Q9H6Y5 (MAGIX_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
PDZ domain-containing protein MAGIX

Gene names

Name:

MAGIX

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 PDZ (DHR) domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H6Y5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H6Y5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: MEPRTGGAAN...PHATIVDHRP → MPLLWITGPRYHLILLSEASCLRANYVHLCPLF

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9H6Y5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: MEPRTGGAAN...PHATIVDHRP → MPLLWITGPRYHLILLSEASCLRANYVHLCPLF
     227-231: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 334

334

PDZ domain-containing protein MAGIX

PRO_0000310542

Regions

Domain

125 – 209

85

PDZ

Amino acid modifications

Modified residue

272

1

Phosphoserine By similarity

Natural variations

Alternative sequence

1 – 92

92

MEPRT…VDHRP → MPLLWITGPRYHLILLSEAS CLRANYVHLCPLF in isoform 2 and isoform 3.

VSP_029319

Alternative sequence

227 – 231

5

Missing in isoform 3.

VSP_029320

Natural variant

53

1

R → H.
Corresponds to variant rs5906744 [ dbSNP | Ensembl ].

VAR_037075

Natural variant

112

1

H → R. Ref.1 Ref.2 Ref.4
Corresponds to variant rs5906744 [ dbSNP | Ensembl ].

VAR_047035

Natural variant

173

1

V → L. Ref.1 Ref.2 Ref.4
Corresponds to variant rs5905720 [ dbSNP | Ensembl ].

VAR_047036

Natural variant

323

1

F → L. Ref.1 Ref.2 Ref.4
Corresponds to variant rs4824462 [ dbSNP | Ensembl ].

VAR_047037

Secondary structure

1

.

.

.

.

.

.

.

.

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.

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.

.

.

.

.

334

Helix Strand Turn

Details...

Beta strand

124 – 129

6

Beta strand

132 – 134

3

Beta strand

137 – 140

4

Beta strand

152 – 156

5

Helix

161 – 165

5

Beta strand

173 – 177

5

Helix

187 – 196

10

Beta strand

199 – 205

7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 14, 2008. Version 3. Checksum: B9081B483134243C	FASTA	334	35,217
	10 20 30 40 50 60 MEPRTGGAAN PKGSRGSRGP SPLAGPSARQ LLARLDARPL AARAAVDVAA LVRRAGATLR 70 80 90 100 110 120 LRRKEAVSVL DSADIEVTDS RLPHATIVDH RPQHRWLETC NAPPQLIQGK AHSAPKPSQA 130 140 150 160 170 180 SGHFSVELVR GYAGFGLTLG GGRDVAGDTP LAVRGLLKDG PAQRCGRLEV GDVVLHINGE 190 200 210 220 230 240 STQGLTHAQA VERIRAGGPQ LHLVIRRPLE THPGKPRGVG EPRKGVVPSW PDRSPDPGGP 250 260 270 280 290 300 EVTGSRSSST SLVQHPPSRT TLKKTRGSPE PSPEAAADGP TVSPPERRAE DPNDQIPGSP 310 320 330 GPWLVPSEER LSRALGVRGA AQFAQEMAAG RRRH
	Isoform 2 [UniParc]. Checksum: 10B6EF9F35DB7444	FASTA	275	29,421
	10 20 30 40 50 60 MPLLWITGPR YHLILLSEAS CLRANYVHLC PLFQHRWLET CNAPPQLIQG KAHSAPKPSQ 70 80 90 100 110 120 ASGHFSVELV RGYAGFGLTL GGGRDVAGDT PLAVRGLLKD GPAQRCGRLE VGDVVLHING 130 140 150 160 170 180 ESTQGLTHAQ AVERIRAGGP QLHLVIRRPL ETHPGKPRGV GEPRKGVVPS WPDRSPDPGG 190 200 210 220 230 240 PEVTGSRSSS TSLVQHPPSR TTLKKTRGSP EPSPEAAADG PTVSPPERRA EDPNDQIPGS 250 260 270 PGPWLVPSEE RLSRALGVRG AAQFAQEMAA GRRRH
	Isoform 3 [UniParc]. Checksum: 34F5A16BEE3BDAA5	FASTA	270	28,855
	10 20 30 40 50 60 MPLLWITGPR YHLILLSEAS CLRANYVHLC PLFQHRWLET CNAPPQLIQG KAHSAPKPSQ 70 80 90 100 110 120 ASGHFSVELV RGYAGFGLTL GGGRDVAGDT PLAVRGLLKD GPAQRCGRLE VGDVVLHING 130 140 150 160 170 180 ESTQGLTHAQ AVERIRAGGP QLHLVIRRPL ETHPGKPRGV GEPRKGVDRS PDPGGPEVTG 190 200 210 220 230 240 SRSSSTSLVQ HPPSRTTLKK TRGSPEPSPE AAADGPTVSP PERRAEDPND QIPGSPGPWL 250 260 270 VPSEERLSRA LGVRGAAQFA QEMAAGRRRH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A computer system platform used to predict novel genes." Yu Z., Zheng Z., Tang T., Fu Y. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANTS ARG-112; LEU-173 AND LEU-323.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-112; LEU-173 AND LEU-323. Tissue: Colon.
[3]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ARG-112; LEU-173 AND LEU-323.
[5]	"Solution structures of the PDZ domain of human unnamed protein product." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 59-150.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

