Q9H6U6 (BCAS3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Breast carcinoma-amplified sequence 3

Alternative name(s):
GAOB1

Gene names

Name:

BCAS3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	928 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus Potential.
Tissue specificity	Expressed in stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leukocyte and mammary epithelial cells. Overexpressed in most breast cancer cell lines. Ref.1
Developmental stage	Fetal.
Involvement in disease	A chromosomal aberration involving BCAS3 has been found in some breast carcinoma cell lines. Translocation t(17;20)(q23;q13) with BCAS4.
Sequence similarities	Belongs to the WD repeat BCAS3 family. Contains 3 WD repeats.
Sequence caution	The sequence AAF70324.1 differs from that shown. Reason: Frameshift at position 693. The sequence AAL99634.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA90966.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB14078.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. Isoform 5: The sequence AK225757 differs from that shown. Reason: Frameshift at position 895. Isoform 5: The sequence CAD54076.1 differs from that shown. Reason: Frameshift at position 894.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Chromosomal rearrangement Polymorphism
Disease	Proto-oncogene
Domain	Repeat WD repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cell periphery Inferred from electronic annotation. Source: Compara cytoplasm Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
VIM	P08670	3	EBI-6083685,EBI-353844

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 2 (identifier: Q9H6U6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q9H6U6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     547-561: Missing.

Isoform 3 (identifier: Q9H6U6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     547-561: Missing.
     879-879: T → TDTALDVAVKTFPPERHVAVKCF

Isoform 4 (identifier: Q9H6U6-8)

The sequence of this isoform differs from the canonical sequence as follows:
     879-879: T → TDTALDVAVKTFPPERHVAVKCF

Isoform 5 (identifier: Q9H6U6-7)

Also known as: Maaab1;

The sequence of this isoform differs from the canonical sequence as follows:
     547-561: Missing.
     880-928: ELQREGSIET...PLSLFPTGFP → DTALDVAVKT...SARGKHRDSE

Note: No experimental confirmation available.

Isoform 6 (identifier: Q9H6U6-6)

Also known as: Maaab2;

The sequence of this isoform differs from the canonical sequence as follows:
     1-229: Missing.
     547-561: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 928	928	Breast carcinoma-amplified sequence 3		PRO_0000050883
Regions
	Repeat	69 – 114	46	WD 1
	Repeat	349 – 389	41	WD 2
	Repeat	403 – 447	45	WD 3
Sites
	Site	824 – 825	2	Breakpoint for translocation to form BCAS4-BCAS3
Amino acid modifications
	Modified residue	480	1	Phosphoserine Ref.9
	Modified residue	869	1	Phosphoserine By similarity
	Modified residue	886	1	Phosphoserine Ref.10
Natural variations
	Alternative sequence	1 – 229	229	Missing in isoform 6.		VSP_040112
	Alternative sequence	547 – 561	15	Missing in isoform 1, isoform 3, isoform 5 and isoform 6.		VSP_007858
	Alternative sequence	879	1	T → TDTALDVAVKTFPPERHVAV KCF in isoform 3 and isoform 4.		VSP_007860
	Alternative sequence	880 – 928	49	ELQRE…PTGFP → DTALDVAVKTFPPERHVAVK CFGKKKGKKKQCQQPSVREQ PNSNKACVRDGGRTSARGKH RDSE in isoform 5.		VSP_040113
	Natural variant	87	1	N → S. Ref.1 Ref.2 Ref.4 Ref.5 Corresponds to variant rs2643103 [ dbSNP | Ensembl ].		VAR_065093
	Natural variant	106	1	I → V. Corresponds to variant rs34712615 [ dbSNP | Ensembl ].		VAR_057583
Experimental info
	Sequence conflict	29	1	E → K in AAL99632. Ref.1
	Sequence conflict	127	1	R → K in AAL99632. Ref.1
	Sequence conflict	199 – 200	2	VV → II in BAB15156. Ref.2
	Sequence conflict	533	1	K → E in BAB14078. Ref.2
	Sequence conflict	533	1	K → E in BAB14380. Ref.2
	Sequence conflict	640	1	D → G in BAB15156. Ref.2
	Sequence conflict	666	1	Q → R in BAB14078. Ref.2
	Sequence conflict	806	1	S → P in BAB15156. Ref.2
Isoform 5:
	Sequence conflict	891	1	G → R in CAD54076. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2 [UniParc]. Last modified November 30, 2010. Version 3. Checksum: 00D82E2EDCD1E8D7	FASTA	928	101,237
	10 20 30 40 50 60 MNEAMATDSP RRPSRCTGGV VVRPQAVTEQ SYMESVVTFL QDVVPQAYSG TPLTEEKEKI 70 80 90 100 110 120 VWVRFENADL NDTSRNLEFH EIHSTGNEPP LLIMIGYSDG MQVWSIPISG EAQELFSVRH 130 140 150 160 170 180 GPIRAARILP APQFGAQKCD NFAEKRPLLG VCKSIGSSGT SPPYCCVDLY SLRTGEMVKS 190 200 210 220 230 240 IQFKTPIYDL HCNKRILVVV LQEKIAAFDS CTFTKKFFVT SCYPCPGPNM NPIALGSRWL 250 260 270 280 290 300 AYAENKLIRC HQSRGGACGD NIQSYTATVI SAAKTLKSGL TMVGKVVTQL TGTLPSGVTE 310 320 330 340 350 360 DDVAIHSNSR RSPLVPGIIT VIDTETVGEG QVLVSEDSDS DGIVAHFPAH EKPVCCMAFN 370 380 390 400 410 420 TSGMLLVTTD TLGHDFHVFQ ILTHPWSSSQ CAVHHLYTLH RGETEAKVQD ICFSHDCRWV 430 440 450 460 470 480 VVSTLRGTSH VFPINPYGGQ PCVRTHMSPR VVNRMSRFQK SAGLEEIEQE LTSKQGGRCS 490 500 510 520 530 540 PVPGLSSSPS GSPLHGKLNS QDSYNNFTNN NPGNPRLSPL PSLMVVMPLA QIKQPMTLGT 550 560 570 580 590 600 ITKRTGPYLF GAGCFSIKAP CKVKPPPQIS PSKSMGGEFC VAAIFGTSRS WFANNAGLKR 610 620 630 640 650 660 EKDQSKQVVV ESLYIISCYG TLVEHMMEPR PLSTAPKISD DTPLEMMTSP RASWTLVRTP 670 680 690 700 710 720 QWNELQPPFN ANHPLLLAAD AVQYYQFLLA GLVPPGSPGP ITRHGSYDSL ASDHSGQEDE 730 740 750 760 770 780 EWLSQVEIVT HTGPHRRLWM GPQFQFKTIH PSGQTTVISS SSSVLQSHGP SDTPQPLLDF 790 800 810 820 830 840 DTDDLDLNSL RIQPVRSDPV SMPGSSRPVS DRRGVSTVID AASGTFDRSV TLLEVCGSWP 850 860 870 880 890 900 EGFGLRHMSS MEHTEEGLRE RLADAMAESP SRDVVGSGTE LQREGSIETL SNSSGSTSGS 910 920 IPRNFDGYRS PLPTNESQPL SLFPTGFP
