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Protein

Ankyrin repeat and SOCS box protein 8

Gene

ASB8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 8
Short name:
ASB-8
Gene namesi
Name:ASB8
ORF Names:PP14212
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:17183. ASB8.

Subcellular locationi

  1. Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25036.

Polymorphism and mutation databases

BioMutaiASB8.
DMDMi29839757.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Ankyrin repeat and SOCS box protein 8PRO_0000066938Add
BLAST

Proteomic databases

PaxDbiQ9H765.
PRIDEiQ9H765.

PTM databases

PhosphoSiteiQ9H765.

Expressioni

Tissue specificityi

Highest level of expression in skeletal muscle. Also expressed in heart, brain, placenta, liver, kidney and pancreas.1 Publication

Gene expression databases

BgeeiQ9H765.
CleanExiHS_ASB8.
ExpressionAtlasiQ9H765. baseline and differential.
GenevestigatoriQ9H765.

Organism-specific databases

HPAiHPA003299.

Interactioni

Protein-protein interaction databases

BioGridi126614. 21 interactions.
IntActiQ9H765. 4 interactions.
STRINGi9606.ENSP00000320893.

Structurei

3D structure databases

ProteinModelPortaliQ9H765.
SMRiQ9H765. Positions 37-287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati52 – 8130ANK 1Add
BLAST
Repeati85 – 11329ANK 2Add
BLAST
Repeati117 – 14630ANK 3Add
BLAST
Repeati150 – 17930ANK 4Add
BLAST
Domaini235 – 28854SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated
Contains 4 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00780000121910.
HOGENOMiHOG000034088.
HOVERGENiHBG001430.
InParanoidiQ9H765.
KOiK10330.
OMAiCACMVAD.
OrthoDBiEOG7BS49X.
PhylomeDBiQ9H765.
TreeFamiTF332452.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_C.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H765-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSMWYIMQ SIQSKYSLSE RLIRTIAAIR SFPHDNVEDL IRGGADVNCT
60 70 80 90 100
HGTLKPLHCA CMVSDADCVE LLLEKGAEVN ALDGYNRTAL HYAAEKDEAC
110 120 130 140 150
VEVLLEYGAN PNALDGNRDT PLHWAAFKNN AECVRALLES GASVNALDYN
160 170 180 190 200
NDTPLSWAAM KGNLESVSIL LDYGAEVRVI NLIGQTPISR LVALLVRGLG
210 220 230 240 250
TEKEDSCFEL LHRAVGHFEL RKNGTMPREV ARDPQLCEKL TVLCSAPGTL
260 270 280
KTLARYAVRR SLGLQYLPDA VKGLPLPASL KEYLLLLE
Length:288
Mass (Da):31,642
Last modified:March 1, 2001 - v1
Checksum:iB10FB7ADBDC3D3D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF464877 mRNA. Translation: AAQ04830.1.
AK024908 mRNA. Translation: BAB15033.1.
AK289957 mRNA. Translation: BAF82646.1.
BC001321 mRNA. Translation: AAH01321.1.
CCDSiCCDS8761.1.
RefSeqiNP_077000.1. NM_024095.3.
XP_005268711.1. XM_005268654.2.
UniGeneiHs.432699.

Genome annotation databases

EnsembliENST00000317697; ENSP00000320893; ENSG00000177981.
ENST00000536549; ENSP00000445622; ENSG00000177981.
GeneIDi140461.
KEGGihsa:140461.
UCSCiuc001rrh.3. human.

Polymorphism and mutation databases

BioMutaiASB8.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF464877 mRNA. Translation: AAQ04830.1.
AK024908 mRNA. Translation: BAB15033.1.
AK289957 mRNA. Translation: BAF82646.1.
BC001321 mRNA. Translation: AAH01321.1.
CCDSiCCDS8761.1.
RefSeqiNP_077000.1. NM_024095.3.
XP_005268711.1. XM_005268654.2.
UniGeneiHs.432699.

3D structure databases

ProteinModelPortaliQ9H765.
SMRiQ9H765. Positions 37-287.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126614. 21 interactions.
IntActiQ9H765. 4 interactions.
STRINGi9606.ENSP00000320893.

PTM databases

PhosphoSiteiQ9H765.

Polymorphism and mutation databases

BioMutaiASB8.
DMDMi29839757.

Proteomic databases

PaxDbiQ9H765.
PRIDEiQ9H765.

Protocols and materials databases

DNASUi140461.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317697; ENSP00000320893; ENSG00000177981.
ENST00000536549; ENSP00000445622; ENSG00000177981.
GeneIDi140461.
KEGGihsa:140461.
UCSCiuc001rrh.3. human.

Organism-specific databases

CTDi140461.
GeneCardsiGC12M048541.
HGNCiHGNC:17183. ASB8.
HPAiHPA003299.
MIMi615053. gene.
neXtProtiNX_Q9H765.
PharmGKBiPA25036.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00780000121910.
HOGENOMiHOG000034088.
HOVERGENiHBG001430.
InParanoidiQ9H765.
KOiK10330.
OMAiCACMVAD.
OrthoDBiEOG7BS49X.
PhylomeDBiQ9H765.
TreeFamiTF332452.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiASB8. human.
GenomeRNAii140461.
NextBioi84121.
PROiQ9H765.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H765.
CleanExiHS_ASB8.
ExpressionAtlasiQ9H765. baseline and differential.
GenevestigatoriQ9H765.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_C.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and characterization of the human ASB-8 gene encoding a novel member of ankyrin repeat and SOCS box containing protein family."
    Liu Y., Li J., Zhang F., Qin W., Yao G., He X., Xue P., Ge C., Wan D., Gu J.
    Biochem. Biophys. Res. Commun. 300:972-979(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Hippocampus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.

Entry informationi

Entry nameiASB8_HUMAN
AccessioniPrimary (citable) accession number: Q9H765
Secondary accession number(s): A8K1P2, Q547Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: March 1, 2001
Last modified: April 29, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.