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Protein

Ankyrin repeat and SOCS box protein 8

Gene

ASB8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 8
Short name:
ASB-8
Gene namesi
Name:ASB8
ORF Names:PP14212
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000177981.10
HGNCiHGNC:17183 ASB8
MIMi615053 gene
neXtProtiNX_Q9H765

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177981
PharmGKBiPA25036

Polymorphism and mutation databases

BioMutaiASB8
DMDMi29839757

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669381 – 288Ankyrin repeat and SOCS box protein 8Add BLAST288

Proteomic databases

PaxDbiQ9H765
PeptideAtlasiQ9H765
PRIDEiQ9H765
ProteomicsDBi81083

PTM databases

iPTMnetiQ9H765
PhosphoSitePlusiQ9H765

Expressioni

Tissue specificityi

Highest level of expression in skeletal muscle. Also expressed in heart, brain, placenta, liver, kidney and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000177981
CleanExiHS_ASB8
ExpressionAtlasiQ9H765 baseline and differential
GenevisibleiQ9H765 HS

Organism-specific databases

HPAiHPA003299

Interactioni

Protein-protein interaction databases

BioGridi126614, 25 interactors
IntActiQ9H765, 6 interactors
STRINGi9606.ENSP00000320893

Structurei

3D structure databases

ProteinModelPortaliQ9H765
SMRiQ9H765
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati52 – 81ANK 1Add BLAST30
Repeati85 – 113ANK 2Add BLAST29
Repeati117 – 146ANK 3Add BLAST30
Repeati150 – 179ANK 4Add BLAST30
Domaini235 – 288SOCS boxPROSITE-ProRule annotationAdd BLAST54

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00910000144039
HOGENOMiHOG000034088
HOVERGENiHBG001430
InParanoidiQ9H765
KOiK10330
OMAiCPNARDY
OrthoDBiEOG091G0DTZ
PhylomeDBiQ9H765
TreeFamiTF332452

Family and domain databases

CDDicd00204 ANK, 1 hit
cd03727 SOCS_ASB8, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR038907 ASB8
IPR037332 ASB8_SOCS
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
PANTHERiPTHR24134 PTHR24134, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS50225 SOCS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H765-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSMWYIMQ SIQSKYSLSE RLIRTIAAIR SFPHDNVEDL IRGGADVNCT
60 70 80 90 100
HGTLKPLHCA CMVSDADCVE LLLEKGAEVN ALDGYNRTAL HYAAEKDEAC
110 120 130 140 150
VEVLLEYGAN PNALDGNRDT PLHWAAFKNN AECVRALLES GASVNALDYN
160 170 180 190 200
NDTPLSWAAM KGNLESVSIL LDYGAEVRVI NLIGQTPISR LVALLVRGLG
210 220 230 240 250
TEKEDSCFEL LHRAVGHFEL RKNGTMPREV ARDPQLCEKL TVLCSAPGTL
260 270 280
KTLARYAVRR SLGLQYLPDA VKGLPLPASL KEYLLLLE
Length:288
Mass (Da):31,642
Last modified:March 1, 2001 - v1
Checksum:iB10FB7ADBDC3D3D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF464877 mRNA Translation: AAQ04830.1
AK024908 mRNA Translation: BAB15033.1
AK289957 mRNA Translation: BAF82646.1
BC001321 mRNA Translation: AAH01321.1
CCDSiCCDS8761.1
RefSeqiNP_001306225.1, NM_001319296.1
NP_001306226.1, NM_001319297.1
NP_001306227.1, NM_001319298.1
NP_001306228.1, NM_001319299.1
NP_001306229.1, NM_001319300.1
NP_001306230.1, NM_001319301.1
NP_077000.1, NM_024095.4
UniGeneiHs.432699

Genome annotation databases

EnsembliENST00000317697; ENSP00000320893; ENSG00000177981
ENST00000536549; ENSP00000445622; ENSG00000177981
GeneIDi140461
KEGGihsa:140461
UCSCiuc001rrh.4 human

Similar proteinsi

Entry informationi

Entry nameiASB8_HUMAN
AccessioniPrimary (citable) accession number: Q9H765
Secondary accession number(s): A8K1P2, Q547Q2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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