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Q9H765

- ASB8_HUMAN

UniProt

Q9H765 - ASB8_HUMAN

Protein

Ankyrin repeat and SOCS box protein 8

Gene

ASB8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

    Pathwayi

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ankyrin repeat and SOCS box protein 8
    Short name:
    ASB-8
    Gene namesi
    Name:ASB8
    ORF Names:PP14212
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:17183. ASB8.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25036.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Ankyrin repeat and SOCS box protein 8PRO_0000066938Add
    BLAST

    Proteomic databases

    PaxDbiQ9H765.
    PRIDEiQ9H765.

    PTM databases

    PhosphoSiteiQ9H765.

    Expressioni

    Tissue specificityi

    Highest level of expression in skeletal muscle. Also expressed in heart, brain, placenta, liver, kidney and pancreas.1 Publication

    Gene expression databases

    ArrayExpressiQ9H765.
    BgeeiQ9H765.
    CleanExiHS_ASB8.
    GenevestigatoriQ9H765.

    Organism-specific databases

    HPAiHPA003299.

    Interactioni

    Protein-protein interaction databases

    BioGridi126614. 18 interactions.
    IntActiQ9H765. 4 interactions.
    STRINGi9606.ENSP00000320893.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H765.
    SMRiQ9H765. Positions 26-287.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati52 – 8130ANK 1Add
    BLAST
    Repeati85 – 11329ANK 2Add
    BLAST
    Repeati117 – 14630ANK 3Add
    BLAST
    Repeati150 – 17930ANK 4Add
    BLAST
    Domaini235 – 28854SOCS boxPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

    Sequence similaritiesi

    Contains 4 ANK repeats.PROSITE-ProRule annotation
    Contains 1 SOCS box domain.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    HOGENOMiHOG000034088.
    HOVERGENiHBG001430.
    InParanoidiQ9H765.
    KOiK10330.
    OMAiCACMVAD.
    OrthoDBiEOG7BS49X.
    PhylomeDBiQ9H765.
    TreeFamiTF332452.

    Family and domain databases

    Gene3Di1.25.40.20. 2 hits.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001496. SOCS_C.
    [Graphical view]
    PfamiPF12796. Ank_2. 1 hit.
    PF07525. SOCS_box. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 4 hits.
    SM00969. SOCS_box. 1 hit.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 4 hits.
    PS50225. SOCS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H765-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSSMWYIMQ SIQSKYSLSE RLIRTIAAIR SFPHDNVEDL IRGGADVNCT    50
    HGTLKPLHCA CMVSDADCVE LLLEKGAEVN ALDGYNRTAL HYAAEKDEAC 100
    VEVLLEYGAN PNALDGNRDT PLHWAAFKNN AECVRALLES GASVNALDYN 150
    NDTPLSWAAM KGNLESVSIL LDYGAEVRVI NLIGQTPISR LVALLVRGLG 200
    TEKEDSCFEL LHRAVGHFEL RKNGTMPREV ARDPQLCEKL TVLCSAPGTL 250
    KTLARYAVRR SLGLQYLPDA VKGLPLPASL KEYLLLLE 288
    Length:288
    Mass (Da):31,642
    Last modified:March 1, 2001 - v1
    Checksum:iB10FB7ADBDC3D3D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF464877 mRNA. Translation: AAQ04830.1.
    AK024908 mRNA. Translation: BAB15033.1.
    AK289957 mRNA. Translation: BAF82646.1.
    BC001321 mRNA. Translation: AAH01321.1.
    CCDSiCCDS8761.1.
    RefSeqiNP_077000.1. NM_024095.3.
    XP_005268711.1. XM_005268654.1.
    UniGeneiHs.432699.

    Genome annotation databases

    EnsembliENST00000317697; ENSP00000320893; ENSG00000177981.
    ENST00000536549; ENSP00000445622; ENSG00000177981.
    GeneIDi140461.
    KEGGihsa:140461.
    UCSCiuc001rrh.3. human.

    Polymorphism databases

    DMDMi29839757.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF464877 mRNA. Translation: AAQ04830.1 .
    AK024908 mRNA. Translation: BAB15033.1 .
    AK289957 mRNA. Translation: BAF82646.1 .
    BC001321 mRNA. Translation: AAH01321.1 .
    CCDSi CCDS8761.1.
    RefSeqi NP_077000.1. NM_024095.3.
    XP_005268711.1. XM_005268654.1.
    UniGenei Hs.432699.

    3D structure databases

    ProteinModelPortali Q9H765.
    SMRi Q9H765. Positions 26-287.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126614. 18 interactions.
    IntActi Q9H765. 4 interactions.
    STRINGi 9606.ENSP00000320893.

    PTM databases

    PhosphoSitei Q9H765.

    Polymorphism databases

    DMDMi 29839757.

    Proteomic databases

    PaxDbi Q9H765.
    PRIDEi Q9H765.

    Protocols and materials databases

    DNASUi 140461.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000317697 ; ENSP00000320893 ; ENSG00000177981 .
    ENST00000536549 ; ENSP00000445622 ; ENSG00000177981 .
    GeneIDi 140461.
    KEGGi hsa:140461.
    UCSCi uc001rrh.3. human.

    Organism-specific databases

    CTDi 140461.
    GeneCardsi GC12M048541.
    HGNCi HGNC:17183. ASB8.
    HPAi HPA003299.
    MIMi 615053. gene.
    neXtProti NX_Q9H765.
    PharmGKBi PA25036.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.
    HOGENOMi HOG000034088.
    HOVERGENi HBG001430.
    InParanoidi Q9H765.
    KOi K10330.
    OMAi CACMVAD.
    OrthoDBi EOG7BS49X.
    PhylomeDBi Q9H765.
    TreeFami TF332452.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

    Miscellaneous databases

    ChiTaRSi ASB8. human.
    GenomeRNAii 140461.
    NextBioi 84121.
    PROi Q9H765.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H765.
    Bgeei Q9H765.
    CleanExi HS_ASB8.
    Genevestigatori Q9H765.

    Family and domain databases

    Gene3Di 1.25.40.20. 2 hits.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001496. SOCS_C.
    [Graphical view ]
    Pfami PF12796. Ank_2. 1 hit.
    PF07525. SOCS_box. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 4 hits.
    SM00969. SOCS_box. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 4 hits.
    PS50225. SOCS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of the human ASB-8 gene encoding a novel member of ankyrin repeat and SOCS box containing protein family."
      Liu Y., Li J., Zhang F., Qin W., Yao G., He X., Xue P., Ge C., Wan D., Gu J.
      Biochem. Biophys. Res. Commun. 300:972-979(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon and Hippocampus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cervix.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiASB8_HUMAN
    AccessioniPrimary (citable) accession number: Q9H765
    Secondary accession number(s): A8K1P2, Q547Q2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 28, 2003
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3