Reviewed, UniProtKB/Swiss-Prot Q9H6X2 (ANTR1_HUMAN)

Names and origin

Protein names

Recommended name:
Anthrax toxin receptor 1

Alternative name(s):
Tumor endothelial marker 8

Gene names

Name:	ANTXR1
Synonyms:	ATR, TEM8

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	564 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. Ref.9 Ref.10
Subunit structure	Interacts with gelatin and type 1 collagen. Interacts with the actin cytoskeleton. Binds to the protective antigen (PA) of Bacillus anthracis. Binding does not occur in the presence of calcium. Ref.9 Ref.10 Ref.2 Ref.6
Subcellular location	Cell membrane; Single-pass type I membrane protein. Cell projection › lamellipodium membrane; Single-pass type I membrane protein. Cell projection › filopodium membrane; Single-pass type I membrane protein. Note: At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia. Ref.10
Tissue specificity	Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells. Ref.9
Induction	Up-regulated in cultured angiogenic umbilical vein endothelial cells. Ref.9
Domain	Binding to PA seems to be effected through the VWA domain.
Sequence similarities	Belongs to the ATR family. Contains 1 VWFA domain.

Ontologies

Keywords
Cellular component	Cell membrane Cell projection Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane
Ligand	Metal-binding
Molecular function	Receptor
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	actin cytoskeleton reorganization Ref.10 Inferred from direct assay. Source: UniProtKB substrate adhesion-dependent cell spreading Ref.10 Inferred from direct assay. Source: UniProtKB
Cellular component	filopodium membrane Ref.10 Inferred from direct assay. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW lamellipodium membrane Ref.10 Inferred from direct assay. Source: UniProtKB
Molecular function	actin filament binding Ref.10 Inferred from direct assay. Source: UniProtKB collagen binding Ref.10 Inferred from direct assay. Source: UniProtKB metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor activity Ref.10 Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LRP6	O75581	1	EBI-905643,EBI-910915
pagA	P13423	2	EBI-905659,EBI-456868	From a different organism.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q9H6X2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 2 (identifier: Q9H6X2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     365-368: EDDD → NKIK
     369-564: Missing.

Isoform 3 (identifier: Q9H6X2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     268-297: NEKPFSVEDTYLLCPAPILKEVGMKAALQV → SKSLQSPWVSSTSGFKEGNSHPCLPARPHT
     298-564: Missing.

Isoform 4 (identifier: Q9H6X2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     319-333: DGSILAIALLILFLL → LHKIASGPTTAACME
     334-564: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 32	32	Potential
	Chain	33 – 564	532	Anthrax toxin receptor 1		PRO_0000002692
Regions
	Topological domain	33 – 321	289	Extracellular Potential
	Transmembrane	322 – 342	21	Potential
	Topological domain	343 – 564	222	Cytoplasmic Potential
	Domain	44 – 215	172	VWFA
	Compositional bias	360 – 368	9	Asp/Glu-rich (highly acidic)
	Compositional bias	506 – 564	59	Pro-rich
Sites
	Metal binding	52	1	Divalent metal cation By similarity
	Metal binding	54	1	Divalent metal cation By similarity
	Metal binding	118	1	Divalent metal cation By similarity
Amino acid modifications
	Modified residue	362	1	Phosphoserine Ref.8
	Modified residue	425	1	Phosphotyrosine Ref.11
	Glycosylation	166	1	N-linked (GlcNAc...) Potential
	Glycosylation	184	1	N-linked (GlcNAc...) Ref.12
	Glycosylation	262	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	268 – 297	30	NEKPF…AALQV → SKSLQSPWVSSTSGFKEGNS HPCLPARPHT in isoform 3.		VSP_000446
	Alternative sequence	298 – 564	267	Missing in isoform 3.		VSP_000447
	Alternative sequence	319 – 333	15	DGSIL…ILFLL → LHKIASGPTTAACME in isoform 4.		VSP_000448
	Alternative sequence	334 – 564	231	Missing in isoform 4.		VSP_000449
	Alternative sequence	365 – 368	4	EDDD → NKIK in isoform 2.		VSP_000444
	Alternative sequence	369 – 564	196	Missing in isoform 2.		VSP_000445
	Natural variant	7	1	R → K: dbSNP rs28365986. Ref.3		VAR_053015

