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Protein

PGAP2-interacting protein

Gene

CWH43

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in lipid remodeling during GPI-anchor maturation.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000109182-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
PGAP2-interacting protein
Alternative name(s):
Cell wall biogenesis protein 43 C-terminal homolog
Gene namesi
Name:CWH43
Synonyms:PGAP2IP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:26133. CWH43.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Transmembranei273 – 293HelicalSequence analysisAdd BLAST21
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Transmembranei349 – 369HelicalSequence analysisAdd BLAST21
Transmembranei390 – 410HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi80157.
OpenTargetsiENSG00000109182.
PharmGKBiPA165663488.

Polymorphism and mutation databases

BioMutaiCWH43.
DMDMi296439265.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003206151 – 699PGAP2-interacting proteinAdd BLAST699

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi455N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9H720.
PeptideAtlasiQ9H720.
PRIDEiQ9H720.

PTM databases

iPTMnetiQ9H720.
PhosphoSitePlusiQ9H720.

Expressioni

Gene expression databases

BgeeiENSG00000109182.
ExpressionAtlasiQ9H720. baseline and differential.
GenevisibleiQ9H720. HS.

Organism-specific databases

HPAiHPA042814.
HPA048140.

Interactioni

Subunit structurei

Interacts with PGAP2/FRAG1.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000226432.

Structurei

3D structure databases

ProteinModelPortaliQ9H720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni607 – 627Required for function in lipid remodelingBy similarityAdd BLAST21

Sequence similaritiesi

Belongs to the PGAP2IP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3979. Eukaryota.
ENOG410XT2T. LUCA.
GeneTreeiENSGT00510000048509.
HOGENOMiHOG000068090.
HOVERGENiHBG106500.
InParanoidiQ9H720.
OMAiGNRDTTQ.
OrthoDBiEOG091G08SE.
PhylomeDBiQ9H720.
TreeFamiTF328857.

Family and domain databases

InterProiIPR005135. Endo/exonuclease/phosphatase.
IPR027317. PGAP2IP.
[Graphical view]
PANTHERiPTHR14859. PTHR14859. 1 hit.
SUPFAMiSSF56219. SSF56219. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H720-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSLWREILL ESLLGCVSWS LYHDLGPMIY YFPLQTLELT GLEGFSIAFL
60 70 80 90 100
SPIFLTITPF WKLVNKKWML TLLRIITIGS IASFQAPNAK LRLMVLALGV
110 120 130 140 150
SSSLIVQAVT WWSGSHLQRY LRIWGFILGQ IVLVVLRIWY TSLNPIWSYQ
160 170 180 190 200
MSNKVILTLS AIATLDRIGT DGDCSKPEEK KTGEVATGMA SRPNWLLAGA
210 220 230 240 250
AFGSLVFLTH WVFGEVSLVS RWAVSGHPHP GPDPNPFGGA VLLCLASGLM
260 270 280 290 300
LPSCLWFRGT GLIWWVTGTA SAAGLLYLHT WAAAVSGCVF AIFTASMWPQ
310 320 330 340 350
TLGHLINSGT NPGKTMTIAM IFYLLEIFFC AWCTAFKFVP GGVYARERSD
360 370 380 390 400
VLLGTMMLII GLNMLFGPKK NLDLLLQTKN SSKVLFRKSE KYMKLFLWLL
410 420 430 440 450
VGVGLLGLGL RHKAYERKLG KVAPTKEVSA AIWPFRFGYD NEGWSSLERS
460 470 480 490 500
AHLLNETGAD FITILESDAS KPYMGNNDLT MWLGEKLGFY TDFGPSTRYH
510 520 530 540 550
TWGIMALSRY PIVKSEHHLL PSPEGEIAPA ITLTVNISGK LVDFVVTHFG
560 570 580 590 600
NHEDDLDRKL QAIAVSKLLK SSSNQVIFLG YITSAPGSRD YLQLTEHGNV
610 620 630 640 650
KDIDSTDHDR WCEYIMYRGL IRLGYARISH AELSDSEIQM AKFRIPDDPT
660 670 680 690
NYRDNQKVVI DHREVSEKIH FNPRFGSYKE GHNYENNHHF HMNTPKYFL
Length:699
Mass (Da):78,584
Last modified:May 18, 2010 - v2
Checksum:i447B687A88083FA4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0392342P → T.2 PublicationsCorresponds to variant rs3747690dbSNPEnsembl.1
Natural variantiVAR_039235689H → N.2 PublicationsCorresponds to variant rs1051447dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025164 mRNA. Translation: BAB15080.1.
AC020593 Genomic DNA. No translation available.
BC137387 mRNA. Translation: AAI37388.1.
BC137388 mRNA. Translation: AAI37389.1.
CCDSiCCDS3486.1.
RefSeqiNP_001273720.1. NM_001286791.1.
NP_079363.2. NM_025087.2.
UniGeneiHs.479703.

Genome annotation databases

EnsembliENST00000226432; ENSP00000226432; ENSG00000109182.
GeneIDi80157.
KEGGihsa:80157.
UCSCiuc003gyv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025164 mRNA. Translation: BAB15080.1.
AC020593 Genomic DNA. No translation available.
BC137387 mRNA. Translation: AAI37388.1.
BC137388 mRNA. Translation: AAI37389.1.
CCDSiCCDS3486.1.
RefSeqiNP_001273720.1. NM_001286791.1.
NP_079363.2. NM_025087.2.
UniGeneiHs.479703.

3D structure databases

ProteinModelPortaliQ9H720.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000226432.

PTM databases

iPTMnetiQ9H720.
PhosphoSitePlusiQ9H720.

Polymorphism and mutation databases

BioMutaiCWH43.
DMDMi296439265.

Proteomic databases

PaxDbiQ9H720.
PeptideAtlasiQ9H720.
PRIDEiQ9H720.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000226432; ENSP00000226432; ENSG00000109182.
GeneIDi80157.
KEGGihsa:80157.
UCSCiuc003gyv.4. human.

Organism-specific databases

CTDi80157.
DisGeNETi80157.
GeneCardsiCWH43.
HGNCiHGNC:26133. CWH43.
HPAiHPA042814.
HPA048140.
neXtProtiNX_Q9H720.
OpenTargetsiENSG00000109182.
PharmGKBiPA165663488.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3979. Eukaryota.
ENOG410XT2T. LUCA.
GeneTreeiENSGT00510000048509.
HOGENOMiHOG000068090.
HOVERGENiHBG106500.
InParanoidiQ9H720.
OMAiGNRDTTQ.
OrthoDBiEOG091G08SE.
PhylomeDBiQ9H720.
TreeFamiTF328857.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000109182-MONOMER.

Miscellaneous databases

GenomeRNAii80157.
PROiQ9H720.

Gene expression databases

BgeeiENSG00000109182.
ExpressionAtlasiQ9H720. baseline and differential.
GenevisibleiQ9H720. HS.

Family and domain databases

InterProiIPR005135. Endo/exonuclease/phosphatase.
IPR027317. PGAP2IP.
[Graphical view]
PANTHERiPTHR14859. PTHR14859. 1 hit.
SUPFAMiSSF56219. SSF56219. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPG2IP_HUMAN
AccessioniPrimary (citable) accession number: Q9H720
Secondary accession number(s): B2RPD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.