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Protein

Zinc finger protein 552

Gene

ZNF552

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri91 – 11323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri119 – 14123C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri212 – 23423C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri244 – 26219C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri296 – 31823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 552
Gene namesi
Name:ZNF552
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26135. ZNF552.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134986961.

Polymorphism and mutation databases

BioMutaiZNF552.
DMDMi147742907.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Zinc finger protein 552PRO_0000286810Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki198 – 198Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki251 – 251Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki266 – 266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ9H707.
PaxDbiQ9H707.
PRIDEiQ9H707.

PTM databases

iPTMnetiQ9H707.
PhosphoSiteiQ9H707.

Expressioni

Gene expression databases

BgeeiQ9H707.
CleanExiHS_ZNF552.
ExpressionAtlasiQ9H707. baseline and differential.
GenevisibleiQ9H707. HS.

Organism-specific databases

HPAiHPA043800.
HPA053762.

Interactioni

Protein-protein interaction databases

BioGridi122913. 2 interactions.
IntActiQ9H707. 4 interactions.
STRINGi9606.ENSP00000375582.

Structurei

3D structure databases

ProteinModelPortaliQ9H707.
SMRiQ9H707. Positions 105-405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 9077KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri91 – 11323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri119 – 14123C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri212 – 23423C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri244 – 26219C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri296 – 31823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9H707.
KOiK09228.
OMAiFFRHKYH.
PhylomeDBiQ9H707.
TreeFamiTF341078.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H707-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAALRFPV QGTVTFEDVA VKFTQEEWNL LSEAQRCLYR DVTLENLALM
60 70 80 90 100
SSLGCWCGVE DEAAPSKQSI YIQRETQVRT PMAGVSPKKA HPCEMCGPIL
110 120 130 140 150
GDILHVADHQ GTHHKQKLHR CEAWGNKLYD SGNFHQHQNE HIGEKPYRGS
160 170 180 190 200
VEEALFAKRC KLHVSGESSV FSESGKDFLL RSGLLQQEAT HTGKSNSKTE
210 220 230 240 250
CVSLFHGGKS HYSCGGCMKH FSTKDILSQH ERLLPTEEPS VWCECGKSSS
260 270 280 290 300
KYDSFSNHQG VHTREKPYTC GICGKLFNSK SHLLVHQRIH TGEKPYECEV
310 320 330 340 350
CQKFFRHKYH LIAHQRVHTG ERPYECSDCG KSFTHSSTFR VHKRVHTGQK
360 370 380 390 400
PYECSECGKS FAESSSLTKH RRVHTGEKPY GCSECEKKFR QISSLRHHQR

VHKRKGL
Length:407
Mass (Da):46,198
Last modified:May 15, 2007 - v2
Checksum:iA2D6783033EEDC61
GO

Sequence cautioni

The sequence BAB15093.1 differs from that shown. Reason: Frameshift at position 388. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti286 – 2861H → R in BAB15093 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti242 – 2421W → C.
Corresponds to variant rs2288538 [ dbSNP | Ensembl ].
VAR_032177

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010645 Genomic DNA. No translation available.
DA345819 mRNA. No translation available.
AK025256 mRNA. Translation: BAB15093.1. Sequence problems.
AK097041 mRNA. Translation: BAG53411.1.
CH471135 Genomic DNA. Translation: EAW72535.1.
BC046237 mRNA. Translation: AAH46237.1.
BC062982 mRNA. Translation: AAH62982.1.
BC082767 mRNA. Translation: AAH82767.1.
CCDSiCCDS12963.1.
RefSeqiNP_079038.2. NM_024762.3.
UniGeneiHs.560727.

Genome annotation databases

EnsembliENST00000391701; ENSP00000375582; ENSG00000178935.
GeneIDi79818.
KEGGihsa:79818.
UCSCiuc002qqg.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010645 Genomic DNA. No translation available.
DA345819 mRNA. No translation available.
AK025256 mRNA. Translation: BAB15093.1. Sequence problems.
AK097041 mRNA. Translation: BAG53411.1.
CH471135 Genomic DNA. Translation: EAW72535.1.
BC046237 mRNA. Translation: AAH46237.1.
BC062982 mRNA. Translation: AAH62982.1.
BC082767 mRNA. Translation: AAH82767.1.
CCDSiCCDS12963.1.
RefSeqiNP_079038.2. NM_024762.3.
UniGeneiHs.560727.

3D structure databases

ProteinModelPortaliQ9H707.
SMRiQ9H707. Positions 105-405.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122913. 2 interactions.
IntActiQ9H707. 4 interactions.
STRINGi9606.ENSP00000375582.

PTM databases

iPTMnetiQ9H707.
PhosphoSiteiQ9H707.

Polymorphism and mutation databases

BioMutaiZNF552.
DMDMi147742907.

Proteomic databases

MaxQBiQ9H707.
PaxDbiQ9H707.
PRIDEiQ9H707.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391701; ENSP00000375582; ENSG00000178935.
GeneIDi79818.
KEGGihsa:79818.
UCSCiuc002qqg.3. human.

Organism-specific databases

CTDi79818.
GeneCardsiZNF552.
HGNCiHGNC:26135. ZNF552.
HPAiHPA043800.
HPA053762.
neXtProtiNX_Q9H707.
PharmGKBiPA134986961.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9H707.
KOiK09228.
OMAiFFRHKYH.
PhylomeDBiQ9H707.
TreeFamiTF341078.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii79818.
PROiQ9H707.

Gene expression databases

BgeeiQ9H707.
CleanExiHS_ZNF552.
ExpressionAtlasiQ9H707. baseline and differential.
GenevisibleiQ9H707. HS.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Small intestine.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 132-407.
    Tissue: Prostate.
  5. "Uncovering global SUMOylation signaling networks in a site-specific manner."
    Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M., Vertegaal A.C.
    Nat. Struct. Mol. Biol. 21:927-936(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-198; LYS-251 AND LYS-266, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZN552_HUMAN
AccessioniPrimary (citable) accession number: Q9H707
Secondary accession number(s): B3KUE9, Q6P5A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: June 8, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.