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Protein

Ribosome production factor 2 homolog

Gene

RPF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.1 Publication

GO - Molecular functioni

  • 5S rRNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • rRNA binding Source: GO_Central

GO - Biological processi

  • maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
  • protein localization to nucleolus Source: UniProtKB
  • regulation of signal transduction by p53 class mediator Source: UniProtKB
  • ribosomal large subunit assembly Source: GO_Central
  • ribosomal large subunit biogenesis Source: UniProtKB

Keywordsi

Biological processRibosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome production factor 2 homolog
Alternative name(s):
Brix domain-containing protein 1
Ribosome biogenesis protein RPF2 homolog
Gene namesi
Name:RPF2
Synonyms:BXDC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000197498.12
HGNCiHGNC:20870 RPF2
neXtProtiNX_Q9H7B2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197498
PharmGKBiPA165618192

Polymorphism and mutation databases

BioMutaiRPF2
DMDMi30581070

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001202231 – 306Ribosome production factor 2 homologAdd BLAST306

Proteomic databases

EPDiQ9H7B2
MaxQBiQ9H7B2
PaxDbiQ9H7B2
PeptideAtlasiQ9H7B2
PRIDEiQ9H7B2

2D gel databases

SWISS-2DPAGEQ9H7B2

PTM databases

iPTMnetiQ9H7B2
PhosphoSitePlusiQ9H7B2
SwissPalmiQ9H7B2

Expressioni

Gene expression databases

BgeeiENSG00000197498
CleanExiHS_BXDC1
ExpressionAtlasiQ9H7B2 baseline and differential
GenevisibleiQ9H7B2 HS

Organism-specific databases

HPAiHPA035475

Interactioni

Protein-protein interaction databases

BioGridi123917, 80 interactors
IntActiQ9H7B2, 20 interactors
MINTiQ9H7B2
STRINGi9606.ENSP00000402338

Structurei

3D structure databases

ProteinModelPortaliQ9H7B2
SMRiQ9H7B2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 234BrixPROSITE-ProRule annotationAdd BLAST204

Sequence similaritiesi

Belongs to the RPF2 family.Curated

Phylogenomic databases

eggNOGiKOG3031 Eukaryota
COG5106 LUCA
GeneTreeiENSGT00390000007279
HOGENOMiHOG000157782
HOVERGENiHBG050749
InParanoidiQ9H7B2
KOiK14847
OMAiKIYMRSY
OrthoDBiEOG091G0EYG
PhylomeDBiQ9H7B2
TreeFamiTF314371

Family and domain databases

InterProiView protein in InterPro
IPR007109 Brix
PfamiView protein in Pfam
PF04427 Brix, 1 hit
SMARTiView protein in SMART
SM00879 Brix, 1 hit
PROSITEiView protein in PROSITE
PS50833 BRIX, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H7B2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTLDRVVKP KTKRAKRFLE KREPKLNENI KNAMLIKGGN ANATVTKVLK
60 70 80 90 100
DVYALKKPYG VLYKKKNITR PFEDQTSLEF FSKKSDCSLF MFGSHNKKRP
110 120 130 140 150
NNLVIGRMYD YHVLDMIELG IENFVSLKDI KNSKCPEGTK PMLIFAGDDF
160 170 180 190 200
DVTEDYRRLK SLLIDFFRGP TVSNIRLAGL EYVLHFTALN GKIYFRSYKL
210 220 230 240 250
LLKKSGCRTP RIELEEMGPS LDLVLRRTHL ASDDLYKLSM KMPKALKPKK
260 270 280 290 300
KKNISHDTFG TTYGRIHMQK QDLSKLQTRK MKGLKKRPAE RITEDHEKKS

KRIKKN
Length:306
Mass (Da):35,583
Last modified:May 9, 2003 - v2
Checksum:i377F53E1371A0BB1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti253N → K in BAB14983 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03363941A → G. Corresponds to variant dbSNP:rs9320350Ensembl.1
Natural variantiVAR_03364060G → S. Corresponds to variant dbSNP:rs6909298Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL357515 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48303.1
BC035314 mRNA Translation: AAH35314.1
AK024740 mRNA Translation: BAB14983.1
CCDSiCCDS5088.1
RefSeqiNP_115570.1, NM_032194.2
UniGeneiHs.372265

Genome annotation databases

EnsembliENST00000441448; ENSP00000402338; ENSG00000197498
GeneIDi84154
KEGGihsa:84154
UCSCiuc003pun.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRPF2_HUMAN
AccessioniPrimary (citable) accession number: Q9H7B2
Secondary accession number(s): Q5VXN1, Q8N4A1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 9, 2003
Last modified: April 25, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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