Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9H6Y2

- WDR55_HUMAN

UniProt

Q9H6Y2 - WDR55_HUMAN

Protein

WD repeat-containing protein 55

Gene

WDR55

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis By similarity.By similarity

    GO - Biological processi

    1. rRNA processing Source: UniProtKB

    Keywords - Biological processi

    rRNA processing

    Enzyme and pathway databases

    SignaLinkiQ9H6Y2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WD repeat-containing protein 55
    Gene namesi
    Name:WDR55
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:25971. WDR55.

    Subcellular locationi

    Nucleusnucleolus By similarity. Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleolus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670590.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 383383WD repeat-containing protein 55PRO_0000237598Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei14 – 141Phosphoserine3 Publications
    Modified residuei378 – 3781Phosphothreonine1 Publication
    Modified residuei382 – 3821Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9H6Y2.
    PaxDbiQ9H6Y2.
    PRIDEiQ9H6Y2.

    PTM databases

    PhosphoSiteiQ9H6Y2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H6Y2.
    BgeeiQ9H6Y2.
    CleanExiHS_WDR55.
    GenevestigatoriQ9H6Y2.

    Organism-specific databases

    HPAiHPA043470.
    HPA048143.

    Interactioni

    Protein-protein interaction databases

    BioGridi120203. 4 interactions.
    IntActiQ9H6Y2. 3 interactions.
    MINTiMINT-3068722.
    STRINGi9606.ENSP00000351100.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H6Y2.
    SMRiQ9H6Y2. Positions 43-323.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati36 – 7540WD 1Add
    BLAST
    Repeati82 – 12140WD 2Add
    BLAST
    Repeati125 – 16339WD 3Add
    BLAST
    Repeati166 – 20540WD 4Add
    BLAST
    Repeati208 – 24740WD 5Add
    BLAST
    Repeati250 – 28940WD 6Add
    BLAST
    Repeati293 – 33240WD 7Add
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat WDR55 family.Curated
    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOGENOMiHOG000242496.
    HOVERGENiHBG054778.
    InParanoidiQ9H6Y2.
    OMAiIFNWNGF.
    PhylomeDBiQ9H6Y2.
    TreeFamiTF315175.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    IPR017422. WD_repeat_p55.
    [Graphical view]
    PfamiPF00400. WD40. 4 hits.
    [Graphical view]
    PIRSFiPIRSF038169. WD_repeat_p55. 1 hit.
    SMARTiSM00320. WD40. 6 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H6Y2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDRTCEERPA EDGSDEEDPD SMEAPTRIRD TPEDIVLEAP ASGLAFHPAR    50
    DLLAAGDVDG DVFVFSYSCQ EGETKELWSS GHHLKACRAV AFSEDGQKLI 100
    TVSKDKAIHV LDVEQGQLER RVSKAHGAPI NSLLLVDENV LATGDDTGGI 150
    CLWDQRKEGP LMDMRQHEEY IADMALDPAK KLLLTASGDG CLGIFNIKRR 200
    RFELLSEPQS GDLTSVTLMK WGKKVACGSS EGTIYLFNWN GFGATSDRFA 250
    LRAESIDCMV PVTESLLCTG STDGVIRAVN ILPNRVVGSV GQHTGEPVEE 300
    LALSHCGRFL ASSGHDQRLK FWDMAQLRAV VVDDYRRRKK KGGPLRALSS 350
    KTWSTDDFFA GLREEGEDSM AQEEKEETGD DSD 383
    Length:383
    Mass (Da):42,070
    Last modified:May 18, 2010 - v2
    Checksum:i757962232E1034EB
    GO
    Isoform 2 (identifier: Q9H6Y2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-218: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:165
    Mass (Da):18,180
    Checksum:iDB52CC29149BD3AE
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti50 – 501R → C.
    Corresponds to variant rs34342435 [ dbSNP | Ensembl ].
    VAR_037056
    Natural varianti151 – 1511C → R.2 Publications
    Corresponds to variant rs2530245 [ dbSNP | Ensembl ].
    VAR_037057
    Natural varianti210 – 2101S → F.
    Corresponds to variant rs2286394 [ dbSNP | Ensembl ].
    VAR_037058
    Natural varianti235 – 2351Y → C.
    Corresponds to variant rs35983033 [ dbSNP | Ensembl ].
    VAR_037059

