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Q9H765 (ASB8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ankyrin repeat and SOCS box protein 8

Short name=ASB-8
Gene names
Name:ASB8
ORF Names:PP14212
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins By similarity.

Pathway

Protein modification; protein ubiquitination.

Subcellular location

Cytoplasm Ref.1.

Tissue specificity

Highest level of expression in skeletal muscle. Also expressed in heart, brain, placenta, liver, kidney and pancreas. Ref.1

Domain

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes By similarity.

Sequence similarities

Contains 4 ANK repeats.

Contains 1 SOCS box domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentCytoplasm
   DomainANK repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processintracellular signal transduction

Inferred from electronic annotation. Source: InterPro

protein ubiquitination

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Ankyrin repeat and SOCS box protein 8
PRO_0000066938

Regions

Repeat52 – 8130ANK 1
Repeat85 – 11329ANK 2
Repeat117 – 14630ANK 3
Repeat150 – 17930ANK 4
Domain235 – 28854SOCS box

Sequences

Sequence LengthMass (Da)Tools
Q9H765 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: B10FB7ADBDC3D3D6

FASTA28831,642
        10         20         30         40         50         60 
MSSSMWYIMQ SIQSKYSLSE RLIRTIAAIR SFPHDNVEDL IRGGADVNCT HGTLKPLHCA 

        70         80         90        100        110        120 
CMVSDADCVE LLLEKGAEVN ALDGYNRTAL HYAAEKDEAC VEVLLEYGAN PNALDGNRDT 

       130        140        150        160        170        180 
PLHWAAFKNN AECVRALLES GASVNALDYN NDTPLSWAAM KGNLESVSIL LDYGAEVRVI 

       190        200        210        220        230        240 
NLIGQTPISR LVALLVRGLG TEKEDSCFEL LHRAVGHFEL RKNGTMPREV ARDPQLCEKL 

       250        260        270        280 
TVLCSAPGTL KTLARYAVRR SLGLQYLPDA VKGLPLPASL KEYLLLLE 

« Hide

References

[1]"Molecular cloning and characterization of the human ASB-8 gene encoding a novel member of ankyrin repeat and SOCS box containing protein family."
Liu Y., Li J., Zhang F., Qin W., Yao G., He X., Xue P., Ge C., Wan D., Gu J.
Biochem. Biophys. Res. Commun. 300:972-979(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon and Hippocampus.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cervix.
[4]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF464877 mRNA. Translation: AAQ04830.1.
AK024908 mRNA. Translation: BAB15033.1.
AK289957 mRNA. Translation: BAF82646.1.
BC001321 mRNA. Translation: AAH01321.1.
RefSeqNP_077000.1. NM_024095.3.
XP_005268711.1. XM_005268654.1.
UniGeneHs.432699.

3D structure databases

ProteinModelPortalQ9H765.
SMRQ9H765. Positions 37-287.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126614. 7 interactions.
IntActQ9H765. 4 interactions.
STRING9606.ENSP00000320893.

PTM databases

PhosphoSiteQ9H765.

Polymorphism databases

DMDM29839757.

Proteomic databases

PaxDbQ9H765.
PRIDEQ9H765.

Protocols and materials databases

DNASU140461.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000317697; ENSP00000320893; ENSG00000177981.
ENST00000536549; ENSP00000445622; ENSG00000177981.
GeneID140461.
KEGGhsa:140461.
UCSCuc001rrh.3. human.

Organism-specific databases

CTD140461.
GeneCardsGC12M048541.
HGNCHGNC:17183. ASB8.
HPAHPA003299.
MIM615053. gene.
neXtProtNX_Q9H765.
PharmGKBPA25036.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0666.
HOGENOMHOG000034088.
HOVERGENHBG001430.
InParanoidQ9H765.
KOK10330.
OMACACMVAD.
OrthoDBEOG7BS49X.
PhylomeDBQ9H765.
TreeFamTF332452.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.
UniPathwayUPA00143.

Gene expression databases

ArrayExpressQ9H765.
BgeeQ9H765.
CleanExHS_ASB8.
GenevestigatorQ9H765.

Family and domain databases

Gene3D1.25.40.20. 2 hits.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_C.
[Graphical view]
PfamPF12796. Ank_2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 4 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSASB8. human.
GenomeRNAi140461.
NextBio84121.
PROQ9H765.
SOURCESearch...

Entry information

Entry nameASB8_HUMAN
AccessionPrimary (citable) accession number: Q9H765
Secondary accession number(s): A8K1P2, Q547Q2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM