Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lipid droplet-associated hydrolase

Gene

LDAH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Serine lipid hydrolase associated with lipid droplets. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei139 – 1391NucleophilePROSITE-ProRule annotation
Active sitei271 – 2711Charge relay systemCurated
Active sitei300 – 3001Charge relay systemCurated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Protein family/group databases

ESTHERihuman-C2orf43. Duf_2305.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid droplet-associated hydrolaseImported (EC:3.1.1.-By similarity)
Alternative name(s):
Lipid droplet-associated serine hydrolase1 Publication
Short name:
hLDAH1 Publication
Gene namesi
Name:LDAH1 PublicationImported
Synonyms:C2orf43Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:26145. LDAH.

Subcellular locationi

  • Lipid droplet 1 Publication
  • Endoplasmic reticulum By similarity

  • Note: Localizes to the endoplasmic reticulum in absence of lipid droplets and translocates to lipid droplets upon lipid storage induction.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Lipid droplet

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA147358698.

Polymorphism and mutation databases

BioMutaiC2orf43.
DMDMi74761484.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Lipid droplet-associated hydrolasePRO_0000300124Add
BLAST

Proteomic databases

EPDiQ9H6V9.
MaxQBiQ9H6V9.
PaxDbiQ9H6V9.
PeptideAtlasiQ9H6V9.
PRIDEiQ9H6V9.

PTM databases

iPTMnetiQ9H6V9.
PhosphoSiteiQ9H6V9.

Expressioni

Tissue specificityi

Present in macrophage-rich areas in atherosclerotic lesionsv(at protein level).1 Publication

Gene expression databases

BgeeiENSG00000118961.
CleanExiHS_C2orf43.
ExpressionAtlasiQ9H6V9. baseline and differential.
GenevisibleiQ9H6V9. HS.

Organism-specific databases

HPAiHPA034729.
HPA034730.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000237822.

Structurei

3D structure databases

ProteinModelPortaliQ9H6V9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. LDAH family.Curated

Phylogenomic databases

eggNOGiKOG3975. Eukaryota.
ENOG410ZTV7. LUCA.
GeneTreeiENSGT00390000009688.
HOGENOMiHOG000045737.
HOVERGENiHBG107578.
InParanoidiQ9H6V9.
PhylomeDBiQ9H6V9.
TreeFamiTF313050.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR019363. LDAH.
[Graphical view]
PANTHERiPTHR13390. PTHR13390. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H6V9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSELKEEIP VHEEFILCGG AETQVLKCGP WTDLFHDQSV KRPKLLIFII
60 70 80 90 100
PGNPGFSAFY VPFAKALYSL TNRRFPVWTI SHAGHALAPK DKKILTTSED
110 120 130 140 150
SNAQEIKDIY GLNGQIEHKL AFLRTHVPKD MKLVLIGHSI GSYFTLQMLK
160 170 180 190 200
RVPELPVIRA FLLFPTIERM SESPNGRIAT PLLCWFRYVL YVTGYLLLKP
210 220 230 240 250
CPETIKSLLI RRGLQVMNLE NEFSPLNILE PFCLANAAYL GGQEMMEVVK
260 270 280 290 300
RDDETIKEHL CKLTFYYGTI DPWCPKEYYE DIKKDFPEGD IRLCEKNIPH
310 320
AFITHFNQEM ADMIADSLKD DLSKM
Length:325
Mass (Da):37,319
Last modified:March 1, 2001 - v1
Checksum:i6D5B414E60028DD1
GO
Isoform 2 (identifier: Q9H6V9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-51: P → PGERKSL

Show »
Length:331
Mass (Da):37,989
Checksum:iA1D4C6BC84EB8A08
GO
Isoform 3 (identifier: Q9H6V9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-99: Missing.

Note: No experimental confirmation available.
Show »
Length:277
Mass (Da):32,029
Checksum:iAF22651FB1A42F49
GO
Isoform 4 (identifier: Q9H6V9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-130: Missing.

Note: No experimental confirmation available.
Show »
Length:195
Mass (Da):22,663
Checksum:i285B7E69BFAA6714
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 130130Missing in isoform 4. 1 PublicationVSP_055283Add
BLAST
Alternative sequencei51 – 511P → PGERKSL in isoform 2. 1 PublicationVSP_042202
Alternative sequencei52 – 9948Missing in isoform 3. 1 PublicationVSP_054624Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025473 mRNA. Translation: BAB15142.1.
AK316162 mRNA. Translation: BAH14533.1.
AK316204 mRNA. Translation: BAH14575.1.
AK316310 mRNA. Translation: BAH14681.1.
DC325170 mRNA. No translation available.
AC012361 Genomic DNA. Translation: AAY14959.1.
AC012065 Genomic DNA. Translation: AAX93236.1.
CH471053 Genomic DNA. Translation: EAX00809.1.
CH471053 Genomic DNA. Translation: EAX00810.1.
BC017473 mRNA. Translation: AAH17473.1.
CCDSiCCDS1702.1. [Q9H6V9-1]
CCDS62864.1. [Q9H6V9-4]
CCDS62865.1. [Q9H6V9-3]
RefSeqiNP_001269649.1. NM_001282720.1. [Q9H6V9-3]
NP_001269650.1. NM_001282721.1. [Q9H6V9-4]
NP_001269651.1. NM_001282722.1. [Q9H6V9-4]
NP_068744.1. NM_021925.3. [Q9H6V9-1]
XP_011531316.1. XM_011533014.2. [Q9H6V9-2]
UniGeneiHs.187823.

