBG050749.
InParanoidiQ9H7B2.
KOiK14847.
OMAiSKKRPNC.
OrthoDBiEOG091G0EYG.
PhylomeDBiQ9H7B2.
TreeFamiTF314371.

Miscellaneous databases

ChiTaRSiRPF2. human.
GenomeRNAii84154.
PROiQ9H7B2.

Gene expression databases

BgeeiENSG00000197498.
CleanExiHS_BXDC1.
ExpressionAtlasiQ9H7B2. baseline and differential.
GenevisibleiQ9H7B2. HS.

Family and domain databases

InterProiIPR007109. Brix.
[Graphical view]
PfamiPF04427. Brix. 1 hit.
[Graphical view]
SMARTiSM00879. Brix. 1 hit.
[Graphical view]
PROSITEiPS50833. BRIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPF2_HUMAN
AccessioniPrimary (citable) accession number: Q9H7B2
Secondary accession number(s): Q5VXN1, Q8N4A1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 9, 2003
Last modified: September 7, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.