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Protein

WD repeat-containing protein 55

Gene

WDR55

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

rRNA processing

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120314-MONOMER.
SignaLinkiQ9H6Y2.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 55
Gene namesi
Name:WDR55
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:25971. WDR55.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54853.
OpenTargetsiENSG00000120314.
PharmGKBiPA142670590.

Polymorphism and mutation databases

BioMutaiWDR55.
DMDMi296453035.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002375981 – 383WD repeat-containing protein 55Add BLAST383

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei354PhosphoserineCombined sources1
Modified residuei378PhosphothreonineCombined sources1
Modified residuei382PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H6Y2.
MaxQBiQ9H6Y2.
PaxDbiQ9H6Y2.
PeptideAtlasiQ9H6Y2.
PRIDEiQ9H6Y2.

PTM databases

iPTMnetiQ9H6Y2.
PhosphoSitePlusiQ9H6Y2.

Expressioni

Gene expression databases

BgeeiENSG00000120314.
CleanExiHS_WDR55.
ExpressionAtlasiQ9H6Y2. baseline and differential.
GenevisibleiQ9H6Y2. HS.

Organism-specific databases

HPAiHPA043470.
HPA048143.

Interactioni

Protein-protein interaction databases

BioGridi120203. 26 interactors.
IntActiQ9H6Y2. 9 interactors.
MINTiMINT-3068722.
STRINGi9606.ENSP00000351100.

Structurei

3D structure databases

ProteinModelPortaliQ9H6Y2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati36 – 75WD 1Add BLAST40
Repeati82 – 121WD 2Add BLAST40
Repeati125 – 163WD 3Add BLAST39
Repeati166 – 205WD 4Add BLAST40
Repeati208 – 247WD 5Add BLAST40
Repeati250 – 289WD 6Add BLAST40
Repeati293 – 332WD 7Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat WDR55 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2444. Eukaryota.
ENOG410ZHU5. LUCA.
GeneTreeiENSGT00530000064256.
HOGENOMiHOG000242496.
HOVERGENiHBG054778.
InParanoidiQ9H6Y2.
OMAiHCDMYPG.
OrthoDBiEOG091G0BYA.
PhylomeDBiQ9H6Y2.
TreeFamiTF315175.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR024977. Apc4_WD40_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR017422. WDR55.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
PIRSFiPIRSF038169. WD_repeat_p55. 1 hit.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H6Y2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRTCEERPA EDGSDEEDPD SMEAPTRIRD TPEDIVLEAP ASGLAFHPAR
60 70 80 90 100
DLLAAGDVDG DVFVFSYSCQ EGETKELWSS GHHLKACRAV AFSEDGQKLI
110 120 130 140 150
TVSKDKAIHV LDVEQGQLER RVSKAHGAPI NSLLLVDENV LATGDDTGGI
160 170 180 190 200
CLWDQRKEGP LMDMRQHEEY IADMALDPAK KLLLTASGDG CLGIFNIKRR
210 220 230 240 250
RFELLSEPQS GDLTSVTLMK WGKKVACGSS EGTIYLFNWN GFGATSDRFA
260 270 280 290 300
LRAESIDCMV PVTESLLCTG STDGVIRAVN ILPNRVVGSV GQHTGEPVEE
310 320 330 340 350
LALSHCGRFL ASSGHDQRLK FWDMAQLRAV VVDDYRRRKK KGGPLRALSS
360 370 380
KTWSTDDFFA GLREEGEDSM AQEEKEETGD DSD
Length:383
Mass (Da):42,070
Last modified:May 18, 2010 - v2
Checksum:i757962232E1034EB
GO
Isoform 2 (identifier: Q9H6Y2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-218: Missing.

Note: No experimental confirmation available.
Show »
Length:165
Mass (Da):18,180
Checksum:iDB52CC29149BD3AE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03705650R → C.Corresponds to variant rs34342435dbSNPEnsembl.1
Natural variantiVAR_037057151C → R.2 PublicationsCorresponds to variant rs2530245dbSNPEnsembl.1
Natural variantiVAR_037058210S → F.Corresponds to variant rs2286394dbSNPEnsembl.1
Natural variantiVAR_037059235Y → C.Corresponds to variant rs35983033dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0372751 – 218Missing in isoform 2. 1 PublicationAdd BLAST218

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000202 mRNA. Translation: BAA91006.1.
AK025355 mRNA. Translation: BAB15118.1.
AC116353 Genomic DNA. No translation available.
BC068485 mRNA. Translation: AAH68485.1.
CCDSiCCDS4235.1. [Q9H6Y2-1]
RefSeqiNP_060176.2. NM_017706.4.
XP_005268526.1. XM_005268469.2. [Q9H6Y2-1]
UniGeneiHs.286261.

Genome annotation databases

EnsembliENST00000358337; ENSP00000351100; ENSG00000120314. [Q9H6Y2-1]
GeneIDi54853.
KEGGihsa:54853.
UCSCiuc003lgr.5. human. [Q9H6Y2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000202 mRNA. Translation: BAA91006.1.
AK025355 mRNA. Translation: BAB15118.1.
AC116353 Genomic DNA. No translation available.
BC068485 mRNA. Translation: AAH68485.1.
CCDSiCCDS4235.1. [Q9H6Y2-1]
RefSeqiNP_060176.2. NM_017706.4.
XP_005268526.1. XM_005268469.2. [Q9H6Y2-1]
UniGeneiHs.286261.

3D structure databases

ProteinModelPortaliQ9H6Y2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120203. 26 interactors.
IntActiQ9H6Y2. 9 interactors.
MINTiMINT-3068722.
STRINGi9606.ENSP00000351100.

PTM databases

iPTMnetiQ9H6Y2.
PhosphoSitePlusiQ9H6Y2.

Polymorphism and mutation databases

BioMutaiWDR55.
DMDMi296453035.

Proteomic databases

EPDiQ9H6Y2.
MaxQBiQ9H6Y2.
PaxDbiQ9H6Y2.
PeptideAtlasiQ9H6Y2.
PRIDEiQ9H6Y2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358337; ENSP00000351100; ENSG00000120314. [Q9H6Y2-1]
GeneIDi54853.
KEGGihsa:54853.
UCSCiuc003lgr.5. human. [Q9H6Y2-1]

Organism-specific databases

CTDi54853.
DisGeNETi54853.
GeneCardsiWDR55.
HGNCiHGNC:25971. WDR55.
HPAiHPA043470.
HPA048143.
neXtProtiNX_Q9H6Y2.
OpenTargetsiENSG00000120314.
PharmGKBiPA142670590.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2444. Eukaryota.
ENOG410ZHU5. LUCA.
GeneTreeiENSGT00530000064256.
HOGENOMiHOG000242496.
HOVERGENiHBG054778.
InParanoidiQ9H6Y2.
OMAiHCDMYPG.
OrthoDBiEOG091G0BYA.
PhylomeDBiQ9H6Y2.
TreeFamiTF315175.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120314-MONOMER.
SignaLinkiQ9H6Y2.

Miscellaneous databases

ChiTaRSiWDR55. human.
GenomeRNAii54853.
PROiQ9H6Y2.

Gene expression databases

BgeeiENSG00000120314.
CleanExiHS_WDR55.
ExpressionAtlasiQ9H6Y2. baseline and differential.
GenevisibleiQ9H6Y2. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR024977. Apc4_WD40_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR017422. WDR55.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
PIRSFiPIRSF038169. WD_repeat_p55. 1 hit.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR55_HUMAN
AccessioniPrimary (citable) accession number: Q9H6Y2
Secondary accession number(s): Q9NXK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.