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Protein

Ran-binding protein 3

Gene

RANBP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.5 Publications

GO - Molecular functioni

  • Ran GTPase binding Source: GO_Central
  • R-SMAD binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

SignaLinkiQ9H6Z4.
SIGNORiQ9H6Z4.

Names & Taxonomyi

Protein namesi
Recommended name:
Ran-binding protein 3
Short name:
RanBP3
Gene namesi
Name:RANBP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:9850. RANBP3.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8498.
OpenTargetsiENSG00000031823.
PharmGKBiPA34211.

Polymorphism and mutation databases

BioMutaiRANBP3.
DMDMi51316528.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000971652 – 567Ran-binding protein 3Add BLAST566

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei9N6-acetyllysineBy similarity1
Modified residuei21N6-acetyllysineCombined sources1
Modified residuei75PhosphothreonineCombined sources1
Modified residuei100PhosphoserineCombined sources1
Modified residuei101PhosphoserineCombined sources1
Modified residuei108PhosphoserineCombined sources1
Modified residuei124PhosphothreonineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Modified residuei219PhosphoserineBy similarity1
Modified residuei333PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Modified residuei355PhosphoserineCombined sources1
Modified residuei372PhosphoserineCombined sources1
Modified residuei539PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H6Z4.
MaxQBiQ9H6Z4.
PaxDbiQ9H6Z4.
PeptideAtlasiQ9H6Z4.
PRIDEiQ9H6Z4.

PTM databases

iPTMnetiQ9H6Z4.
PhosphoSitePlusiQ9H6Z4.

Expressioni

Tissue specificityi

Widely expressed with high levels in testis and heart.1 Publication

Gene expression databases

BgeeiENSG00000031823.
CleanExiHS_RANBP3.
ExpressionAtlasiQ9H6Z4. baseline and differential.
GenevisibleiQ9H6Z4. HS.

Organism-specific databases

HPAiHPA043375.
HPA043389.

Interactioni

Subunit structurei

Interacts with CHC1 in a Ran-stimulated manner. Interacts with XPO1. Interacts (via its C-terminal R domain) with SMAD2 (dephosphorylated form via its MH1 and MH2 domains); the interaction results in the nuclear export of SMAD2 and termination of the TGF-beta signaling. Interacts (via its C-terminal R domain) with SMAD3 (dephosphorylated form via its MH1 domain); the interaction results in the nuclear export of SMAD3 and termination of the TGF-beta signaling.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PPM1AP358134EBI-992681,EBI-989143
RCC1P187542EBI-992681,EBI-992720
SMAD2Q157962EBI-992681,EBI-1040141

GO - Molecular functioni

  • Ran GTPase binding Source: GO_Central
  • R-SMAD binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114070. 45 interactors.
IntActiQ9H6Z4. 9 interactors.
MINTiMINT-3068756.
STRINGi9606.ENSP00000341483.

Structurei

Secondary structure

1567
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni389 – 391Combined sources3
Beta strandi399 – 412Combined sources14
Turni413 – 416Combined sources4
Beta strandi417 – 432Combined sources16
Turni434 – 436Combined sources3
Beta strandi439 – 447Combined sources9
Turni448 – 450Combined sources3
Beta strandi453 – 458Combined sources6
Beta strandi465 – 469Combined sources5
Beta strandi472 – 476Combined sources5
Beta strandi487 – 491Combined sources5
Helixi494 – 519Combined sources26

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CRFNMR-A380-516[»]
2Y8FX-ray2.10A/B/C/D388-522[»]
2Y8GX-ray1.61A/B388-522[»]
ProteinModelPortaliQ9H6Z4.
SMRiQ9H6Z4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H6Z4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini378 – 518RanBD1PROSITE-ProRule annotationAdd BLAST141

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi76 – 81Poly-Pro6
Compositional biasi537 – 543Poly-Asp7

