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Q9H773

- DCTP1_HUMAN

UniProt

Q9H773 - DCTP1_HUMAN

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Protein

dCTP pyrophosphatase 1

Gene

DCTPP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases (By similarity).By similarity

Catalytic activityi

dCTP + H2O = dCMP + diphosphate.

Cofactori

Magnesium. Probably binds two or three magnesium ions per subunit (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381SubstrateBy similarity
Metal bindingi63 – 631MagnesiumBy similarity
Metal bindingi66 – 661MagnesiumBy similarity
Binding sitei73 – 731SubstrateBy similarity
Metal bindingi95 – 951MagnesiumBy similarity
Metal bindingi98 – 981MagnesiumBy similarity
Binding sitei102 – 1021SubstrateBy similarity

GO - Molecular functioni

  1. dCTP diphosphatase activity Source: UniProtKB-EC
  2. magnesium ion binding Source: UniProtKB
  3. nucleoside-triphosphate diphosphatase activity Source: UniProtKB
  4. pyrimidine deoxyribonucleotide binding Source: Ensembl

GO - Biological processi

  1. nucleoside triphosphate catabolic process Source: UniProtKB
  2. protein homotetramerization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP pyrophosphatase 1 (EC:3.6.1.12)
Alternative name(s):
Deoxycytidine-triphosphatase 1
Short name:
dCTPase 1
RS21C6
XTP3-transactivated gene A protein
Gene namesi
Name:DCTPP1
Synonyms:XTP3TPA
ORF Names:CDA03
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:28777. DCTPP1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164718733.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 170169dCTP pyrophosphatase 1PRO_0000291769Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine2 Publications
Modified residuei2 – 21Phosphoserine1 Publication
Modified residuei12 – 121Phosphothreonine1 Publication
Modified residuei85 – 851Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9H773.
PaxDbiQ9H773.
PeptideAtlasiQ9H773.
PRIDEiQ9H773.

PTM databases

PhosphoSiteiQ9H773.

Expressioni

Gene expression databases

BgeeiQ9H773.
ExpressionAtlasiQ9H773. baseline and differential.
GenevestigatoriQ9H773.

Organism-specific databases

HPAiHPA002832.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi122527. 21 interactions.
IntActiQ9H773. 4 interactions.
STRINGi9606.ENSP00000322524.

Structurei

3D structure databases

ProteinModelPortaliQ9H773.
SMRiQ9H773. Positions 23-123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati29 – 7547EARAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni47 – 515Substrate bindingBy similarity

Sequence similaritiesi

Contains 1 EAR repeat.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG131091.
GeneTreeiENSGT00390000017709.
HOGENOMiHOG000056700.
InParanoidiQ9H773.
KOiK16904.
OMAiGPQAWPP.
OrthoDBiEOG70S774.
PhylomeDBiQ9H773.
TreeFamiTF300237.

Family and domain databases

InterProiIPR009039. EAR.
IPR004518. MazG_cat.
[Graphical view]
PfamiPF03819. MazG. 1 hit.
[Graphical view]
PROSITEiPS50912. EAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H773-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVAGGEIRG DTGGEDTAAP GRFSFSPEPT LEDIRRLHAE FAAERDWEQF
60 70 80 90 100
HQPRNLLLAL VGEVGELAEL FQWKTDGEPG PQGWSPRERA ALQEELSDVL
110 120 130 140 150
IYLVALAARC RVDLPLAVLS KMDINRRRYP AHLARSSSRK YTELPHGAIS
160 170
EDQAVGPADI PCDSTGQTST
Length:170
Mass (Da):18,681
Last modified:March 1, 2001 - v1
Checksum:i23BC932D5461320B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY453409 mRNA. Translation: AAR26724.1.
AF212242 mRNA. Translation: AAK14927.1.
AF210430 mRNA. Translation: AAK48422.1.
CR457335 mRNA. Translation: CAG33616.1.
AK024843 mRNA. Translation: BAB15025.1.
BC001344 mRNA. Translation: AAH01344.1.
CCDSiCCDS10680.1.
RefSeqiNP_077001.1. NM_024096.1.
UniGeneiHs.632191.

Genome annotation databases

EnsembliENST00000319285; ENSP00000322524; ENSG00000179958.
GeneIDi79077.
KEGGihsa:79077.
UCSCiuc002dyf.3. human.

Polymorphism databases

DMDMi74733624.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY453409 mRNA. Translation: AAR26724.1 .
AF212242 mRNA. Translation: AAK14927.1 .
AF210430 mRNA. Translation: AAK48422.1 .
CR457335 mRNA. Translation: CAG33616.1 .
AK024843 mRNA. Translation: BAB15025.1 .
BC001344 mRNA. Translation: AAH01344.1 .
CCDSi CCDS10680.1.
RefSeqi NP_077001.1. NM_024096.1.
UniGenei Hs.632191.

3D structure databases

ProteinModelPortali Q9H773.
SMRi Q9H773. Positions 23-123.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122527. 21 interactions.
IntActi Q9H773. 4 interactions.
STRINGi 9606.ENSP00000322524.

Chemistry

BindingDBi Q9H773.

PTM databases

PhosphoSitei Q9H773.

Polymorphism databases

DMDMi 74733624.

Proteomic databases

MaxQBi Q9H773.
PaxDbi Q9H773.
PeptideAtlasi Q9H773.
PRIDEi Q9H773.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000319285 ; ENSP00000322524 ; ENSG00000179958 .
GeneIDi 79077.
KEGGi hsa:79077.
UCSCi uc002dyf.3. human.

Organism-specific databases

CTDi 79077.
GeneCardsi GC16M030435.
HGNCi HGNC:28777. DCTPP1.
HPAi HPA002832.
neXtProti NX_Q9H773.
PharmGKBi PA164718733.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG131091.
GeneTreei ENSGT00390000017709.
HOGENOMi HOG000056700.
InParanoidi Q9H773.
KOi K16904.
OMAi GPQAWPP.
OrthoDBi EOG70S774.
PhylomeDBi Q9H773.
TreeFami TF300237.

Miscellaneous databases

GeneWikii XTP3-transactivated_gene_A_protein.
GenomeRNAii 79077.
NextBioi 67876.
PROi Q9H773.

Gene expression databases

Bgeei Q9H773.
ExpressionAtlasi Q9H773. baseline and differential.
Genevestigatori Q9H773.

Family and domain databases

InterProi IPR009039. EAR.
IPR004518. MazG_cat.
[Graphical view ]
Pfami PF03819. MazG. 1 hit.
[Graphical view ]
PROSITEi PS50912. EAR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Screening and cloning of the target genes transactivated by XTP3 using a suppression subtractive hybridization technique."
    Wang C., Cheng J., Lang Z., Wu Y., Yang Y., Zhang L., Ji D.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A novel gene expressed in human pheochromocytoma."
    Li Y., Huang Q., Peng Y., Song H., Yu Y., Xu S., Ren S., Chen Z., Han Z.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pheochromocytoma.
  3. Zhang J., Chen W.F., Wang H.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; THR-12 AND SER-85, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDCTP1_HUMAN
AccessioniPrimary (citable) accession number: Q9H773
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3