Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9H772

- GREM2_HUMAN

UniProt

Q9H772 - GREM2_HUMAN

Protein

Gremlin-2

Gene

GREM2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells By similarity.By similarity

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB

    GO - Biological processi

    1. BMP signaling pathway Source: Reactome
    2. cytokine-mediated signaling pathway Source: UniProtKB
    3. embryonic body morphogenesis Source: UniProtKB
    4. regulation of cytokine activity Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine, Developmental protein

    Keywords - Ligandi

    Heparin-binding

    Enzyme and pathway databases

    ReactomeiREACT_12034. Signaling by BMP.
    SignaLinkiQ9H772.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gremlin-2
    Alternative name(s):
    Cysteine knot superfamily 1, BMP antagonist 2
    DAN domain family member 3
    Protein related to DAN and cerberus
    Gene namesi
    Name:GREM2
    Synonyms:CKTSF1B2, DAND3, PRDC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:17655. GREM2.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134968998.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 168147Gremlin-2PRO_0000006720Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi73 ↔ 123PROSITE-ProRule annotation
    Disulfide bondi87 ↔ 137PROSITE-ProRule annotation
    Disulfide bondi97 ↔ 155PROSITE-ProRule annotation
    Disulfide bondi101 ↔ 157PROSITE-ProRule annotation
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9H772.
    PRIDEiQ9H772.

    PTM databases

    PhosphoSiteiQ9H772.

    Expressioni

    Gene expression databases

    BgeeiQ9H772.
    CleanExiHS_GREM2.
    GenevestigatoriQ9H772.

    Organism-specific databases

    HPAiCAB009920.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with BMP2, BMP4 and BMP7, but has lower affinity for BMP7 than for BMP2 and BMP4. Binds heparin; this impairs the interaction with BMP2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi122150. 1 interaction.
    STRINGi9606.ENSP00000318650.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H772.
    SMRiQ9H772. Positions 50-160.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini73 – 16391CTCKPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the DAN family.Curated
    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG41424.
    HOGENOMiHOG000237358.
    HOVERGENiHBG051837.
    InParanoidiQ9H772.
    OMAiCAFCKPH.
    OrthoDBiEOG7Q2N7B.
    PhylomeDBiQ9H772.
    TreeFamiTF106445.

    Family and domain databases

    InterProiIPR006207. Cys_knot_C.
    IPR004133. DAN.
    IPR017159. Gremlin_precursor.
    [Graphical view]
    PfamiPF03045. DAN. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037254. Gremlin_precursor. 1 hit.
    SMARTiSM00041. CT. 1 hit.
    [Graphical view]
    PROSITEiPS01225. CTCK_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9H772-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFWKLSLSLF LVAVLVKVAE ARKNRPAGAI PSPYKDGSSN NSERWQHQIK    50
    EVLASSQEAL VVTERKYLKS DWCKTQPLRQ TVSEEGCRSR TILNRFCYGQ 100
    CNSFYIPRHV KKEEESFQSC AFCKPQRVTS VLVELECPGL DPPFRLKKIQ 150
    KVKQCRCMSV NLSDSDKQ 168
    Length:168
    Mass (Da):19,320
    Last modified:March 1, 2001 - v1
    Checksum:iD5A4E4E818BF8C0E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti11 – 111L → M in AAH46632. (PubMed:15489334)Curated
    Sequence conflicti31 – 311P → H in AAH46632. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti131 – 1311V → I.
    Corresponds to variant rs34188522 [ dbSNP | Ensembl ].
    VAR_048876

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK024848 mRNA. Translation: BAB15026.1.
    AL358176 Genomic DNA. Translation: CAH74074.1.
    BC046632 mRNA. Translation: AAH46632.1.
    CCDSiCCDS31070.1.
    RefSeqiNP_071914.3. NM_022469.3.
    UniGeneiHs.98206.

    Genome annotation databases

    EnsembliENST00000318160; ENSP00000318650; ENSG00000180875.
    GeneIDi64388.
    KEGGihsa:64388.
    UCSCiuc001hys.3. human.

    Polymorphism databases

    DMDMi62510699.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK024848 mRNA. Translation: BAB15026.1 .
    AL358176 Genomic DNA. Translation: CAH74074.1 .
    BC046632 mRNA. Translation: AAH46632.1 .
    CCDSi CCDS31070.1.
    RefSeqi NP_071914.3. NM_022469.3.
    UniGenei Hs.98206.

    3D structure databases

    ProteinModelPortali Q9H772.
    SMRi Q9H772. Positions 50-160.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122150. 1 interaction.
    STRINGi 9606.ENSP00000318650.

    PTM databases

    PhosphoSitei Q9H772.

    Polymorphism databases

    DMDMi 62510699.

    Proteomic databases

    PaxDbi Q9H772.
    PRIDEi Q9H772.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318160 ; ENSP00000318650 ; ENSG00000180875 .
    GeneIDi 64388.
    KEGGi hsa:64388.
    UCSCi uc001hys.3. human.

    Organism-specific databases

    CTDi 64388.
    GeneCardsi GC01M240652.
    HGNCi HGNC:17655. GREM2.
    HPAi CAB009920.
    MIMi 608832. gene.
    neXtProti NX_Q9H772.
    PharmGKBi PA134968998.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41424.
    HOGENOMi HOG000237358.
    HOVERGENi HBG051837.
    InParanoidi Q9H772.
    OMAi CAFCKPH.
    OrthoDBi EOG7Q2N7B.
    PhylomeDBi Q9H772.
    TreeFami TF106445.

    Enzyme and pathway databases

    Reactomei REACT_12034. Signaling by BMP.
    SignaLinki Q9H772.

    Miscellaneous databases

    GenomeRNAii 64388.
    NextBioi 66317.
    PROi Q9H772.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H772.
    CleanExi HS_GREM2.
    Genevestigatori Q9H772.

    Family and domain databases

    InterProi IPR006207. Cys_knot_C.
    IPR004133. DAN.
    IPR017159. Gremlin_precursor.
    [Graphical view ]
    Pfami PF03045. DAN. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037254. Gremlin_precursor. 1 hit.
    SMARTi SM00041. CT. 1 hit.
    [Graphical view ]
    PROSITEi PS01225. CTCK_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Identification and characterization of human CKTSF1B2 and CKTSF1B3 genes in silico."
      Katoh M., Katoh M.
      Oncol. Rep. 12:423-427(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiGREM2_HUMAN
    AccessioniPrimary (citable) accession number: Q9H772
    Secondary accession number(s): Q86UD9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3