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Q9H6U6

- BCAS3_HUMAN

UniProt

Q9H6U6 - BCAS3_HUMAN

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Protein

Breast carcinoma-amplified sequence 3

Gene

BCAS3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin.By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei824 – 8252Breakpoint for translocation to form BCAS4-BCAS3

GO - Molecular functioni

  1. acetyltransferase activator activity Source: UniProtKB
  2. beta-tubulin binding Source: UniProtKB
  3. chromatin binding Source: UniProtKB
  4. histone acetyltransferase binding Source: UniProtKB
  5. histone binding Source: UniProtKB
  6. nuclear hormone receptor binding Source: UniProtKB
  7. transcription factor binding Source: UniProtKB

GO - Biological processi

  1. activation of Cdc42 GTPase activity Source: UniProtKB
  2. cellular response to estrogen stimulus Source: UniProtKB
  3. Golgi organization Source: UniProtKB
  4. microtubule organizing center organization Source: UniProtKB
  5. negative regulation of focal adhesion assembly Source: UniProtKB
  6. negative regulation of Rho GTPase activity Source: UniProtKB
  7. positive regulation of actin cytoskeleton reorganization Source: UniProtKB
  8. positive regulation of catalytic activity Source: UniProtKB
  9. positive regulation of Cdc42 GTPase activity Source: UniProtKB
  10. positive regulation of endothelial cell migration Source: UniProtKB
  11. positive regulation of filopodium assembly Source: UniProtKB
  12. positive regulation of intracellular protein transport Source: UniProtKB
  13. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  14. regulation of establishment of cell polarity Source: UniProtKB
  15. tube formation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Angiogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

SignaLinkiQ9H6U6.

Names & Taxonomyi

Protein namesi
Recommended name:
Breast carcinoma-amplified sequence 3Imported
Alternative name(s):
GAOB1
Gene namesi
Name:BCAS3Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:14347. BCAS3.

Subcellular locationi

Nucleus 2 Publications. Cytoplasm 3 Publications. Cytoplasmcytoskeleton By similarity
Note: Localizes in the cytoplasm in stationary cells. Translocates from the cytoplasm to the leading edge in motile cells. Colocalizes with microtubules and intermediate filaments in both stationary and motile cells (By similarity). Associates with chromatin. Recruited to estrogen receptor-induced promoters in a PELP1-dependent manner.By similarity1 Publication

GO - Cellular componenti

  1. cell leading edge Source: UniProtKB
  2. cell periphery Source: Ensembl
  3. cytoplasm Source: UniProtKB
  4. cytoplasmic microtubule Source: UniProtKB
  5. intermediate filament cytoskeleton Source: UniProtKB
  6. nucleus Source: UniProtKB
  7. transcriptionally active chromatin Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving BCAS3 has been found in some breast carcinoma cell lines. Translocation t(17;20)(q23;q13) with BCAS4.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA25286.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 928928Breast carcinoma-amplified sequence 3PRO_0000050883Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei480 – 4801Phosphoserine1 Publication
Modified residuei886 – 8861Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9H6U6.
PaxDbiQ9H6U6.
PRIDEiQ9H6U6.

PTM databases

PhosphoSiteiQ9H6U6.

Expressioni

Tissue specificityi

Expressed in stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leukocyte and mammary epithelial cells. Expressed in undifferentiated ES cells. Expressed in blood islands and nascent blood vessels derived from differentiated ES cells into embryoid bodies (BD). Expressed in endothelial cells. Not detected in brain. Expressed in brain tumors (at protein level). Expressed in brain. Highly expressed in breast cancers and in glioma cell lines.3 Publications

Developmental stagei

Fetal.

Inductioni

By estrogen.1 Publication

Gene expression databases

BgeeiQ9H6U6.
ExpressionAtlasiQ9H6U6. baseline and differential.
GenevestigatoriQ9H6U6.

Organism-specific databases

HPAiHPA052409.

