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Protein

Leucine-rich repeat-containing protein 19

Gene

LRRC19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31042-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 19
Gene namesi
Name:LRRC19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23379. LRRC19.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 270ExtracellularSequence analysisAdd BLAST246
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 370CytoplasmicSequence analysisAdd BLAST79

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184434.
PharmGKBiPA134892454.

Polymorphism and mutation databases

BioMutaiLRRC19.
DMDMi51701695.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000002161025 – 370Leucine-rich repeat-containing protein 19Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi32N-linked (GlcNAc...)Sequence analysis1
Glycosylationi37N-linked (GlcNAc...)Sequence analysis1
Glycosylationi62N-linked (GlcNAc...)Sequence analysis1
Glycosylationi95N-linked (GlcNAc...)Sequence analysis1
Glycosylationi179N-linked (GlcNAc...)Sequence analysis1
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1
Glycosylationi195N-linked (GlcNAc...)Sequence analysis1
Glycosylationi202N-linked (GlcNAc...)Sequence analysis1
Glycosylationi251N-linked (GlcNAc...)Sequence analysis1
Glycosylationi256N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9H756.
PeptideAtlasiQ9H756.
PRIDEiQ9H756.

PTM databases

iPTMnetiQ9H756.
PhosphoSitePlusiQ9H756.

Expressioni

Gene expression databases

BgeeiENSG00000184434.
CleanExiHS_LRRC19.
GenevisibleiQ9H756. HS.

Organism-specific databases

HPAiHPA014541.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369395.

Structurei

3D structure databases

ProteinModelPortaliQ9H756.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati48 – 68LRR 1Add BLAST21
Repeati74 – 95LRR 2Add BLAST22
Repeati98 – 119LRR 3Add BLAST22
Repeati122 – 143LRR 4Add BLAST22
Repeati146 – 169LRR 5Add BLAST24
Domaini176 – 228LRRCTAdd BLAST53

Sequence similaritiesi

Contains 5 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00790000122963.
HOGENOMiHOG000049223.
HOVERGENiHBG052345.
InParanoidiQ9H756.
OMAiFDVPQLF.
OrthoDBiEOG091G0BMC.
PhylomeDBiQ9H756.
TreeFamiTF335466.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H756-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVTGITILF WPLSMILLSD KIQSSKREVQ CNFTEKNYTL IPADIKKDVT
60 70 80 90 100
ILDLSYNQIT LNGTDTRVLQ TYFLLTELYL IENKVTILHN NGFGNLSSLE
110 120 130 140 150
ILNICRNSIY VIQQGAFLGL NKLKQLYLCQ NKIEQLNADV FVPLRSLKLL
160 170 180 190 200
NLQGNLISYL DVPPLFHLEL ITLYGNLWNC SCSLFNLQNW LNTSNVTLEN
210 220 230 240 250
ENITMCSYPN SLQSYNIKTV PHKAECHSKF PSSVTEDLYI HFQPISNSIF
260 270 280 290 300
NSSSNNLTRN SEHEPLGKSW AFLVGVVVTV LTTSLLIFIA IKCPIWYNIL
310 320 330 340 350
LSYNHHRLEE HEAETYEDGF TGNPSSLSQI PETNSEETTV IFEQLHSFVV
360 370
DDDGFIEDKY IDIHELCEEN
Length:370
Mass (Da):42,334
Last modified:March 1, 2001 - v1
Checksum:i9B59E08CF766E902
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024955 mRNA. Translation: BAB15042.1.
BC126156 mRNA. Translation: AAI26157.1.
BC136298 mRNA. Translation: AAI36299.1.
CCDSiCCDS6518.1.
RefSeqiNP_075052.1. NM_022901.2.
UniGeneiHs.128071.

Genome annotation databases

EnsembliENST00000380055; ENSP00000369395; ENSG00000184434.
GeneIDi64922.
KEGGihsa:64922.
UCSCiuc003zqh.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024955 mRNA. Translation: BAB15042.1.
BC126156 mRNA. Translation: AAI26157.1.
BC136298 mRNA. Translation: AAI36299.1.
CCDSiCCDS6518.1.
RefSeqiNP_075052.1. NM_022901.2.
UniGeneiHs.128071.

3D structure databases

ProteinModelPortaliQ9H756.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000369395.

PTM databases

iPTMnetiQ9H756.
PhosphoSitePlusiQ9H756.

Polymorphism and mutation databases

BioMutaiLRRC19.
DMDMi51701695.

Proteomic databases

PaxDbiQ9H756.
PeptideAtlasiQ9H756.
PRIDEiQ9H756.

Protocols and materials databases

DNASUi64922.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380055; ENSP00000369395; ENSG00000184434.
GeneIDi64922.
KEGGihsa:64922.
UCSCiuc003zqh.4. human.

Organism-specific databases

CTDi64922.
GeneCardsiLRRC19.
HGNCiHGNC:23379. LRRC19.
HPAiHPA014541.
neXtProtiNX_Q9H756.
OpenTargetsiENSG00000184434.
PharmGKBiPA134892454.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00790000122963.
HOGENOMiHOG000049223.
HOVERGENiHBG052345.
InParanoidiQ9H756.
OMAiFDVPQLF.
OrthoDBiEOG091G0BMC.
PhylomeDBiQ9H756.
TreeFamiTF335466.

Enzyme and pathway databases

BioCyciZFISH:G66-31042-MONOMER.

Miscellaneous databases

GenomeRNAii64922.
PROiQ9H756.

Gene expression databases

BgeeiENSG00000184434.
CleanExiHS_LRRC19.
GenevisibleiQ9H756. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLRC19_HUMAN
AccessioniPrimary (citable) accession number: Q9H756
Secondary accession number(s): A0AV00, B9EG91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.