Reviewed, UniProtKB/Swiss-Prot Q9H714 (CM018_HUMAN)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein C13orf18

Gene names

Name:

C13orf18

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	662 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H714-5)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q9H714-4)

The sequence of this isoform differs from the canonical sequence as follows:
     545-662: ALKEFEQVPG...LLESVASAAT → CVKERALFVN...MITPICVYYW

Note: No experimental confirmation available.

Isoform 2 (identifier: Q9H714-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MVSQSTVRQD...HFVTDAASPS → MVSNHYFLLCVNLPLREIHTP

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9H714-1)

The sequence of this isoform differs from the canonical sequence as follows:
     309-321: ELGDFNDITETCS → VSLMSQTSILQNY
     322-662: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 4 (identifier: Q9H714-2)

The sequence of this isoform differs from the canonical sequence as follows:
     136-147: MVRPGYSHRVSL → KACMRKPRSWTE
     148-662: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 662	662	Uncharacterized protein C13orf18		PRO_0000089880
Regions
	Compositional bias	86 – 131	46	Ser-rich
Natural variations
	Alternative sequence	1 – 88	88	MVSQS…AASPS → MVSNHYFLLCVNLPLREIHT P in isoform 2.		VSP_014708
	Alternative sequence	136 – 147	12	MVRPG…HRVSL → KACMRKPRSWTE in isoform 4.		VSP_014709
	Alternative sequence	148 – 662	515	Missing in isoform 4.		VSP_014710
	Alternative sequence	309 – 321	13	ELGDF…TETCS → VSLMSQTSILQNY in isoform 3.		VSP_014711
	Alternative sequence	322 – 662	341	Missing in isoform 3.		VSP_014712
	Alternative sequence	545 – 662	118	ALKEF…ASAAT → CVKERALFVNFARIRLSSSH FRQQHVEDVQRAGLAFTNSA SSPPSAPGVRGSQRGENFWK VWPLQQHDAPEYCEKDCSTC LMITPICVYYW in isoform 5.		VSP_014713
	Natural variant	152	1	G → R: dbSNP rs1408184. Ref.1 Ref.3		VAR_022912
Experimental info
	Sequence conflict	234 – 236	3	TES → ARG in AAH04495. Ref.3
	Sequence conflict	469	1	S → P in BAG52649. Ref.1
	Sequence conflict	549	1	F → L in BAG52649. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 23, 2008. Version 3. Checksum: 0AAA3C0F76CDAED8	FASTA	662	73,457
	10 20 30 40 50 60 MVSQSTVRQD SPVEPWEGIS DHSGIIDGSP RLLNTDHPPC QLDIRLMRHK AVWINPQDVQ 70 80 90 100 110 120 QQPQDLQSQV PAAGNSGTHF VTDAASPSGP SPSCLGDSLA ETTLSEDTTD SVGSASPHGS 130 140 150 160 170 180 SEKSSSFSLS STEVHMVRPG YSHRVSLPTS PGILATSPYP ETDSAFFEPS HLTSAADEGA 190 200 210 220 230 240 VQVSRRTISS NSFSPEVFVL PVDVEKENAH FYVADMIISA MEKMKCNILS QQQTESWSKE 250 260 270 280 290 300 VSGLLGSDQP DSEMTFDTNI KQESGSSTSS YSGYEGCAVL QVSPVTETRT YHDVKEICKC 310 320 330 340 350 360 DVDEFVILEL GDFNDITETC SCSCSSSKSV TYEPDFNSAE LLAKELYRVF QKCWILSVVN 370 380 390 400 410 420 SQLAGSLSAA GSIVVNEECV RKDFESSMNV VQEIKFKSRI RGTEDWAPPR FQIIFNIHPP 430 440 450 460 470 480 LKRDLVVAAQ NFFCAGCGTP VEPKFVKRLR YCEYLGKYFC DCCHSYAESC IPARILMMWD 490 500 510 520 530 540 FKKYYVSNFS KQLLDSIWHQ PIFNLLSIGQ SLYAKAKELD RVKEIQEQLF HIKKLLKTCR 550 560 570 580 590 600 FANSALKEFE QVPGHLTDEL HLFSLEDLVR IKKGLLAPLL KDILKASLAH VAGCELCQGK 610 620 630 640 650 660 GFICEFCQNT TVIFPFQTAT CRRCSACRAC FHKQCFQSSE CPRCARITAR RKLLESVASA AT
