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Protein

Pseudopodium-enriched atypical kinase 1

Gene

PEAK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Tyrosine kinase that may play a role in cell spreading and migration on fibronectin. May directly or indirectly affect phosphorylation levels of cytoskeleton-associated proteins MAPK1/ERK and PXN.1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1359ATPPROSITE-ProRule annotation1
Active sitei1516Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1319 – 1327ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • non-membrane spanning protein tyrosine kinase activity Source: UniProtKB

GO - Biological processi

  • cell migration Source: UniProtKB
  • protein autophosphorylation Source: UniProtKB
  • substrate adhesion-dependent cell spreading Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS10680-MONOMER.
SignaLinkiQ9H792.

Names & Taxonomyi

Protein namesi
Recommended name:
Pseudopodium-enriched atypical kinase 1 (EC:2.7.10.2)
Alternative name(s):
Sugen kinase 269
Tyrosine-protein kinase SgK269
Gene namesi
Name:PEAK1
Synonyms:KIAA2002
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:29431. PEAK1.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: UniProtKB
  • cytoplasm Source: HPA
  • focal adhesion Source: UniProtKB
  • nucleoplasm Source: HPA
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi79834.
OpenTargetsiENSG00000173517.

Chemistry databases

ChEMBLiCHEMBL3627585.

Polymorphism and mutation databases

BioMutaiPEAK1.
DMDMi223634730.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002505891 – 1746Pseudopodium-enriched atypical kinase 1Add BLAST1746

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei281PhosphoserineCombined sources1
Modified residuei540PhosphoserineCombined sources1
Modified residuei572PhosphoserineCombined sources1
Modified residuei587PhosphoserineCombined sources1
Modified residuei635PhosphotyrosineCombined sources1
Modified residuei641PhosphotyrosineBy similarity1
Modified residuei648PhosphoserineCombined sources1
Modified residuei826PhosphoserineBy similarity1
Modified residuei854PhosphoserineCombined sources1
Modified residuei898PhosphoserineCombined sources1
Modified residuei1151PhosphothreonineCombined sources1
Modified residuei1374PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine in a CSK-dependent manner in response to adhesion to fibronectin and to EGF stimulation. Autophosphorylated in vitro.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H792.
MaxQBiQ9H792.
PaxDbiQ9H792.
PeptideAtlasiQ9H792.
PRIDEiQ9H792.

PTM databases

iPTMnetiQ9H792.
PhosphoSitePlusiQ9H792.

Expressioni

Gene expression databases

BgeeiENSG00000173517.
ExpressionAtlasiQ9H792. baseline and differential.
GenevisibleiQ9H792. HS.

Organism-specific databases

HPAiHPA026313.
HPA026517.

Interactioni

Subunit structurei

Interacts with BCAR1 and CRK.1 Publication

Protein-protein interaction databases

BioGridi122926. 19 interactors.
DIPiDIP-56276N.
IntActiQ9H792. 11 interactors.
STRINGi9606.ENSP00000309230.

Structurei

3D structure databases

ProteinModelPortaliQ9H792.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1313 – 1675Protein kinasePROSITE-ProRule annotationAdd BLAST363

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi117 – 120Poly-Asn4
Compositional biasi324 – 406Ser-richAdd BLAST83
Compositional biasi500 – 503Poly-Ser4
Compositional biasi776 – 873Pro-richAdd BLAST98
Compositional biasi964 – 967Poly-Pro4

Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IJMD. Eukaryota.
ENOG4110SRP. LUCA.
GeneTreeiENSGT00460000041554.
HOVERGENiHBG093946.
InParanoidiQ9H792.
KOiK17538.
OMAiNDCYKRS.
OrthoDBiEOG091G03K2.
PhylomeDBiQ9H792.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H792-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSACNTFTEH VWKPGECKNC FKPKSLHQLP PDPEKAPITH GNVKTNANHS
60 70 80 90 100
NNHRIRNTGN FRPPVAKKPT IAVKPTMIVA DGQSICGELS IQEHCENKPV
110 120 130 140 150
IIGWNRNRAA LSQKPLNNNN EDDEGISHVP KPYGNNDSAK KMSDNNNGLT
160 170 180 190 200
EVLKEIAGLD TAPQIRGNET NSRETFLGRI NDCYKRSLER KLPPSCMIGG
210 220 230 240 250
IKETQGKHVI LSGSTEVISN EGGRFCYPEF SSGEESEEDV LFSNMEEEHE
260 270 280 290 300
SWDESDEELL AMEIRMRGQP RFANFRANTL SPVRFFVDKK WNTIPLRNKS
310 320 330 340 350
LQRICAVDYD DSYDEILNGY EENSVVSYGQ GSIQSMVSSD STSPDSSLTE
360 370 380 390 400
ESRSETASSL SQKICNGGLS PGNPGDSKDM KEIEPNYESP SSNNQDKDSS
410 420 430 440 450
QASKSSIKVP ETHKAVLALR LEEKDGKIAV QTEKEESKAS TDVAGQAVTI
460 470 480 490 500
NLVPTEEQAK PYRVVNLEQP LCKPYTVVDV SAAMASEHLE GPVNSPKTKS
510 520 530 540 550
SSSTPNSPVT SSSLTPGQIS AHFQKSSAIR YQEVWTSSTS PRQKIPKVEL
560 570 580 590 600
ITSGTGPNVP PRKNCHKSAP TSPTATNISS KTIPVKSPNL SEIKFNSYNN
610 620 630 640 650
AGMPPFPIII HDEPTYARSS KNAIKVPIVI NPNAYDNLAI YKSFLGTSGE
660 670 680 690 700
LSVKEKTTSV ISHTYEEIET ESKVPDNTTS KTTDCLQTKG FSNSTEHKRG
710 720 730 740 750
SVAQKVQEFN NCLNRGQSSP QRSYSSSHSS PAKIQRATQE PVAKIEGTQE
760 770 780 790 800
SQMVGSSSTR EKASTVLSQI VASIQPPQSP PETPQSGPKA CSVEELYAIP
810 820 830 840 850
PDADVAKSTP KSTPVRPKSL FTSQPSGEAE APQTTDSPTT KVQKDPSIKP
860 870 880 890 900
VTPSPSKLVT SPQSEPPAPF PPPRSTSSPY HAGNLLQRHF TNWTKPTSPT
910 920 930 940 950
RSTEAESVLH SEGSRRAADA KPKRWISFKS FFRRRKTDEE DDKEKEREKG
960 970 980 990 1000
KLVGLDGTVI HMLPPPPVQR HHWFTEAKGE SSEKPAIVFM YRCDPAQGQL
1010 1020 1030 1040 1050
SVDQSKARTD QAAVMEKGRA ENALLQDSEK KRSHSSPSQI PKKILSHMTH
1060 1070 1080 1090 1100
EVTEDFSPRD PRTVVGKQDG RGCTSVTTAL SLPELEREDG KEDISDPMDP
1110 1120 1130 1140 1150
NPCSATYSNL GQSRAAMIPP KQPRQPKGAV DDAIAFGGKT DQEAPNASQP
1160 1170 1180 1190 1200
TPPPLPKKMI IRANTEPISK DLQKSMESSL CVMANPTYDI DPNWDASSAG
1210 1220 1230 1240 1250
SSISYELKGL DIESYDSLER PLRKERPVPS AANSISSLTT LSIKDRFSNS
1260 1270 1280 1290 1300
MESLSSRRGP SCRQGRGIQK PQRQALYRGL ENREEVVGKI RSLHTDALKK
1310 1320 1330 1340 1350
LAVKCEDLFM AGQKDQLRFG VDSWSDFRLT SDKPCCEAGD AVYYTASYAK
1360 1370 1380 1390 1400
DPLNNYAVKI CKSKAKESQQ YYHSLAVRQS LAVHFNIQQD CGHFLAEVPN
1410 1420 1430 1440 1450
RLLPWEDPDD PEKDEDDMEE TEEDAKGETD GKNPKPCSEA ASSQKENQGV
1460 1470 1480 1490 1500
MSKKQRSHVV VITREVPCLT VADFVRDSLA QHGKSPDLYE RQVCLLLLQL
1510 1520 1530 1540 1550
CSGLEHLKPY HVTHCDLRLE NLLLVHYQPG GTAQGFGPAE PSPTSSYPTR
1560 1570 1580 1590 1600
LIVSNFSQAK QKSHLVDPEI LRDQSRLAPE IITATQYKKC DEFQTGILIY
1610 1620 1630 1640 1650
EMLHLPNPFD ENPELKEREY TRADLPRIPF RSPYSRGLQQ LASCLLNPNP
1660 1670 1680 1690 1700
SERILISDAK GILQCLLWGP REDLFQTFTA CPSLVQRNTL LQNWLDIKRT
1710 1720 1730 1740
LLMIKFAEKS LDREGGISLE DWLCAQYLAF ATTDSLSCIV KILQHR
Length:1,746
Mass (Da):193,106
Last modified:February 10, 2009 - v4
Checksum:i7C9A9F60BBCF6C61
GO