	Isoform 1 [UniParc]. Checksum: 33A29CCC2357D75B	FASTA	913	99,681
	10 20 30 40 50 60 MNEAMATDSP RRPSRCTGGV VVRPQAVTEQ SYMESVVTFL QDVVPQAYSG TPLTEEKEKI 70 80 90 100 110 120 VWVRFENADL NDTSRNLEFH EIHSTGNEPP LLIMIGYSDG MQVWSIPISG EAQELFSVRH 130 140 150 160 170 180 GPIRAARILP APQFGAQKCD NFAEKRPLLG VCKSIGSSGT SPPYCCVDLY SLRTGEMVKS 190 200 210 220 230 240 IQFKTPIYDL HCNKRILVVV LQEKIAAFDS CTFTKKFFVT SCYPCPGPNM NPIALGSRWL 250 260 270 280 290 300 AYAENKLIRC HQSRGGACGD NIQSYTATVI SAAKTLKSGL TMVGKVVTQL TGTLPSGVTE 310 320 330 340 350 360 DDVAIHSNSR RSPLVPGIIT VIDTETVGEG QVLVSEDSDS DGIVAHFPAH EKPVCCMAFN 370 380 390 400 410 420 TSGMLLVTTD TLGHDFHVFQ ILTHPWSSSQ CAVHHLYTLH RGETEAKVQD ICFSHDCRWV 430 440 450 460 470 480 VVSTLRGTSH VFPINPYGGQ PCVRTHMSPR VVNRMSRFQK SAGLEEIEQE LTSKQGGRCS 490 500 510 520 530 540 PVPGLSSSPS GSPLHGKLNS QDSYNNFTNN NPGNPRLSPL PSLMVVMPLA QIKQPMTLGT 550 560 570 580 590 600 ITKRTGKVKP PPQISPSKSM GGEFCVAAIF GTSRSWFANN AGLKREKDQS KQVVVESLYI 610 620 630 640 650 660 ISCYGTLVEH MMEPRPLSTA PKISDDTPLE MMTSPRASWT LVRTPQWNEL QPPFNANHPL 670 680 690 700 710 720 LLAADAVQYY QFLLAGLVPP GSPGPITRHG SYDSLASDHS GQEDEEWLSQ VEIVTHTGPH 730 740 750 760 770 780 RRLWMGPQFQ FKTIHPSGQT TVISSSSSVL QSHGPSDTPQ PLLDFDTDDL DLNSLRIQPV 790 800 810 820 830 840 RSDPVSMPGS SRPVSDRRGV STVIDAASGT FDRSVTLLEV CGSWPEGFGL RHMSSMEHTE 850 860 870 880 890 900 EGLRERLADA MAESPSRDVV GSGTELQREG SIETLSNSSG STSGSIPRNF DGYRSPLPTN 910 ESQPLSLFPT GFP
	Isoform 3 [UniParc]. Checksum: C5012DE917714AAB	FASTA	935	102,107
	10 20 30 40 50 60 MNEAMATDSP RRPSRCTGGV VVRPQAVTEQ SYMESVVTFL QDVVPQAYSG TPLTEEKEKI 70 80 90 100 110 120 VWVRFENADL NDTSRNLEFH EIHSTGNEPP LLIMIGYSDG MQVWSIPISG EAQELFSVRH 130 140 150 160 170 180 GPIRAARILP APQFGAQKCD NFAEKRPLLG VCKSIGSSGT SPPYCCVDLY SLRTGEMVKS 190 200 210 220 230 240 IQFKTPIYDL HCNKRILVVV LQEKIAAFDS CTFTKKFFVT SCYPCPGPNM NPIALGSRWL 250 260 270 280 290 300 AYAENKLIRC HQSRGGACGD NIQSYTATVI SAAKTLKSGL TMVGKVVTQL TGTLPSGVTE 310 320 330 340 350 360 DDVAIHSNSR RSPLVPGIIT VIDTETVGEG QVLVSEDSDS DGIVAHFPAH EKPVCCMAFN 370 380 390 400 410 420 TSGMLLVTTD TLGHDFHVFQ ILTHPWSSSQ CAVHHLYTLH RGETEAKVQD ICFSHDCRWV 430 440 450 460 470 480 VVSTLRGTSH VFPINPYGGQ PCVRTHMSPR VVNRMSRFQK SAGLEEIEQE LTSKQGGRCS 490 500 510 520 530 540 PVPGLSSSPS GSPLHGKLNS QDSYNNFTNN NPGNPRLSPL PSLMVVMPLA QIKQPMTLGT 550 560 570 580 590 600 ITKRTGKVKP PPQISPSKSM GGEFCVAAIF GTSRSWFANN AGLKREKDQS KQVVVESLYI 610 620 630 640 650 660 ISCYGTLVEH MMEPRPLSTA PKISDDTPLE MMTSPRASWT LVRTPQWNEL QPPFNANHPL 670 680 690 700 710 720 LLAADAVQYY QFLLAGLVPP GSPGPITRHG SYDSLASDHS GQEDEEWLSQ VEIVTHTGPH 730 740 750 760 770 780 RRLWMGPQFQ FKTIHPSGQT TVISSSSSVL QSHGPSDTPQ PLLDFDTDDL DLNSLRIQPV 790 800 810 820 830 840 RSDPVSMPGS SRPVSDRRGV STVIDAASGT FDRSVTLLEV CGSWPEGFGL RHMSSMEHTE 850 860 870 880 890 900 EGLRERLADA MAESPSRDVV GSGTDTALDV AVKTFPPERH VAVKCFELQR EGSIETLSNS 910 920 930 SGSTSGSIPR NFDGYRSPLP TNESQPLSLF PTGFP