Interactioni

Subunit structurei

Interacts with histone H3, ESR1, KAT2B and PELP1; the interactions occur in a estrogen-dependent manner. Interacts with beta-tubulin and VIM.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
VIMP086703EBI-6083685,EBI-353844

Protein-protein interaction databases

BioGridi120182. 3 interactions.
IntActiQ9H6U6. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9H6U6.
SMRiQ9H6U6. Positions 348-381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati69 – 11446WD 1Add
BLAST
Repeati349 – 38941WD 2Add
BLAST
Repeati403 – 44745WD 3Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat BCAS3 family.Curated
Contains 3 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG321894.
GeneTreeiENSGT00390000006454.
HOVERGENiHBG050676.
InParanoidiQ9H6U6.
OMAiPQFGAQK.
OrthoDBiEOG75MVVN.
PhylomeDBiQ9H6U6.
TreeFamiTF105856.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR022175. BCAS3.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12490. BCAS3. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 2 (identifier: Q9H6U6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNEAMATDSP RRPSRCTGGV VVRPQAVTEQ SYMESVVTFL QDVVPQAYSG
60 70 80 90 100
TPLTEEKEKI VWVRFENADL NDTSRNLEFH EIHSTGNEPP LLIMIGYSDG
110 120 130 140 150
MQVWSIPISG EAQELFSVRH GPIRAARILP APQFGAQKCD NFAEKRPLLG
160 170 180 190 200
VCKSIGSSGT SPPYCCVDLY SLRTGEMVKS IQFKTPIYDL HCNKRILVVV
210 220 230 240 250
LQEKIAAFDS CTFTKKFFVT SCYPCPGPNM NPIALGSRWL AYAENKLIRC
260 270 280 290 300
HQSRGGACGD NIQSYTATVI SAAKTLKSGL TMVGKVVTQL TGTLPSGVTE
310 320 330 340 350
DDVAIHSNSR RSPLVPGIIT VIDTETVGEG QVLVSEDSDS DGIVAHFPAH
360 370 380 390 400
EKPVCCMAFN TSGMLLVTTD TLGHDFHVFQ ILTHPWSSSQ CAVHHLYTLH
410 420 430 440 450
RGETEAKVQD ICFSHDCRWV VVSTLRGTSH VFPINPYGGQ PCVRTHMSPR
460 470 480 490 500
VVNRMSRFQK SAGLEEIEQE LTSKQGGRCS PVPGLSSSPS GSPLHGKLNS
510 520 530 540 550
QDSYNNFTNN NPGNPRLSPL PSLMVVMPLA QIKQPMTLGT ITKRTGPYLF
560 570 580 590 600
GAGCFSIKAP CKVKPPPQIS PSKSMGGEFC VAAIFGTSRS WFANNAGLKR
610 620 630 640 650
EKDQSKQVVV ESLYIISCYG TLVEHMMEPR PLSTAPKISD DTPLEMMTSP
660 670 680 690 700
RASWTLVRTP QWNELQPPFN ANHPLLLAAD AVQYYQFLLA GLVPPGSPGP
710 720 730 740 750
ITRHGSYDSL ASDHSGQEDE EWLSQVEIVT HTGPHRRLWM GPQFQFKTIH
760 770 780 790 800
PSGQTTVISS SSSVLQSHGP SDTPQPLLDF DTDDLDLNSL RIQPVRSDPV
810 820 830 840 850
SMPGSSRPVS DRRGVSTVID AASGTFDRSV TLLEVCGSWP EGFGLRHMSS
860 870 880 890 900
MEHTEEGLRE RLADAMAESP SRDVVGSGTE LQREGSIETL SNSSGSTSGS
910 920
IPRNFDGYRS PLPTNESQPL SLFPTGFP
Length:928
Mass (Da):101,237
Last modified:November 30, 2010 - v3
Checksum:i00D82E2EDCD1E8D7
GO
Isoform 1 (identifier: Q9H6U6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     547-561: Missing.

Show »
Length:913
Mass (Da):99,681
Checksum:i33A29CCC2357D75B
GO
Isoform 3 (identifier: Q9H6U6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     547-561: Missing.
     879-879: T → TDTALDVAVKTFPPERHVAVKCF

Show »
Length:935
Mass (Da):102,107
Checksum:iC5012DE917714AAB
GO
Isoform 4 (identifier: Q9H6U6-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     879-879: T → TDTALDVAVKTFPPERHVAVKCF

Show »
Length:950
Mass (Da):103,662
Checksum:i1515C78689B7ABB1
GO
Isoform 5 (identifier: Q9H6U6-7) [UniParc]FASTAAdd to Basket

