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Protein

Uncharacterized protein KIAA0226-like

Gene

KIAA0226L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein KIAA0226-like
Gene namesi
Name:KIAA0226L
Synonyms:C13orf18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:20420. KIAA0226L.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134942431.

Polymorphism and mutation databases

BioMutaiKIAA0226L.
DMDMi206729926.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 662662Uncharacterized protein KIAA0226-likePRO_0000089880Add
BLAST

Proteomic databases

MaxQBiQ9H714.
PaxDbiQ9H714.
PeptideAtlasiQ9H714.
PRIDEiQ9H714.

PTM databases

iPTMnetiQ9H714.
PhosphoSiteiQ9H714.

Expressioni

Gene expression databases

BgeeiENSG00000102445.
CleanExiHS_C13orf18.
ExpressionAtlasiQ9H714. baseline and differential.
GenevisibleiQ9H714. HS.

Organism-specific databases

HPAiHPA026614.

Interactioni

Protein-protein interaction databases

BioGridi123162. 9 interactions.
IntActiQ9H714. 3 interactions.
STRINGi9606.ENSP00000374558.

Structurei

3D structure databases

ProteinModelPortaliQ9H714.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi86 – 13146Ser-richAdd
BLAST

Phylogenomic databases

eggNOGiENOG410ITGP. Eukaryota.
ENOG410YE6N. LUCA.
GeneTreeiENSGT00550000074570.
HOGENOMiHOG000082444.
HOVERGENiHBG081255.
InParanoidiQ9H714.
OMAiVASCELC.
OrthoDBiEOG091G05ZY.
PhylomeDBiQ9H714.
TreeFamiTF317067.

Family and domain databases

InterProiIPR025258. Zf-RING_9.
[Graphical view]
PfamiPF13901. zf-RING_9. 1 hit.
[Graphical view]
SMARTiSM01175. DUF4206. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H714-5) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSQSTVRQD SPVEPWEGIS DHSGIIDGSP RLLNTDHPPC QLDIRLMRHK
60 70 80 90 100
AVWINPQDVQ QQPQDLQSQV PAAGNSGTHF VTDAASPSGP SPSCLGDSLA
110 120 130 140 150
ETTLSEDTTD SVGSASPHGS SEKSSSFSLS STEVHMVRPG YSHRVSLPTS
160 170 180 190 200
PGILATSPYP ETDSAFFEPS HLTSAADEGA VQVSRRTISS NSFSPEVFVL
210 220 230 240 250
PVDVEKENAH FYVADMIISA MEKMKCNILS QQQTESWSKE VSGLLGSDQP
260 270 280 290 300
DSEMTFDTNI KQESGSSTSS YSGYEGCAVL QVSPVTETRT YHDVKEICKC
310 320 330 340 350
DVDEFVILEL GDFNDITETC SCSCSSSKSV TYEPDFNSAE LLAKELYRVF
360 370 380 390 400
QKCWILSVVN SQLAGSLSAA GSIVVNEECV RKDFESSMNV VQEIKFKSRI
410 420 430 440 450
RGTEDWAPPR FQIIFNIHPP LKRDLVVAAQ NFFCAGCGTP VEPKFVKRLR
460 470 480 490 500
YCEYLGKYFC DCCHSYAESC IPARILMMWD FKKYYVSNFS KQLLDSIWHQ
510 520 530 540 550
PIFNLLSIGQ SLYAKAKELD RVKEIQEQLF HIKKLLKTCR FANSALKEFE
560 570 580 590 600
QVPGHLTDEL HLFSLEDLVR IKKGLLAPLL KDILKASLAH VAGCELCQGK
610 620 630 640 650
GFICEFCQNT TVIFPFQTAT CRRCSACRAC FHKQCFQSSE CPRCARITAR
660
RKLLESVASA AT
Note: No experimental confirmation available.
Length:662
Mass (Da):73,457
Last modified:September 23, 2008 - v3
Checksum:i0AAA3C0F76CDAED8
GO
Isoform 5 (identifier: Q9H714-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     545-662: ALKEFEQVPG...LLESVASAAT → CVKERALFVN...MITPICVYYW