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 218218Missing in isoform 2. 1 PublicationVSP_037275Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000202 mRNA. Translation: BAA91006.1.
    AK025355 mRNA. Translation: BAB15118.1.
    AC116353 Genomic DNA. No translation available.
    BC068485 mRNA. Translation: AAH68485.1.
    CCDSiCCDS4235.1. [Q9H6Y2-1]
    RefSeqiNP_060176.2. NM_017706.4.
    XP_005268526.1. XM_005268469.1. [Q9H6Y2-1]
    UniGeneiHs.286261.

    Genome annotation databases

    EnsembliENST00000358337; ENSP00000351100; ENSG00000120314. [Q9H6Y2-1]
    GeneIDi54853.
    KEGGihsa:54853.
    UCSCiuc003lgr.4. human. [Q9H6Y2-1]

    Polymorphism databases

    DMDMi296453035.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000202 mRNA. Translation: BAA91006.1 .
    AK025355 mRNA. Translation: BAB15118.1 .
    AC116353 Genomic DNA. No translation available.
    BC068485 mRNA. Translation: AAH68485.1 .
    CCDSi CCDS4235.1. [Q9H6Y2-1 ]
    RefSeqi NP_060176.2. NM_017706.4.
    XP_005268526.1. XM_005268469.1. [Q9H6Y2-1 ]
    UniGenei Hs.286261.

    3D structure databases

    ProteinModelPortali Q9H6Y2.
    SMRi Q9H6Y2. Positions 43-323.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120203. 4 interactions.
    IntActi Q9H6Y2. 3 interactions.
    MINTi MINT-3068722.
    STRINGi 9606.ENSP00000351100.

    PTM databases

    PhosphoSitei Q9H6Y2.

    Polymorphism databases

    DMDMi 296453035.

    Proteomic databases

    MaxQBi Q9H6Y2.
    PaxDbi Q9H6Y2.
    PRIDEi Q9H6Y2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358337 ; ENSP00000351100 ; ENSG00000120314 . [Q9H6Y2-1 ]
    GeneIDi 54853.
    KEGGi hsa:54853.
    UCSCi uc003lgr.4. human. [Q9H6Y2-1 ]

    Organism-specific databases

    CTDi 54853.
    GeneCardsi GC05P140044.
    HGNCi HGNC:25971. WDR55.
    HPAi HPA043470.
    HPA048143.
    neXtProti NX_Q9H6Y2.
    PharmGKBi PA142670590.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOGENOMi HOG000242496.
    HOVERGENi HBG054778.
    InParanoidi Q9H6Y2.
    OMAi IFNWNGF.
    PhylomeDBi Q9H6Y2.
    TreeFami TF315175.

    Enzyme and pathway databases

    SignaLinki Q9H6Y2.

    Miscellaneous databases

    ChiTaRSi WDR55. human.
    GenomeRNAii 54853.
    NextBioi 57710.
    PROi Q9H6Y2.

    Gene expression databases

    ArrayExpressi Q9H6Y2.
    Bgeei Q9H6Y2.
    CleanExi HS_WDR55.
    Genevestigatori Q9H6Y2.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    IPR017422. WD_repeat_p55.
    [Graphical view ]
    Pfami PF00400. WD40. 4 hits.
    [Graphical view ]
    PIRSFi PIRSF038169. WD_repeat_p55. 1 hit.
    SMARTi SM00320. WD40. 6 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-151.
      Tissue: Colon and Colon mucosa.
    2. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-151.
      Tissue: Placenta.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; THR-378 AND SER-382, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiWDR55_HUMAN
    AccessioniPrimary (citable) accession number: Q9H6Y2
    Secondary accession number(s): Q9NXK4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3