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Q9H6U6

- BCAS3_HUMAN

UniProt

Q9H6U6 - BCAS3_HUMAN

Protein

Breast carcinoma-amplified sequence 3

Gene

BCAS3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 3 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei824 – 8252Breakpoint for translocation to form BCAS4-BCAS3

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Enzyme and pathway databases

    SignaLinkiQ9H6U6.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Breast carcinoma-amplified sequence 3
    Alternative name(s):
    GAOB1
    Gene namesi
    Name:BCAS3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:14347. BCAS3.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cell periphery Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving BCAS3 has been found in some breast carcinoma cell lines. Translocation t(17;20)(q23;q13) with BCAS4.

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    PharmGKBiPA25286.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 928928Breast carcinoma-amplified sequence 3PRO_0000050883Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei480 – 4801Phosphoserine1 Publication
    Modified residuei886 – 8861Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9H6U6.
    PaxDbiQ9H6U6.
    PRIDEiQ9H6U6.

    PTM databases

    PhosphoSiteiQ9H6U6.

    Expressioni

    Tissue specificityi

    Expressed in stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leukocyte and mammary epithelial cells. Highly expressed in breast cancers.2 Publications

    Developmental stagei

    Fetal.

    Inductioni

    By estrogen.1 Publication

    Gene expression databases

    ArrayExpressiQ9H6U6.
    BgeeiQ9H6U6.
    GenevestigatoriQ9H6U6.

    Organism-specific databases

    HPAiHPA052409.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    VIMP086703EBI-6083685,EBI-353844

    Protein-protein interaction databases

    BioGridi120182. 1 interaction.
    IntActiQ9H6U6. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H6U6.
    SMRiQ9H6U6. Positions 347-373.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati69 – 11446WD 1Add
    BLAST
    Repeati349 – 38941WD 2Add
    BLAST
    Repeati403 – 44745WD 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat BCAS3 family.Curated
    Contains 3 WD repeats.Curated

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG321894.
    HOVERGENiHBG050676.
    OMAiPQFGAQK.
    OrthoDBiEOG75MVVN.
    PhylomeDBiQ9H6U6.
    TreeFamiTF105856.

    Family and domain databases

    Gene3Di2.130.10.10. 2 hits.
    InterProiIPR022175. BCAS3.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF12490. BCAS3. 1 hit.
    PF00400. WD40. 1 hit.
    [Graphical view]
    SMARTiSM00320. WD40. 2 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 2 hits.

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 2 (identifier: Q9H6U6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNEAMATDSP RRPSRCTGGV VVRPQAVTEQ SYMESVVTFL QDVVPQAYSG    50
    TPLTEEKEKI VWVRFENADL NDTSRNLEFH EIHSTGNEPP LLIMIGYSDG 100
    MQVWSIPISG EAQELFSVRH GPIRAARILP APQFGAQKCD NFAEKRPLLG 150
    VCKSIGSSGT SPPYCCVDLY SLRTGEMVKS IQFKTPIYDL HCNKRILVVV 200
    LQEKIAAFDS CTFTKKFFVT SCYPCPGPNM NPIALGSRWL AYAENKLIRC 250
    HQSRGGACGD NIQSYTATVI SAAKTLKSGL TMVGKVVTQL TGTLPSGVTE 300
    DDVAIHSNSR RSPLVPGIIT VIDTETVGEG QVLVSEDSDS DGIVAHFPAH 350
    EKPVCCMAFN TSGMLLVTTD TLGHDFHVFQ ILTHPWSSSQ CAVHHLYTLH 400
    RGETEAKVQD ICFSHDCRWV VVSTLRGTSH VFPINPYGGQ PCVRTHMSPR 450
    VVNRMSRFQK SAGLEEIEQE LTSKQGGRCS PVPGLSSSPS GSPLHGKLNS 500
    QDSYNNFTNN NPGNPRLSPL PSLMVVMPLA QIKQPMTLGT ITKRTGPYLF 550
    GAGCFSIKAP CKVKPPPQIS PSKSMGGEFC VAAIFGTSRS WFANNAGLKR 600
    EKDQSKQVVV ESLYIISCYG TLVEHMMEPR PLSTAPKISD DTPLEMMTSP 650
    RASWTLVRTP QWNELQPPFN ANHPLLLAAD AVQYYQFLLA GLVPPGSPGP 700
    ITRHGSYDSL ASDHSGQEDE EWLSQVEIVT HTGPHRRLWM GPQFQFKTIH 750
    PSGQTTVISS SSSVLQSHGP SDTPQPLLDF DTDDLDLNSL RIQPVRSDPV 800
    SMPGSSRPVS DRRGVSTVID AASGTFDRSV TLLEVCGSWP EGFGLRHMSS 850
    MEHTEEGLRE RLADAMAESP SRDVVGSGTE LQREGSIETL SNSSGSTSGS 900
    IPRNFDGYRS PLPTNESQPL SLFPTGFP 928
    Length:928
    Mass (Da):101,237
    Last modified:November 30, 2010 - v3
    Checksum:i00D82E2EDCD1E8D7
    GO
    Isoform 1 (identifier: Q9H6U6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         547-561: Missing.