	Isoform 5. Checksum: 940B4217A7A5CB00	FASTA	635	70,804
	10 20 30 40 50 60 MVSQSTVRQD SPVEPWEGIS DHSGIIDGSP RLLNTDHPPC QLDIRLMRHK AVWINPQDVQ 70 80 90 100 110 120 QQPQDLQSQV PAAGNSGTHF VTDAASPSGP SPSCLGDSLA ETTLSEDTTD SVGSASPHGS 130 140 150 160 170 180 SEKSSSFSLS STEVHMVRPG YSHRVSLPTS PGILATSPYP ETDSAFFEPS HLTSAADEGA 190 200 210 220 230 240 VQVSRRTISS NSFSPEVFVL PVDVEKENAH FYVADMIISA MEKMKCNILS QQQTESWSKE 250 260 270 280 290 300 VSGLLGSDQP DSEMTFDTNI KQESGSSTSS YSGYEGCAVL QVSPVTETRT YHDVKEICKC 310 320 330 340 350 360 DVDEFVILEL GDFNDITETC SCSCSSSKSV TYEPDFNSAE LLAKELYRVF QKCWILSVVN 370 380 390 400 410 420 SQLAGSLSAA GSIVVNEECV RKDFESSMNV VQEIKFKSRI RGTEDWAPPR FQIIFNIHPP 430 440 450 460 470 480 LKRDLVVAAQ NFFCAGCGTP VEPKFVKRLR YCEYLGKYFC DCCHSYAESC IPARILMMWD 490 500 510 520 530 540 FKKYYVSNFS KQLLDSIWHQ PIFNLLSIGQ SLYAKAKELD RVKEIQEQLF HIKKLLKTCR 550 560 570 580 590 600 FANSCVKERA LFVNFARIRL SSSHFRQQHV EDVQRAGLAF TNSASSPPSA PGVRGSQRGE 610 620 630 NFWKVWPLQQ HDAPEYCEKD CSTCLMITPI CVYYW
	Isoform 2. Checksum: 236D8B25EF1598F5	FASTA	595	66,332
	10 20 30 40 50 60 MVSNHYFLLC VNLPLREIHT PGPSPSCLGD SLAETTLSED TTDSVGSASP HGSSEKSSSF 70 80 90 100 110 120 SLSSTEVHMV RPGYSHRVSL PTSPGILATS PYPETDSAFF EPSHLTSAAD EGAVQVSRRT 130 140 150 160 170 180 ISSNSFSPEV FVLPVDVEKE NAHFYVADMI ISAMEKMKCN ILSQQQTESW SKEVSGLLGS 190 200 210 220 230 240 DQPDSEMTFD TNIKQESGSS TSSYSGYEGC AVLQVSPVTE TRTYHDVKEI CKCDVDEFVI 250 260 270 280 290 300 LELGDFNDIT ETCSCSCSSS KSVTYEPDFN SAELLAKELY RVFQKCWILS VVNSQLAGSL 310 320 330 340 350 360 SAAGSIVVNE ECVRKDFESS MNVVQEIKFK SRIRGTEDWA PPRFQIIFNI HPPLKRDLVV 370 380 390 400 410 420 AAQNFFCAGC GTPVEPKFVK RLRYCEYLGK YFCDCCHSYA ESCIPARILM MWDFKKYYVS 430 440 450 460 470 480 NFSKQLLDSI WHQPIFNLLS IGQSLYAKAK ELDRVKEIQE QLFHIKKLLK TCRFANSALK 490 500 510 520 530 540 EFEQVPGHLT DELHLFSLED LVRIKKGLLA PLLKDILKAS LAHVAGCELC QGKGFICEFC 550 560 570 580 590 QNTTVIFPFQ TATCRRCSAC RACFHKQCFQ SSECPRCARI TARRKLLESV ASAAT
	Isoform 3. Checksum: FE0420F7D72F8E25	FASTA	321	34,713
	10 20 30 40 50 60 MVSQSTVRQD SPVEPWEGIS DHSGIIDGSP RLLNTDHPPC QLDIRLMRHK AVWINPQDVQ 70 80 90 100 110 120 QQPQDLQSQV PAAGNSGTHF VTDAASPSGP SPSCLGDSLA ETTLSEDTTD SVGSASPHGS 130 140 150 160 170 180 SEKSSSFSLS STEVHMVRPG YSHRVSLPTS PGILATSPYP ETDSAFFEPS HLTSAADEGA 190 200 210 220 230 240 VQVSRRTISS NSFSPEVFVL PVDVEKENAH FYVADMIISA MEKMKCNILS QQQTESWSKE 250 260 270 280 290 300 VSGLLGSDQP DSEMTFDTNI KQESGSSTSS YSGYEGCAVL QVSPVTETRT YHDVKEICKC 310 320 DVDEFVILVS LMSQTSILQN Y
	Isoform 4. Checksum: FF8A9EDB6424872E	FASTA	147	15,736
	10 20 30 40 50 60 MVSQSTVRQD SPVEPWEGIS DHSGIIDGSP RLLNTDHPPC QLDIRLMRHK AVWINPQDVQ 70 80 90 100 110 120 QQPQDLQSQV PAAGNSGTHF VTDAASPSGP SPSCLGDSLA ETTLSEDTTD SVGSASPHGS 130 140 SEKSSSFSLS STEVHKACMR KPRSWTE