Genome annotation databases

EnsembliENST00000237822; ENSP00000237822; ENSG00000118961. [Q9H6V9-1]
ENST00000541941; ENSP00000440570; ENSG00000118961. [Q9H6V9-4]
ENST00000619656; ENSP00000483067; ENSG00000118961. [Q9H6V9-4]
ENST00000626491; ENSP00000487592; ENSG00000118961. [Q9H6V9-3]
GeneIDi60526.
KEGGihsa:60526.
UCSCiuc002rec.5. human. [Q9H6V9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025473 mRNA. Translation: BAB15142.1.
AK316162 mRNA. Translation: BAH14533.1.
AK316204 mRNA. Translation: BAH14575.1.
AK316310 mRNA. Translation: BAH14681.1.
DC325170 mRNA. No translation available.
AC012361 Genomic DNA. Translation: AAY14959.1.
AC012065 Genomic DNA. Translation: AAX93236.1.
CH471053 Genomic DNA. Translation: EAX00809.1.
CH471053 Genomic DNA. Translation: EAX00810.1.
BC017473 mRNA. Translation: AAH17473.1.
CCDSiCCDS1702.1. [Q9H6V9-1]
CCDS62864.1. [Q9H6V9-4]
CCDS62865.1. [Q9H6V9-3]
RefSeqiNP_001269649.1. NM_001282720.1. [Q9H6V9-3]
NP_001269650.1. NM_001282721.1. [Q9H6V9-4]
NP_001269651.1. NM_001282722.1. [Q9H6V9-4]
NP_068744.1. NM_021925.3. [Q9H6V9-1]
XP_011531316.1. XM_011533014.2. [Q9H6V9-2]
UniGeneiHs.187823.

3D structure databases

ProteinModelPortaliQ9H6V9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000237822.

Protein family/group databases

ESTHERihuman-C2orf43. Duf_2305.

PTM databases

iPTMnetiQ9H6V9.
PhosphoSiteiQ9H6V9.

Polymorphism and mutation databases

BioMutaiC2orf43.
DMDMi74761484.

Proteomic databases

EPDiQ9H6V9.
MaxQBiQ9H6V9.
PaxDbiQ9H6V9.
PeptideAtlasiQ9H6V9.
PRIDEiQ9H6V9.

Protocols and materials databases

DNASUi60526.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000237822; ENSP00000237822; ENSG00000118961. [Q9H6V9-1]
ENST00000541941; ENSP00000440570; ENSG00000118961. [Q9H6V9-4]
ENST00000619656; ENSP00000483067; ENSG00000118961. [Q9H6V9-4]
ENST00000626491; ENSP00000487592; ENSG00000118961. [Q9H6V9-3]
GeneIDi60526.
KEGGihsa:60526.
UCSCiuc002rec.5. human. [Q9H6V9-1]

Organism-specific databases

CTDi60526.
GeneCardsiLDAH.
H-InvDBHIX0001861.
HGNCiHGNC:26145. LDAH.
HPAiHPA034729.
HPA034730.
MIMi613570. gene.
neXtProtiNX_Q9H6V9.
PharmGKBiPA147358698.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3975. Eukaryota.
ENOG410ZTV7. LUCA.
GeneTreeiENSGT00390000009688.
HOGENOMiHOG000045737.
HOVERGENiHBG107578.
InParanoidiQ9H6V9.
PhylomeDBiQ9H6V9.
TreeFamiTF313050.

Miscellaneous databases

ChiTaRSiC2orf43. human.
GenomeRNAii60526.
PROiQ9H6V9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118961.
CleanExiHS_C2orf43.
ExpressionAtlasiQ9H6V9. baseline and differential.
GenevisibleiQ9H6V9. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR019363. LDAH.
[Graphical view]
PANTHERiPTHR13390. PTHR13390. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLDAH_HUMAN
AccessioniPrimary (citable) accession number: Q9H6V9
Secondary accession number(s): B7ZA47
, B7ZAJ5, D6W530, E7ESN0, Q53T37, Q53T58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.