Note: No experimental confirmation available.
Show »
Length:635
Mass (Da):70,804
Checksum:i940B4217A7A5CB00
GO
Isoform 2 (identifier: Q9H714-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: MVSQSTVRQD...HFVTDAASPS → MVSNHYFLLCVNLPLREIHTP

Note: No experimental confirmation available.
Show »
Length:595
Mass (Da):66,332
Checksum:i236D8B25EF1598F5
GO
Isoform 3 (identifier: Q9H714-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     309-321: ELGDFNDITETCS → VSLMSQTSILQNY
     322-662: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:321
Mass (Da):34,713
Checksum:iFE0420F7D72F8E25
GO
Isoform 4 (identifier: Q9H714-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-147: MVRPGYSHRVSL → KACMRKPRSWTE
     148-662: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:147
Mass (Da):15,736
Checksum:iFF8A9EDB6424872E
GO
Isoform 6 (identifier: Q9H714-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.

Note: No experimental confirmation available.
Show »
Length:527
Mass (Da):59,214
Checksum:iC01D8165ADF32673
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti234 – 2363TES → ARG in AAH04495 (PubMed:15489334).Curated
Sequence conflicti469 – 4691S → P in BAG52649 (PubMed:14702039).Curated
Sequence conflicti549 – 5491F → L in BAG52649 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti152 – 1521G → R.2 Publications
Corresponds to variant rs1408184 [ dbSNP | Ensembl ].
VAR_022912

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 135135Missing in isoform 6. 1 PublicationVSP_055260Add
BLAST
Alternative sequencei1 – 8888MVSQS…AASPS → MVSNHYFLLCVNLPLREIHT P in isoform 2. 1 PublicationVSP_014708Add
BLAST
Alternative sequencei136 – 14712MVRPG…HRVSL → KACMRKPRSWTE in isoform 4. 1 PublicationVSP_014709Add
BLAST
Alternative sequencei148 – 662515Missing in isoform 4. 1 PublicationVSP_014710Add
BLAST
Alternative sequencei309 – 32113ELGDF…TETCS → VSLMSQTSILQNY in isoform 3. 1 PublicationVSP_014711Add
BLAST
Alternative sequencei322 – 662341Missing in isoform 3. 1 PublicationVSP_014712Add
BLAST
Alternative sequencei545 – 662118ALKEF…ASAAT → CVKERALFVNFARIRLSSSH FRQQHVEDVQRAGLAFTNSA SSPPSAPGVRGSQRGENFWK VWPLQQHDAPEYCEKDCSTC LMITPICVYYW in isoform 5. 1 PublicationVSP_014713Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025215 mRNA. Translation: BAB15086.1.
AK093073 mRNA. Translation: BAG52649.1.
AK293034 mRNA. Translation: BAF85723.1.
AL139801 Genomic DNA. Translation: CAH71680.2.
AL139801 Genomic DNA. Translation: CAH71682.2.
AL139801 Genomic DNA. Translation: CAP19142.1.
BC004495 mRNA. Translation: AAH04495.1.
BC021097 mRNA. No translation available.
BC032311 mRNA. No translation available.
BC043488 mRNA. Translation: AAH43488.1.
CCDSiCCDS31970.2. [Q9H714-5]
CCDS66542.1. [Q9H714-6]
CCDS66543.1. [Q9H714-4]
CCDS66545.1. [Q9H714-3]
RefSeqiNP_001273690.1. NM_001286761.1. [Q9H714-5]
NP_001273691.1. NM_001286762.1. [Q9H714-4]
NP_001273692.1. NM_001286763.1. [Q9H714-3]
NP_001273693.1. NM_001286764.1. [Q9H714-6]
NP_001273694.1. NM_001286765.1.
NP_001273695.1. NM_001286766.1.
NP_079389.2. NM_025113.3. [Q9H714-5]
UniGeneiHs.98117.