Sequence cautioni

The sequence BAB15006 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC87076 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti779S → F in BAC87076 (PubMed:14702039).Curated1
Sequence conflicti1046 – 1049SHMT → RYVK in AK091802 (PubMed:14702039).Curated4
Sequence conflicti1112 – 1120QSRAAMIPP → KCKCPISSI in BAB84983 (Ref. 3) Curated9
Sequence conflicti1375 – 1378LAVR → SQEF in BAC87076 (PubMed:14702039).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041817213G → R.1 PublicationCorresponds to variant rs35459975dbSNPEnsembl.1
Natural variantiVAR_041818240V → I.1 PublicationCorresponds to variant rs56129428dbSNPEnsembl.1
Natural variantiVAR_041819440S → P.1 PublicationCorresponds to variant rs35335169dbSNPEnsembl.1
Natural variantiVAR_041820611H → Q in a bladder carcinoma NOS sample; somatic mutation. 1 Publication1
Natural variantiVAR_041821792S → I.1 PublicationCorresponds to variant rs34885462dbSNPEnsembl.1
Natural variantiVAR_041822836D → E.1 PublicationCorresponds to variant rs56388121dbSNPEnsembl.1
Natural variantiVAR_0418231035S → F in a metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0418241071R → K.1 PublicationCorresponds to variant rs12909704dbSNPEnsembl.1
Natural variantiVAR_0418251077T → P.1 PublicationCorresponds to variant rs56133554dbSNPEnsembl.1
Natural variantiVAR_0418261145P → L in a metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0418271408P → Q.1 PublicationCorresponds to variant rs56079860dbSNPEnsembl.1
Natural variantiVAR_0418281542S → T.1 PublicationCorresponds to variant rs1867780dbSNPEnsembl.1
Natural variantiVAR_0418291699R → G.1 PublicationCorresponds to variant rs34004337dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087465 Genomic DNA. No translation available.
AC107883 Genomic DNA. No translation available.
AK024793 mRNA. Translation: BAB15006.1. Different initiation.
AK091802 mRNA. No translation available.
AK127658 mRNA. Translation: BAC87076.1. Different initiation.
AK074157 mRNA. Translation: BAB84983.1.
AB082533 mRNA. Translation: BAC02711.1.
CCDSiCCDS42062.1.
RefSeqiNP_079052.2. NM_024776.3.
XP_005254727.1. XM_005254670.2.
XP_005254728.1. XM_005254671.2.
XP_005254730.1. XM_005254673.2.
XP_005254731.1. XM_005254674.2.
XP_005254732.1. XM_005254675.4.
XP_011520335.1. XM_011522033.2.
XP_011520336.1. XM_011522034.2.
XP_011520337.1. XM_011522035.2.
XP_011520338.1. XM_011522036.2.
XP_011520339.1. XM_011522037.2.
XP_011520340.1. XM_011522038.2.
XP_011520341.1. XM_011522039.2.
UniGeneiHs.731402.
Hs.9587.

