Q9H765 (ASB8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ankyrin repeat and SOCS box protein 8
Short name=ASB-8

Gene names

Name:	ASB8
ORF Names:	PP14212

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins By similarity.
Pathway	Protein modification; protein ubiquitination.
Subcellular location	Cytoplasm Ref.1.
Tissue specificity	Highest level of expression in skeletal muscle. Also expressed in heart, brain, placenta, liver, kidney and pancreas. Ref.1
Domain	The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes By similarity.
Sequence similarities	Contains 4 ANK repeats. Contains 1 SOCS box domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Cytoplasm
Domain	ANK repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro protein ubiquitination Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	Ankyrin repeat and SOCS box protein 8		PRO_0000066938
Regions
	Repeat	52 – 81	30	ANK 1
	Repeat	85 – 113	29	ANK 2
	Repeat	117 – 146	30	ANK 3
	Repeat	150 – 179	30	ANK 4
	Domain	235 – 288	54	SOCS box

Sequences

	Sequence		Length	Mass (Da)
	Q9H765 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: B10FB7ADBDC3D3D6	FASTA	288	31,642
	10 20 30 40 50 60 MSSSMWYIMQ SIQSKYSLSE RLIRTIAAIR SFPHDNVEDL IRGGADVNCT HGTLKPLHCA 70 80 90 100 110 120 CMVSDADCVE LLLEKGAEVN ALDGYNRTAL HYAAEKDEAC VEVLLEYGAN PNALDGNRDT 130 140 150 160 170 180 PLHWAAFKNN AECVRALLES GASVNALDYN NDTPLSWAAM KGNLESVSIL LDYGAEVRVI 190 200 210 220 230 240 NLIGQTPISR LVALLVRGLG TEKEDSCFEL LHRAVGHFEL RKNGTMPREV ARDPQLCEKL 250 260 270 280 TVLCSAPGTL KTLARYAVRR SLGLQYLPDA VKGLPLPASL KEYLLLLE

References

[1]	"Molecular cloning and characterization of the human ASB-8 gene encoding a novel member of ankyrin repeat and SOCS box containing protein family." Liu Y., Li J., Zhang F., Qin W., Yao G., He X., Xue P., Ge C., Wan D., Gu J. Biochem. Biophys. Res. Commun. 300:972-979(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon and Hippocampus.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF464877 mRNA. Translation: AAQ04830.1. AK024908 mRNA. Translation: BAB15033.1. AK289957 mRNA. Translation: BAF82646.1. BC001321 mRNA. Translation: AAH01321.1.
IPI	IPI00012196.
RefSeq	NP_077000.1. NM_024095.3.
UniGene	Hs.432699.
3D structure databases
ProteinModelPortal	Q9H765.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H765. 4 interactions.
STRING	9606.ENSP00000320893.
PTM databases
PhosphoSite	Q9H765.
Polymorphism databases
DMDM	29839757.
Proteomic databases
PaxDb	Q9H765.
PRIDE	Q9H765.
Protocols and materials databases
DNASU	140461.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000317697; ENSP00000320893; ENSG00000177981. ENST00000536549; ENSP00000445622; ENSG00000177981.
GeneID	140461.
KEGG	hsa:140461.
UCSC	uc001rrh.3. human.
Organism-specific databases
CTD	140461.
GeneCards	GC12M048541.
HGNC	HGNC:17183. ASB8.
HPA	HPA003299.
MIM	615053. gene.
neXtProt	NX_Q9H765.
PharmGKB	PA25036.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0666.
HOGENOM	HOG000034088.
HOVERGEN	HBG001430.
InParanoid	Q9H765.
KO	K10330.
OMA	CACMVAD.
OrthoDB	EOG4V171C.
PhylomeDB	Q9H765.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
UniPathway	UPA00143.
Gene expression databases
ArrayExpress	Q9H765.
Bgee	Q9H765.
CleanEx	HS_ASB8.
Genevestigator	Q9H765.
GermOnline	ENSG00000177981. Homo sapiens.
Family and domain databases
Gene3D	1.25.40.20. 2 hits.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR001496. SOCS_C. [Graphical view]
Pfam	PF12796. Ank_2. 1 hit. PF07525. SOCS_box. 1 hit. [Graphical view]
SMART	SM00248. ANK. 4 hits. SM00969. SOCS_box. 1 hit. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 4 hits. PS50225. SOCS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ASB8. human.
GenomeRNAi	140461.
NextBio	84121.
SOURCE	Search...

Entry information

Entry name

ASB8_HUMAN

Accession

Primary (citable) accession number: Q9H765
Secondary accession number(s): A8K1P2, Q547Q2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 28, 2003
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.