Sequence similaritiesi

Contains 1 RanBD1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0866. Eukaryota.
ENOG4111NCK. LUCA.
GeneTreeiENSGT00530000063644.
HOVERGENiHBG061383.
InParanoidiQ9H6Z4.
KOiK15304.
OMAiIMSHIPE.
OrthoDBiEOG091G076E.
PhylomeDBiQ9H6Z4.
TreeFamiTF313181.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR000156. Ran_bind_dom.
[Graphical view]
PfamiPF00638. Ran_BP1. 1 hit.
[Graphical view]
SMARTiSM00160. RanBD. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50196. RANBD1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H6Z4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADLANEEKP AIAPPVFVFQ KDKGQKSPAE QKNLSDSGEE PRGEAEAPHH
60 70 80 90 100
GTGHPESAGE HALEPPAPAG ASASTPPPPA PEAQLPPFPR ELAGRSAGGS
110 120 130 140 150
SPEGGEDSDR EDGNYCPPVK RERTSSLTQF PPSQSEERSS GFRLKPPTLI
160 170 180 190 200
HGQAPSAGLP SQKPKEQQRS VLRPAVLQAP QPKALSQTVP SSGTNGVSLP
210 220 230 240 250
ADCTGAVPAA SPDTAAWRSP SEAADEVCAL EEKEPQKNES SNASEEEACE
260 270 280 290 300
KKDPATQQAF VFGQNLRDRV KLINESVDEA DMENAGHPSA DTPTATNYFL
310 320 330 340 350
QYISSSLENS TNSADASSNK FVFGQNMSER VLSPPKLNEV SSDANRENAA
360 370 380 390 400
AESGSESSSQ EATPEKESLA ESAAAYTKAT ARKCLLEKVE VITGEEAESN
410 420 430 440 450
VLQMQCKLFV FDKTSQSWVE RGRGLLRLND MASTDDGTLQ SRLVMRTQGS
460 470 480 490 500
LRLILNTKLW AQMQIDKASE KSIRITAMDT EDQGVKVFLI SASSKDTGQL
510 520 530 540 550
YAALHHRILA LRSRVEQEQE AKMPAPEPGA APSNEEDDSD DDDVLAPSGA
560
TAAGAGDEGD GQTTGST
Length:567
Mass (Da):60,210
Last modified:March 1, 2001 - v1
Checksum:i203B5A900512743C
GO
Isoform 2 (identifier: Q9H6Z4-2) [UniParc]FASTAAdd to basket
Also known as: Ranbp3-a

The sequence of this isoform differs from the canonical sequence as follows:
     226-230: Missing.

Show »
Length:562
Mass (Da):59,694
Checksum:i453AF2CD380BA7F1
GO
Isoform 3 (identifier: Q9H6Z4-3) [UniParc]FASTAAdd to basket
Also known as: Ranbp3-b

The sequence of this isoform differs from the canonical sequence as follows:
     27-94: Missing.

Show »
Length:499
Mass (Da):53,411
Checksum:i3356FC66E6A21796
GO

Sequence cautioni

The sequence AAH04349 differs from that shown. Aberrant splicing.Curated
The sequence CAB43293 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti358 – 359SS → PF in CAA69956 (PubMed:9637251).Curated2
Sequence conflicti367E → G in CAA69957 (PubMed:9637251).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051303314A → V.Corresponds to variant rs10417885dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01116327 – 94Missing in isoform 3. 3 PublicationsAdd BLAST68
Alternative sequenceiVSP_011162226 – 230Missing in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08697 mRNA. Translation: CAA69956.1.
Y08698 mRNA. Translation: CAA69957.1.
AK025300 mRNA. Translation: BAB15106.1.
AK314343 mRNA. Translation: BAG36985.1.
AL050149 mRNA. Translation: CAB43293.1. Different initiation.
AC004602 Genomic DNA. Translation: AAC14485.1.
AC104532 Genomic DNA. No translation available.
AC093050 Genomic DNA. No translation available.
AC005784 Genomic DNA. No translation available.
BC004349 mRNA. Translation: AAH04349.1. Sequence problems.
CCDSiCCDS42477.1. [Q9H6Z4-3]
CCDS42478.1. [Q9H6Z4-1]
CCDS45935.1. [Q9H6Z4-2]
PIRiT08778.
RefSeqiNP_001287794.1. NM_001300865.1.
NP_003615.2. NM_003624.2. [Q9H6Z4-2]
NP_015559.2. NM_007320.2. [Q9H6Z4-3]
NP_015561.1. NM_007322.2. [Q9H6Z4-1]
UniGeneiHs.531752.