	Isoform 4 [UniParc]. Checksum: 1515C78689B7ABB1	FASTA	950	103,662
	10 20 30 40 50 60 MNEAMATDSP RRPSRCTGGV VVRPQAVTEQ SYMESVVTFL QDVVPQAYSG TPLTEEKEKI 70 80 90 100 110 120 VWVRFENADL NDTSRNLEFH EIHSTGNEPP LLIMIGYSDG MQVWSIPISG EAQELFSVRH 130 140 150 160 170 180 GPIRAARILP APQFGAQKCD NFAEKRPLLG VCKSIGSSGT SPPYCCVDLY SLRTGEMVKS 190 200 210 220 230 240 IQFKTPIYDL HCNKRILVVV LQEKIAAFDS CTFTKKFFVT SCYPCPGPNM NPIALGSRWL 250 260 270 280 290 300 AYAENKLIRC HQSRGGACGD NIQSYTATVI SAAKTLKSGL TMVGKVVTQL TGTLPSGVTE 310 320 330 340 350 360 DDVAIHSNSR RSPLVPGIIT VIDTETVGEG QVLVSEDSDS DGIVAHFPAH EKPVCCMAFN 370 380 390 400 410 420 TSGMLLVTTD TLGHDFHVFQ ILTHPWSSSQ CAVHHLYTLH RGETEAKVQD ICFSHDCRWV 430 440 450 460 470 480 VVSTLRGTSH VFPINPYGGQ PCVRTHMSPR VVNRMSRFQK SAGLEEIEQE LTSKQGGRCS 490 500 510 520 530 540 PVPGLSSSPS GSPLHGKLNS QDSYNNFTNN NPGNPRLSPL PSLMVVMPLA QIKQPMTLGT 550 560 570 580 590 600 ITKRTGPYLF GAGCFSIKAP CKVKPPPQIS PSKSMGGEFC VAAIFGTSRS WFANNAGLKR 610 620 630 640 650 660 EKDQSKQVVV ESLYIISCYG TLVEHMMEPR PLSTAPKISD DTPLEMMTSP RASWTLVRTP 670 680 690 700 710 720 QWNELQPPFN ANHPLLLAAD AVQYYQFLLA GLVPPGSPGP ITRHGSYDSL ASDHSGQEDE 730 740 750 760 770 780 EWLSQVEIVT HTGPHRRLWM GPQFQFKTIH PSGQTTVISS SSSVLQSHGP SDTPQPLLDF 790 800 810 820 830 840 DTDDLDLNSL RIQPVRSDPV SMPGSSRPVS DRRGVSTVID AASGTFDRSV TLLEVCGSWP 850 860 870 880 890 900 EGFGLRHMSS MEHTEEGLRE RLADAMAESP SRDVVGSGTD TALDVAVKTF PPERHVAVKC 910 920 930 940 950 FELQREGSIE TLSNSSGSTS GSIPRNFDGY RSPLPTNESQ PLSLFPTGFP
	Isoform 5 (Maaab1) [UniParc]. Checksum: EAA80786E40CE757	FASTA	928	101,516
	10 20 30 40 50 60 MNEAMATDSP RRPSRCTGGV VVRPQAVTEQ SYMESVVTFL QDVVPQAYSG TPLTEEKEKI 70 80 90 100 110 120 VWVRFENADL NDTSRNLEFH EIHSTGNEPP LLIMIGYSDG MQVWSIPISG EAQELFSVRH 130 140 150 160 170 180 GPIRAARILP APQFGAQKCD NFAEKRPLLG VCKSIGSSGT SPPYCCVDLY SLRTGEMVKS 190 200 210 220 230 240 IQFKTPIYDL HCNKRILVVV LQEKIAAFDS CTFTKKFFVT SCYPCPGPNM NPIALGSRWL 250 260 270 280 290 300 AYAENKLIRC HQSRGGACGD NIQSYTATVI SAAKTLKSGL TMVGKVVTQL TGTLPSGVTE 310 320 330 340 350 360 DDVAIHSNSR RSPLVPGIIT VIDTETVGEG QVLVSEDSDS DGIVAHFPAH EKPVCCMAFN 370 380 390 400 410 420 TSGMLLVTTD TLGHDFHVFQ ILTHPWSSSQ CAVHHLYTLH RGETEAKVQD ICFSHDCRWV 430 440 450 460 470 480 VVSTLRGTSH VFPINPYGGQ PCVRTHMSPR VVNRMSRFQK SAGLEEIEQE LTSKQGGRCS 490 500 510 520 530 540 PVPGLSSSPS GSPLHGKLNS QDSYNNFTNN NPGNPRLSPL PSLMVVMPLA QIKQPMTLGT 550 560 570 580 590 600 ITKRTGKVKP PPQISPSKSM GGEFCVAAIF GTSRSWFANN AGLKREKDQS KQVVVESLYI 610 620 630 640 650 660 ISCYGTLVEH MMEPRPLSTA PKISDDTPLE MMTSPRASWT LVRTPQWNEL QPPFNANHPL 670 680 690 700 710 720 LLAADAVQYY QFLLAGLVPP GSPGPITRHG SYDSLASDHS GQEDEEWLSQ VEIVTHTGPH 730 740 750 760 770 780 RRLWMGPQFQ FKTIHPSGQT TVISSSSSVL QSHGPSDTPQ PLLDFDTDDL DLNSLRIQPV 790 800 810 820 830 840 RSDPVSMPGS SRPVSDRRGV STVIDAASGT FDRSVTLLEV CGSWPEGFGL RHMSSMEHTE 850 860 870 880 890 900 EGLRERLADA MAESPSRDVV GSGTDTALDV AVKTFPPERH VAVKCFGKKK GKKKQCQQPS 910 920 VREQPNSNKA CVRDGGRTSA RGKHRDSE