Genome annotation databases

EnsembliENST00000378784; ENSP00000368061; ENSG00000102445. [Q9H714-3]
ENST00000378787; ENSP00000368064; ENSG00000102445. [Q9H714-4]
ENST00000389908; ENSP00000374558; ENSG00000102445. [Q9H714-5]
ENST00000429979; ENSP00000396935; ENSG00000102445. [Q9H714-5]
ENST00000631139; ENSP00000485932; ENSG00000102445. [Q9H714-6]
GeneIDi80183.
KEGGihsa:80183.
UCSCiuc001vbe.6. human. [Q9H714-5]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025215 mRNA. Translation: BAB15086.1.
AK093073 mRNA. Translation: BAG52649.1.
AK293034 mRNA. Translation: BAF85723.1.
AL139801 Genomic DNA. Translation: CAH71680.2.
AL139801 Genomic DNA. Translation: CAH71682.2.
AL139801 Genomic DNA. Translation: CAP19142.1.
BC004495 mRNA. Translation: AAH04495.1.
BC021097 mRNA. No translation available.
BC032311 mRNA. No translation available.
BC043488 mRNA. Translation: AAH43488.1.
CCDSiCCDS31970.2. [Q9H714-5]
CCDS66542.1. [Q9H714-6]
CCDS66543.1. [Q9H714-4]
CCDS66545.1. [Q9H714-3]
RefSeqiNP_001273690.1. NM_001286761.1. [Q9H714-5]
NP_001273691.1. NM_001286762.1. [Q9H714-4]
NP_001273692.1. NM_001286763.1. [Q9H714-3]
NP_001273693.1. NM_001286764.1. [Q9H714-6]
NP_001273694.1. NM_001286765.1.
NP_001273695.1. NM_001286766.1.
NP_079389.2. NM_025113.3. [Q9H714-5]
UniGeneiHs.98117.

3D structure databases

ProteinModelPortaliQ9H714.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123162. 9 interactions.
IntActiQ9H714. 3 interactions.
STRINGi9606.ENSP00000374558.

PTM databases

iPTMnetiQ9H714.
PhosphoSiteiQ9H714.

Polymorphism and mutation databases

BioMutaiKIAA0226L.
DMDMi206729926.

Proteomic databases

MaxQBiQ9H714.
PaxDbiQ9H714.
PeptideAtlasiQ9H714.
PRIDEiQ9H714.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378784; ENSP00000368061; ENSG00000102445. [Q9H714-3]
ENST00000378787; ENSP00000368064; ENSG00000102445. [Q9H714-4]
ENST00000389908; ENSP00000374558; ENSG00000102445. [Q9H714-5]
ENST00000429979; ENSP00000396935; ENSG00000102445. [Q9H714-5]
ENST00000631139; ENSP00000485932; ENSG00000102445. [Q9H714-6]
GeneIDi80183.
KEGGihsa:80183.
UCSCiuc001vbe.6. human. [Q9H714-5]

Organism-specific databases

CTDi80183.
GeneCardsiKIAA0226L.
H-InvDBHIX0011299.
HGNCiHGNC:20420. KIAA0226L.
HPAiHPA026614.
neXtProtiNX_Q9H714.
PharmGKBiPA134942431.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITGP. Eukaryota.
ENOG410YE6N. LUCA.
GeneTreeiENSGT00550000074570.
HOGENOMiHOG000082444.
HOVERGENiHBG081255.
InParanoidiQ9H714.
OMAiVASCELC.
OrthoDBiEOG091G05ZY.
PhylomeDBiQ9H714.
TreeFamiTF317067.

Miscellaneous databases

ChiTaRSiKIAA0226L. human.
GenomeRNAii80183.
PROiQ9H714.

Gene expression databases

BgeeiENSG00000102445.
CleanExiHS_C13orf18.
ExpressionAtlasiQ9H714. baseline and differential.
GenevisibleiQ9H714. HS.

Family and domain databases

InterProiIPR025258. Zf-RING_9.
[Graphical view]
PfamiPF13901. zf-RING_9. 1 hit.
[Graphical view]
SMARTiSM01175. DUF4206. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK226L_HUMAN
AccessioniPrimary (citable) accession number: Q9H714
Secondary accession number(s): A8KAG9
, A8XR19, B3KS87, Q5W051, Q5W053, Q6PJ74, Q6PK94, Q86XH7, Q8N5J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: September 23, 2008
Last modified: September 7, 2016
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.