    Show »
    Length:913
    Mass (Da):99,681
    Checksum:i33A29CCC2357D75B
    GO
    Isoform 3 (identifier: Q9H6U6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         547-561: Missing.
         879-879: T → TDTALDVAVKTFPPERHVAVKCF

    Show »
    Length:935
    Mass (Da):102,107
    Checksum:iC5012DE917714AAB
    GO
    Isoform 4 (identifier: Q9H6U6-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         879-879: T → TDTALDVAVKTFPPERHVAVKCF

    Show »
    Length:950
    Mass (Da):103,662
    Checksum:i1515C78689B7ABB1
    GO
    Isoform 5 (identifier: Q9H6U6-7) [UniParc]FASTAAdd to Basket

    Also known as: Maaab1

    The sequence of this isoform differs from the canonical sequence as follows:
         547-561: Missing.
         880-928: ELQREGSIET...PLSLFPTGFP → DTALDVAVKT...SARGKHRDSE

    Note: No experimental confirmation available.Curated

    Show »
    Length:928
    Mass (Da):101,516
    Checksum:iEAA80786E40CE757
    GO
    Isoform 6 (identifier: Q9H6U6-6) [UniParc]FASTAAdd to Basket

    Also known as: Maaab2

    The sequence of this isoform differs from the canonical sequence as follows:
         1-229: Missing.
         547-561: Missing.

    Show »
    Length:684
    Mass (Da):74,240
    Checksum:i2BA7C3218D9B40F3
    GO

    Sequence cautioni

    The sequence AAF70324.1 differs from that shown. Reason: Frameshift at position 693.
    Isoform 5 : The sequence AK225757 differs from that shown. Reason: Frameshift at position 895.
    Isoform 5 : The sequence CAD54076.1 differs from that shown. Reason: Frameshift at position 894.
    The sequence AAL99634.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA90966.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB14078.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti29 – 291E → K in AAL99632. (PubMed:12378525)Curated
    Sequence conflicti127 – 1271R → K in AAL99632. (PubMed:12378525)Curated
    Sequence conflicti199 – 2002VV → II in BAB15156. (PubMed:14702039)Curated
    Sequence conflicti533 – 5331K → E in BAB14078. (PubMed:14702039)Curated
    Sequence conflicti533 – 5331K → E in BAB14380. (PubMed:14702039)Curated
    Sequence conflicti640 – 6401D → G in BAB15156. (PubMed:14702039)Curated
    Sequence conflicti666 – 6661Q → R in BAB14078. (PubMed:14702039)Curated
    Sequence conflicti806 – 8061S → P in BAB15156. (PubMed:14702039)Curated
    Isoform 5 (identifier: Q9H6U6-7)
    Sequence conflicti891 – 8911G → R in CAD54076. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti87 – 871N → S.4 Publications
    Corresponds to variant rs2643103 [ dbSNP | Ensembl ].
    VAR_065093
    Natural varianti106 – 1061I → V.
    Corresponds to variant rs34712615 [ dbSNP | Ensembl ].
    VAR_057583

