ID WDR55_HUMAN Reviewed; 383 AA. AC Q9H6Y2; Q9NXK4; DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot. DT 18-MAY-2010, sequence version 2. DT 24-JAN-2024, entry version 173. DE RecName: Full=WD repeat-containing protein 55; GN Name=WDR55; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT RP ARG-151. RC TISSUE=Colon, and Colon mucosa; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15372022; DOI=10.1038/nature02919; RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.; RT "The DNA sequence and comparative analysis of human chromosome 5."; RL Nature 431:268-274(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ARG-151. RC TISSUE=Placenta; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; THR-378 AND SER-382, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [5] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Leukemic T-cell; RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [6] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.; RT "Quantitative phosphoproteomics reveals widespread full phosphorylation RT site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21406692; DOI=10.1126/scisignal.2001570; RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.; RT "System-wide temporal characterization of the proteome and phosphoproteome RT of human embryonic stem cell differentiation."; RL Sci. Signal. 4:RS3-RS3(2011). RN [8] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14 AND SER-354, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma, and Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). CC -!- FUNCTION: Nucleolar protein that acts as a modulator of rRNA synthesis. CC Plays a central role during organogenesis (By similarity). CC {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Cytoplasm CC {ECO:0000250}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q9H6Y2-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9H6Y2-2; Sequence=VSP_037275; CC -!- SIMILARITY: Belongs to the WD repeat WDR55 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK000202; BAA91006.1; -; mRNA. DR EMBL; AK025355; BAB15118.1; -; mRNA. DR EMBL; AC116353; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC068485; AAH68485.1; -; mRNA. DR CCDS; CCDS4235.1; -. [Q9H6Y2-1] DR RefSeq; NP_060176.2; NM_017706.4. [Q9H6Y2-1] DR RefSeq; XP_005268526.1; XM_005268469.2. [Q9H6Y2-1] DR PDB; 7KQQ; X-ray; 1.80 A; A/B=21-334. DR PDB; 8FKY; EM; 2.67 A; BC=1-383. DR PDBsum; 7KQQ; -. DR PDBsum; 8FKY; -. DR AlphaFoldDB; Q9H6Y2; -. DR EMDB; EMD-29261; -. DR SMR; Q9H6Y2; -. DR BioGRID; 120203; 104. DR IntAct; Q9H6Y2; 29. DR MINT; Q9H6Y2; -. DR STRING; 9606.ENSP00000351100; -. DR GlyGen; Q9H6Y2; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q9H6Y2; -. DR PhosphoSitePlus; Q9H6Y2; -. DR SwissPalm; Q9H6Y2; -. DR BioMuta; WDR55; -. DR DMDM; 296453035; -. DR EPD; Q9H6Y2; -. DR jPOST; Q9H6Y2; -. DR MassIVE; Q9H6Y2; -. DR MaxQB; Q9H6Y2; -. DR PaxDb; 9606-ENSP00000351100; -. DR PeptideAtlas; Q9H6Y2; -. DR ProteomicsDB; 81057; -. [Q9H6Y2-1] DR ProteomicsDB; 81058; -. [Q9H6Y2-2] DR Pumba; Q9H6Y2; -. DR Antibodypedia; 45472; 36 antibodies from 15 providers. DR DNASU; 54853; -. DR Ensembl; ENST00000358337.10; ENSP00000351100.5; ENSG00000120314.19. [Q9H6Y2-1] DR GeneID; 54853; -. DR KEGG; hsa:54853; -. DR MANE-Select; ENST00000358337.10; ENSP00000351100.5; NM_017706.5; NP_060176.3. DR UCSC; uc003lgr.5; human. [Q9H6Y2-1] DR AGR; HGNC:25971; -. DR CTD; 54853; -. DR DisGeNET; 54853; -. DR GeneCards; WDR55; -. DR HGNC; HGNC:25971; WDR55. DR HPA; ENSG00000120314; Low tissue specificity. DR neXtProt; NX_Q9H6Y2; -. DR OpenTargets; ENSG00000120314; -. DR PharmGKB; PA142670590; -. DR VEuPathDB; HostDB:ENSG00000120314; -. DR eggNOG; KOG2444; Eukaryota. DR GeneTree; ENSGT00940000153727; -. DR HOGENOM; CLU_035848_0_1_1; -. DR InParanoid; Q9H6Y2; -. DR OMA; MFENLCT; -. DR OrthoDB; 153323at2759; -. DR PhylomeDB; Q9H6Y2; -. DR TreeFam; TF315175; -. DR PathwayCommons; Q9H6Y2; -. DR SignaLink; Q9H6Y2; -. DR BioGRID-ORCS; 54853; 613 hits in 1177 CRISPR screens. DR ChiTaRS; WDR55; human. DR GenomeRNAi; 54853; -. DR Pharos; Q9H6Y2; Tdark. DR PRO; PR:Q9H6Y2; -. DR Proteomes; UP000005640; Chromosome 5. DR RNAct; Q9H6Y2; Protein. DR Bgee; ENSG00000120314; Expressed in granulocyte and 162 other cell types or tissues. DR ExpressionAtlas; Q9H6Y2; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005730; C:nucleolus; IDA:HPA. DR GO; GO:0005654; C:nucleoplasm; IDA:HPA. DR GO; GO:0006364; P:rRNA processing; ISS:UniProtKB. DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2. DR InterPro; IPR024977; Apc4-like_WD40_dom. DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf. DR InterPro; IPR019775; WD40_repeat_CS. DR InterPro; IPR036322; WD40_repeat_dom_sf. DR InterPro; IPR001680; WD40_rpt. DR InterPro; IPR017422; WDR55. DR PANTHER; PTHR44019; WD REPEAT-CONTAINING PROTEIN 55; 1. DR PANTHER; PTHR44019:SF20; WD REPEAT-CONTAINING PROTEIN 55; 1. DR Pfam; PF12894; ANAPC4_WD40; 1. DR Pfam; PF00400; WD40; 2. DR PIRSF; PIRSF038169; WD_repeat_p55; 1. DR SMART; SM00320; WD40; 6. DR SUPFAM; SSF50978; WD40 repeat-like; 1. DR PROSITE; PS00678; WD_REPEATS_1; 1. DR PROSITE; PS50082; WD_REPEATS_2; 2. DR PROSITE; PS50294; WD_REPEATS_REGION; 1. DR Genevisible; Q9H6Y2; HS. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Cytoplasm; Nucleus; Phosphoprotein; KW Reference proteome; Repeat; rRNA processing; WD repeat. FT CHAIN 1..383 FT /note="WD repeat-containing protein 55" FT /id="PRO_0000237598" FT REPEAT 36..75 FT /note="WD 1" FT REPEAT 82..121 FT /note="WD 2" FT REPEAT 125..163 FT /note="WD 3" FT REPEAT 166..205 FT /note="WD 4" FT REPEAT 208..247 FT /note="WD 5" FT REPEAT 250..289 FT /note="WD 6" FT REPEAT 293..332 FT /note="WD 7" FT REGION 1..33 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 363..383 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 14 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:18669648, FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, FT ECO:0007744|PubMed:23186163" FT MOD_RES 354 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163" FT MOD_RES 378 FT /note="Phosphothreonine" FT /evidence="ECO:0007744|PubMed:18669648" FT MOD_RES 382 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:18669648" FT VAR_SEQ 1..218 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_037275" FT VARIANT 50 FT /note="R -> C (in dbSNP:rs34342435)" FT /id="VAR_037056" FT VARIANT 151 FT /note="C -> R (in dbSNP:rs2530245)" FT /evidence="ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:15489334" FT /id="VAR_037057" FT VARIANT 210 FT /note="S -> F (in dbSNP:rs2286394)" FT /id="VAR_037058" FT VARIANT 235 FT /note="Y -> C (in dbSNP:rs35983033)" FT /id="VAR_037059" FT STRAND 41..46 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 48..57 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 62..66 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 75..80 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 87..92 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 96..103 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 108..112 FT /evidence="ECO:0007829|PDB:7KQQ" FT TURN 113..115 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 118..122 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 125..128 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 130..135 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 137..145 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 150..154 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 157..159 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 161..164 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 171..176 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 180..187 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 192..196 FT /evidence="ECO:0007829|PDB:7KQQ" FT TURN 197..200 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 201..205 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 213..219 FT /evidence="ECO:0007829|PDB:7KQQ" FT TURN 220..223 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 224..229 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 232..238 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 246..250 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 252..254 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 258..270 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 274..280 FT /evidence="ECO:0007829|PDB:7KQQ" FT TURN 281..284 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 285..292 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 298..303 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 307..314 FT /evidence="ECO:0007829|PDB:7KQQ" FT TURN 315..317 FT /evidence="ECO:0007829|PDB:7KQQ" FT STRAND 318..323 FT /evidence="ECO:0007829|PDB:7KQQ" FT HELIX 324..327 FT /evidence="ECO:0007829|PDB:7KQQ" SQ SEQUENCE 383 AA; 42070 MW; 757962232E1034EB CRC64; MDRTCEERPA EDGSDEEDPD SMEAPTRIRD TPEDIVLEAP ASGLAFHPAR DLLAAGDVDG DVFVFSYSCQ EGETKELWSS GHHLKACRAV AFSEDGQKLI TVSKDKAIHV LDVEQGQLER RVSKAHGAPI NSLLLVDENV LATGDDTGGI CLWDQRKEGP LMDMRQHEEY IADMALDPAK KLLLTASGDG CLGIFNIKRR RFELLSEPQS GDLTSVTLMK WGKKVACGSS EGTIYLFNWN GFGATSDRFA LRAESIDCMV PVTESLLCTG STDGVIRAVN ILPNRVVGSV GQHTGEPVEE LALSHCGRFL ASSGHDQRLK FWDMAQLRAV VVDDYRRRKK KGGPLRALSS KTWSTDDFFA GLREEGEDSM AQEEKEETGD DSD //