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), VARIANT ARG-152. Tissue: Colon and Testis.
[2]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 234-662 (ISOFORMS 1/2), VARIANT ARG-152. Tissue: B-cell, Leukocyte and Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK025215 mRNA. Translation: BAB15086.1. AK093073 mRNA. Translation: BAG52649.1. AL139801 Genomic DNA. Translation: CAH71680.2. AL139801 Genomic DNA. Translation: CAH71682.2. AL139801 Genomic DNA. Translation: CAP19142.1. BC004495 mRNA. Translation: AAH04495.1. BC021097 mRNA. No translation available. BC032311 mRNA. No translation available. BC043488 mRNA. Translation: AAH43488.1.
IPI	IPI00448906. IPI00640058. IPI00796975. IPI00878675. IPI00879266.
RefSeq	NP_079389.2.
UniGene	Hs.98117
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9H714.
PTM databases
PhosphoSite	Q9H714.
Genome annotation databases
Ensembl	ENST00000389908; ENSP00000374558; ENSG00000102445; Homo sapiens. [Genome view] ENST00000429979; ENSP00000396935; ENSG00000102445; Homo sapiens. [Genome view]
GeneID	80183.
KEGG	hsa:80183.
UCSC	uc001vbe.2. human. uc010aco.1. human.
Organism-specific databases
CTD	80183.
GeneCards	GC13M045815.
HGNC	HGNC:20420. C13orf18.
PharmGKB	PA134942431.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9H714.
OMA	CRRCSAC
OrthoDB	EOG9HQH43
Enzyme and pathway databases
BioCyc	CATTLE:ENSBTAG00000013371-MON.
Gene expression databases
ArrayExpress	Q9H714.
Bgee	Q9H714.
CleanEx	HS_C13orf18.
Genevestigator	Q9H714.
GermOnline	ENSG00000102445. Homo sapiens.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

CM018_HUMAN

Accession

Primary (citable) accession number: Q9H714
Secondary accession number(s): A8XR19 , B3KS87, Q5W051, Q5W053, Q6PJ74, Q6PK94, Q86XH7, Q8N5J6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	September 23, 2008
Last modified:	November 24, 2009
This is version 53 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.