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Protein

dCTP pyrophosphatase 1

Gene

DCTPP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases (By similarity).By similarity

Catalytic activityi

dCTP + H2O = dCMP + diphosphate.

Cofactori

Mg2+By similarityNote: Probably binds two or three Mg2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38SubstrateBy similarity1
Metal bindingi63MagnesiumBy similarity1
Metal bindingi66MagnesiumBy similarity1
Binding sitei73SubstrateBy similarity1
Metal bindingi95MagnesiumBy similarity1
Metal bindingi98MagnesiumBy similarity1
Binding sitei102SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS17396-MONOMER.
ReactomeiR-HSA-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP pyrophosphatase 1 (EC:3.6.1.12)
Alternative name(s):
Deoxycytidine-triphosphatase 1
Short name:
dCTPase 1
RS21C6
XTP3-transactivated gene A protein
Gene namesi
Name:DCTPP1
Synonyms:XTP3TPA
ORF Names:CDA03
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:28777. DCTPP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179958.
PharmGKBiPA164718733.

Polymorphism and mutation databases

BioMutaiDCTPP1.
DMDMi74733624.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002917692 – 170dCTP pyrophosphatase 1Add BLAST169

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei12PhosphothreonineCombined sources1
Modified residuei85PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H773.
MaxQBiQ9H773.
PaxDbiQ9H773.
PeptideAtlasiQ9H773.
PRIDEiQ9H773.
TopDownProteomicsiQ9H773.

PTM databases

iPTMnetiQ9H773.
PhosphoSitePlusiQ9H773.
SwissPalmiQ9H773.

Expressioni

Gene expression databases

BgeeiENSG00000179958.
ExpressionAtlasiQ9H773. baseline and differential.
GenevisibleiQ9H773. HS.

Organism-specific databases

HPAiHPA002832.

Interactioni

Subunit structurei

Homotetramer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
itself5EBI-723569,EBI-723569
SDCBPO005603EBI-723569,EBI-727004
WDYHV1Q96HA83EBI-723569,EBI-741158

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi122527. 26 interactors.
IntActiQ9H773. 9 interactors.
STRINGi9606.ENSP00000322524.

Chemistry databases

BindingDBiQ9H773.

Structurei

3D structure databases

ProteinModelPortaliQ9H773.
SMRiQ9H773.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati29 – 75EARAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni47 – 51Substrate bindingBy similarity5

Sequence similaritiesi

Contains 1 EAR repeat.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IXWQ. Eukaryota.
ENOG4111PYX. LUCA.
GeneTreeiENSGT00390000017709.
HOGENOMiHOG000056700.
InParanoidiQ9H773.
KOiK16904.
OMAiWKTDGEP.
OrthoDBiEOG091G0RYZ.
PhylomeDBiQ9H773.
TreeFamiTF300237.

Family and domain databases

CDDicd11537. NTP-PPase_RS21-C6_like. 1 hit.
InterProiIPR025984. DCTPP.
IPR009039. EAR.
[Graphical view]
PfamiPF12643. MazG-like. 1 hit.
[Graphical view]
PROSITEiPS50912. EAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H773-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVAGGEIRG DTGGEDTAAP GRFSFSPEPT LEDIRRLHAE FAAERDWEQF
60 70 80 90 100
HQPRNLLLAL VGEVGELAEL FQWKTDGEPG PQGWSPRERA ALQEELSDVL
110 120 130 140 150
IYLVALAARC RVDLPLAVLS KMDINRRRYP AHLARSSSRK YTELPHGAIS
160 170
EDQAVGPADI PCDSTGQTST
Length:170
Mass (Da):18,681
Last modified:March 1, 2001 - v1
Checksum:i23BC932D5461320B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY453409 mRNA. Translation: AAR26724.1.
AF212242 mRNA. Translation: AAK14927.1.
AF210430 mRNA. Translation: AAK48422.1.
CR457335 mRNA. Translation: CAG33616.1.
AK024843 mRNA. Translation: BAB15025.1.
BC001344 mRNA. Translation: AAH01344.1.
CCDSiCCDS10680.1.
RefSeqiNP_077001.1. NM_024096.1.
UniGeneiHs.632191.

Genome annotation databases

EnsembliENST00000319285; ENSP00000322524; ENSG00000179958.
GeneIDi79077.
KEGGihsa:79077.
UCSCiuc002dyf.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY453409 mRNA. Translation: AAR26724.1.
AF212242 mRNA. Translation: AAK14927.1.
AF210430 mRNA. Translation: AAK48422.1.
CR457335 mRNA. Translation: CAG33616.1.
AK024843 mRNA. Translation: BAB15025.1.
BC001344 mRNA. Translation: AAH01344.1.
CCDSiCCDS10680.1.
RefSeqiNP_077001.1. NM_024096.1.
UniGeneiHs.632191.

3D structure databases

ProteinModelPortaliQ9H773.
SMRiQ9H773.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122527. 26 interactors.
IntActiQ9H773. 9 interactors.
STRINGi9606.ENSP00000322524.

Chemistry databases

BindingDBiQ9H773.

PTM databases

iPTMnetiQ9H773.
PhosphoSitePlusiQ9H773.
SwissPalmiQ9H773.

Polymorphism and mutation databases

BioMutaiDCTPP1.
DMDMi74733624.

Proteomic databases

EPDiQ9H773.
MaxQBiQ9H773.
PaxDbiQ9H773.
PeptideAtlasiQ9H773.
PRIDEiQ9H773.
TopDownProteomicsiQ9H773.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319285; ENSP00000322524; ENSG00000179958.
GeneIDi79077.
KEGGihsa:79077.
UCSCiuc002dyf.4. human.

Organism-specific databases

CTDi79077.
GeneCardsiDCTPP1.
HGNCiHGNC:28777. DCTPP1.
HPAiHPA002832.
MIMi615840. gene.
neXtProtiNX_Q9H773.
OpenTargetsiENSG00000179958.
PharmGKBiPA164718733.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXWQ. Eukaryota.
ENOG4111PYX. LUCA.
GeneTreeiENSGT00390000017709.
HOGENOMiHOG000056700.
InParanoidiQ9H773.
KOiK16904.
OMAiWKTDGEP.
OrthoDBiEOG091G0RYZ.
PhylomeDBiQ9H773.
TreeFamiTF300237.

Enzyme and pathway databases

BioCyciZFISH:HS17396-MONOMER.
ReactomeiR-HSA-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Miscellaneous databases

GeneWikiiXTP3-transactivated_gene_A_protein.
GenomeRNAii79077.
PROiQ9H773.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179958.
ExpressionAtlasiQ9H773. baseline and differential.
GenevisibleiQ9H773. HS.

Family and domain databases

CDDicd11537. NTP-PPase_RS21-C6_like. 1 hit.
InterProiIPR025984. DCTPP.
IPR009039. EAR.
[Graphical view]
PfamiPF12643. MazG-like. 1 hit.
[Graphical view]
PROSITEiPS50912. EAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCTP1_HUMAN
AccessioniPrimary (citable) accession number: Q9H773
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.