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 229229Missing in isoform 6. 2 PublicationsVSP_040112Add
    BLAST
    Alternative sequencei547 – 56115Missing in isoform 1, isoform 3, isoform 5 and isoform 6. 4 PublicationsVSP_007858Add
    BLAST
    Alternative sequencei879 – 8791T → TDTALDVAVKTFPPERHVAV KCF in isoform 3 and isoform 4. 2 PublicationsVSP_007860
    Alternative sequencei880 – 92849ELQRE…PTGFP → DTALDVAVKTFPPERHVAVK CFGKKKGKKKQCQQPSVREQ PNSNKACVRDGGRTSARGKH RDSE in isoform 5. 1 PublicationVSP_040113Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF361219 mRNA. Translation: AAL99632.1.
    AF361221 mRNA. Translation: AAL99634.1. Different initiation.
    AK000135 mRNA. Translation: BAA90966.1. Different initiation.
    AK022526 mRNA. Translation: BAB14078.1. Different initiation.
    AK023054 mRNA. Translation: BAB14380.1.
    AK025510 mRNA. Translation: BAB15156.1.
    AK225757 mRNA. No translation available.
    AC005746 Genomic DNA. No translation available.
    AC005856 Genomic DNA. No translation available.
    AC005884 Genomic DNA. No translation available.
    AC015876 Genomic DNA. No translation available.
    AC079005 Genomic DNA. No translation available.
    AC110602 Genomic DNA. No translation available.
    CH471179 Genomic DNA. Translation: EAW51414.1.
    BC001250 mRNA. Translation: AAH01250.2.
    BC117275 mRNA. Translation: AAI17276.1.
    BC143386 mRNA. Translation: AAI43387.1.
    AJ511332 mRNA. Translation: CAD54076.1. Frameshift.
    AJ518105 mRNA. Translation: CAD57723.1.
    AL831895 mRNA. Translation: CAD38568.1.
    AF260268 mRNA. Translation: AAF70324.1. Frameshift.
    CCDSiCCDS11626.1. [Q9H6U6-2]
    CCDS45749.1. [Q9H6U6-1]
    RefSeqiNP_001092902.1. NM_001099432.1. [Q9H6U6-1]
    NP_060149.3. NM_017679.3. [Q9H6U6-2]
    XP_005257529.1. XM_005257472.1. [Q9H6U6-8]
    XP_005257531.1. XM_005257474.1. [Q9H6U6-3]
    XP_005257532.1. XM_005257475.1. [Q9H6U6-7]
    UniGeneiHs.655028.

    Genome annotation databases

    EnsembliENST00000390652; ENSP00000375067; ENSG00000141376. [Q9H6U6-1]
    ENST00000407086; ENSP00000385323; ENSG00000141376. [Q9H6U6-2]
    ENST00000408905; ENSP00000386173; ENSG00000141376. [Q9H6U6-3]
    ENST00000588462; ENSP00000468592; ENSG00000141376. [Q9H6U6-8]
    ENST00000588874; ENSP00000464825; ENSG00000141376. [Q9H6U6-6]
    ENST00000589222; ENSP00000466078; ENSG00000141376. [Q9H6U6-7]
    GeneIDi54828.
    KEGGihsa:54828.
    UCSCiuc002iyu.4. human. [Q9H6U6-2]
    uc002iyv.4. human. [Q9H6U6-1]
    uc002iyw.4. human. [Q9H6U6-7]
    uc002iyy.4. human. [Q9H6U6-6]
    uc002iyz.4. human. [Q9H6U6-8]
    uc002iza.4. human. [Q9H6U6-3]

    Polymorphism databases

    DMDMi313104248.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF361219 mRNA. Translation: AAL99632.1 .
    AF361221 mRNA. Translation: AAL99634.1 . Different initiation.
    AK000135 mRNA. Translation: BAA90966.1 . Different initiation.
    AK022526 mRNA. Translation: BAB14078.1 . Different initiation.
    AK023054 mRNA. Translation: BAB14380.1 .
    AK025510 mRNA. Translation: BAB15156.1 .
    AK225757 mRNA. No translation available.
    AC005746 Genomic DNA. No translation available.
    AC005856 Genomic DNA. No translation available.
    AC005884 Genomic DNA. No translation available.
    AC015876 Genomic DNA. No translation available.
    AC079005 Genomic DNA. No translation available.
    AC110602 Genomic DNA. No translation available.
    CH471179 Genomic DNA. Translation: EAW51414.1 .
    BC001250 mRNA. Translation: AAH01250.2 .
    BC117275 mRNA. Translation: AAI17276.1 .
    BC143386 mRNA. Translation: AAI43387.1 .
    AJ511332 mRNA. Translation: CAD54076.1 . Frameshift.
    AJ518105 mRNA. Translation: CAD57723.1 .
    AL831895 mRNA. Translation: CAD38568.1 .
    AF260268 mRNA. Translation: AAF70324.1 . Frameshift.
    CCDSi CCDS11626.1. [Q9H6U6-2 ]
    CCDS45749.1. [Q9H6U6-1 ]
    RefSeqi NP_001092902.1. NM_001099432.1. [Q9H6U6-1 ]
    NP_060149.3. NM_017679.3. [Q9H6U6-2 ]
    XP_005257529.1. XM_005257472.1. [Q9H6U6-8 ]
    XP_005257531.1. XM_005257474.1. [Q9H6U6-3 ]
    XP_005257532.1. XM_005257475.1. [Q9H6U6-7 ]
    UniGenei Hs.655028.