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 2, 2001. Version 2. Checksum: B118A00AD5DF2233	FASTA	564	62,789
	10 20 30 40 50 60 MATAERRALG IGFQWLSLAT LVLICAGQGG RREDGGPACY GGFDLYFILD KSGSVLHHWN 70 80 90 100 110 120 EIYYFVEQLA HKFISPQLRM SFIVFSTRGT TLMKLTEDRE QIRQGLEELQ KVLPGGDTYM 130 140 150 160 170 180 HEGFERASEQ IYYENRQGYR TASVIIALTD GELHEDLFFY SEREANRSRD LGAIVYCVGV 190 200 210 220 230 240 KDFNETQLAR IADSKDHVFP VNDGFQALQG IIHSILKKSC IEILAAEPST ICAGESFQVV 250 260 270 280 290 300 VRGNGFRHAR NVDRVLCSFK INDSVTLNEK PFSVEDTYLL CPAPILKEVG MKAALQVSMN 310 320 330 340 350 360 DGLSFISSSV IITTTHCSDG SILAIALLIL FLLLALALLW WFWPLCCTVI IKEVPPPPAE 370 380 390 400 410 420 ESEEEDDDGL PKKKWPTVDA SYYGGRGVGG IKRMEVRWGE KGSTEEGAKL EKAKNARVKM 430 440 450 460 470 480 PEQEYEFPEP RNLNNNMRRP SSPRKWYSPI KGKLDALWVL LRKGYDRVSV MRPQPGDTGR 490 500 510 520 530 540 CINFTRVKNN QPAKYPLNNA YHTSSPPPAP IYTPPPPAPH CPPPPPSAPT PPIPSPPSTL 550 560 PPPPQAPPPN RAPPPSRPPP RPSV
	Isoform 2. Checksum: 8A87B13FFA7D8753	FASTA	368	41,157
	10 20 30 40 50 60 MATAERRALG IGFQWLSLAT LVLICAGQGG RREDGGPACY GGFDLYFILD KSGSVLHHWN 70 80 90 100 110 120 EIYYFVEQLA HKFISPQLRM SFIVFSTRGT TLMKLTEDRE QIRQGLEELQ KVLPGGDTYM 130 140 150 160 170 180 HEGFERASEQ IYYENRQGYR TASVIIALTD GELHEDLFFY SEREANRSRD LGAIVYCVGV 190 200 210 220 230 240 KDFNETQLAR IADSKDHVFP VNDGFQALQG IIHSILKKSC IEILAAEPST ICAGESFQVV 250 260 270 280 290 300 VRGNGFRHAR NVDRVLCSFK INDSVTLNEK PFSVEDTYLL CPAPILKEVG MKAALQVSMN 310 320 330 340 350 360 DGLSFISSSV IITTTHCSDG SILAIALLIL FLLLALALLW WFWPLCCTVI IKEVPPPPAE ESEENKIK
	Isoform 3. Checksum: 96C8BB0E8EBB0C4A	FASTA	297	33,280
	10 20 30 40 50 60 MATAERRALG IGFQWLSLAT LVLICAGQGG RREDGGPACY GGFDLYFILD KSGSVLHHWN 70 80 90 100 110 120 EIYYFVEQLA HKFISPQLRM SFIVFSTRGT TLMKLTEDRE QIRQGLEELQ KVLPGGDTYM 130 140 150 160 170 180 HEGFERASEQ IYYENRQGYR TASVIIALTD GELHEDLFFY SEREANRSRD LGAIVYCVGV 190 200 210 220 230 240 KDFNETQLAR IADSKDHVFP VNDGFQALQG IIHSILKKSC IEILAAEPST ICAGESFQVV 250 260 270 280 290 VRGNGFRHAR NVDRVLCSFK INDSVTLSKS LQSPWVSSTS GFKEGNSHPC LPARPHT
	Isoform 4. Checksum: F864586DEE043BBD	FASTA	333	37,055
	10 20 30 40 50 60 MATAERRALG IGFQWLSLAT LVLICAGQGG RREDGGPACY GGFDLYFILD KSGSVLHHWN 70 80 90 100 110 120 EIYYFVEQLA HKFISPQLRM SFIVFSTRGT TLMKLTEDRE QIRQGLEELQ KVLPGGDTYM 130 140 150 160 170 180 HEGFERASEQ IYYENRQGYR TASVIIALTD GELHEDLFFY SEREANRSRD LGAIVYCVGV 190 200 210 220 230 240 KDFNETQLAR IADSKDHVFP VNDGFQALQG IIHSILKKSC IEILAAEPST ICAGESFQVV 250 260 270 280 290 300 VRGNGFRHAR NVDRVLCSFK INDSVTLNEK PFSVEDTYLL CPAPILKEVG MKAALQVSMN 310 320 330 DGLSFISSSV IITTTHCSLH KIASGPTTAA CME