DQ884401 mRNA. Translation: ABI63368.1.
AK025340 mRNA. Translation: BAB15115.1.
AF196779 Genomic DNA. No translation available.
CH471224 Genomic DNA. Translation: EAW50691.1.

IPI

IPI00016344.
IPI00647032.
IPI00871845.

RefSeq

NP_001093150.1. NM_001099680.1.
NP_001093151.1. NM_001099681.1.
NP_001093152.1. NM_001099682.1.
NP_079135.2. NM_024859.2.

UniGene

Hs.193170.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DJT	NMR	-	A	119-209	[»]

ProteinModelPortal

Q9H6Y5.

SMR

Q9H6Y5. Positions 19-62, 123-209.

ModBase

Search...

PTM databases

PhosphoSite

Q9H6Y5.

Polymorphism databases

DMDM

209572736.

Proteomic databases

PRIDE

Q9H6Y5.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000376338; ENSP00000365516; ENSG00000017621.
ENST00000399915; ENSP00000382799; ENSG00000017621.
ENST00000412696; ENSP00000387928; ENSG00000017621.

GeneID

79917.

KEGG

hsa:79917.

UCSC

uc004dmu.2. human.
uc010nin.1. human.

Organism-specific databases

CTD

79917.

GeneCards

GC0XP049019.

HGNC

HGNC:30006. MAGIX.

HPA

HPA035302.

neXtProt

NX_Q9H6Y5.

PharmGKB

PA162394882.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG17180.

GeneTree

ENSGT00530000063259.

HOGENOM

HBG507275.

HOVERGEN

HBG108115.

OMA

DQIPGSP.

Gene expression databases

ArrayExpress

Q9H6Y5.

Bgee

Q9H6Y5.

CleanEx

HS_MAGIX.

Genevestigator

Q9H6Y5.

Family and domain databases

InterPro

IPR001478. PDZ/DHR/GLGF.
[Graphical view]

Pfam

PF00595. PDZ. 1 hit.
[Graphical view]

SMART

SM00228. PDZ. 1 hit.
[Graphical view]

SUPFAM

SSF50156. PDZ. 1 hit.

PROSITE

PS50106. PDZ. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

69796.

Entry information

Entry name

MAGIX_HUMAN

Accession

Primary (citable) accession number: Q9H6Y5
Secondary accession number(s): A6XND4 , A8MSX9, B7WP26, Q14C81

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	October 14, 2008
Last modified:	January 25, 2012
This is version 63 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.