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Q9H6Y2

- WDR55_HUMAN

UniProt

Q9H6Y2 - WDR55_HUMAN

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Protein
WD repeat-containing protein 55
Gene
WDR55
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis By similarity.

GO - Biological processi

  1. rRNA processing Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

rRNA processing

Enzyme and pathway databases

SignaLinkiQ9H6Y2.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 55
Gene namesi
Name:WDR55
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:25971. WDR55.

Subcellular locationi

Nucleusnucleolus By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670590.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383WD repeat-containing protein 55
PRO_0000237598Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141Phosphoserine3 Publications
Modified residuei378 – 3781Phosphothreonine1 Publication
Modified residuei382 – 3821Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H6Y2.
PaxDbiQ9H6Y2.
PRIDEiQ9H6Y2.

PTM databases

PhosphoSiteiQ9H6Y2.

Expressioni

Gene expression databases

ArrayExpressiQ9H6Y2.
BgeeiQ9H6Y2.
CleanExiHS_WDR55.
GenevestigatoriQ9H6Y2.

Organism-specific databases

HPAiHPA043470.
HPA048143.

Interactioni

Protein-protein interaction databases

BioGridi120203. 4 interactions.
IntActiQ9H6Y2. 2 interactions.
MINTiMINT-3068722.
STRINGi9606.ENSP00000351100.

Structurei

3D structure databases

ProteinModelPortaliQ9H6Y2.
SMRiQ9H6Y2. Positions 43-323.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati36 – 7540WD 1
Add
BLAST
Repeati82 – 12140WD 2
Add
BLAST
Repeati125 – 16339WD 3
Add
BLAST
Repeati166 – 20540WD 4
Add
BLAST
Repeati208 – 24740WD 5
Add
BLAST
Repeati250 – 28940WD 6
Add
BLAST
Repeati293 – 33240WD 7
Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat WDR55 family.
Contains 7 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
HOGENOMiHOG000242496.
HOVERGENiHBG054778.
InParanoidiQ9H6Y2.
OMAiIFNWNGF.
PhylomeDBiQ9H6Y2.
TreeFamiTF315175.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR017422. WD_repeat_p55.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PIRSFiPIRSF038169. WD_repeat_p55. 1 hit.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H6Y2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDRTCEERPA EDGSDEEDPD SMEAPTRIRD TPEDIVLEAP ASGLAFHPAR    50
DLLAAGDVDG DVFVFSYSCQ EGETKELWSS GHHLKACRAV AFSEDGQKLI 100
TVSKDKAIHV LDVEQGQLER RVSKAHGAPI NSLLLVDENV LATGDDTGGI 150
CLWDQRKEGP LMDMRQHEEY IADMALDPAK KLLLTASGDG CLGIFNIKRR 200
RFELLSEPQS GDLTSVTLMK WGKKVACGSS EGTIYLFNWN GFGATSDRFA 250
LRAESIDCMV PVTESLLCTG STDGVIRAVN ILPNRVVGSV GQHTGEPVEE 300
LALSHCGRFL ASSGHDQRLK FWDMAQLRAV VVDDYRRRKK KGGPLRALSS 350
KTWSTDDFFA GLREEGEDSM AQEEKEETGD DSD 383
Length:383
Mass (Da):42,070
Last modified:May 18, 2010 - v2
Checksum:i757962232E1034EB
GO
Isoform 2 (identifier: Q9H6Y2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-218: Missing.

Note: No experimental confirmation available.

Show »
Length:165
Mass (Da):18,180
Checksum:iDB52CC29149BD3AE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501R → C.
Corresponds to variant rs34342435 [ dbSNP | Ensembl ].
VAR_037056
Natural varianti151 – 1511C → R.2 Publications
Corresponds to variant rs2530245 [ dbSNP | Ensembl ].
VAR_037057
Natural varianti210 – 2101S → F.
Corresponds to variant rs2286394 [ dbSNP | Ensembl ].
VAR_037058
Natural varianti235 – 2351Y → C.
Corresponds to variant rs35983033 [ dbSNP | Ensembl ].
VAR_037059

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 218218Missing in isoform 2.
VSP_037275Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000202 mRNA. Translation: BAA91006.1.
AK025355 mRNA. Translation: BAB15118.1.
AC116353 Genomic DNA. No translation available.
BC068485 mRNA. Translation: AAH68485.1.
CCDSiCCDS4235.1. [Q9H6Y2-1]
RefSeqiNP_060176.2. NM_017706.4.
XP_005268526.1. XM_005268469.1. [Q9H6Y2-1]
UniGeneiHs.286261.

Genome annotation databases

EnsembliENST00000358337; ENSP00000351100; ENSG00000120314. [Q9H6Y2-1]
GeneIDi54853.
KEGGihsa:54853.
UCSCiuc003lgr.4. human. [Q9H6Y2-1]

Polymorphism databases

DMDMi296453035.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000202 mRNA. Translation: BAA91006.1 .
AK025355 mRNA. Translation: BAB15118.1 .
AC116353 Genomic DNA. No translation available.
BC068485 mRNA. Translation: AAH68485.1 .
CCDSi CCDS4235.1. [Q9H6Y2-1 ]
RefSeqi NP_060176.2. NM_017706.4.
XP_005268526.1. XM_005268469.1. [Q9H6Y2-1 ]
UniGenei Hs.286261.

3D structure databases

ProteinModelPortali Q9H6Y2.
SMRi Q9H6Y2. Positions 43-323.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120203. 4 interactions.
IntActi Q9H6Y2. 2 interactions.
MINTi MINT-3068722.
STRINGi 9606.ENSP00000351100.

PTM databases

PhosphoSitei Q9H6Y2.

Polymorphism databases

DMDMi 296453035.

Proteomic databases

MaxQBi Q9H6Y2.
PaxDbi Q9H6Y2.
PRIDEi Q9H6Y2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000358337 ; ENSP00000351100 ; ENSG00000120314 . [Q9H6Y2-1 ]
GeneIDi 54853.
KEGGi hsa:54853.
UCSCi uc003lgr.4. human. [Q9H6Y2-1 ]

Organism-specific databases

CTDi 54853.
GeneCardsi GC05P140044.
HGNCi HGNC:25971. WDR55.
HPAi HPA043470.
HPA048143.
neXtProti NX_Q9H6Y2.
PharmGKBi PA142670590.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
HOGENOMi HOG000242496.
HOVERGENi HBG054778.
InParanoidi Q9H6Y2.
OMAi IFNWNGF.
PhylomeDBi Q9H6Y2.
TreeFami TF315175.

Enzyme and pathway databases

SignaLinki Q9H6Y2.

Miscellaneous databases

ChiTaRSi WDR55. human.
GenomeRNAii 54853.
NextBioi 57710.
PROi Q9H6Y2.

Gene expression databases

ArrayExpressi Q9H6Y2.
Bgeei Q9H6Y2.
CleanExi HS_WDR55.
Genevestigatori Q9H6Y2.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR017422. WD_repeat_p55.
[Graphical view ]
Pfami PF00400. WD40. 4 hits.
[Graphical view ]
PIRSFi PIRSF038169. WD_repeat_p55. 1 hit.
SMARTi SM00320. WD40. 6 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-151.
    Tissue: Colon and Colon mucosa.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-151.
    Tissue: Placenta.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; THR-378 AND SER-382, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiWDR55_HUMAN
AccessioniPrimary (citable) accession number: Q9H6Y2
Secondary accession number(s): Q9NXK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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