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Q9H765

- ASB8_HUMAN

UniProt

Q9H765 - ASB8_HUMAN

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Protein
Ankyrin repeat and SOCS box protein 8
Gene
ASB8, PP14212
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins By similarity.

Pathwayi

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 8
Short name:
ASB-8
Gene namesi
Name:ASB8
ORF Names:PP14212
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:17183. ASB8.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25036.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Ankyrin repeat and SOCS box protein 8
PRO_0000066938Add
BLAST

Proteomic databases

PaxDbiQ9H765.
PRIDEiQ9H765.

PTM databases

PhosphoSiteiQ9H765.

Expressioni

Tissue specificityi

Highest level of expression in skeletal muscle. Also expressed in heart, brain, placenta, liver, kidney and pancreas.1 Publication

Gene expression databases

ArrayExpressiQ9H765.
BgeeiQ9H765.
CleanExiHS_ASB8.
GenevestigatoriQ9H765.

Organism-specific databases

HPAiHPA003299.

Interactioni

Protein-protein interaction databases

BioGridi126614. 18 interactions.
IntActiQ9H765. 4 interactions.
STRINGi9606.ENSP00000320893.

Structurei

3D structure databases

ProteinModelPortaliQ9H765.
SMRiQ9H765. Positions 26-287.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati52 – 8130ANK 1
Add
BLAST
Repeati85 – 11329ANK 2
Add
BLAST
Repeati117 – 14630ANK 3
Add
BLAST
Repeati150 – 17930ANK 4
Add
BLAST
Domaini235 – 28854SOCS box
Add
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes By similarity.

Sequence similaritiesi

Contains 4 ANK repeats.
Contains 1 SOCS box domain.

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
HOGENOMiHOG000034088.
HOVERGENiHBG001430.
InParanoidiQ9H765.
KOiK10330.
OMAiCACMVAD.
OrthoDBiEOG7BS49X.
PhylomeDBiQ9H765.
TreeFamiTF332452.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_C.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H765-1 [UniParc]FASTAAdd to Basket

« Hide

MSSSMWYIMQ SIQSKYSLSE RLIRTIAAIR SFPHDNVEDL IRGGADVNCT    50
HGTLKPLHCA CMVSDADCVE LLLEKGAEVN ALDGYNRTAL HYAAEKDEAC 100
VEVLLEYGAN PNALDGNRDT PLHWAAFKNN AECVRALLES GASVNALDYN 150
NDTPLSWAAM KGNLESVSIL LDYGAEVRVI NLIGQTPISR LVALLVRGLG 200
TEKEDSCFEL LHRAVGHFEL RKNGTMPREV ARDPQLCEKL TVLCSAPGTL 250
KTLARYAVRR SLGLQYLPDA VKGLPLPASL KEYLLLLE 288
Length:288
Mass (Da):31,642
Last modified:March 1, 2001 - v1
Checksum:iB10FB7ADBDC3D3D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF464877 mRNA. Translation: AAQ04830.1.
AK024908 mRNA. Translation: BAB15033.1.
AK289957 mRNA. Translation: BAF82646.1.
BC001321 mRNA. Translation: AAH01321.1.
CCDSiCCDS8761.1.
RefSeqiNP_077000.1. NM_024095.3.
XP_005268711.1. XM_005268654.1.
UniGeneiHs.432699.

Genome annotation databases

EnsembliENST00000317697; ENSP00000320893; ENSG00000177981.
ENST00000536549; ENSP00000445622; ENSG00000177981.
GeneIDi140461.
KEGGihsa:140461.
UCSCiuc001rrh.3. human.

Polymorphism databases

DMDMi29839757.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF464877 mRNA. Translation: AAQ04830.1 .
AK024908 mRNA. Translation: BAB15033.1 .
AK289957 mRNA. Translation: BAF82646.1 .
BC001321 mRNA. Translation: AAH01321.1 .
CCDSi CCDS8761.1.
RefSeqi NP_077000.1. NM_024095.3.
XP_005268711.1. XM_005268654.1.
UniGenei Hs.432699.

3D structure databases

ProteinModelPortali Q9H765.
SMRi Q9H765. Positions 26-287.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126614. 18 interactions.
IntActi Q9H765. 4 interactions.
STRINGi 9606.ENSP00000320893.

PTM databases

PhosphoSitei Q9H765.

Polymorphism databases

DMDMi 29839757.

Proteomic databases

PaxDbi Q9H765.
PRIDEi Q9H765.

Protocols and materials databases

DNASUi 140461.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000317697 ; ENSP00000320893 ; ENSG00000177981 .
ENST00000536549 ; ENSP00000445622 ; ENSG00000177981 .
GeneIDi 140461.
KEGGi hsa:140461.
UCSCi uc001rrh.3. human.

Organism-specific databases

CTDi 140461.
GeneCardsi GC12M048541.
HGNCi HGNC:17183. ASB8.
HPAi HPA003299.
MIMi 615053. gene.
neXtProti NX_Q9H765.
PharmGKBi PA25036.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0666.
HOGENOMi HOG000034088.
HOVERGENi HBG001430.
InParanoidi Q9H765.
KOi K10330.
OMAi CACMVAD.
OrthoDBi EOG7BS49X.
PhylomeDBi Q9H765.
TreeFami TF332452.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSi ASB8. human.
GenomeRNAii 140461.
NextBioi 84121.
PROi Q9H765.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9H765.
Bgeei Q9H765.
CleanExi HS_ASB8.
Genevestigatori Q9H765.

Family and domain databases

Gene3Di 1.25.40.20. 2 hits.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_C.
[Graphical view ]
Pfami PF12796. Ank_2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 4 hits.
SM00969. SOCS_box. 1 hit.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50225. SOCS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of the human ASB-8 gene encoding a novel member of ankyrin repeat and SOCS box containing protein family."
    Liu Y., Li J., Zhang F., Qin W., Yao G., He X., Xue P., Ge C., Wan D., Gu J.
    Biochem. Biophys. Res. Commun. 300:972-979(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Hippocampus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiASB8_HUMAN
AccessioniPrimary (citable) accession number: Q9H765
Secondary accession number(s): A8K1P2, Q547Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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