Also known as: Maaab1

The sequence of this isoform differs from the canonical sequence as follows:
     547-561: Missing.
     880-928: ELQREGSIET...PLSLFPTGFP → DTALDVAVKT...SARGKHRDSE

Note: No experimental confirmation available.Curated

Show »
Length:928
Mass (Da):101,516
Checksum:iEAA80786E40CE757
GO
Isoform 6 (identifier: Q9H6U6-6) [UniParc]FASTAAdd to Basket

Also known as: Maaab2

The sequence of this isoform differs from the canonical sequence as follows:
     1-229: Missing.
     547-561: Missing.

Show »
Length:684
Mass (Da):74,240
Checksum:i2BA7C3218D9B40F3
GO

Sequence cautioni

The sequence AAF70324.1 differs from that shown. Reason: Frameshift at position 693.
Isoform 5 : The sequence AK225757 differs from that shown. Reason: Frameshift at position 895.
Isoform 5 : The sequence CAD54076.1 differs from that shown. Reason: Frameshift at position 894.
The sequence AAL99634.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA90966.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB14078.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291E → K in AAL99632. (PubMed:12378525)Curated
Sequence conflicti127 – 1271R → K in AAL99632. (PubMed:12378525)Curated
Sequence conflicti199 – 2002VV → II in BAB15156. (PubMed:14702039)Curated
Sequence conflicti533 – 5331K → E in BAB14078. (PubMed:14702039)Curated
Sequence conflicti533 – 5331K → E in BAB14380. (PubMed:14702039)Curated
Sequence conflicti640 – 6401D → G in BAB15156. (PubMed:14702039)Curated
Sequence conflicti666 – 6661Q → R in BAB14078. (PubMed:14702039)Curated
Sequence conflicti806 – 8061S → P in BAB15156. (PubMed:14702039)Curated
Isoform 5 (identifier: Q9H6U6-7)
Sequence conflicti891 – 8911G → R in CAD54076. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti87 – 871N → S.4 Publications
Corresponds to variant rs2643103 [ dbSNP | Ensembl ].
VAR_065093
Natural varianti106 – 1061I → V.
Corresponds to variant rs34712615 [ dbSNP | Ensembl ].
VAR_057583

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 229229Missing in isoform 6. 2 PublicationsVSP_040112Add
BLAST
Alternative sequencei547 – 56115Missing in isoform 1, isoform 3, isoform 5 and isoform 6. 4 PublicationsVSP_007858Add
BLAST
Alternative sequencei879 – 8791T → TDTALDVAVKTFPPERHVAV KCF in isoform 3 and isoform 4. 2 PublicationsVSP_007860
Alternative sequencei880 – 92849ELQRE…PTGFP → DTALDVAVKTFPPERHVAVK CFGKKKGKKKQCQQPSVREQ PNSNKACVRDGGRTSARGKH RDSE in isoform 5. 1 PublicationVSP_040113Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF361219 mRNA. Translation: AAL99632.1.
AF361221 mRNA. Translation: AAL99634.1. Different initiation.
AK000135 mRNA. Translation: BAA90966.1. Different initiation.
AK022526 mRNA. Translation: BAB14078.1. Different initiation.
AK023054 mRNA. Translation: BAB14380.1.
AK025510 mRNA. Translation: BAB15156.1.
AK225757 mRNA. No translation available.
AC005746 Genomic DNA. No translation available.
AC005856 Genomic DNA. No translation available.
AC005884 Genomic DNA. No translation available.
AC015876 Genomic DNA. No translation available.
AC079005 Genomic DNA. No translation available.
AC110602 Genomic DNA. No translation available.
CH471179 Genomic DNA. Translation: EAW51414.1.
BC001250 mRNA. Translation: AAH01250.2.
BC117275 mRNA. Translation: AAI17276.1.
BC143386 mRNA. Translation: AAI43387.1.
AJ511332 mRNA. Translation: CAD54076.1. Frameshift.
AJ518105 mRNA. Translation: CAD57723.1.
AL831895 mRNA. Translation: CAD38568.1.
AF260268 mRNA. Translation: AAF70324.1. Frameshift.
CCDSiCCDS11626.1. [Q9H6U6-2]
CCDS45749.1. [Q9H6U6-1]
RefSeqiNP_001092902.1. NM_001099432.1. [Q9H6U6-1]
NP_060149.3. NM_017679.3. [Q9H6U6-2]
XP_005257529.1. XM_005257472.1. [Q9H6U6-8]
XP_005257531.1. XM_005257474.1. [Q9H6U6-3]
XP_005257532.1. XM_005257475.1. [Q9H6U6-7]
UniGeneiHs.655028.

