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Protein

Leucine-rich repeat-containing protein 19

Gene

LRRC19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 19
Gene namesi
Name:LRRC19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23379. LRRC19.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 270246ExtracellularSequence analysisAdd
BLAST
Transmembranei271 – 29121HelicalSequence analysisAdd
BLAST
Topological domaini292 – 37079CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134892454.

Polymorphism and mutation databases

BioMutaiLRRC19.
DMDMi51701695.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 370346Leucine-rich repeat-containing protein 19PRO_0000021610Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence analysis
Glycosylationi37 – 371N-linked (GlcNAc...)Sequence analysis
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence analysis
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence analysis
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence analysis
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence analysis
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence analysis
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence analysis
Glycosylationi251 – 2511N-linked (GlcNAc...)Sequence analysis
Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9H756.
PeptideAtlasiQ9H756.
PRIDEiQ9H756.

PTM databases

iPTMnetiQ9H756.
PhosphoSiteiQ9H756.

Expressioni

Gene expression databases

BgeeiENSG00000184434.
CleanExiHS_LRRC19.
GenevisibleiQ9H756. HS.

Organism-specific databases

HPAiHPA014541.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369395.

Structurei

3D structure databases

ProteinModelPortaliQ9H756.
SMRiQ9H756. Positions 24-218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati48 – 6821LRR 1Add
BLAST
Repeati74 – 9522LRR 2Add
BLAST
Repeati98 – 11922LRR 3Add
BLAST
Repeati122 – 14322LRR 4Add
BLAST
Repeati146 – 16924LRR 5Add
BLAST
Domaini176 – 22853LRRCTAdd
BLAST

Sequence similaritiesi

Contains 5 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00830000128419.
HOGENOMiHOG000049223.
HOVERGENiHBG052345.
InParanoidiQ9H756.
OMAiFDVPQLF.
OrthoDBiEOG091G0BMC.
PhylomeDBiQ9H756.
TreeFamiTF335466.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H756-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVTGITILF WPLSMILLSD KIQSSKREVQ CNFTEKNYTL IPADIKKDVT
60 70 80 90 100
ILDLSYNQIT LNGTDTRVLQ TYFLLTELYL IENKVTILHN NGFGNLSSLE
110 120 130 140 150
ILNICRNSIY VIQQGAFLGL NKLKQLYLCQ NKIEQLNADV FVPLRSLKLL
160 170 180 190 200
NLQGNLISYL DVPPLFHLEL ITLYGNLWNC SCSLFNLQNW LNTSNVTLEN
210 220 230 240 250
ENITMCSYPN SLQSYNIKTV PHKAECHSKF PSSVTEDLYI HFQPISNSIF
260 270 280 290 300
NSSSNNLTRN SEHEPLGKSW AFLVGVVVTV LTTSLLIFIA IKCPIWYNIL
310 320 330 340 350
LSYNHHRLEE HEAETYEDGF TGNPSSLSQI PETNSEETTV IFEQLHSFVV
360 370
DDDGFIEDKY IDIHELCEEN
Length:370
Mass (Da):42,334
Last modified:March 1, 2001 - v1
Checksum:i9B59E08CF766E902
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024955 mRNA. Translation: BAB15042.1.
BC126156 mRNA. Translation: AAI26157.1.
BC136298 mRNA. Translation: AAI36299.1.
CCDSiCCDS6518.1.
RefSeqiNP_075052.1. NM_022901.2.
UniGeneiHs.128071.

Genome annotation databases

EnsembliENST00000380055; ENSP00000369395; ENSG00000184434.
GeneIDi64922.
KEGGihsa:64922.
UCSCiuc003zqh.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024955 mRNA. Translation: BAB15042.1.
BC126156 mRNA. Translation: AAI26157.1.
BC136298 mRNA. Translation: AAI36299.1.
CCDSiCCDS6518.1.
RefSeqiNP_075052.1. NM_022901.2.
UniGeneiHs.128071.

3D structure databases

ProteinModelPortaliQ9H756.
SMRiQ9H756. Positions 24-218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000369395.

PTM databases

iPTMnetiQ9H756.
PhosphoSiteiQ9H756.

Polymorphism and mutation databases

BioMutaiLRRC19.
DMDMi51701695.

Proteomic databases

PaxDbiQ9H756.
PeptideAtlasiQ9H756.
PRIDEiQ9H756.

Protocols and materials databases

DNASUi64922.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380055; ENSP00000369395; ENSG00000184434.
GeneIDi64922.
KEGGihsa:64922.
UCSCiuc003zqh.4. human.

Organism-specific databases

CTDi64922.
GeneCardsiLRRC19.
HGNCiHGNC:23379. LRRC19.
HPAiHPA014541.
neXtProtiNX_Q9H756.
PharmGKBiPA134892454.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00830000128419.
HOGENOMiHOG000049223.
HOVERGENiHBG052345.
InParanoidiQ9H756.
OMAiFDVPQLF.
OrthoDBiEOG091G0BMC.
PhylomeDBiQ9H756.
TreeFamiTF335466.

Miscellaneous databases

GenomeRNAii64922.
PROiQ9H756.

Gene expression databases

BgeeiENSG00000184434.
CleanExiHS_LRRC19.
GenevisibleiQ9H756. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLRC19_HUMAN
AccessioniPrimary (citable) accession number: Q9H756
Secondary accession number(s): A0AV00, B9EG91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.