	Isoform 6 (Maaab2) [UniParc]. Checksum: 2BA7C3218D9B40F3	FASTA	684	74,240
	10 20 30 40 50 60 MNPIALGSRW LAYAENKLIR CHQSRGGACG DNIQSYTATV ISAAKTLKSG LTMVGKVVTQ 70 80 90 100 110 120 LTGTLPSGVT EDDVAIHSNS RRSPLVPGII TVIDTETVGE GQVLVSEDSD SDGIVAHFPA 130 140 150 160 170 180 HEKPVCCMAF NTSGMLLVTT DTLGHDFHVF QILTHPWSSS QCAVHHLYTL HRGETEAKVQ 190 200 210 220 230 240 DICFSHDCRW VVVSTLRGTS HVFPINPYGG QPCVRTHMSP RVVNRMSRFQ KSAGLEEIEQ 250 260 270 280 290 300 ELTSKQGGRC SPVPGLSSSP SGSPLHGKLN SQDSYNNFTN NNPGNPRLSP LPSLMVVMPL 310 320 330 340 350 360 AQIKQPMTLG TITKRTGKVK PPPQISPSKS MGGEFCVAAI FGTSRSWFAN NAGLKREKDQ 370 380 390 400 410 420 SKQVVVESLY IISCYGTLVE HMMEPRPLST APKISDDTPL EMMTSPRASW TLVRTPQWNE 430 440 450 460 470 480 LQPPFNANHP LLLAADAVQY YQFLLAGLVP PGSPGPITRH GSYDSLASDH SGQEDEEWLS 490 500 510 520 530 540 QVEIVTHTGP HRRLWMGPQF QFKTIHPSGQ TTVISSSSSV LQSHGPSDTP QPLLDFDTDD 550 560 570 580 590 600 LDLNSLRIQP VRSDPVSMPG SSRPVSDRRG VSTVIDAASG TFDRSVTLLE VCGSWPEGFG 610 620 630 640 650 660 LRHMSSMEHT EEGLRERLAD AMAESPSRDV VGSGTELQRE GSIETLSNSS GSTSGSIPRN 670 680 FDGYRSPLPT NESQPLSLFP TGFP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer." Baerlund M., Monni O., Weaver J.D., Kauraniemi P., Sauter G., Heiskanen M., Kallioniemi O.-P., Kallioniemi A. Genes Chromosomes Cancer 35:311-317(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, CHROMOSOMAL TRANSLOCATION WITH BCAS4, VARIANT SER-87. Tissue: Liver.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 5 AND 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 478-928 (ISOFORM 3), VARIANT SER-87. Tissue: Colon.
[3]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-87.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-87. Tissue: Brain and Cervix.
[6]	"Cloning and sequencing of a new isoform similar to FLJ20128 and BCAS3." Bauer M. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-433 (ISOFORM 6), PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 475-928 (ISOFORM 4). Tissue: Brain.
[8]	"Five novel genes from 17q23 amplicon have different amplification and overexpression frequency in breast cancer." Wu G., Couch F.J. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 510-928 (ISOFORMS 1/6).
