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Protein

Epithelial splicing regulatory protein 2

Gene

ESRP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.1 Publication

GO - Molecular functioni

  • mRNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-6803529 FGFR2 alternative splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial splicing regulatory protein 2
Alternative name(s):
RNA-binding motif protein 35B
RNA-binding protein 35B
Gene namesi
Name:ESRP2
Synonyms:RBM35B
ORF Names:PP7059
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103067.11
HGNCiHGNC:26152 ESRP2
MIMi612960 gene
neXtProtiNX_Q9H6T0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi80004
OpenTargetsiENSG00000103067
PharmGKBiPA164719361

Polymorphism and mutation databases

BioMutaiESRP2
DMDMi74761482

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002730501 – 727Epithelial splicing regulatory protein 2Add BLAST727

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83PhosphoserineBy similarity1
Modified residuei573PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H6T0
PaxDbiQ9H6T0
PeptideAtlasiQ9H6T0
PRIDEiQ9H6T0

PTM databases

iPTMnetiQ9H6T0
PhosphoSitePlusiQ9H6T0

Expressioni

Tissue specificityi

Epithelial cell-specific.1 Publication

Inductioni

Down-regulated during the epithelial-to-mesenchymal transition (EMT).1 Publication

Gene expression databases

BgeeiENSG00000103067
CleanExiHS_RBM35B
ExpressionAtlasiQ9H6T0 baseline and differential
GenevisibleiQ9H6T0 HS

Organism-specific databases

HPAiHPA040751
HPA048597
HPA048618

Interactioni

Protein-protein interaction databases

BioGridi123061, 9 interactors
IntActiQ9H6T0, 4 interactors
MINTiQ9H6T0
STRINGi9606.ENSP00000418748

Structurei

3D structure databases

ProteinModelPortaliQ9H6T0
SMRiQ9H6T0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini257 – 353RRM 1Add BLAST97
Domaini358 – 438RRM 2Add BLAST81
Domaini475 – 555RRM 3Add BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 27Pro-richAdd BLAST25

Sequence similaritiesi

Belongs to the ESRP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1365 Eukaryota
ENOG410XPZU LUCA
GeneTreeiENSGT00760000119102
HOGENOMiHOG000112401
InParanoidiQ9H6T0
KOiK14947
OMAiEFHVQHP
OrthoDBiEOG091G06HY
PhylomeDBiQ9H6T0
TreeFamiTF316157

Family and domain databases

Gene3Di3.30.420.10, 1 hit
3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR034431 ESRP2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR000504 RRM_dom
PANTHERiPTHR13976:SF30 PTHR13976:SF30, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF53098 SSF53098, 1 hit
SSF54928 SSF54928, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H6T0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPPPPPPPP PGPDPAADPA ADPCPWPGSL VVLFGATAGA LGRDLGSDET
60 70 80 90 100
DLILLVWQVV EPRSRQVGTL HKSLVRAEAA ALSTQCREAS GLSADSLARA
110 120 130 140 150
EPLDKVLQQF SQLVNGDVAL LGGGPYMLCT DGQQLLRQVL HPEASRKNLV
160 170 180 190 200
LPDMFFSFYD LRREFHMQHP STCPARDLTV ATMAQGLGLE TDATEDDFGV
210 220 230 240 250
WEVKTMVAVI LHLLKEPSSQ LFSKPEVIKQ KYETGPCSDS TVPCPYSSKA
260 270 280 290 300
DVVDSETVVR ARGLPWQSSD QDVARFFKGL NVARGGVALC LNAQGRRNGE
310 320 330 340 350
ALIRFVDSEQ RDLALQRHKH HMGVRYIEVY KATGEEFVKI AGGTSLEVAR
360 370 380 390 400
FLSREDQVIL RLRGLPFSAG PTDVLGFLGP ECPVTGGTEG LLFVRHPDGR
410 420 430 440 450
PTGDAFALFA CEELAQAALR RHKGMLGKRY IELFRSTAAE VQQVLNRYAS
460 470 480 490 500
GPLLPTLTAP LLPIPFPLAP GTGRDCVRLR GLPYTATIED ILSFLGEAAA
510 520 530 540 550
DIRPHGVHMV LNQQGRPSGD AFIQMTSAER ALAAAQRCHK KVMKERYVEV
560 570 580 590 600
VPCSTEEMSR VLMGGTLGRS GMSPPPCKLP CLSPPTYTTF QATPTLIPTE
610 620 630 640 650
TAALYPSSAL LPAARVPAAP TPVAYYPGPA TQLYLNYTAY YPSPPVSPTT
660 670 680 690 700
VGYLTTPTAA LASAPTSVLS QSGALVRMQG VPYTAGMKDL LSVFQAYQLP
710 720
ADDYTSLMPV GDPPRTVLQA PKEWVCL
Length:727
Mass (Da):78,401
Last modified:March 1, 2001 - v1
Checksum:i8831BA8284D6BD60
GO
Isoform 2 (identifier: Q9H6T0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-247: Missing.

Note: No experimental confirmation available.
Show »
Length:717
Mass (Da):77,364
Checksum:i4AB000FD043A92BC
GO

Sequence cautioni

The sequence AAL55761 differs from that shown. Reason: Frameshift at position 370.Curated
The sequence BAB15275 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti586T → I in BAB15275 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030074111S → L. Corresponds to variant dbSNP:rs12597504Ensembl.1
Natural variantiVAR_030075528A → V. Corresponds to variant dbSNP:rs3743738Ensembl.1
Natural variantiVAR_057245627P → S. Corresponds to variant dbSNP:rs36054935Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022474238 – 247Missing in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025571 mRNA Translation: BAB15173.1
AK025901 mRNA Translation: BAB15275.1 Different initiation.
BC030146 mRNA Translation: AAH30146.1
AF289577 mRNA Translation: AAL55761.1 Frameshift.
CCDSiCCDS10863.1 [Q9H6T0-2]
RefSeqiNP_079215.2, NM_024939.2 [Q9H6T0-2]
UniGeneiHs.436585
Hs.592053

Genome annotation databases

EnsembliENST00000473183; ENSP00000418748; ENSG00000103067 [Q9H6T0-2]
ENST00000565858; ENSP00000454554; ENSG00000103067 [Q9H6T0-1]
GeneIDi80004
KEGGihsa:80004
UCSCiuc002evq.2 human [Q9H6T0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiESRP2_HUMAN
AccessioniPrimary (citable) accession number: Q9H6T0
Secondary accession number(s): Q8N6H8, Q8WZ15, Q9H6I4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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