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genes expressed in human tumor endothelium." St Croix B., Rago C., Velculescu V.E., Traverso G., Romans K.E., Montgomery E., Lal A., Riggins G.J., Lengauer C., Vogelstein B., Kinzler K.W. Science 289:1197-1202(2000) [PubMed: 10947988] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Identification of the cellular receptor for anthrax toxin." Bradley K.A., Mogridge J., Mourez M., Collier R.J., Young J.A.T. Nature 414:225-229(2001) [PubMed: 11700562] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH ANTHRAX TOXIN.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 184-564 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), VARIANT LYS-7.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Kidney.
[6]	"Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor." Scobie H.M., Rainey G.J.A., Bradley K.A., Young J.A.T. Proc. Natl. Acad. Sci. U.S.A. 100:5170-5174(2003) [PubMed: 12700348] [Abstract] Cited for: INTERACTION WITH ANTHRAX TOXIN. Tissue: Placenta.
[7]	"An unappreciated role for RNA surveillance." Hillman R.T., Green R.E., Brenner S.E. Genome Biol. 5:R8.1-R8.16(2004) [PubMed: 14759258] [Abstract] Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362, MASS SPECTROMETRY. Tissue: Epithelium.
[9]	"TEM8 expression stimulates endothelial cell adhesion and migration by regulating cell-matrix interactions on collagen." Hotchkiss K.A., Basile C.M., Spring S.C., Bonuccelli G., Lisanti M.P., Terman B.I. Exp. Cell Res. 305:133-144(2005) [PubMed: 15777794] [Abstract] Cited for: FUNCTION, INDUCTION, INTERACTION WITH TYPE 1 COLLAGEN AND GELATIN, TISSUE SPECIFICITY.
[10]	"Anthrax toxin receptor 1/tumor endothelium marker 8 mediates cell spreading by coupling extracellular ligands to the actin cytoskeleton." Werner E., Kowalczyk A.P., Faundez V. J. Biol. Chem. 281:23227-23236(2006) [PubMed: 16762926] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TYPE 1 COLLAGEN; THE ACTIN CYTOSKELETON AND BACILLUS ANTHRACIS PROTECTIVE ANTIGEN.
[11]	"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. , Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J. Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-425, MASS SPECTROMETRY.
[12]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed: 19349973] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-184, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF279145 mRNA. Translation: AAK52094.1. AF421380 mRNA. Translation: AAL26496.1. AK001463 mRNA. Translation: BAA91707.1. Frameshift. AK025429 mRNA. Translation: BAB15128.1. Different initiation. AK292113 mRNA. Translation: BAF84802.1. AC112230 Genomic DNA. Translation: AAX88860.1. AC114802 Genomic DNA. Translation: AAY24067.1. BC012074 mRNA. Translation: AAH12074.1.
IPI	IPI00030431. IPI00071177. IPI00219619. IPI00871735.
RefSeq	NP_060623.2. NP_115584.1. NP_444262.1.
UniGene	Hs.165859
3D structure databases
SMR	Q9H6X2. Positions 41-321.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H6X2. 2 interactions.
STRING	Q9H6X2.
PTM databases
PhosphoSite	Q9H6X2.
Proteomic databases
PRIDE	Q9H6X2.
Genome annotation databases
Ensembl	ENST00000303714; ENSP00000301945; ENSG00000169604; Homo sapiens. [Genome view]
GeneID	84168.
KEGG	hsa:84168.
UCSC	uc002sfd.1. human. uc002sfe.1. human. uc002sff.1. human. uc002sfg.1. human.
Organism-specific databases
CTD	84168.
GeneCards	GC02P069152.
H-InvDB	HIX0002125.
HGNC	HGNC:21014. ANTXR1.
MIM	606410. gene.
PharmGKB	PA134956382.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG443624.
HOVERGEN	HBG050514.
InParanoid	Q9H6X2.
OMA	QGGRRED.
OrthoDB	EOG90P6RX.
PhylomeDB	Q9H6X2.
Enzyme and pathway databases
Pathway_Interaction_DB	anthraxpathway. Cellular roles of Anthrax toxin.
Gene expression databases
ArrayExpress	Q9H6X2.
Bgee	Q9H6X2.
CleanEx	HS_ANTXR1. HS_ATR.
Genevestigator	Q9H6X2.
GermOnline	ENSG00000169604. Homo sapiens.
Family and domain databases
InterPro	IPR017360. Anthrax_toxin_rcpt_2. IPR008399. Anthrax_toxin_rcpt_C. IPR008400. Anthrax_toxin_rcpt_extracel. IPR002035. VWF_A. [Graphical view]
Pfam	PF05586. Ant_C. 1 hit. PF05587. Anth_Ig. 1 hit. PF00092. VWA. 1 hit. [Graphical view]
PIRSF	PIRSF038023. Anthrax_toxin_receptor_2. 1 hit.
ProDom	PD377005. Anthrax_toxin_rcpt_C. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00327. VWA. 1 hit. [Graphical view]
PROSITE	PS50234. VWFA. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	73524.
SOURCE	Search...

Entry information

Entry name

ANTR1_HUMAN

Accession

Primary (citable) accession number: Q9H6X2
Secondary accession number(s): A8K7U8 , Q4ZFV6, Q53QD8, Q96P02, Q9NVP3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
Last sequence update:	November 2, 2001
Last modified:	March 2, 2010
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.