Genome annotation databases

EnsembliENST00000390652; ENSP00000375067; ENSG00000141376. [Q9H6U6-1]
ENST00000407086; ENSP00000385323; ENSG00000141376. [Q9H6U6-2]
ENST00000408905; ENSP00000386173; ENSG00000141376. [Q9H6U6-3]
ENST00000588462; ENSP00000468592; ENSG00000141376. [Q9H6U6-8]
ENST00000588874; ENSP00000464825; ENSG00000141376. [Q9H6U6-6]
ENST00000589222; ENSP00000466078; ENSG00000141376. [Q9H6U6-7]
GeneIDi54828.
KEGGihsa:54828.
UCSCiuc002iyu.4. human. [Q9H6U6-2]
uc002iyv.4. human. [Q9H6U6-1]
uc002iyw.4. human. [Q9H6U6-7]
uc002iyy.4. human. [Q9H6U6-6]
uc002iyz.4. human. [Q9H6U6-8]
uc002iza.4. human. [Q9H6U6-3]

Polymorphism databases

DMDMi313104248.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF361219 mRNA. Translation: AAL99632.1 .
AF361221 mRNA. Translation: AAL99634.1 . Different initiation.
AK000135 mRNA. Translation: BAA90966.1 . Different initiation.
AK022526 mRNA. Translation: BAB14078.1 . Different initiation.
AK023054 mRNA. Translation: BAB14380.1 .
AK025510 mRNA. Translation: BAB15156.1 .
AK225757 mRNA. No translation available.
AC005746 Genomic DNA. No translation available.
AC005856 Genomic DNA. No translation available.
AC005884 Genomic DNA. No translation available.
AC015876 Genomic DNA. No translation available.
AC079005 Genomic DNA. No translation available.
AC110602 Genomic DNA. No translation available.
CH471179 Genomic DNA. Translation: EAW51414.1 .
BC001250 mRNA. Translation: AAH01250.2 .
BC117275 mRNA. Translation: AAI17276.1 .
BC143386 mRNA. Translation: AAI43387.1 .
AJ511332 mRNA. Translation: CAD54076.1 . Frameshift.
AJ518105 mRNA. Translation: CAD57723.1 .
AL831895 mRNA. Translation: CAD38568.1 .
AF260268 mRNA. Translation: AAF70324.1 . Frameshift.
CCDSi CCDS11626.1. [Q9H6U6-2 ]
CCDS45749.1. [Q9H6U6-1 ]
RefSeqi NP_001092902.1. NM_001099432.1. [Q9H6U6-1 ]
NP_060149.3. NM_017679.3. [Q9H6U6-2 ]
XP_005257529.1. XM_005257472.1. [Q9H6U6-8 ]
XP_005257531.1. XM_005257474.1. [Q9H6U6-3 ]
XP_005257532.1. XM_005257475.1. [Q9H6U6-7 ]
UniGenei Hs.655028.

3D structure databases

ProteinModelPortali Q9H6U6.
SMRi Q9H6U6. Positions 348-381.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120182. 3 interactions.
IntActi Q9H6U6. 2 interactions.

PTM databases

PhosphoSitei Q9H6U6.

Polymorphism databases

DMDMi 313104248.