    3D structure databases

    ProteinModelPortali Q9H6U6.
    SMRi Q9H6U6. Positions 347-373.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120182. 1 interaction.
    IntActi Q9H6U6. 2 interactions.

    PTM databases

    PhosphoSitei Q9H6U6.

    Polymorphism databases

    DMDMi 313104248.

    Proteomic databases

    MaxQBi Q9H6U6.
    PaxDbi Q9H6U6.
    PRIDEi Q9H6U6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000390652 ; ENSP00000375067 ; ENSG00000141376 . [Q9H6U6-1 ]
    ENST00000407086 ; ENSP00000385323 ; ENSG00000141376 . [Q9H6U6-2 ]
    ENST00000408905 ; ENSP00000386173 ; ENSG00000141376 . [Q9H6U6-3 ]
    ENST00000588462 ; ENSP00000468592 ; ENSG00000141376 . [Q9H6U6-8 ]
    ENST00000588874 ; ENSP00000464825 ; ENSG00000141376 . [Q9H6U6-6 ]
    ENST00000589222 ; ENSP00000466078 ; ENSG00000141376 . [Q9H6U6-7 ]
    GeneIDi 54828.
    KEGGi hsa:54828.
    UCSCi uc002iyu.4. human. [Q9H6U6-2 ]
    uc002iyv.4. human. [Q9H6U6-1 ]
    uc002iyw.4. human. [Q9H6U6-7 ]
    uc002iyy.4. human. [Q9H6U6-6 ]
    uc002iyz.4. human. [Q9H6U6-8 ]
    uc002iza.4. human. [Q9H6U6-3 ]

    Organism-specific databases

    CTDi 54828.
    GeneCardsi GC17P058755.
    H-InvDB HIX0021877.
    HGNCi HGNC:14347. BCAS3.
    HPAi HPA052409.
    MIMi 607470. gene.
    neXtProti NX_Q9H6U6.
    PharmGKBi PA25286.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG321894.
    HOVERGENi HBG050676.
    OMAi PQFGAQK.
    OrthoDBi EOG75MVVN.
    PhylomeDBi Q9H6U6.
    TreeFami TF105856.

    Enzyme and pathway databases

    SignaLinki Q9H6U6.

    Miscellaneous databases

    ChiTaRSi BCAS3. human.
    GeneWikii BCAS3.
    GenomeRNAii 54828.
    NextBioi 57598.
    PROi Q9H6U6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H6U6.
    Bgeei Q9H6U6.
    Genevestigatori Q9H6U6.

    Family and domain databases

    Gene3Di 2.130.10.10. 2 hits.
    InterProi IPR022175. BCAS3.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF12490. BCAS3. 1 hit.
    PF00400. WD40. 1 hit.
    [Graphical view ]
    SMARTi SM00320. WD40. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer."
      Baerlund M., Monni O., Weaver J.D., Kauraniemi P., Sauter G., Heiskanen M., Kallioniemi O.-P., Kallioniemi A.
      Genes Chromosomes Cancer 35:311-317(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, CHROMOSOMAL TRANSLOCATION WITH BCAS4, VARIANT SER-87.
      Tissue: Liver.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 5 AND 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 478-928 (ISOFORM 3), VARIANT SER-87.
      Tissue: Colon.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-87.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-87.
      Tissue: Brain and Cervix.
    6. "Cloning and sequencing of a new isoform similar to FLJ20128 and BCAS3."
      Bauer M.
      Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-433 (ISOFORM 6), PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 475-928 (ISOFORM 4).
      Tissue: Brain.
    8. "Five novel genes from 17q23 amplicon have different amplification and overexpression frequency in breast cancer."
      Wu G., Couch F.J.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 510-928 (ISOFORMS 1/6).
    9. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
    10. Erratum
      Gururaj A.E., Singh R.R., Rayala S.K., Holm C., den Hollander P., Zhang H., Balasenthil S., Talukder A.H., Landberg G., Kumar R.
      Proc. Natl. Acad. Sci. U.S.A. 110:4147-4148(2013)
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-886, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiBCAS3_HUMAN
    AccessioniPrimary (citable) accession number: Q9H6U6
    Secondary accession number(s): Q17RM0
    , Q6KF21, Q8IXI6, Q8NDR8, Q8TDL9, Q8TDM1, Q8WY55, Q9BVF0, Q9H957, Q9H9Y9, Q9NXP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2003
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 117 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3