Genome annotation databases

EnsembliENST00000034275; ENSP00000034275; ENSG00000031823. [Q9H6Z4-3]
ENST00000340578; ENSP00000341483; ENSG00000031823. [Q9H6Z4-1]
ENST00000439268; ENSP00000404837; ENSG00000031823. [Q9H6Z4-2]
GeneIDi8498.
KEGGihsa:8498.
UCSCiuc002mdw.4. human. [Q9H6Z4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08697 mRNA. Translation: CAA69956.1.
Y08698 mRNA. Translation: CAA69957.1.
AK025300 mRNA. Translation: BAB15106.1.
AK314343 mRNA. Translation: BAG36985.1.
AL050149 mRNA. Translation: CAB43293.1. Different initiation.
AC004602 Genomic DNA. Translation: AAC14485.1.
AC104532 Genomic DNA. No translation available.
AC093050 Genomic DNA. No translation available.
AC005784 Genomic DNA. No translation available.
BC004349 mRNA. Translation: AAH04349.1. Sequence problems.
CCDSiCCDS42477.1. [Q9H6Z4-3]
CCDS42478.1. [Q9H6Z4-1]
CCDS45935.1. [Q9H6Z4-2]
PIRiT08778.
RefSeqiNP_001287794.1. NM_001300865.1.
NP_003615.2. NM_003624.2. [Q9H6Z4-2]
NP_015559.2. NM_007320.2. [Q9H6Z4-3]
NP_015561.1. NM_007322.2. [Q9H6Z4-1]
UniGeneiHs.531752.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CRFNMR-A380-516[»]
2Y8FX-ray2.10A/B/C/D388-522[»]
2Y8GX-ray1.61A/B388-522[»]
ProteinModelPortaliQ9H6Z4.
SMRiQ9H6Z4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114070. 45 interactors.
IntActiQ9H6Z4. 9 interactors.
MINTiMINT-3068756.
STRINGi9606.ENSP00000341483.

PTM databases

iPTMnetiQ9H6Z4.
PhosphoSitePlusiQ9H6Z4.

Polymorphism and mutation databases

BioMutaiRANBP3.
DMDMi51316528.

Proteomic databases

EPDiQ9H6Z4.
MaxQBiQ9H6Z4.
PaxDbiQ9H6Z4.
PeptideAtlasiQ9H6Z4.
PRIDEiQ9H6Z4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000034275; ENSP00000034275; ENSG00000031823. [Q9H6Z4-3]
ENST00000340578; ENSP00000341483; ENSG00000031823. [Q9H6Z4-1]
ENST00000439268; ENSP00000404837; ENSG00000031823. [Q9H6Z4-2]
GeneIDi8498.
KEGGihsa:8498.
UCSCiuc002mdw.4. human. [Q9H6Z4-1]

Organism-specific databases

CTDi8498.
DisGeNETi8498.
GeneCardsiRANBP3.
HGNCiHGNC:9850. RANBP3.
HPAiHPA043375.
HPA043389.
MIMi603327. gene.
neXtProtiNX_Q9H6Z4.
OpenTargetsiENSG00000031823.
PharmGKBiPA34211.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0866. Eukaryota.
ENOG4111NCK. LUCA.
GeneTreeiENSGT00530000063644.
HOVERGENiHBG061383.
InParanoidiQ9H6Z4.
KOiK15304.
OMAiIMSHIPE.
OrthoDBiEOG091G076E.
PhylomeDBiQ9H6Z4.
TreeFamiTF313181.

Enzyme and pathway databases

SignaLinkiQ9H6Z4.
SIGNORiQ9H6Z4.

Miscellaneous databases

ChiTaRSiRANBP3. human.
EvolutionaryTraceiQ9H6Z4.
GeneWikiiRANBP3.
GenomeRNAii8498.
PROiQ9H6Z4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000031823.
CleanExiHS_RANBP3.
ExpressionAtlasiQ9H6Z4. baseline and differential.
GenevisibleiQ9H6Z4. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR000156. Ran_bind_dom.
[Graphical view]
PfamiPF00638. Ran_BP1. 1 hit.
[Graphical view]
SMARTiSM00160. RanBD. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50196. RANBD1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRANB3_HUMAN
AccessioniPrimary (citable) accession number: Q9H6Z4
Secondary accession number(s): B2RAT8
, O60405, O75759, O75760, Q9BT47, Q9UG74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.