Proteomic databases

MaxQBi Q9H6U6.
PaxDbi Q9H6U6.
PRIDEi Q9H6U6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000390652 ; ENSP00000375067 ; ENSG00000141376 . [Q9H6U6-1 ]
ENST00000407086 ; ENSP00000385323 ; ENSG00000141376 . [Q9H6U6-2 ]
ENST00000408905 ; ENSP00000386173 ; ENSG00000141376 . [Q9H6U6-3 ]
ENST00000588462 ; ENSP00000468592 ; ENSG00000141376 . [Q9H6U6-8 ]
ENST00000588874 ; ENSP00000464825 ; ENSG00000141376 . [Q9H6U6-6 ]
ENST00000589222 ; ENSP00000466078 ; ENSG00000141376 . [Q9H6U6-7 ]
GeneIDi 54828.
KEGGi hsa:54828.
UCSCi uc002iyu.4. human. [Q9H6U6-2 ]
uc002iyv.4. human. [Q9H6U6-1 ]
uc002iyw.4. human. [Q9H6U6-7 ]
uc002iyy.4. human. [Q9H6U6-6 ]
uc002iyz.4. human. [Q9H6U6-8 ]
uc002iza.4. human. [Q9H6U6-3 ]

Organism-specific databases

CTDi 54828.
GeneCardsi GC17P058755.
H-InvDB HIX0021877.
HGNCi HGNC:14347. BCAS3.
HPAi HPA052409.
MIMi 607470. gene.
neXtProti NX_Q9H6U6.
PharmGKBi PA25286.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG321894.
GeneTreei ENSGT00390000006454.
HOVERGENi HBG050676.
InParanoidi Q9H6U6.
OMAi PQFGAQK.
OrthoDBi EOG75MVVN.
PhylomeDBi Q9H6U6.
TreeFami TF105856.

Enzyme and pathway databases

SignaLinki Q9H6U6.

Miscellaneous databases

ChiTaRSi BCAS3. human.
GeneWikii BCAS3.
GenomeRNAii 54828.
NextBioi 57598.
PROi Q9H6U6.
SOURCEi Search...

Gene expression databases

Bgeei Q9H6U6.
ExpressionAtlasi Q9H6U6. baseline and differential.
Genevestigatori Q9H6U6.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
InterProi IPR022175. BCAS3.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF12490. BCAS3. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view ]
SMARTi SM00320. WD40. 2 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer."
    Baerlund M., Monni O., Weaver J.D., Kauraniemi P., Sauter G., Heiskanen M., Kallioniemi O.-P., Kallioniemi A.
    Genes Chromosomes Cancer 35:311-317(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, CHROMOSOMAL TRANSLOCATION WITH BCAS4, VARIANT SER-87.
    Tissue: Liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 5 AND 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 478-928 (ISOFORM 3), VARIANT SER-87.
    Tissue: Colon.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-87.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-87.
    Tissue: Brain and Cervix.
  6. "Cloning and sequencing of a new isoform similar to FLJ20128 and BCAS3."
    Bauer M.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-433 (ISOFORM 6), PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 475-928 (ISOFORM 4).
    Tissue: Brain.
  8. "Five novel genes from 17q23 amplicon have different amplification and overexpression frequency in breast cancer."
    Wu G., Couch F.J.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 510-928 (ISOFORMS 1/6).
  9. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
  10. Erratum
    Gururaj A.E., Singh R.R., Rayala S.K., Holm C., den Hollander P., Zhang H., Balasenthil S., Talukder A.H., Landberg G., Kumar R.
    Proc. Natl. Acad. Sci. U.S.A. 110:4147-4148(2013)
  11. "Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)."
    Gururaj A.E., Peng S., Vadlamudi R.K., Kumar R.
    Mol. Endocrinol. 21:1847-1860(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH HISTONE H3; ESR1; KAT2B AND PELP1, SUBCELLULAR LOCATION, CHROMATIN-BINDING.
  12. "Human BCAS3 expression in embryonic stem cells and vascular precursors suggests a role in human embryogenesis and tumor angiogenesis."
    Siva K., Venu P., Mahadevan A., Shankar S.K., Inamdar M.S.
    PLoS ONE 2:E1202-E1202(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-886, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Rudhira/BCAS3 is a cytoskeletal protein that controls Cdc42 activation and directional cell migration during angiogenesis."
    Jain M., Bhat G.P., Vijayra havan K., Inamdar M.S.
    Exp. Cell Res. 318:753-767(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BETA-TUBULIN AND VIM.
  17. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBCAS3_HUMAN
AccessioniPrimary (citable) accession number: Q9H6U6
Secondary accession number(s): Q17RM0
, Q6KF21, Q8IXI6, Q8NDR8, Q8TDL9, Q8TDM1, Q8WY55, Q9BVF0, Q9H957, Q9H9Y9, Q9NXP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3