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-886, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF361219 mRNA. Translation: AAL99632.1. AF361221 mRNA. Translation: AAL99634.1. Different initiation. AK000135 mRNA. Translation: BAA90966.1. Different initiation. AK022526 mRNA. Translation: BAB14078.1. Different initiation. AK023054 mRNA. Translation: BAB14380.1. AK025510 mRNA. Translation: BAB15156.1. AK225757 mRNA. No translation available. AC005746 Genomic DNA. No translation available. AC005856 Genomic DNA. No translation available. AC005884 Genomic DNA. No translation available. AC015876 Genomic DNA. No translation available. AC079005 Genomic DNA. No translation available. AC110602 Genomic DNA. No translation available. CH471179 Genomic DNA. Translation: EAW51414.1. BC001250 mRNA. Translation: AAH01250.2. BC117275 mRNA. Translation: AAI17276.1. BC143386 mRNA. Translation: AAI43387.1. AJ511332 mRNA. Translation: CAD54076.1. Frameshift. AJ518105 mRNA. Translation: CAD57723.1. AL831895 mRNA. Translation: CAD38568.1. AF260268 mRNA. Translation: AAF70324.1. Frameshift.
IPI	IPI00332095. IPI00332097. IPI00411606. IPI00783452. IPI00902682. IPI00973013.
RefSeq	NP_001092902.1. NM_001099432.1. NP_060149.3. NM_017679.3.
UniGene	Hs.655028.
3D structure databases
ProteinModelPortal	Q9H6U6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H6U6. 1 interaction.
PTM databases
PhosphoSite	Q9H6U6.
Polymorphism databases
DMDM	33514881.
Proteomic databases
PaxDb	Q9H6U6.
PRIDE	Q9H6U6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000390652; ENSP00000375067; ENSG00000141376. ENST00000407086; ENSP00000385323; ENSG00000141376. ENST00000408905; ENSP00000386173; ENSG00000141376. ENST00000588462; ENSP00000468592; ENSG00000141376. ENST00000588874; ENSP00000464825; ENSG00000141376. ENST00000589222; ENSP00000466078; ENSG00000141376.
GeneID	54828.
KEGG	hsa:54828.
UCSC	uc002iyu.4. human. uc002iyv.4. human. uc002iyw.4. human. uc002iyy.4. human. uc002iyz.4. human. uc002iza.4. human.
Organism-specific databases
CTD	54828.
GeneCards	GC17P058755.
H-InvDB	HIX0021877.
HGNC	HGNC:14347. BCAS3.
HPA	HPA052409.
MIM	607470. gene.
neXtProt	NX_Q9H6U6.
PharmGKB	PA25286.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG321894.
HOVERGEN	HBG050676.
OMA	PQFGAQK.
Gene expression databases
Bgee	Q9H6U6.
Genevestigator	Q9H6U6.
GermOnline	ENSG00000141376. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 2 hits.
InterPro	IPR022175. BCAS3. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. [Graphical view]
Pfam	PF12490. BCAS3. 1 hit. PF00400. WD40. 1 hit. [Graphical view]
SMART	SM00320. WD40. 2 hits. [Graphical view]
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	BCAS3. human.
GenomeRNAi	54828.
NextBio	57598.
SOURCE	Search...

Entry information

Entry name

BCAS3_HUMAN

Accession

Primary (citable) accession number: Q9H6U6
Secondary accession number(s): Q17RM0 , Q6KF21, Q8IXI6, Q8NDR8, Q8TDL9, Q8TDM1, Q8WY55, Q9BVF0, Q9H957, Q9H9Y9, Q9NXP4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2003
Last sequence update:	November 30, 2010
Last modified:	May 1, 2013
This is version 104 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.