Genome annotation databases

EnsembliENST00000312493; ENSP00000309230; ENSG00000173517.
ENST00000560626; ENSP00000452796; ENSG00000173517.
GeneIDi79834.
KEGGihsa:79834.
UCSCiuc059lyw.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087465 Genomic DNA. No translation available.
AC107883 Genomic DNA. No translation available.
AK024793 mRNA. Translation: BAB15006.1. Different initiation.
AK091802 mRNA. No translation available.
AK127658 mRNA. Translation: BAC87076.1. Different initiation.
AK074157 mRNA. Translation: BAB84983.1.
AB082533 mRNA. Translation: BAC02711.1.
CCDSiCCDS42062.1.
RefSeqiNP_079052.2. NM_024776.3.
XP_005254727.1. XM_005254670.2.
XP_005254728.1. XM_005254671.2.
XP_005254730.1. XM_005254673.2.
XP_005254731.1. XM_005254674.2.
XP_005254732.1. XM_005254675.4.
XP_011520335.1. XM_011522033.2.
XP_011520336.1. XM_011522034.2.
XP_011520337.1. XM_011522035.2.
XP_011520338.1. XM_011522036.2.
XP_011520339.1. XM_011522037.2.
XP_011520340.1. XM_011522038.2.
XP_011520341.1. XM_011522039.2.
UniGeneiHs.731402.
Hs.9587.

3D structure databases

ProteinModelPortaliQ9H792.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122926. 19 interactors.
DIPiDIP-56276N.
IntActiQ9H792. 11 interactors.
STRINGi9606.ENSP00000309230.

Chemistry databases

ChEMBLiCHEMBL3627585.

PTM databases

iPTMnetiQ9H792.
PhosphoSitePlusiQ9H792.

Polymorphism and mutation databases

BioMutaiPEAK1.
DMDMi223634730.

Proteomic databases

EPDiQ9H792.
MaxQBiQ9H792.
PaxDbiQ9H792.
PeptideAtlasiQ9H792.
PRIDEiQ9H792.

Protocols and materials databases

DNASUi79834.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312493; ENSP00000309230; ENSG00000173517.
ENST00000560626; ENSP00000452796; ENSG00000173517.
GeneIDi79834.
KEGGihsa:79834.
UCSCiuc059lyw.1. human.

Organism-specific databases

CTDi79834.
DisGeNETi79834.
GeneCardsiPEAK1.
H-InvDBHIX0012463.
HGNCiHGNC:29431. PEAK1.
HPAiHPA026313.
HPA026517.
MIMi614248. gene.
neXtProtiNX_Q9H792.
OpenTargetsiENSG00000173517.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJMD. Eukaryota.
ENOG4110SRP. LUCA.
GeneTreeiENSGT00460000041554.
HOVERGENiHBG093946.
InParanoidiQ9H792.
KOiK17538.
OMAiNDCYKRS.
OrthoDBiEOG091G03K2.
PhylomeDBiQ9H792.

Enzyme and pathway databases

BioCyciZFISH:HS10680-MONOMER.
SignaLinkiQ9H792.

Miscellaneous databases

ChiTaRSiPEAK1. human.
GenomeRNAii79834.
PROiQ9H792.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173517.
ExpressionAtlasiQ9H792. baseline and differential.
GenevisibleiQ9H792. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEAK1_HUMAN
AccessioniPrimary (citable) accession number: Q9H792
Secondary accession number(s): Q6ZS78
, Q8NAZ4, Q8NCM3, Q8TEG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: February 10, 2009
Last modified: November 30, 2016
This is version 131 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.