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Protein

UPF0454 protein C12orf49

Gene

C12orf49

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0454 protein C12orf49
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:26128. C12orf49.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394721.

Polymorphism and mutation databases

BioMutaiC12orf49.
DMDMi74733622.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Chaini34 – 205172UPF0454 protein C12orf49PRO_0000294329Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9H741.
PaxDbiQ9H741.
PRIDEiQ9H741.

PTM databases

iPTMnetiQ9H741.

Expressioni

Gene expression databases

BgeeiQ9H741.
CleanExiHS_C12orf49.
ExpressionAtlasiQ9H741. baseline and differential.
GenevisibleiQ9H741. HS.

Organism-specific databases

HPAiHPA026905.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT31Q153233EBI-2836158,EBI-948001
TRIM54Q9BYV23EBI-2836158,EBI-2130429

Protein-protein interaction databases

BioGridi122892. 18 interactions.
IntActiQ9H741. 3 interactions.
STRINGi9606.ENSP00000261318.

Structurei

3D structure databases

ProteinModelPortaliQ9H741.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi103 – 13533Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the UPF0454 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3136. Eukaryota.
ENOG4110XXW. LUCA.
GeneTreeiENSGT00390000008031.
HOGENOMiHOG000044706.
HOVERGENiHBG097587.
InParanoidiQ9H741.
OMAiNTYRNPQ.
OrthoDBiEOG7K9K3Q.
PhylomeDBiQ9H741.
TreeFamiTF323884.

Family and domain databases

InterProiIPR019352. UPF0454.
[Graphical view]
PANTHERiPTHR13481. PTHR13481. 1 hit.
PfamiPF10218. DUF2054. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H741-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNLAAMVWR RLLRKRWVLA LVFGLSLVYF LSSTFKQEER AVRDRNLLQV
60 70 80 90 100
HDHNQPIPWK VQFNLGNSSR PSNQCRNSIQ GKHLITDELG YVCERKDLLV
110 120 130 140 150
NGCCNVNVPS TKQYCCDGCW PNGCCSAYEY CVSCCLQPNK QLLLERFLNR
160 170 180 190 200
AAVAFQNLFM AVEDHFELCL AKCRTSSQSV QHENTYRDPI AKYCYGESPP

ELFPA
Length:205
Mass (Da):23,594
Last modified:March 1, 2001 - v1
Checksum:iFA477B84FC8AD499
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti143 – 1431L → P in BAD96703 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti55 – 551Q → R.
Corresponds to variant rs10507274 [ dbSNP | Ensembl ].
VAR_033154

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025068 mRNA. Translation: BAB15058.1.
AK222983 mRNA. Translation: BAD96703.1.
BC019843 mRNA. Translation: AAH19843.1.
CCDSiCCDS9179.1.
RefSeqiNP_079014.1. NM_024738.2.
UniGeneiHs.592011.

Genome annotation databases

EnsembliENST00000261318; ENSP00000261318; ENSG00000111412.
GeneIDi79794.
KEGGihsa:79794.
UCSCiuc001tvz.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025068 mRNA. Translation: BAB15058.1.
AK222983 mRNA. Translation: BAD96703.1.
BC019843 mRNA. Translation: AAH19843.1.
CCDSiCCDS9179.1.
RefSeqiNP_079014.1. NM_024738.2.
UniGeneiHs.592011.

3D structure databases

ProteinModelPortaliQ9H741.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122892. 18 interactions.
IntActiQ9H741. 3 interactions.
STRINGi9606.ENSP00000261318.

PTM databases

iPTMnetiQ9H741.

Polymorphism and mutation databases

BioMutaiC12orf49.
DMDMi74733622.

Proteomic databases

MaxQBiQ9H741.
PaxDbiQ9H741.
PRIDEiQ9H741.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261318; ENSP00000261318; ENSG00000111412.
GeneIDi79794.
KEGGihsa:79794.
UCSCiuc001tvz.2. human.

Organism-specific databases

CTDi79794.
GeneCardsiC12orf49.
HGNCiHGNC:26128. C12orf49.
HPAiHPA026905.
neXtProtiNX_Q9H741.
PharmGKBiPA128394721.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3136. Eukaryota.
ENOG4110XXW. LUCA.
GeneTreeiENSGT00390000008031.
HOGENOMiHOG000044706.
HOVERGENiHBG097587.
InParanoidiQ9H741.
OMAiNTYRNPQ.
OrthoDBiEOG7K9K3Q.
PhylomeDBiQ9H741.
TreeFamiTF323884.

Miscellaneous databases

GenomeRNAii79794.
PROiQ9H741.

Gene expression databases

BgeeiQ9H741.
CleanExiHS_C12orf49.
ExpressionAtlasiQ9H741. baseline and differential.
GenevisibleiQ9H741. HS.

Family and domain databases

InterProiIPR019352. UPF0454.
[Graphical view]
PANTHERiPTHR13481. PTHR13481. 1 hit.
PfamiPF10218. DUF2054. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Small intestine.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.

Entry informationi

Entry nameiCL049_HUMAN
AccessioniPrimary (citable) accession number: Q9H741
Secondary accession number(s): Q53GE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.